Q0GE19 (NTCP7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/bile acid cotransporter 7

Alternative name(s):
Na(+)/bile acid cotransporter 7
Solute carrier family 10 member 7

Gene names

Name:	SLC10A7
Synonyms:	C4orf13, P7
ORF Names:	PSEC0051

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the unknown BART superfamily-1 (UBS1) (TC 2.A.93) family. [View classification]
Sequence caution	The sequence BAC11571.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Symport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q0GE19-1)

Also known as: C;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q0GE19-2)

Also known as: A;

The sequence of this isoform differs from the canonical sequence as follows:
     332-358: KLLQTRGPLANLNNPEGLEYLSIKFGH → GVKLTRPTV

Isoform 3 (identifier: Q0GE19-3)

The sequence of this isoform differs from the canonical sequence as follows:
     133-145: Missing.
     332-358: KLLQTRGPLANLNNPEGLEYLSIKFGH → GVKLTRPTV

Isoform 4 (identifier: Q0GE19-4)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     186-186: I → E
     187-358: Missing.

Isoform 5 (identifier: Q0GE19-5)

The sequence of this isoform differs from the canonical sequence as follows:
     146-159: GIVITPLLLLLFLG → VSKHSLTCLLQLLL
     160-358: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q0GE19-6)

The sequence of this isoform differs from the canonical sequence as follows:
     62-62: E → L
     65-358: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: Q0GE19-7)

The sequence of this isoform differs from the canonical sequence as follows:
     62-85: ELTSALVHLKLHLFIQIFTLAFFP → FADSRLHASACVFCSDFNQGSWWK
     86-358: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Sodium/bile acid cotransporter 7		PRO_0000278250
Regions
	Transmembrane	11 – 31	21	Helical; Potential
	Transmembrane	38 – 58	21	Helical; Potential
	Transmembrane	72 – 92	21	Helical; Potential
	Transmembrane	117 – 137	21	Helical; Potential
	Transmembrane	139 – 159	21	Helical; Potential
	Transmembrane	164 – 184	21	Helical; Potential
	Transmembrane	202 – 222	21	Helical; Potential
	Transmembrane	235 – 255	21	Helical; Potential
	Transmembrane	271 – 291	21	Helical; Potential
	Transmembrane	299 – 319	21	Helical; Potential
Natural variations
	Alternative sequence	62 – 85	24	ELTSA…LAFFP → FADSRLHASACVFCSDFNQG SWWK in isoform 7.		VSP_023215
	Alternative sequence	62	1	E → L in isoform 6.		VSP_023216
	Alternative sequence	65 – 358	294	Missing in isoform 6.		VSP_023217
	Alternative sequence	86 – 358	273	Missing in isoform 7.		VSP_023218
	Alternative sequence	133 – 145	13	Missing in isoform 3.		VSP_023219
	Alternative sequence	146 – 159	14	GIVIT…LLFLG → VSKHSLTCLLQLLL in isoform 5.		VSP_023220
	Alternative sequence	160 – 358	199	Missing in isoform 5.		VSP_023221
	Alternative sequence	186	1	I → E in isoform 4.		VSP_023222
	Alternative sequence	187 – 358	172	Missing in isoform 4.		VSP_023223
	Alternative sequence	332 – 358	27	KLLQT…IKFGH → GVKLTRPTV in isoform 2 and isoform 3.		VSP_023224
Experimental info
	Sequence conflict	296	1	H → Y in BAC11571. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (C) [UniParc]. Last modified October 3, 2006. Version 1. Checksum: D23352F5F3990822	FASTA	358	39,485
	10 20 30 40 50 60 MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI FFNSGLSLKT 70 80 90 100 110 120 EELTSALVHL KLHLFIQIFT LAFFPATIWL FLQLLSITPI NEWLLKGLQT VGCMPPPVSS 130 140 150 160 170 180 AVILTKAVGG NEAAAIFNSA FGSFLGIVIT PLLLLLFLGS SSSVPFTSIF SQLFMTVVVP 190 200 210 220 230 240 LIIGQIVRRY IKDWLERKKP PFGAISSSVL LMIIYTTFCD TFSNPNIDLD KFSLVLILFI 250 260 270 280 290 300 IFSIQLSFML LTFIFSTRNN SGFTPADTVA IIFCSTHKSL TLGIPMLKIV FAGHEHLSLI 310 320 330 340 350 SVPLLIYHPA QILLGSVLVP TIKSWMVSRQ KKLLQTRGPL ANLNNPEGLE YLSIKFGH
	Isoform 2 (A) [UniParc]. Checksum: B9D4F4FFAF6DC9DF	FASTA	340	37,432
	10 20 30 40 50 60 MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI FFNSGLSLKT 70 80 90 100 110 120 EELTSALVHL KLHLFIQIFT LAFFPATIWL FLQLLSITPI NEWLLKGLQT VGCMPPPVSS 130 140 150 160 170 180 AVILTKAVGG NEAAAIFNSA FGSFLGIVIT PLLLLLFLGS SSSVPFTSIF SQLFMTVVVP 190 200 210 220 230 240 LIIGQIVRRY IKDWLERKKP PFGAISSSVL LMIIYTTFCD TFSNPNIDLD KFSLVLILFI 250 260 270 280 290 300 IFSIQLSFML LTFIFSTRNN SGFTPADTVA IIFCSTHKSL TLGIPMLKIV FAGHEHLSLI 310 320 330 340 SVPLLIYHPA QILLGSVLVP TIKSWMVSRQ KGVKLTRPTV
	Isoform 3 [UniParc]. Checksum: 865D59F098CD5C7C	FASTA	327	36,134
	10 20 30 40 50 60 MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI FFNSGLSLKT 70 80 90 100 110 120 EELTSALVHL KLHLFIQIFT LAFFPATIWL FLQLLSITPI NEWLLKGLQT VGCMPPPVSS 130 140 150 160 170 180 AVILTKAVGG NEGIVITPLL LLLFLGSSSS VPFTSIFSQL FMTVVVPLII GQIVRRYIKD 190 200 210 220 230 240 WLERKKPPFG AISSSVLLMI IYTTFCDTFS NPNIDLDKFS LVLILFIIFS IQLSFMLLTF 250 260 270 280 290 300 IFSTRNNSGF TPADTVAIIF CSTHKSLTLG IPMLKIVFAG HEHLSLISVP LLIYHPAQIL 310 320 LGSVLVPTIK SWMVSRQKGV KLTRPTV
	Isoform 4 (B) [UniParc]. Checksum: 6B62BA3395691D22	FASTA	186	20,093
	10 20 30 40 50 60 MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI FFNSGLSLKT 70 80 90 100 110 120 EELTSALVHL KLHLFIQIFT LAFFPATIWL FLQLLSITPI NEWLLKGLQT VGCMPPPVSS 130 140 150 160 170 180 AVILTKAVGG NEAAAIFNSA FGSFLGIVIT PLLLLLFLGS SSSVPFTSIF SQLFMTVVVP LIIGQE
	Isoform 5 [UniParc]. Checksum: F92AC92F76B5F229	FASTA	159	17,283
	10 20 30 40 50 60 MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI FFNSGLSLKT 70 80 90 100 110 120 EELTSALVHL KLHLFIQIFT LAFFPATIWL FLQLLSITPI NEWLLKGLQT VGCMPPPVSS 130 140 150 AVILTKAVGG NEAAAIFNSA FGSFLVSKHS LTCLLQLLL
	Isoform 6 [UniParc]. Checksum: 14DD8861CECDB2CF	FASTA	64	6,978
	10 20 30 40 50 60 MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI FFNSGLSLKT ELLT
	Isoform 7 [UniParc]. Checksum: DA0C615FA70F592B	FASTA	85	9,396
	10 20 30 40 50 60 MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI FFNSGLSLKT 70 80 EFADSRLHAS ACVFCSDFNQ GSWWK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel human C4orf13 gene, tentatively a member of the sodium bile acid cotransporter family." Zou X., Wang D., Qiu G., Ji C., Jin F., Wu M., Zheng H., Li X., Sun L., Wang Y., Tang R., Zhao R.C., Mao Y. Biochem. Genet. 43:165-173(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[2]	"Cloning of P7 from human heart." Godoy J.R., Geyer J., Petzinger E. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 4). Tissue: Heart.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Heart.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 5; 6 AND 7). Tissue: Prostate.
[6]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-145. Tissue: Kidney.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-358 (ISOFORM 2). Tissue: Teratocarcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY346324 mRNA. Translation: AAQ84722.1. DQ122860 mRNA. Translation: AAZ32256.1. DQ122861 mRNA. Translation: AAZ32257.1. DQ871036 mRNA. Translation: ABI31650.1. CR933647 mRNA. Translation: CAI45948.1. CH471056 Genomic DNA. Translation: EAX05026.1. BC023288 mRNA. Translation: AAH23288.1. BC063471 mRNA. Translation: AAH63471.1. BC120971 mRNA. Translation: AAI20972.1. BC127626 mRNA. Translation: AAI27627.1. BC127627 mRNA. Translation: AAI27628.1. BC120970 mRNA. Translation: AAI20971.1. BC148252 mRNA. Translation: AAI48253.1. BC150308 mRNA. Translation: AAI50309.1. AL136728 mRNA. Translation: CAB66662.2. AK075364 mRNA. Translation: BAC11571.1. Different initiation.
IPI	IPI00030239. IPI00553225. IPI00640513. IPI00827490. IPI00827683. IPI00827918. IPI00828068.
RefSeq	NP_001025169.1. NM_001029998.3. NP_115504.1. NM_032128.3.
UniGene	Hs.659209.
3D structure databases
ProteinModelPortal	Q0GE19.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4721825.
Protein family/group databases
TCDB	2.A.93.1.1. unknown BART superfamily-1 (UBS1) family.
PTM databases
PhosphoSite	Q0GE19.
Polymorphism databases
DMDM	121946408.
Proteomic databases
PRIDE	Q0GE19.
Protocols and materials databases
DNASU	84068.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264986; ENSP00000264986; ENSG00000120519. ENST00000335472; ENSP00000334594; ENSG00000120519. ENST00000394059; ENSP00000377623; ENSG00000120519. ENST00000394062; ENSP00000377626; ENSG00000120519. ENST00000432059; ENSP00000411297; ENSG00000120519. ENST00000502607; ENSP00000422577; ENSG00000120519. ENST00000507030; ENSP00000421275; ENSG00000120519. ENST00000511374; ENSP00000421603; ENSG00000120519.
GeneID	84068.
KEGG	hsa:84068.
UCSC	uc003ikr.2. human. uc003ikt.3. human. uc010ioz.2. human. uc010ipa.2. human.
Organism-specific databases
CTD	84068.
GeneCards	GC04M147175.
H-InvDB	HIX0004549.
HGNC	HGNC:23088. SLC10A7.
HPA	HPA039996.
MIM	611459. gene.
neXtProt	NX_Q0GE19.
PharmGKB	PA162403478.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0385.
HOVERGEN	HBG082064.
InParanoid	Q0GE19.
KO	K14347.
OMA	PMAQVLF.
Gene expression databases
ArrayExpress	Q0GE19.
Bgee	Q0GE19.
Genevestigator	Q0GE19.
Family and domain databases
InterPro	IPR016833. Put_Na-Bile_cotransptr. [Graphical view]
PANTHER	PTHR18640. PTHR18640. 1 hit.
Pfam	PF13593. DUF4137. 1 hit. [Graphical view]
PIRSF	PIRSF026166. UCP026166. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	84068.
NextBio	73253.
SOURCE	Search...

Entry information

Entry name

NTCP7_HUMAN

Accession

Primary (citable) accession number: Q0GE19
Secondary accession number(s): A7E2E6 , A7MAX9, Q0VAP9, Q45NG1, Q45NG2, Q5H9S6, Q6P4E6, Q8IZ62, Q8NBP8, Q9H0M9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	October 3, 2006
Last modified:	May 29, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.