Reviewed, UniProtKB/Swiss-Prot Q0GP30 (PAP1_HSPV)

Names and origin

Protein names

Recommended name:
    Poly(A) polymerase catalytic subunit
    EC=2.7.7.19
Alternative name(s):
    Poly(A) polymerase large subunit
      Short name=PAP-L

Gene names

Name:	PAPL
Ordered Locus Names:	HSPV058

Organism

Horsepox virus (HSPV)

Taxonomic identifier

397342 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus

Virus host

Homo sapiens (Human) [TaxID: 9606]
Equus caballus (Horse) [TaxID: 9796]
Bos taurus (Bovine) [TaxID: 9913]

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Polymerase that creates the 3'-poly(A) tail of mRNA's.
Catalytic activity	ATP + RNA(n) = diphosphate + RNA(n+1).
Subunit structure	Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit By similarity.
Sequence similarities	Belongs to the poxviridae poly(A) polymerase catalytic subunit family.

Ontologies

Keywords
Biological process	Transcription mRNA processing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Gene Ontology (GO)
Biological process	mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW polynucleotide adenylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Poly(A) polymerase catalytic subunit		PRO_0000308933
Sites
	Active site	202	1	By similarity
	Active site	204	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0GP30-1 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: BEE615306F051AF5	FASTA	479	55,566
	10 20 30 40 50 60 MNRNPDQNTF PNITLKIIET YLSRVPSVNE YHMLKLQARN IQKITVFNKD IFVSLVKKNK 70 80 90 100 110 120 KRFFSDVNTS ASEIKDRILS YFSKQTQTYN IGKLFTIIEL QSVLVTTYTD ILGVLTIKAP 130 140 150 160 170 180 NVISSKISYN VTSMEELARD MLNSMNVAII DKAKVMGRHN VSSLVKNVNK LMEEYLRRHN 190 200 210 220 230 240 KSCICYGSYS LYLINPNILY GDIDILQTNS RTFLIDLAFL IKFITGNNII LSKIPYLRNY 250 260 270 280 290 300 MVIKDENDNH IIDSFNIRQD TMNVVPKIFI DNIYIVDPTF QLLNMIKMFS QIDRLEDLSK 310 320 330 340 350 360 DPEKFNARMA TMLEYVRYTH GIVFDGKRNN MPMKCIIDEN NRIVTVTTKD YFSFKKCLVY 370 380 390 400 410 420 LDENVLSSDI LDLNADTSCD FESVTNSVYL IHDNIMYTYF SNTILLSDKG KVHEISARGL 430 440 450 460 470 CAHILLYQML TSGEYKQCLS DLLNSMMNRD KIPIYSHTER DKKPGRHGFI NIEKDIIVF

References

[1]	"Genome of horsepox virus." Tulman E.R., Delhon G., Afonso C.L., Lu Z., Zsak L., Sandybaev N.T., Kerembekova U.Z., Zaitsev V.L., Kutish G.F., Rock D.L. J. Virol. 80:9244-9258(2006) [PubMed: 16940536] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MNR-76.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ792504 Genomic DNA. Translation: ABH08161.1.
3D structure databases
SMR	Q0GP30. Positions 12-479.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.7.19. 305723.
Family and domain databases
InterPro	IPR004976. PolyA_pol_cat_poxviral. [Graphical view]
Pfam	PF03296. Pox_polyA_pol. 1 hit. [Graphical view]
PIRSF	PIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PAP1_HSPV

Accession

Primary (citable) accession number: Q0GP30

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 3, 2006
Last modified:	June 16, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)