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Q0GNE1 (CISY_AMBCR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase, mitochondrial

EC=2.3.3.1
Gene names
Name:CS
OrganismAmblyrhynchus cristatus (Galapagos marine iguana)
Taxonomic identifier51208 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaIguanidaeIguaninaeAmblyrhynchus

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3131Mitochondrion By similarity
Chain32 – 469438Citrate synthase, mitochondrial
PRO_0000253900

Sites

Active site3041 By similarity
Active site3501 By similarity
Active site4051 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0GNE1 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 8216158BB22D9A27

FASTA46952,003
        10         20         30         40         50         60 
MTLLTASSRA AARLLGAKNS SCIIFAARHA STSTNLKDVL ANMIPKEQAR IKSFRQQYGS 

        70         80         90        100        110        120 
TVIGQITVDM LYGGMRGMKG LIYETSVLDP DEGIRFRGYS IPECQKLLPK APGGAEPLPE 

       130        140        150        160        170        180 
GLFWLLVTGE IPSQEQVNWV SREWAKRAAL PSHVVTMLDN FPTNLHPMSQ LSAAVTALNS 

       190        200        210        220        230        240 
ESTFARAYSE GISRTKYWEF IYEDSMDLIA KLPCIAAKIY RNLYREGSSI GAIDPALDWS 

       250        260        270        280        290        300 
HNFTNMLGYT DTQFIELMRL YLTIHSDHEG GNVSAHTSHL VGSALSDPYL AFAAAMNGLA 

       310        320        330        340        350        360 
GPLHGLANQE VLVWLTNLQK ELGEDVSDQK LRDFIWNTLN SGRVVPGYGH AVLRKTDPRY 

       370        380        390        400        410        420 
TCQREFALKH LPKDPLFKLV AQLYKIVPNV LLEQGKAKNP WPNVDAHSGV LLQYYGMKEM 

       430        440        450        460 
NYYTVLFGVS RALGVLSQLI WSRALGFPLE RPKSMSTDGL MVLVGAKSV 

« Hide

References

[1]"Temperature adaptation in muscle-type lactate dehydrogenase and citrate synthase of Amblyrhynchus cristatus, the Galapagos marine iguana."
Fields P.A., Strothers C.M.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ829807 mRNA. Translation: ABI21881.1.

3D structure databases

ProteinModelPortalQ0GNE1.
SMRQ0GNE1. Positions 33-460.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ0GNE1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG005336.

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01793. cit_synth_euk. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_AMBCR
AccessionPrimary (citable) accession number: Q0GNE1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 3, 2006
Last modified: October 16, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways