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Protein

Hge-scorpine

Gene
N/A
Organism
Hadrurus gertschi (Scorpion)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hge-scorpine has antibacterial activity against B.subtilis, but not against S.aureus. Also has hemolytic and cytolytic activities.1 Publication
Hge36 peptide blocks Kv1.1/KCNA1 (IC50=185 nM) potassium channels. Shows a weak hemolytic activity.1 Publication

Miscellaneous

The C-terminus (AA 52-95) blocks Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.3/KCNA2 potassium channels, showing a potential important role of AA 48-51.
Hge36 peptide does not block Kv1.2/KCNA2 and Kv1.3/KCNA3.1 Publication

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Fungicide, Ion channel impairing toxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin
Biological processCytolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Hge-scorpine
Alternative name(s):
Hg-scorpine-like 1
Short name:
HgeScplp1
Short name:
Hgscplike1
Cleaved into the following chain:
OrganismiHadrurus gertschi (Scorpion)
Taxonomic identifieri380989 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaIuroideaHadrurus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 192 PublicationsAdd BLAST19
ChainiPRO_000027468220 – 95Hge-scorpineAdd BLAST76
ChainiPRO_000035688748 – 95Hge36Add BLAST48

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 81By similarity
Disulfide bondi68 ↔ 86By similarity
Disulfide bondi72 ↔ 88By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni50 – 52Combined sources3
Beta strandi53 – 55Combined sources3
Helixi68 – 74Combined sources7
Beta strandi77 – 81Combined sources5
Beta strandi86 – 92Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IPONMR-A48-95[»]
5JYHNMR-A52-95[»]
SMRiQ0GY40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR029237. Long_scorpion_toxin.
PfamiView protein in Pfam
PF14866. Toxin_38. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0GY40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTKLTVLCF LGIVTIVSCG WMSEKKVQGI LDKKLPEGII RNAAKAIVHK
60 70 80 90
MAKNQFGCFA NVDVKGDCKR HCKAEDKEGI CHGTKCKCGV PISYL
Length:95
Mass (Da):10,412
Last modified:October 3, 2006 - v1
Checksum:iEA797C1F58CF6C3C
GO

Mass spectrometryi

Molecular mass is 8370.0 Da from positions 20 - 95. Determined by ESI. 1 Publication
Molecular mass is 8370.0 Da from positions 20 - 95. Determined by MALDI. 1 Publication
Molecular mass is 5294.95 Da from positions 48 - 95. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ465351 mRNA. Translation: ABE98267.1.
EF613116 Genomic DNA. Translation: ABU94956.1.
EL698908 mRNA. No translation available.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKBX3_HADGE
AccessioniPrimary (citable) accession number: Q0GY40
Secondary accession number(s): A8SDT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families