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Q0GE19

- NTCP7_HUMAN

UniProt

Q0GE19 - NTCP7_HUMAN

Protein

Sodium/bile acid cotransporter 7

Gene

SLC10A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Protein family/group databases

    TCDBi2.A.93.1.1. the unknown bart superfamily-1 (ubs1) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/bile acid cotransporter 7
    Alternative name(s):
    Na(+)/bile acid cotransporter 7
    Solute carrier family 10 member 7
    Gene namesi
    Name:SLC10A7
    Synonyms:C4orf13, P7
    ORF Names:PSEC0051
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:23088. SLC10A7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162403478.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Sodium/bile acid cotransporter 7PRO_0000278250Add
    BLAST

    Proteomic databases

    MaxQBiQ0GE19.
    PRIDEiQ0GE19.

    PTM databases

    PhosphoSiteiQ0GE19.

    Expressioni

    Gene expression databases

    ArrayExpressiQ0GE19.
    BgeeiQ0GE19.
    GenevestigatoriQ0GE19.

    Organism-specific databases

    HPAiHPA039996.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4721825.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0GE19.
    SMRiQ0GE19. Positions 47-214.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei299 – 31921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0385.
    HOVERGENiHBG082064.
    InParanoidiQ0GE19.
    KOiK14347.
    OMAiTSALMHI.
    OrthoDBiEOG78H3TG.
    PhylomeDBiQ0GE19.
    TreeFamiTF329411.

    Family and domain databases

    InterProiIPR016833. Put_Na-Bile_cotransptr.
    [Graphical view]
    PANTHERiPTHR18640. PTHR18640. 1 hit.
    PfamiPF13593. DUF4137. 1 hit.
    [Graphical view]
    PIRSFiPIRSF026166. UCP026166. 1 hit.

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q0GE19-1) [UniParc]FASTAAdd to Basket

    Also known as: C

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI    50
    FFNSGLSLKT EELTSALVHL KLHLFIQIFT LAFFPATIWL FLQLLSITPI 100
    NEWLLKGLQT VGCMPPPVSS AVILTKAVGG NEAAAIFNSA FGSFLGIVIT 150
    PLLLLLFLGS SSSVPFTSIF SQLFMTVVVP LIIGQIVRRY IKDWLERKKP 200
    PFGAISSSVL LMIIYTTFCD TFSNPNIDLD KFSLVLILFI IFSIQLSFML 250
    LTFIFSTRNN SGFTPADTVA IIFCSTHKSL TLGIPMLKIV FAGHEHLSLI 300
    SVPLLIYHPA QILLGSVLVP TIKSWMVSRQ KKLLQTRGPL ANLNNPEGLE 350
    YLSIKFGH 358
    Length:358
    Mass (Da):39,485
    Last modified:October 3, 2006 - v1
    Checksum:iD23352F5F3990822
    GO
    Isoform 2 (identifier: Q0GE19-2) [UniParc]FASTAAdd to Basket

    Also known as: A

    The sequence of this isoform differs from the canonical sequence as follows:
         332-358: KLLQTRGPLANLNNPEGLEYLSIKFGH → GVKLTRPTV

    Show »
    Length:340
    Mass (Da):37,432
    Checksum:iB9D4F4FFAF6DC9DF
    GO
    Isoform 3 (identifier: Q0GE19-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         133-145: Missing.
         332-358: KLLQTRGPLANLNNPEGLEYLSIKFGH → GVKLTRPTV

    Show »
    Length:327
    Mass (Da):36,134
    Checksum:i865D59F098CD5C7C
    GO
    Isoform 4 (identifier: Q0GE19-4) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         186-186: I → E
         187-358: Missing.

    Show »
    Length:186
    Mass (Da):20,093
    Checksum:i6B62BA3395691D22
    GO
    Isoform 5 (identifier: Q0GE19-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         146-159: GIVITPLLLLLFLG → VSKHSLTCLLQLLL
         160-358: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:159
    Mass (Da):17,283
    Checksum:iF92AC92F76B5F229
    GO
    Isoform 6 (identifier: Q0GE19-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         62-62: E → L
         65-358: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:64
    Mass (Da):6,978
    Checksum:i14DD8861CECDB2CF
    GO
    Isoform 7 (identifier: Q0GE19-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         62-85: ELTSALVHLKLHLFIQIFTLAFFP → FADSRLHASACVFCSDFNQGSWWK
         86-358: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:85
    Mass (Da):9,396
    Checksum:iDA0C615FA70F592B
    GO

    Sequence cautioni

    The sequence BAC11571.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti296 – 2961H → Y in BAC11571. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei62 – 8524ELTSA…LAFFP → FADSRLHASACVFCSDFNQG SWWK in isoform 7. 1 PublicationVSP_023215Add
    BLAST
    Alternative sequencei62 – 621E → L in isoform 6. 1 PublicationVSP_023216
    Alternative sequencei65 – 358294Missing in isoform 6. 1 PublicationVSP_023217Add
    BLAST
    Alternative sequencei86 – 358273Missing in isoform 7. 1 PublicationVSP_023218Add
    BLAST
    Alternative sequencei133 – 14513Missing in isoform 3. 1 PublicationVSP_023219Add
    BLAST
    Alternative sequencei146 – 15914GIVIT…LLFLG → VSKHSLTCLLQLLL in isoform 5. 1 PublicationVSP_023220Add
    BLAST
    Alternative sequencei160 – 358199Missing in isoform 5. 1 PublicationVSP_023221Add
    BLAST
    Alternative sequencei186 – 1861I → E in isoform 4. 1 PublicationVSP_023222
    Alternative sequencei187 – 358172Missing in isoform 4. 1 PublicationVSP_023223Add
    BLAST
    Alternative sequencei332 – 35827KLLQT…IKFGH → GVKLTRPTV in isoform 2 and isoform 3. 5 PublicationsVSP_023224Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY346324 mRNA. Translation: AAQ84722.1.
    DQ122860 mRNA. Translation: AAZ32256.1.
    DQ122861 mRNA. Translation: AAZ32257.1.
    DQ871036 mRNA. Translation: ABI31650.1.
    CR933647 mRNA. Translation: CAI45948.1.
    CH471056 Genomic DNA. Translation: EAX05026.1.
    BC023288 mRNA. Translation: AAH23288.1.
    BC063471 mRNA. Translation: AAH63471.1.
    BC120971 mRNA. Translation: AAI20972.1.
    BC127626 mRNA. Translation: AAI27627.1.
    BC127627 mRNA. Translation: AAI27628.1.
    BC120970 mRNA. Translation: AAI20971.1.
    BC148252 mRNA. Translation: AAI48253.1.
    BC150308 mRNA. Translation: AAI50309.1.
    AL136728 mRNA. Translation: CAB66662.2.
    AK075364 mRNA. Translation: BAC11571.1. Different initiation.
    CCDSiCCDS34073.1. [Q0GE19-2]
    CCDS3768.1. [Q0GE19-5]
    RefSeqiNP_001025169.1. NM_001029998.3. [Q0GE19-2]
    NP_115504.1. NM_032128.3. [Q0GE19-5]
    XP_005263333.1. XM_005263276.1. [Q0GE19-1]
    UniGeneiHs.659209.

    Genome annotation databases

    EnsembliENST00000335472; ENSP00000334594; ENSG00000120519. [Q0GE19-2]
    ENST00000394059; ENSP00000377623; ENSG00000120519. [Q0GE19-5]
    ENST00000432059; ENSP00000411297; ENSG00000120519. [Q0GE19-3]
    ENST00000502607; ENSP00000422577; ENSG00000120519. [Q0GE19-6]
    ENST00000507030; ENSP00000421275; ENSG00000120519. [Q0GE19-1]
    ENST00000511374; ENSP00000421603; ENSG00000120519. [Q0GE19-7]
    GeneIDi84068.
    KEGGihsa:84068.
    UCSCiuc003ikr.2. human. [Q0GE19-2]
    uc003ikt.3. human. [Q0GE19-5]
    uc010ioz.2. human. [Q0GE19-1]
    uc010ipa.2. human. [Q0GE19-3]

    Polymorphism databases

    DMDMi121946408.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY346324 mRNA. Translation: AAQ84722.1 .
    DQ122860 mRNA. Translation: AAZ32256.1 .
    DQ122861 mRNA. Translation: AAZ32257.1 .
    DQ871036 mRNA. Translation: ABI31650.1 .
    CR933647 mRNA. Translation: CAI45948.1 .
    CH471056 Genomic DNA. Translation: EAX05026.1 .
    BC023288 mRNA. Translation: AAH23288.1 .
    BC063471 mRNA. Translation: AAH63471.1 .
    BC120971 mRNA. Translation: AAI20972.1 .
    BC127626 mRNA. Translation: AAI27627.1 .
    BC127627 mRNA. Translation: AAI27628.1 .
    BC120970 mRNA. Translation: AAI20971.1 .
    BC148252 mRNA. Translation: AAI48253.1 .
    BC150308 mRNA. Translation: AAI50309.1 .
    AL136728 mRNA. Translation: CAB66662.2 .
    AK075364 mRNA. Translation: BAC11571.1 . Different initiation.
    CCDSi CCDS34073.1. [Q0GE19-2 ]
    CCDS3768.1. [Q0GE19-5 ]
    RefSeqi NP_001025169.1. NM_001029998.3. [Q0GE19-2 ]
    NP_115504.1. NM_032128.3. [Q0GE19-5 ]
    XP_005263333.1. XM_005263276.1. [Q0GE19-1 ]
    UniGenei Hs.659209.

    3D structure databases

    ProteinModelPortali Q0GE19.
    SMRi Q0GE19. Positions 47-214.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4721825.

    Protein family/group databases

    TCDBi 2.A.93.1.1. the unknown bart superfamily-1 (ubs1) family.

    PTM databases

    PhosphoSitei Q0GE19.

    Polymorphism databases

    DMDMi 121946408.

    Proteomic databases

    MaxQBi Q0GE19.
    PRIDEi Q0GE19.

    Protocols and materials databases

    DNASUi 84068.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335472 ; ENSP00000334594 ; ENSG00000120519 . [Q0GE19-2 ]
    ENST00000394059 ; ENSP00000377623 ; ENSG00000120519 . [Q0GE19-5 ]
    ENST00000432059 ; ENSP00000411297 ; ENSG00000120519 . [Q0GE19-3 ]
    ENST00000502607 ; ENSP00000422577 ; ENSG00000120519 . [Q0GE19-6 ]
    ENST00000507030 ; ENSP00000421275 ; ENSG00000120519 . [Q0GE19-1 ]
    ENST00000511374 ; ENSP00000421603 ; ENSG00000120519 . [Q0GE19-7 ]
    GeneIDi 84068.
    KEGGi hsa:84068.
    UCSCi uc003ikr.2. human. [Q0GE19-2 ]
    uc003ikt.3. human. [Q0GE19-5 ]
    uc010ioz.2. human. [Q0GE19-1 ]
    uc010ipa.2. human. [Q0GE19-3 ]

    Organism-specific databases

    CTDi 84068.
    GeneCardsi GC04M147175.
    H-InvDB HIX0004549.
    HGNCi HGNC:23088. SLC10A7.
    HPAi HPA039996.
    MIMi 611459. gene.
    neXtProti NX_Q0GE19.
    PharmGKBi PA162403478.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0385.
    HOVERGENi HBG082064.
    InParanoidi Q0GE19.
    KOi K14347.
    OMAi TSALMHI.
    OrthoDBi EOG78H3TG.
    PhylomeDBi Q0GE19.
    TreeFami TF329411.

    Miscellaneous databases

    GeneWikii SLC10A7.
    GenomeRNAii 84068.
    NextBioi 73253.
    PROi Q0GE19.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q0GE19.
    Bgeei Q0GE19.
    Genevestigatori Q0GE19.

    Family and domain databases

    InterProi IPR016833. Put_Na-Bile_cotransptr.
    [Graphical view ]
    PANTHERi PTHR18640. PTHR18640. 1 hit.
    Pfami PF13593. DUF4137. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF026166. UCP026166. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel human C4orf13 gene, tentatively a member of the sodium bile acid cotransporter family."
      Zou X., Wang D., Qiu G., Ji C., Jin F., Wu M., Zheng H., Li X., Sun L., Wang Y., Tang R., Zhao R.C., Mao Y.
      Biochem. Genet. 43:165-173(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    2. "Cloning of P7 from human heart."
      Godoy J.R., Geyer J., Petzinger E.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 4).
      Tissue: Heart.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Heart.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 5; 6 AND 7).
      Tissue: Prostate.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-145.
      Tissue: Kidney.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-358 (ISOFORM 2).
      Tissue: Teratocarcinoma.

    Entry informationi

    Entry nameiNTCP7_HUMAN
    AccessioniPrimary (citable) accession number: Q0GE19
    Secondary accession number(s): A7E2E6
    , A7MAX9, Q0VAP9, Q45NG1, Q45NG2, Q5H9S6, Q6P4E6, Q8IZ62, Q8NBP8, Q9H0M9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3