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Protein

Sodium/bile acid cotransporter 7

Gene

SLC10A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.28.3.1. the bile acid:na(+) symporter (bass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter 7
Alternative name(s):
Na(+)/bile acid cotransporter 7
Solute carrier family 10 member 7
Gene namesi
Name:SLC10A7
Synonyms:C4orf13, P7
ORF Names:PSEC0051
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:23088. SLC10A7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84068.
OpenTargetsiENSG00000120519.
PharmGKBiPA162403478.

Polymorphism and mutation databases

BioMutaiSLC10A7.
DMDMi121946408.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002782501 – 358Sodium/bile acid cotransporter 7Add BLAST358

Proteomic databases

MaxQBiQ0GE19.
PaxDbiQ0GE19.
PeptideAtlasiQ0GE19.
PRIDEiQ0GE19.

PTM databases

iPTMnetiQ0GE19.
PhosphoSitePlusiQ0GE19.

Expressioni

Gene expression databases

BgeeiENSG00000120519.
GenevisibleiQ0GE19. HS.

Organism-specific databases

HPAiHPA039996.
HPA057906.

Interactioni

Protein-protein interaction databases

BioGridi123863. 11 interactors.
MINTiMINT-4721825.
STRINGi9606.ENSP00000334594.

Structurei

3D structure databases

ProteinModelPortaliQ0GE19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4821. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00390000011932.
HOVERGENiHBG082064.
InParanoidiQ0GE19.
KOiK14347.
OMAiFFFYGLK.
OrthoDBiEOG091G0GR7.
PhylomeDBiQ0GE19.
TreeFamiTF329411.

Family and domain databases

InterProiIPR016833. Put_Na-Bile_cotransptr.
[Graphical view]
PANTHERiPTHR18640. PTHR18640. 1 hit.
PfamiPF13593. SBF_like. 1 hit.
[Graphical view]
PIRSFiPIRSF026166. UCP026166. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0GE19-1) [UniParc]FASTAAdd to basket
Also known as: C

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI
60 70 80 90 100
FFNSGLSLKT EELTSALVHL KLHLFIQIFT LAFFPATIWL FLQLLSITPI
110 120 130 140 150
NEWLLKGLQT VGCMPPPVSS AVILTKAVGG NEAAAIFNSA FGSFLGIVIT
160 170 180 190 200
PLLLLLFLGS SSSVPFTSIF SQLFMTVVVP LIIGQIVRRY IKDWLERKKP
210 220 230 240 250
PFGAISSSVL LMIIYTTFCD TFSNPNIDLD KFSLVLILFI IFSIQLSFML
260 270 280 290 300
LTFIFSTRNN SGFTPADTVA IIFCSTHKSL TLGIPMLKIV FAGHEHLSLI
310 320 330 340 350
SVPLLIYHPA QILLGSVLVP TIKSWMVSRQ KKLLQTRGPL ANLNNPEGLE

YLSIKFGH
Length:358
Mass (Da):39,485
Last modified:October 3, 2006 - v1
Checksum:iD23352F5F3990822
GO
Isoform 2 (identifier: Q0GE19-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     332-358: KLLQTRGPLANLNNPEGLEYLSIKFGH → GVKLTRPTV

Show »
Length:340
Mass (Da):37,432
Checksum:iB9D4F4FFAF6DC9DF
GO
Isoform 3 (identifier: Q0GE19-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-145: Missing.
     332-358: KLLQTRGPLANLNNPEGLEYLSIKFGH → GVKLTRPTV

Show »
Length:327
Mass (Da):36,134
Checksum:i865D59F098CD5C7C
GO
Isoform 4 (identifier: Q0GE19-4) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     186-186: I → E
     187-358: Missing.

Show »
Length:186
Mass (Da):20,093
Checksum:i6B62BA3395691D22
GO
Isoform 5 (identifier: Q0GE19-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-159: GIVITPLLLLLFLG → VSKHSLTCLLQLLL
     160-358: Missing.

Note: No experimental confirmation available.
Show »
Length:159
Mass (Da):17,283
Checksum:iF92AC92F76B5F229
GO
Isoform 6 (identifier: Q0GE19-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-62: E → L
     65-358: Missing.

Note: No experimental confirmation available.
Show »
Length:64
Mass (Da):6,978
Checksum:i14DD8861CECDB2CF
GO
Isoform 7 (identifier: Q0GE19-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-85: ELTSALVHLKLHLFIQIFTLAFFP → FADSRLHASACVFCSDFNQGSWWK
     86-358: Missing.

Note: No experimental confirmation available.
Show »
Length:85
Mass (Da):9,396
Checksum:iDA0C615FA70F592B
GO

Sequence cautioni

The sequence BAC11571 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti296H → Y in BAC11571 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02321562 – 85ELTSA…LAFFP → FADSRLHASACVFCSDFNQG SWWK in isoform 7. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_02321662E → L in isoform 6. 1 Publication1
Alternative sequenceiVSP_02321765 – 358Missing in isoform 6. 1 PublicationAdd BLAST294
Alternative sequenceiVSP_02321886 – 358Missing in isoform 7. 1 PublicationAdd BLAST273
Alternative sequenceiVSP_023219133 – 145Missing in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_023220146 – 159GIVIT…LLFLG → VSKHSLTCLLQLLL in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_023221160 – 358Missing in isoform 5. 1 PublicationAdd BLAST199
Alternative sequenceiVSP_023222186I → E in isoform 4. 1 Publication1
Alternative sequenceiVSP_023223187 – 358Missing in isoform 4. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_023224332 – 358KLLQT…IKFGH → GVKLTRPTV in isoform 2 and isoform 3. 5 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY346324 mRNA. Translation: AAQ84722.1.
DQ122860 mRNA. Translation: AAZ32256.1.
DQ122861 mRNA. Translation: AAZ32257.1.
DQ871036 mRNA. Translation: ABI31650.1.
CR933647 mRNA. Translation: CAI45948.1.
CH471056 Genomic DNA. Translation: EAX05026.1.
BC023288 mRNA. Translation: AAH23288.1.
BC063471 mRNA. Translation: AAH63471.1.
BC120971 mRNA. Translation: AAI20972.1.
BC127626 mRNA. Translation: AAI27627.1.
BC127627 mRNA. Translation: AAI27628.1.
BC120970 mRNA. Translation: AAI20971.1.
BC148252 mRNA. Translation: AAI48253.1.
BC150308 mRNA. Translation: AAI50309.1.
AL136728 mRNA. Translation: CAB66662.2.
AK075364 mRNA. Translation: BAC11571.1. Different initiation.
CCDSiCCDS34073.1. [Q0GE19-2]
CCDS3768.1. [Q0GE19-5]
CCDS75198.1. [Q0GE19-1]
CCDS82962.1. [Q0GE19-7]
CCDS82963.1. [Q0GE19-3]
CCDS82964.1. [Q0GE19-6]
RefSeqiNP_001025169.1. NM_001029998.5. [Q0GE19-2]
NP_001287771.1. NM_001300842.2. [Q0GE19-1]
NP_001304745.1. NM_001317816.1. [Q0GE19-3]
NP_001304746.1. NM_001317817.1. [Q0GE19-7]
NP_001304747.1. NM_001317818.1. [Q0GE19-6]
NP_115504.1. NM_032128.4. [Q0GE19-5]
XP_016864181.1. XM_017008692.1. [Q0GE19-7]
UniGeneiHs.659209.

Genome annotation databases

EnsembliENST00000335472; ENSP00000334594; ENSG00000120519. [Q0GE19-2]
ENST00000394059; ENSP00000377623; ENSG00000120519. [Q0GE19-5]
ENST00000432059; ENSP00000411297; ENSG00000120519. [Q0GE19-3]
ENST00000502607; ENSP00000422577; ENSG00000120519. [Q0GE19-6]
ENST00000507030; ENSP00000421275; ENSG00000120519. [Q0GE19-1]
ENST00000511374; ENSP00000421603; ENSG00000120519. [Q0GE19-7]
GeneIDi84068.
KEGGihsa:84068.
UCSCiuc003ikr.3. human. [Q0GE19-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY346324 mRNA. Translation: AAQ84722.1.
DQ122860 mRNA. Translation: AAZ32256.1.
DQ122861 mRNA. Translation: AAZ32257.1.
DQ871036 mRNA. Translation: ABI31650.1.
CR933647 mRNA. Translation: CAI45948.1.
CH471056 Genomic DNA. Translation: EAX05026.1.
BC023288 mRNA. Translation: AAH23288.1.
BC063471 mRNA. Translation: AAH63471.1.
BC120971 mRNA. Translation: AAI20972.1.
BC127626 mRNA. Translation: AAI27627.1.
BC127627 mRNA. Translation: AAI27628.1.
BC120970 mRNA. Translation: AAI20971.1.
BC148252 mRNA. Translation: AAI48253.1.
BC150308 mRNA. Translation: AAI50309.1.
AL136728 mRNA. Translation: CAB66662.2.
AK075364 mRNA. Translation: BAC11571.1. Different initiation.
CCDSiCCDS34073.1. [Q0GE19-2]
CCDS3768.1. [Q0GE19-5]
CCDS75198.1. [Q0GE19-1]
CCDS82962.1. [Q0GE19-7]
CCDS82963.1. [Q0GE19-3]
CCDS82964.1. [Q0GE19-6]
RefSeqiNP_001025169.1. NM_001029998.5. [Q0GE19-2]
NP_001287771.1. NM_001300842.2. [Q0GE19-1]
NP_001304745.1. NM_001317816.1. [Q0GE19-3]
NP_001304746.1. NM_001317817.1. [Q0GE19-7]
NP_001304747.1. NM_001317818.1. [Q0GE19-6]
NP_115504.1. NM_032128.4. [Q0GE19-5]
XP_016864181.1. XM_017008692.1. [Q0GE19-7]
UniGeneiHs.659209.

3D structure databases

ProteinModelPortaliQ0GE19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123863. 11 interactors.
MINTiMINT-4721825.
STRINGi9606.ENSP00000334594.

Protein family/group databases

TCDBi2.A.28.3.1. the bile acid:na(+) symporter (bass) family.

PTM databases

iPTMnetiQ0GE19.
PhosphoSitePlusiQ0GE19.

Polymorphism and mutation databases

BioMutaiSLC10A7.
DMDMi121946408.

Proteomic databases

MaxQBiQ0GE19.
PaxDbiQ0GE19.
PeptideAtlasiQ0GE19.
PRIDEiQ0GE19.

Protocols and materials databases

DNASUi84068.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335472; ENSP00000334594; ENSG00000120519. [Q0GE19-2]
ENST00000394059; ENSP00000377623; ENSG00000120519. [Q0GE19-5]
ENST00000432059; ENSP00000411297; ENSG00000120519. [Q0GE19-3]
ENST00000502607; ENSP00000422577; ENSG00000120519. [Q0GE19-6]
ENST00000507030; ENSP00000421275; ENSG00000120519. [Q0GE19-1]
ENST00000511374; ENSP00000421603; ENSG00000120519. [Q0GE19-7]
GeneIDi84068.
KEGGihsa:84068.
UCSCiuc003ikr.3. human. [Q0GE19-1]

Organism-specific databases

CTDi84068.
DisGeNETi84068.
GeneCardsiSLC10A7.
H-InvDBHIX0004549.
HGNCiHGNC:23088. SLC10A7.
HPAiHPA039996.
HPA057906.
MIMi611459. gene.
neXtProtiNX_Q0GE19.
OpenTargetsiENSG00000120519.
PharmGKBiPA162403478.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4821. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00390000011932.
HOVERGENiHBG082064.
InParanoidiQ0GE19.
KOiK14347.
OMAiFFFYGLK.
OrthoDBiEOG091G0GR7.
PhylomeDBiQ0GE19.
TreeFamiTF329411.

Miscellaneous databases

ChiTaRSiSLC10A7. human.
GeneWikiiSLC10A7.
GenomeRNAii84068.
PROiQ0GE19.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120519.
GenevisibleiQ0GE19. HS.

Family and domain databases

InterProiIPR016833. Put_Na-Bile_cotransptr.
[Graphical view]
PANTHERiPTHR18640. PTHR18640. 1 hit.
PfamiPF13593. SBF_like. 1 hit.
[Graphical view]
PIRSFiPIRSF026166. UCP026166. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNTCP7_HUMAN
AccessioniPrimary (citable) accession number: Q0GE19
Secondary accession number(s): A7E2E6
, A7MAX9, Q0VAP9, Q45NG1, Q45NG2, Q5H9S6, Q6P4E6, Q8IZ62, Q8NBP8, Q9H0M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.