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Protein

Zinc finger protein 541

Gene

Znf541

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 221C2H2-type 3PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri838 – 860C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1301 – 1323C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 541
Alternative name(s):
Spermatogenic cell HDAC-interacting protein 11 Publication
Gene namesi
Name:Znf541
Synonyms:Ship11 Publication, Zfp541
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3647699. Zfp541.

Subcellular locationi

GO - Cellular componenti

  • histone deacetylase complex Source: UniProtKB
  • nucleus Source: UniProtKB
  • transcription factor complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003615451 – 1363Zinc finger protein 541Add BLAST1363

Proteomic databases

PaxDbiQ0GGX2.
PRIDEiQ0GGX2.

PTM databases

iPTMnetiQ0GGX2.
PhosphoSitePlusiQ0GGX2.

Expressioni

Tissue specificityi

Germ-cell-specific. Specifically present in testicular spermatogenic cells, but not in testicular and mature sperm. During spermatogenesis, it is present in spermatocytes and round spermatids only (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000078796.
GenevisibleiQ0GGX2. MM.

Interactioni

Subunit structurei

Interacts with DNTTIP1 (PubMed:18849567). Identified in a complex with KCDT19, HDAC1 and HSPA2 (PubMed:18849567). Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ0GGX2. 1 interactor.
MINTiMINT-8174128.
STRINGi10090.ENSMUSP00000104149.

Structurei

3D structure databases

ProteinModelPortaliQ0GGX2.
SMRiQ0GGX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1063 – 1155ELM2PROSITE-ProRule annotationAdd BLAST93
Domaini1170 – 1221SANTPROSITE-ProRule annotationAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1345 – 1353Poly-Glu9

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 1 SANT domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 221C2H2-type 3PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri838 – 860C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1301 – 1323C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
KOG4167. Eukaryota.
ENOG4110BKZ. LUCA.
GeneTreeiENSGT00530000063277.
HOGENOMiHOG000155802.
HOVERGENiHBG108770.
InParanoidiQ0GGX2.
OMAiERKHVCK.
OrthoDBiEOG091G01H7.
PhylomeDBiQ0GGX2.
TreeFamiTF106431.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0GGX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPYSLGEEG ALPSEGHLPS FSESQVLNCS DTLNRDLGPS TRDLLYAGLS
60 70 80 90 100
GLDLDPSLST SDMPSEVLED NLDTLSLYSG KDSDSVKLLE EYADSESQTS
110 120 130 140 150
LQDLGLGALK VPKEADEGGR ATGSTRKGKR QHSSPQNPLL DCSLCGKVFS
160 170 180 190 200
SASSLSKHYL THSQERKHVC KVCSKAFKRQ DHLTGHMLTH QKTKPFVCIE
210 220 230 240 250
QGCSKSYCDY RSLRRHYEVQ HGVCILKETP PEEEAYGDPT HNHDVANQPP
260 270 280 290 300
PSGLRSLGPP EARSPGSVLP NRDLLRCIVS SIVHQKIPSP GPAVGPSDTE
310 320 330 340 350
ARSSACACPT SLGSSSCTPA STPVALGTLG SEIPEETHPP RKEAATEVFT
360 370 380 390 400
PVQSRAAENG VPDPPESELE SESPRLQRPS SLEGWPEGSS LPACLPLFRG
410 420 430 440 450
HSVPSGSQPS SHNFQWLRNL PGCPKNKGSN VFMVHKPPAV ASREGSEGGG
460 470 480 490 500
SGPSSTPTSV EPSPSLGTTQ EELLPFPPAL LKAPGEASSE VRQAAGEDET
510 520 530 540 550
WAPKKCKPDC ESFPWQSPTE LGLQDAQNPG GLPSDATPLF RQLFMKSQES
560 570 580 590 600
LVSHEQMQVL QMIAKSQRIF SHTQVATASA QRPGPEGKQS TLKPLQGPWP
610 620 630 640 650
PQTLPPAPTV DSFQIGPGHS EPEGSPVRRR KTMPAVSRET SPGGPRRDTK
660 670 680 690 700
GGPKVASAPP SLTGPGLLPS RNPDSSSLAK GTLDLGDIIP NAGSRQSQLG
710 720 730 740 750
GDEPAGTQLV GKQGQGENGL ASGAMRGEKG PACPRGGGYR LFSGHPRAQR
760 770 780 790 800
FSGFRKEKVK MDVCCAASPS QVAMASFSSA GPLADPPRDM KSKLTIFNRI
810 820 830 840 850
QGGNIYRLPH PVKEESLAGG CHQPNGGPTD WMESKSTFVC KNCSQMFYTE
860 870 880 890 900
KGLSSHMCFH SDQWPSPRGK QEQQVKGQMV ASVKRKAGRE EGAVEDMKRH
910 920 930 940 950
YDCSSSEPQD VTILSMLVSS GSCGVTPVVL SSLLQGQEKD GEERDSKESC
960 970 980 990 1000
QYRKRKKRPQ PKALFAPPAP SALGEPGPGG CHQSCLHSPV FLVDHLLKGL
1010 1020 1030 1040 1050
FQCSPYTPPP MLSPIREGSG LYFNTLCSTS RAGPHLISPV LDQVDSSFGI
1060 1070 1080 1090 1100
CVVKDDTKIS IEPHINVGSR FQAEIPELQE RLLARVDENV ASLVWKPWGD
1110 1120 1130 1140 1150
VMTNPETQDR VMELCNVACS SVMPGGGTNL ELALHCLHDA QGSVQVALET
1160 1170 1180 1190 1200
LLLRGPQKPR THPLADYRYT GSDIWTPMEK RLFKKAFCAH KKDFYLIHKM
1210 1220 1230 1240 1250
IQTKSVAQCV EYYYIWKKMV KFDCGRAPGL EKRGRRELDE VERTEDKVTC
1260 1270 1280 1290 1300
SPRERPTHRP TPELKIKTKS YRRESILHSS PSAAPKRTPE PPGSVESQGV
1310 1320 1330 1340 1350
FPCRECERVF DKIKSRNAHM KRHRLQEHVE PVRVKWPVKP YPLKEEEEEE
1360
EEELGADMGP LQW
Length:1,363
Mass (Da):148,297
Last modified:October 3, 2006 - v1
Checksum:iBAE2FD52F1E72934
GO
Isoform 2 (identifier: Q0GGX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     874-934: Missing.

Note: No experimental confirmation available.
Show »
Length:1,302
Mass (Da):141,833
Checksum:i3F8D9850A84EE539
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26V → G in AAI57963 (PubMed:15489334).Curated1
Sequence conflicti1200M → T in AAI57963 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036221874 – 934Missing in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ864732 mRNA. Translation: ABI17929.1.
BC157962 mRNA. Translation: AAI57963.1.
CCDSiCCDS39781.1. [Q0GGX2-1]
RefSeqiNP_001092747.1. NM_001099277.1. [Q0GGX2-1]
XP_006540359.1. XM_006540296.3. [Q0GGX2-2]
UniGeneiMm.290718.

Genome annotation databases

EnsembliENSMUST00000108509; ENSMUSP00000104149; ENSMUSG00000078796. [Q0GGX2-1]
ENSMUST00000209369; ENSMUSP00000147475; ENSMUSG00000078796. [Q0GGX2-1]
ENSMUST00000210805; ENSMUSP00000148143; ENSMUSG00000078796. [Q0GGX2-2]
GeneIDi666528.
KEGGimmu:666528.
UCSCiuc009fgv.1. mouse. [Q0GGX2-1]
uc012fab.1. mouse. [Q0GGX2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ864732 mRNA. Translation: ABI17929.1.
BC157962 mRNA. Translation: AAI57963.1.
CCDSiCCDS39781.1. [Q0GGX2-1]
RefSeqiNP_001092747.1. NM_001099277.1. [Q0GGX2-1]
XP_006540359.1. XM_006540296.3. [Q0GGX2-2]
UniGeneiMm.290718.

3D structure databases

ProteinModelPortaliQ0GGX2.
SMRiQ0GGX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ0GGX2. 1 interactor.
MINTiMINT-8174128.
STRINGi10090.ENSMUSP00000104149.

PTM databases

iPTMnetiQ0GGX2.
PhosphoSitePlusiQ0GGX2.

Proteomic databases

PaxDbiQ0GGX2.
PRIDEiQ0GGX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108509; ENSMUSP00000104149; ENSMUSG00000078796. [Q0GGX2-1]
ENSMUST00000209369; ENSMUSP00000147475; ENSMUSG00000078796. [Q0GGX2-1]
ENSMUST00000210805; ENSMUSP00000148143; ENSMUSG00000078796. [Q0GGX2-2]
GeneIDi666528.
KEGGimmu:666528.
UCSCiuc009fgv.1. mouse. [Q0GGX2-1]
uc012fab.1. mouse. [Q0GGX2-2]

Organism-specific databases

CTDi666528.
MGIiMGI:3647699. Zfp541.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
KOG4167. Eukaryota.
ENOG4110BKZ. LUCA.
GeneTreeiENSGT00530000063277.
HOGENOMiHOG000155802.
HOVERGENiHBG108770.
InParanoidiQ0GGX2.
OMAiERKHVCK.
OrthoDBiEOG091G01H7.
PhylomeDBiQ0GGX2.
TreeFamiTF106431.

Miscellaneous databases

PROiQ0GGX2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078796.
GenevisibleiQ0GGX2. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN541_MOUSE
AccessioniPrimary (citable) accession number: Q0GGX2
Secondary accession number(s): B2RXS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.