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Protein

Interleukin-2

Gene

IL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation
Biological processAdaptive immunityUniRule annotation, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2UniRule annotation
Short name:
IL-2UniRule annotation
Gene namesi
Name:IL2UniRule annotationImported
ORF Names:hCG_38828Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000109471.4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA195

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_501420571921 – 153Interleukin-2UniRule annotationAdd BLAST133

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000109471

Interactioni

GO - Molecular functioni

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili76 – 96Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the IL-2 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J049 Eukaryota
ENOG41119SF LUCA
HOVERGENiHBG007496
KOiK05429
OMAiKWITFCQ
OrthoDBiEOG091G0VTZ

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000779 IL-2
IPR030477 IL-2_CS
PANTHERiPTHR45426 PTHR45426, 1 hit
PfamiView protein in Pfam
PF00715 IL2, 1 hit
PRINTSiPR00265 INTERLEUKIN2
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649 Interleukin-2, 1 hit
SMARTiView protein in SMART
SM00189 IL2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00424 INTERLEUKIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q0GK43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN
60 70 80 90 100
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL
110 120 130 140 150
RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS

TLT
Length:153
Mass (Da):17,628
Last modified:October 3, 2006 - v1
Checksum:i59E2F40F25860F84
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei153Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ861285 mRNA Translation: ABI20697.1
AB451325 mRNA Translation: BAG70139.1
AB451454 mRNA Translation: BAG70268.1
CH471056 Genomic DNA Translation: EAX05227.1
RefSeqiNP_000577.2, NM_000586.3
UniGeneiHs.89679

Genome annotation databases

GeneIDi3558
KEGGihsa:3558
UCSCiuc003ier.4 human

Similar proteinsi

Entry informationi

Entry nameiQ0GK43_HUMAN
AccessioniPrimary (citable) accession number: Q0GK43
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health