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Q0GY40

- KBX3_HADGE

UniProt

Q0GY40 - KBX3_HADGE

Protein

Hge-scorpine

Gene
N/A
Organism
Hadrurus gertschi (Scorpion)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Hge-scorpine has antibacterial activity against B.subtilis, but not against S.aureus. Also has hemolytic and cytolytic activities.1 Publication
    Hge36 peptide blocks Kv1.1/KCNA1 (IC50=185 nM) potassium channels. Shows a weak hemolytic activity.1 Publication

    GO - Biological processi

    1. cytolysis Source: UniProtKB-KW
    2. defense response to bacterium Source: UniProtKB-KW
    3. defense response to fungus Source: UniProtKB-KW
    4. killing of cells of other organism Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Fungicide, Ion channel impairing toxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Keywords - Biological processi

    Cytolysis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hge-scorpine
    Alternative name(s):
    Hg-scorpine-like 1
    Short name:
    HgeScplp1
    Short name:
    Hgscplike1
    Cleaved into the following chain:
    OrganismiHadrurus gertschi (Scorpion)
    Taxonomic identifieri380989 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaIuroideaHadrurus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19192 PublicationsAdd
    BLAST
    Chaini20 – 9576Hge-scorpinePRO_0000274682Add
    BLAST
    Chaini48 – 9548Hge36PRO_0000356887Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 81By similarity
    Disulfide bondi68 ↔ 86By similarity
    Disulfide bondi72 ↔ 88By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR029237. Long_scorpion_toxin.
    [Graphical view]
    PfamiPF14866. Toxin_38. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0GY40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTKLTVLCF LGIVTIVSCG WMSEKKVQGI LDKKLPEGII RNAAKAIVHK   50
    MAKNQFGCFA NVDVKGDCKR HCKAEDKEGI CHGTKCKCGV PISYL 95
    Length:95
    Mass (Da):10,412
    Last modified:October 3, 2006 - v1
    Checksum:iEA797C1F58CF6C3C
    GO

    Mass spectrometryi

    Molecular mass is 8370.0 Da from positions 20 - 95. Determined by ESI. 1 Publication
    Molecular mass is 8370.0 Da from positions 20 - 95. Determined by MALDI. 1 Publication
    Molecular mass is 5294.95 Da from positions 48 - 95. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ465351 mRNA. Translation: ABE98267.1.
    EF613116 Genomic DNA. Translation: ABU94956.1.
    EL698908 mRNA. No translation available.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ465351 mRNA. Translation: ABE98267.1 .
    EF613116 Genomic DNA. Translation: ABU94956.1 .
    EL698908 mRNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR029237. Long_scorpion_toxin.
    [Graphical view ]
    Pfami PF14866. Toxin_38. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones)."
      Schwartz E.F., Diego-Garcia E., Rodriguez de la Vega R.C., Possani L.D.
      BMC Genomics 8:119-119(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Venom gland.
    2. "Wide phylogenetic distribution of scorpine and long-chain beta-KTx-like peptides in scorpion venoms: identification of 'orphan' components."
      Diego-Garcia E., Schwartz E.F., D'Suze G., Gonzalez S.A., Batista C.V., Garcia B.I., Rodriguez de la Vega R.C., Possani L.D.
      Peptides 28:31-37(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-64, MASS SPECTROMETRY.
      Tissue: Venom and Venom gland.
    3. "Cytolytic and K+ channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms."
      Diego-Garcia E., Abdel-Mottaleb Y., Schwartz E.F., Rodriguez de la Vega R.C., Tytgat J., Possani L.D.
      Cell. Mol. Life Sci. 65:187-200(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-64, MASS SPECTROMETRY, FUNCTION.

    Entry informationi

    Entry nameiKBX3_HADGE
    AccessioniPrimary (citable) accession number: Q0GY40
    Secondary accession number(s): A8SDT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    The C-terminus (AA 52-95) blocks Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.3/KCNA2 potassium channels, showing a potential important role of AA 48-51.
    Hge36 peptide does not block Kv1.2/KCNA2 and Kv1.3/KCNA3.1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3