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Q0GNE0

- CISY_IGUIG

UniProt

Q0GNE0 - CISY_IGUIG

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Protein

Citrate synthase, mitochondrial

Gene

CS

Organism
Iguana iguana (Common iguana)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei304 – 3041PROSITE-ProRule annotation
Active sitei350 – 3501PROSITE-ProRule annotation
Active sitei405 – 4051PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.1)
Alternative name(s):
Citrate (Si)-synthase
Gene namesi
Name:CS
OrganismiIguana iguana (Common iguana)
Taxonomic identifieri8517 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaIguanidaeIguaninaeIguana

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131MitochondrionBy similarityAdd
BLAST
Chaini32 – 469438Citrate synthase, mitochondrialPRO_0000253901Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ0GNE0.
SMRiQ0GNE0. Positions 33-460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG005336.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0GNE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLLTASSRA AARLLGAKNS SCIIFAARHA STSTNLKDVL ANMIPKEQAR
60 70 80 90 100
IKSFRQQYGS TVIGQITVDM LYGGMRGMKG LIYETSVLDP DEGIRFRGYS
110 120 130 140 150
IPECQKLLPK APGGAEPLPE GLFWLLVTGE IPSQEQVNWV SREWAKRAAL
160 170 180 190 200
PSHVVTMLDN FPTNLHPMSQ LSAAVTALNS ESTFARAYSE GISRTKYWEF
210 220 230 240 250
IYEDSMDLIA KLPCIAAKIY RNLYREGSSI GAIDPALDWS HNFTNMLGYT
260 270 280 290 300
DPQFIELMRL YLTIHSDHEG GNVSAHTSHL VGSALSDPYL AFAAAMNGLA
310 320 330 340 350
GPLHGLANQE VLVWLTNLQK ELGEDVSDQK LRDFIWNTLN SGRVVPGYGH
360 370 380 390 400
AVLRKTDPRY TCQREFALKH LPKDPLFKLV AQLYKIVPNV LLEQGKAKNP
410 420 430 440 450
WPNVDAHSGV LLQYYGMKEM NYYTVLFGVS RALGVLSQLI WSRALGFPLE
460
RPKSMSTDGL MVLVGAKSG
Length:469
Mass (Da):51,957
Last modified:October 3, 2006 - v1
Checksum:i40C89727DCADD889
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ829808 mRNA. Translation: ABI21882.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ829808 mRNA. Translation: ABI21882.1 .

3D structure databases

ProteinModelPortali Q0GNE0.
SMRi Q0GNE0. Positions 33-460.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005336.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Temperature adaptation in muscle-type lactate dehydrogenase and citrate synthase of Amblyrhynchus cristatus, the Galapagos marine iguana."
    Fields P.A., Strothers C.M.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCISY_IGUIG
AccessioniPrimary (citable) accession number: Q0GNE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 3, 2006
Last modified: October 1, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3