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Q0GY40

- KBX3_HADGE

UniProt

Q0GY40 - KBX3_HADGE

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Protein

Hge-scorpine

Gene
N/A
Organism
Hadrurus gertschi (Scorpion)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Hge-scorpine has antibacterial activity against B.subtilis, but not against S.aureus. Also has hemolytic and cytolytic activities.1 Publication
Hge36 peptide blocks Kv1.1/KCNA1 (IC50=185 nM) potassium channels. Shows a weak hemolytic activity.1 Publication

GO - Biological processi

  1. cytolysis Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB-KW
  3. defense response to fungus Source: UniProtKB-KW
  4. killing of cells of other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Fungicide, Ion channel impairing toxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Keywords - Biological processi

Cytolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Hge-scorpine
Alternative name(s):
Hg-scorpine-like 1
Short name:
HgeScplp1
Short name:
Hgscplike1
Cleaved into the following chain:
OrganismiHadrurus gertschi (Scorpion)
Taxonomic identifieri380989 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaIuroideaHadrurus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19192 PublicationsAdd
BLAST
Chaini20 – 9576Hge-scorpinePRO_0000274682Add
BLAST
Chaini48 – 9548Hge36PRO_0000356887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 81By similarity
Disulfide bondi68 ↔ 86By similarity
Disulfide bondi72 ↔ 88By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamiPF14866. Toxin_38. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0GY40-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTKLTVLCF LGIVTIVSCG WMSEKKVQGI LDKKLPEGII RNAAKAIVHK
60 70 80 90
MAKNQFGCFA NVDVKGDCKR HCKAEDKEGI CHGTKCKCGV PISYL
Length:95
Mass (Da):10,412
Last modified:October 3, 2006 - v1
Checksum:iEA797C1F58CF6C3C
GO

Mass spectrometryi

Molecular mass is 8370.0 Da from positions 20 - 95. Determined by ESI. 1 Publication
Molecular mass is 8370.0 Da from positions 20 - 95. Determined by MALDI. 1 Publication
Molecular mass is 5294.95 Da from positions 48 - 95. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ465351 mRNA. Translation: ABE98267.1.
EF613116 Genomic DNA. Translation: ABU94956.1.
EL698908 mRNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ465351 mRNA. Translation: ABE98267.1 .
EF613116 Genomic DNA. Translation: ABU94956.1 .
EL698908 mRNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR029237. Long_scorpion_toxin.
[Graphical view ]
Pfami PF14866. Toxin_38. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones)."
    Schwartz E.F., Diego-Garcia E., Rodriguez de la Vega R.C., Possani L.D.
    BMC Genomics 8:119-119(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Venom gland.
  2. "Wide phylogenetic distribution of scorpine and long-chain beta-KTx-like peptides in scorpion venoms: identification of 'orphan' components."
    Diego-Garcia E., Schwartz E.F., D'Suze G., Gonzalez S.A., Batista C.V., Garcia B.I., Rodriguez de la Vega R.C., Possani L.D.
    Peptides 28:31-37(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-64, MASS SPECTROMETRY.
    Tissue: Venom and Venom gland.
  3. "Cytolytic and K+ channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms."
    Diego-Garcia E., Abdel-Mottaleb Y., Schwartz E.F., Rodriguez de la Vega R.C., Tytgat J., Possani L.D.
    Cell. Mol. Life Sci. 65:187-200(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-64, MASS SPECTROMETRY, FUNCTION.

Entry informationi

Entry nameiKBX3_HADGE
AccessioniPrimary (citable) accession number: Q0GY40
Secondary accession number(s): A8SDT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

The C-terminus (AA 52-95) blocks Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.3/KCNA2 potassium channels, showing a potential important role of AA 48-51.
Hge36 peptide does not block Kv1.2/KCNA2 and Kv1.3/KCNA3.1 Publication

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3