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Protein

Sodium/bile acid cotransporter 7

Gene

SLC10A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.93.1.1. the unknown bart superfamily-1 (ubs1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter 7
Alternative name(s):
Na(+)/bile acid cotransporter 7
Solute carrier family 10 member 7
Gene namesi
Name:SLC10A7
Synonyms:C4orf13, P7
ORF Names:PSEC0051
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:23088. SLC10A7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence AnalysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence AnalysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence AnalysisAdd
BLAST
Transmembranei271 – 29121HelicalSequence AnalysisAdd
BLAST
Transmembranei299 – 31921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403478.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Sodium/bile acid cotransporter 7PRO_0000278250Add
BLAST

Proteomic databases

MaxQBiQ0GE19.
PRIDEiQ0GE19.

PTM databases

PhosphoSiteiQ0GE19.

Expressioni

Gene expression databases

BgeeiQ0GE19.
ExpressionAtlasiQ0GE19. baseline and differential.
GenevestigatoriQ0GE19.

Organism-specific databases

HPAiHPA039996.
HPA057906.

Interactioni

Protein-protein interaction databases

BioGridi123863. 1 interaction.
MINTiMINT-4721825.

Structurei

3D structure databases

ProteinModelPortaliQ0GE19.
SMRiQ0GE19. Positions 47-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0385.
GeneTreeiENSGT00390000011932.
HOVERGENiHBG082064.
InParanoidiQ0GE19.
KOiK14347.
OMAiLKFVDQG.
OrthoDBiEOG78H3TG.
PhylomeDBiQ0GE19.
TreeFamiTF329411.

Family and domain databases

InterProiIPR016833. Put_Na-Bile_cotransptr.
[Graphical view]
PANTHERiPTHR18640. PTHR18640. 1 hit.
PfamiPF13593. DUF4137. 1 hit.
[Graphical view]
PIRSFiPIRSF026166. UCP026166. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0GE19-1) [UniParc]FASTAAdd to basket

Also known as: C

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI
60 70 80 90 100
FFNSGLSLKT EELTSALVHL KLHLFIQIFT LAFFPATIWL FLQLLSITPI
110 120 130 140 150
NEWLLKGLQT VGCMPPPVSS AVILTKAVGG NEAAAIFNSA FGSFLGIVIT
160 170 180 190 200
PLLLLLFLGS SSSVPFTSIF SQLFMTVVVP LIIGQIVRRY IKDWLERKKP
210 220 230 240 250
PFGAISSSVL LMIIYTTFCD TFSNPNIDLD KFSLVLILFI IFSIQLSFML
260 270 280 290 300
LTFIFSTRNN SGFTPADTVA IIFCSTHKSL TLGIPMLKIV FAGHEHLSLI
310 320 330 340 350
SVPLLIYHPA QILLGSVLVP TIKSWMVSRQ KKLLQTRGPL ANLNNPEGLE

YLSIKFGH
Length:358
Mass (Da):39,485
Last modified:October 2, 2006 - v1
Checksum:iD23352F5F3990822
GO
Isoform 2 (identifier: Q0GE19-2) [UniParc]FASTAAdd to basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     332-358: KLLQTRGPLANLNNPEGLEYLSIKFGH → GVKLTRPTV

Show »
Length:340
Mass (Da):37,432
Checksum:iB9D4F4FFAF6DC9DF
GO
Isoform 3 (identifier: Q0GE19-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-145: Missing.
     332-358: KLLQTRGPLANLNNPEGLEYLSIKFGH → GVKLTRPTV

Show »
Length:327
Mass (Da):36,134
Checksum:i865D59F098CD5C7C
GO
Isoform 4 (identifier: Q0GE19-4) [UniParc]FASTAAdd to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     186-186: I → E
     187-358: Missing.

Show »
Length:186
Mass (Da):20,093
Checksum:i6B62BA3395691D22
GO
Isoform 5 (identifier: Q0GE19-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-159: GIVITPLLLLLFLG → VSKHSLTCLLQLLL
     160-358: Missing.

Note: No experimental confirmation available.

Show »
Length:159
Mass (Da):17,283
Checksum:iF92AC92F76B5F229
GO
Isoform 6 (identifier: Q0GE19-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-62: E → L
     65-358: Missing.

Note: No experimental confirmation available.

Show »
Length:64
Mass (Da):6,978
Checksum:i14DD8861CECDB2CF
GO
Isoform 7 (identifier: Q0GE19-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-85: ELTSALVHLKLHLFIQIFTLAFFP → FADSRLHASACVFCSDFNQGSWWK
     86-358: Missing.

Note: No experimental confirmation available.

Show »
Length:85
Mass (Da):9,396
Checksum:iDA0C615FA70F592B
GO

Sequence cautioni

The sequence BAC11571.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti296 – 2961H → Y in BAC11571 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei62 – 8524ELTSA…LAFFP → FADSRLHASACVFCSDFNQG SWWK in isoform 7. 1 PublicationVSP_023215Add
BLAST
Alternative sequencei62 – 621E → L in isoform 6. 1 PublicationVSP_023216
Alternative sequencei65 – 358294Missing in isoform 6. 1 PublicationVSP_023217Add
BLAST
Alternative sequencei86 – 358273Missing in isoform 7. 1 PublicationVSP_023218Add
BLAST
Alternative sequencei133 – 14513Missing in isoform 3. 1 PublicationVSP_023219Add
BLAST
Alternative sequencei146 – 15914GIVIT…LLFLG → VSKHSLTCLLQLLL in isoform 5. 1 PublicationVSP_023220Add
BLAST
Alternative sequencei160 – 358199Missing in isoform 5. 1 PublicationVSP_023221Add
BLAST
Alternative sequencei186 – 1861I → E in isoform 4. 1 PublicationVSP_023222
Alternative sequencei187 – 358172Missing in isoform 4. 1 PublicationVSP_023223Add
BLAST
Alternative sequencei332 – 35827KLLQT…IKFGH → GVKLTRPTV in isoform 2 and isoform 3. 5 PublicationsVSP_023224Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY346324 mRNA. Translation: AAQ84722.1.
DQ122860 mRNA. Translation: AAZ32256.1.
DQ122861 mRNA. Translation: AAZ32257.1.
DQ871036 mRNA. Translation: ABI31650.1.
CR933647 mRNA. Translation: CAI45948.1.
CH471056 Genomic DNA. Translation: EAX05026.1.
BC023288 mRNA. Translation: AAH23288.1.
BC063471 mRNA. Translation: AAH63471.1.
BC120971 mRNA. Translation: AAI20972.1.
BC127626 mRNA. Translation: AAI27627.1.
BC127627 mRNA. Translation: AAI27628.1.
BC120970 mRNA. Translation: AAI20971.1.
BC148252 mRNA. Translation: AAI48253.1.
BC150308 mRNA. Translation: AAI50309.1.
AL136728 mRNA. Translation: CAB66662.2.
AK075364 mRNA. Translation: BAC11571.1. Different initiation.
CCDSiCCDS34073.1. [Q0GE19-2]
CCDS3768.1. [Q0GE19-5]
CCDS75198.1. [Q0GE19-1]
RefSeqiNP_001025169.1. NM_001029998.4. [Q0GE19-2]
NP_001287771.1. NM_001300842.1. [Q0GE19-1]
NP_115504.1. NM_032128.3. [Q0GE19-5]
UniGeneiHs.659209.

Genome annotation databases

EnsembliENST00000335472; ENSP00000334594; ENSG00000120519. [Q0GE19-2]
ENST00000394059; ENSP00000377623; ENSG00000120519. [Q0GE19-5]
ENST00000432059; ENSP00000411297; ENSG00000120519. [Q0GE19-3]
ENST00000502607; ENSP00000422577; ENSG00000120519. [Q0GE19-6]
ENST00000507030; ENSP00000421275; ENSG00000120519. [Q0GE19-1]
ENST00000511374; ENSP00000421603; ENSG00000120519. [Q0GE19-7]
GeneIDi84068.
KEGGihsa:84068.
UCSCiuc003ikr.2. human. [Q0GE19-2]
uc003ikt.3. human. [Q0GE19-5]
uc010ioz.2. human. [Q0GE19-1]
uc010ipa.2. human. [Q0GE19-3]

Polymorphism databases

DMDMi121946408.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY346324 mRNA. Translation: AAQ84722.1.
DQ122860 mRNA. Translation: AAZ32256.1.
DQ122861 mRNA. Translation: AAZ32257.1.
DQ871036 mRNA. Translation: ABI31650.1.
CR933647 mRNA. Translation: CAI45948.1.
CH471056 Genomic DNA. Translation: EAX05026.1.
BC023288 mRNA. Translation: AAH23288.1.
BC063471 mRNA. Translation: AAH63471.1.
BC120971 mRNA. Translation: AAI20972.1.
BC127626 mRNA. Translation: AAI27627.1.
BC127627 mRNA. Translation: AAI27628.1.
BC120970 mRNA. Translation: AAI20971.1.
BC148252 mRNA. Translation: AAI48253.1.
BC150308 mRNA. Translation: AAI50309.1.
AL136728 mRNA. Translation: CAB66662.2.
AK075364 mRNA. Translation: BAC11571.1. Different initiation.
CCDSiCCDS34073.1. [Q0GE19-2]
CCDS3768.1. [Q0GE19-5]
CCDS75198.1. [Q0GE19-1]
RefSeqiNP_001025169.1. NM_001029998.4. [Q0GE19-2]
NP_001287771.1. NM_001300842.1. [Q0GE19-1]
NP_115504.1. NM_032128.3. [Q0GE19-5]
UniGeneiHs.659209.

3D structure databases

ProteinModelPortaliQ0GE19.
SMRiQ0GE19. Positions 47-214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123863. 1 interaction.
MINTiMINT-4721825.

Protein family/group databases

TCDBi2.A.93.1.1. the unknown bart superfamily-1 (ubs1) family.

PTM databases

PhosphoSiteiQ0GE19.

Polymorphism databases

DMDMi121946408.

Proteomic databases

MaxQBiQ0GE19.
PRIDEiQ0GE19.

Protocols and materials databases

DNASUi84068.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335472; ENSP00000334594; ENSG00000120519. [Q0GE19-2]
ENST00000394059; ENSP00000377623; ENSG00000120519. [Q0GE19-5]
ENST00000432059; ENSP00000411297; ENSG00000120519. [Q0GE19-3]
ENST00000502607; ENSP00000422577; ENSG00000120519. [Q0GE19-6]
ENST00000507030; ENSP00000421275; ENSG00000120519. [Q0GE19-1]
ENST00000511374; ENSP00000421603; ENSG00000120519. [Q0GE19-7]
GeneIDi84068.
KEGGihsa:84068.
UCSCiuc003ikr.2. human. [Q0GE19-2]
uc003ikt.3. human. [Q0GE19-5]
uc010ioz.2. human. [Q0GE19-1]
uc010ipa.2. human. [Q0GE19-3]

Organism-specific databases

CTDi84068.
GeneCardsiGC04M147175.
H-InvDBHIX0004549.
HGNCiHGNC:23088. SLC10A7.
HPAiHPA039996.
HPA057906.
MIMi611459. gene.
neXtProtiNX_Q0GE19.
PharmGKBiPA162403478.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0385.
GeneTreeiENSGT00390000011932.
HOVERGENiHBG082064.
InParanoidiQ0GE19.
KOiK14347.
OMAiLKFVDQG.
OrthoDBiEOG78H3TG.
PhylomeDBiQ0GE19.
TreeFamiTF329411.

Miscellaneous databases

ChiTaRSiSLC10A7. human.
GeneWikiiSLC10A7.
GenomeRNAii84068.
NextBioi73253.
PROiQ0GE19.
SOURCEiSearch...

Gene expression databases

BgeeiQ0GE19.
ExpressionAtlasiQ0GE19. baseline and differential.
GenevestigatoriQ0GE19.

Family and domain databases

InterProiIPR016833. Put_Na-Bile_cotransptr.
[Graphical view]
PANTHERiPTHR18640. PTHR18640. 1 hit.
PfamiPF13593. DUF4137. 1 hit.
[Graphical view]
PIRSFiPIRSF026166. UCP026166. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human C4orf13 gene, tentatively a member of the sodium bile acid cotransporter family."
    Zou X., Wang D., Qiu G., Ji C., Jin F., Wu M., Zheng H., Li X., Sun L., Wang Y., Tang R., Zhao R.C., Mao Y.
    Biochem. Genet. 43:165-173(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "Cloning of P7 from human heart."
    Godoy J.R., Geyer J., Petzinger E.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 4).
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Heart.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 5; 6 AND 7).
    Tissue: Prostate.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-145.
    Tissue: Kidney.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-358 (ISOFORM 2).
    Tissue: Teratocarcinoma.

Entry informationi

Entry nameiNTCP7_HUMAN
AccessioniPrimary (citable) accession number: Q0GE19
Secondary accession number(s): A7E2E6
, A7MAX9, Q0VAP9, Q45NG1, Q45NG2, Q5H9S6, Q6P4E6, Q8IZ62, Q8NBP8, Q9H0M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 19, 2007
Last sequence update: October 2, 2006
Last modified: March 3, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.