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Q0GNE1

- CISY_AMBCR

UniProt

Q0GNE1 - CISY_AMBCR

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Protein
Citrate synthase, mitochondrial
Gene
CS
Organism
Amblyrhynchus cristatus (Galapagos marine iguana)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei304 – 3041 By similarity
Active sitei350 – 3501 By similarity
Active sitei405 – 4051 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.1)
Alternative name(s):
Citrate (Si)-synthase
Gene namesi
Name:CS
OrganismiAmblyrhynchus cristatus (Galapagos marine iguana)
Taxonomic identifieri51208 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaIguanidaeIguaninaeAmblyrhynchus

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131Mitochondrion By similarity
Add
BLAST
Chaini32 – 469438Citrate synthase, mitochondrial
PRO_0000253900Add
BLAST

Proteomic databases

PRIDEiQ0GNE1.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ0GNE1.
SMRiQ0GNE1. Positions 33-460.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG005336.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0GNE1-1 [UniParc]FASTAAdd to Basket

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MTLLTASSRA AARLLGAKNS SCIIFAARHA STSTNLKDVL ANMIPKEQAR    50
IKSFRQQYGS TVIGQITVDM LYGGMRGMKG LIYETSVLDP DEGIRFRGYS 100
IPECQKLLPK APGGAEPLPE GLFWLLVTGE IPSQEQVNWV SREWAKRAAL 150
PSHVVTMLDN FPTNLHPMSQ LSAAVTALNS ESTFARAYSE GISRTKYWEF 200
IYEDSMDLIA KLPCIAAKIY RNLYREGSSI GAIDPALDWS HNFTNMLGYT 250
DTQFIELMRL YLTIHSDHEG GNVSAHTSHL VGSALSDPYL AFAAAMNGLA 300
GPLHGLANQE VLVWLTNLQK ELGEDVSDQK LRDFIWNTLN SGRVVPGYGH 350
AVLRKTDPRY TCQREFALKH LPKDPLFKLV AQLYKIVPNV LLEQGKAKNP 400
WPNVDAHSGV LLQYYGMKEM NYYTVLFGVS RALGVLSQLI WSRALGFPLE 450
RPKSMSTDGL MVLVGAKSV 469
Length:469
Mass (Da):52,003
Last modified:October 3, 2006 - v1
Checksum:i8216158BB22D9A27
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ829807 mRNA. Translation: ABI21881.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ829807 mRNA. Translation: ABI21881.1 .

3D structure databases

ProteinModelPortali Q0GNE1.
SMRi Q0GNE1. Positions 33-460.
ModBasei Search...

Proteomic databases

PRIDEi Q0GNE1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005336.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Temperature adaptation in muscle-type lactate dehydrogenase and citrate synthase of Amblyrhynchus cristatus, the Galapagos marine iguana."
    Fields P.A., Strothers C.M.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCISY_AMBCR
AccessioniPrimary (citable) accession number: Q0GNE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 3, 2006
Last modified: May 14, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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