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Q0GE19 (NTCP7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/bile acid cotransporter 7
Alternative name(s):
Na(+)/bile acid cotransporter 7
Solute carrier family 10 member 7
Gene names
Name:SLC10A7
Synonyms:C4orf13, P7
ORF Names:PSEC0051
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the unknown BART superfamily-1 (UBS1) (TC 2.A.93) family. [View classification]

Sequence caution

The sequence BAC11571.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processIon transport
Sodium transport
Symport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsodium ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionsymporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q0GE19-1)

Also known as: C;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q0GE19-2)

Also known as: A;

The sequence of this isoform differs from the canonical sequence as follows:
     332-358: KLLQTRGPLANLNNPEGLEYLSIKFGH → GVKLTRPTV
Isoform 3 (identifier: Q0GE19-3)

The sequence of this isoform differs from the canonical sequence as follows:
     133-145: Missing.
     332-358: KLLQTRGPLANLNNPEGLEYLSIKFGH → GVKLTRPTV
Isoform 4 (identifier: Q0GE19-4)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     186-186: I → E
     187-358: Missing.
Isoform 5 (identifier: Q0GE19-5)

The sequence of this isoform differs from the canonical sequence as follows:
     146-159: GIVITPLLLLLFLG → VSKHSLTCLLQLLL
     160-358: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: Q0GE19-6)

The sequence of this isoform differs from the canonical sequence as follows:
     62-62: E → L
     65-358: Missing.
Note: No experimental confirmation available.
Isoform 7 (identifier: Q0GE19-7)

The sequence of this isoform differs from the canonical sequence as follows:
     62-85: ELTSALVHLKLHLFIQIFTLAFFP → FADSRLHASACVFCSDFNQGSWWK
     86-358: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Sodium/bile acid cotransporter 7
PRO_0000278250

Regions

Transmembrane11 – 3121Helical; Potential
Transmembrane38 – 5821Helical; Potential
Transmembrane72 – 9221Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane139 – 15921Helical; Potential
Transmembrane164 – 18421Helical; Potential
Transmembrane202 – 22221Helical; Potential
Transmembrane235 – 25521Helical; Potential
Transmembrane271 – 29121Helical; Potential
Transmembrane299 – 31921Helical; Potential

Natural variations

Alternative sequence62 – 8524ELTSA…LAFFP → FADSRLHASACVFCSDFNQG SWWK in isoform 7.
VSP_023215
Alternative sequence621E → L in isoform 6.
VSP_023216
Alternative sequence65 – 358294Missing in isoform 6.
VSP_023217
Alternative sequence86 – 358273Missing in isoform 7.
VSP_023218
Alternative sequence133 – 14513Missing in isoform 3.
VSP_023219
Alternative sequence146 – 15914GIVIT…LLFLG → VSKHSLTCLLQLLL in isoform 5.
VSP_023220
Alternative sequence160 – 358199Missing in isoform 5.
VSP_023221
Alternative sequence1861I → E in isoform 4.
VSP_023222
Alternative sequence187 – 358172Missing in isoform 4.
VSP_023223
Alternative sequence332 – 35827KLLQT…IKFGH → GVKLTRPTV in isoform 2 and isoform 3.
VSP_023224

Experimental info

Sequence conflict2961H → Y in BAC11571. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (C) [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: D23352F5F3990822

FASTA35839,485
        10         20         30         40         50         60 
MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI FFNSGLSLKT 

        70         80         90        100        110        120 
EELTSALVHL KLHLFIQIFT LAFFPATIWL FLQLLSITPI NEWLLKGLQT VGCMPPPVSS 

       130        140        150        160        170        180 
AVILTKAVGG NEAAAIFNSA FGSFLGIVIT PLLLLLFLGS SSSVPFTSIF SQLFMTVVVP 

       190        200        210        220        230        240 
LIIGQIVRRY IKDWLERKKP PFGAISSSVL LMIIYTTFCD TFSNPNIDLD KFSLVLILFI 

       250        260        270        280        290        300 
IFSIQLSFML LTFIFSTRNN SGFTPADTVA IIFCSTHKSL TLGIPMLKIV FAGHEHLSLI 

       310        320        330        340        350 
SVPLLIYHPA QILLGSVLVP TIKSWMVSRQ KKLLQTRGPL ANLNNPEGLE YLSIKFGH 

« Hide

Isoform 2 (A) [UniParc].

Checksum: B9D4F4FFAF6DC9DF
Show »

FASTA34037,432
Isoform 3 [UniParc].

Checksum: 865D59F098CD5C7C
Show »

FASTA32736,134
Isoform 4 (B) [UniParc].

Checksum: 6B62BA3395691D22
Show »

FASTA18620,093
Isoform 5 [UniParc].

Checksum: F92AC92F76B5F229
Show »

FASTA15917,283
Isoform 6 [UniParc].

Checksum: 14DD8861CECDB2CF
Show »

FASTA646,978
Isoform 7 [UniParc].

Checksum: DA0C615FA70F592B
Show »

FASTA859,396

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel human C4orf13 gene, tentatively a member of the sodium bile acid cotransporter family."
Zou X., Wang D., Qiu G., Ji C., Jin F., Wu M., Zheng H., Li X., Sun L., Wang Y., Tang R., Zhao R.C., Mao Y.
Biochem. Genet. 43:165-173(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[2]"Cloning of P7 from human heart."
Godoy J.R., Geyer J., Petzinger E.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 4).
Tissue: Heart.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Heart.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 5; 6 AND 7).
Tissue: Prostate.
[6]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-145.
Tissue: Kidney.
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-358 (ISOFORM 2).
Tissue: Teratocarcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY346324 mRNA. Translation: AAQ84722.1.
DQ122860 mRNA. Translation: AAZ32256.1.
DQ122861 mRNA. Translation: AAZ32257.1.
DQ871036 mRNA. Translation: ABI31650.1.
CR933647 mRNA. Translation: CAI45948.1.
CH471056 Genomic DNA. Translation: EAX05026.1.
BC023288 mRNA. Translation: AAH23288.1.
BC063471 mRNA. Translation: AAH63471.1.
BC120971 mRNA. Translation: AAI20972.1.
BC127626 mRNA. Translation: AAI27627.1.
BC127627 mRNA. Translation: AAI27628.1.
BC120970 mRNA. Translation: AAI20971.1.
BC148252 mRNA. Translation: AAI48253.1.
BC150308 mRNA. Translation: AAI50309.1.
AL136728 mRNA. Translation: CAB66662.2.
AK075364 mRNA. Translation: BAC11571.1. Different initiation.
RefSeqNP_001025169.1. NM_001029998.3.
NP_115504.1. NM_032128.3.
XP_005263333.1. XM_005263276.1.
UniGeneHs.659209.

3D structure databases

ProteinModelPortalQ0GE19.
SMRQ0GE19. Positions 47-214.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4721825.

Protein family/group databases

TCDB2.A.93.1.1. the unknown bart superfamily-1 (ubs1) family.

PTM databases

PhosphoSiteQ0GE19.

Polymorphism databases

DMDM121946408.

Proteomic databases

PRIDEQ0GE19.

Protocols and materials databases

DNASU84068.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264986; ENSP00000264986; ENSG00000120519. [Q0GE19-7]
ENST00000335472; ENSP00000334594; ENSG00000120519. [Q0GE19-2]
ENST00000394059; ENSP00000377623; ENSG00000120519. [Q0GE19-5]
ENST00000394062; ENSP00000377626; ENSG00000120519. [Q0GE19-1]
ENST00000432059; ENSP00000411297; ENSG00000120519. [Q0GE19-3]
ENST00000502607; ENSP00000422577; ENSG00000120519. [Q0GE19-6]
ENST00000507030; ENSP00000421275; ENSG00000120519. [Q0GE19-1]
ENST00000511374; ENSP00000421603; ENSG00000120519. [Q0GE19-7]
GeneID84068.
KEGGhsa:84068.
UCSCuc003ikr.2. human. [Q0GE19-2]
uc003ikt.3. human. [Q0GE19-5]
uc010ioz.2. human. [Q0GE19-1]
uc010ipa.2. human. [Q0GE19-3]

Organism-specific databases

CTD84068.
GeneCardsGC04M147175.
H-InvDBHIX0004549.
HGNCHGNC:23088. SLC10A7.
HPAHPA039996.
MIM611459. gene.
neXtProtNX_Q0GE19.
PharmGKBPA162403478.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0385.
HOVERGENHBG082064.
InParanoidQ0GE19.
KOK14347.
OMAEITAVFC.
OrthoDBEOG78H3TG.
PhylomeDBQ0GE19.
TreeFamTF329411.

Gene expression databases

ArrayExpressQ0GE19.
BgeeQ0GE19.
GenevestigatorQ0GE19.

Family and domain databases

InterProIPR016833. Put_Na-Bile_cotransptr.
[Graphical view]
PANTHERPTHR18640. PTHR18640. 1 hit.
PfamPF13593. DUF4137. 1 hit.
[Graphical view]
PIRSFPIRSF026166. UCP026166. 1 hit.
ProtoNetSearch...

Other

GeneWikiSLC10A7.
GenomeRNAi84068.
NextBio73253.
PROQ0GE19.
SOURCESearch...

Entry information

Entry nameNTCP7_HUMAN
AccessionPrimary (citable) accession number: Q0GE19
Secondary accession number(s): A7E2E6 expand/collapse secondary AC list , A7MAX9, Q0VAP9, Q45NG1, Q45NG2, Q5H9S6, Q6P4E6, Q8IZ62, Q8NBP8, Q9H0M9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 3, 2006
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM