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Protein
Submitted name:

Interleukin 2

Gene

IL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 2Imported
Submitted name:
Interleukin-2Imported
Gene namesi
Name:IL2Imported
ORF Names:hCG_38828Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA195.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500877915621 – 153Sequence analysisAdd BLAST133

Expressioni

Gene expression databases

BgeeiENSG00000109471.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000226730.

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
HOVERGENiHBG007496.
KOiK05429.
OMAiLMSNINV.
OrthoDBiEOG091G0VTZ.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0GK43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN
60 70 80 90 100
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL
110 120 130 140 150
RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS

TLT
Length:153
Mass (Da):17,628
Last modified:October 3, 2006 - v1
Checksum:i59E2F40F25860F84
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei153Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ861285 mRNA. Translation: ABI20697.1.
AB451325 mRNA. Translation: BAG70139.1.
AB451454 mRNA. Translation: BAG70268.1.
CH471056 Genomic DNA. Translation: EAX05227.1.
RefSeqiNP_000577.2. NM_000586.3.
UniGeneiHs.89679.

Genome annotation databases

GeneIDi3558.
KEGGihsa:3558.
UCSCiuc003ier.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ861285 mRNA. Translation: ABI20697.1.
AB451325 mRNA. Translation: BAG70139.1.
AB451454 mRNA. Translation: BAG70268.1.
CH471056 Genomic DNA. Translation: EAX05227.1.
RefSeqiNP_000577.2. NM_000586.3.
UniGeneiHs.89679.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000226730.

Protocols and materials databases

DNASUi3558.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3558.
KEGGihsa:3558.
UCSCiuc003ier.4. human.

Organism-specific databases

CTDi3558.
PharmGKBiPA195.

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
HOVERGENiHBG007496.
KOiK05429.
OMAiLMSNINV.
OrthoDBiEOG091G0VTZ.

Miscellaneous databases

ChiTaRSiIL2. human.
GenomeRNAii3558.

Gene expression databases

BgeeiENSG00000109471.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ0GK43_HUMAN
AccessioniPrimary (citable) accession number: Q0GK43
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.