Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-2

Gene

IL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation
Biological processAdaptive immunityUniRule annotation, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2UniRule annotation
Short name:
IL-2UniRule annotation
Gene namesi
Name:IL2UniRule annotationImported
ORF Names:hCG_38828Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA195.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_500999837221 – 153Interleukin-2UniRule annotationAdd BLAST133

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000109471.
ExpressionAtlasiQ0GK43. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ0GK43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
HOVERGENiHBG007496.
KOiK05429.
OMAiKWITFCQ.
OrthoDBiEOG091G0VTZ.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
PANTHERiPTHR10078:SF32. PTHR10078:SF32. 1 hit.
PfamiView protein in Pfam
PF00715. IL2. 1 hit.
PRINTSiPR00265. INTERLEUKIN2.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649. Interleukin-2. 1 hit.
SMARTiView protein in SMART
SM00189. IL2. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00424. INTERLEUKIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0GK43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN
60 70 80 90 100
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL
110 120 130 140 150
RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS

TLT
Length:153
Mass (Da):17,628
Last modified:October 3, 2006 - v1
Checksum:i59E2F40F25860F84
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei153Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ861285 mRNA. Translation: ABI20697.1.
AB451325 mRNA. Translation: BAG70139.1.
AB451454 mRNA. Translation: BAG70268.1.
CH471056 Genomic DNA. Translation: EAX05227.1.
RefSeqiNP_000577.2. NM_000586.3.
UniGeneiHs.89679.

Genome annotation databases

GeneIDi3558.
KEGGihsa:3558.
UCSCiuc003ier.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ0GK43_HUMAN
AccessioniPrimary (citable) accession number: Q0GK43
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 5, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.