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Q0GBY4

- NCAP_RABVR

UniProt

Q0GBY4 - NCAP_RABVR

Protein

Nucleoprotein

Gene

N

Organism
Rabies virus (strain China/MRV) (RABV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein, Superantigen

    Keywords - Ligandi

    RNA-binding, Viral nucleoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoprotein
    Short name:
    NP
    Alternative name(s):
    Nucleocapsid protein
    Short name:
    Protein N
    Gene namesi
    Name:N
    OrganismiRabies virus (strain China/MRV) (RABV)
    Taxonomic identifieri445791 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesRhabdoviridaeLyssavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Mammalia [TaxID: 40674]
    ProteomesiUP000008650: Genome

    Subcellular locationi

    Virion. Host cytoplasm By similarity

    GO - Cellular componenti

    1. helical viral capsid Source: UniProtKB-KW
    2. host cell cytoplasm Source: UniProtKB-SubCell
    3. ribonucleoprotein complex Source: UniProtKB-KW
    4. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Helical capsid protein, Host cytoplasm, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450NucleoproteinPRO_0000295213Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei389 – 3891Phosphoserine; by host CK2By similarity

    Post-translational modificationi

    Phosphorylated by host CK2. Unphosphorylated protein N seems to have a better affinity for leader viral promoter encapsidation. Phosphorylation of protein N in ribonucleocapsid may stabilize the interaction with protein P, thereby playing an important role in viral transcription/replication By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. In nucleocapsid, binds protein P and thereby positions the polymerase on the template. Protein P acts as a chaperone on free protein N to prevent it from aggregation before encapsidating genomic RNA By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ0GBY4.
    SMRiQ0GBY4. Positions 5-448.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.3570.10. 1 hit.
    1.10.3610.10. 1 hit.
    InterProiIPR000448. Rhabdo_ncapsid.
    IPR023331. Rhabdovirus_ncapsid_C.
    IPR023330. Rhabdovirus_ncapsid_N.
    [Graphical view]
    PfamiPF00945. Rhabdo_ncap. 1 hit.
    [Graphical view]
    ProDomiPD002087. Rhabd_nucleocap. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF140809. SSF140809. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0GBY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDADKIVFKV NNQVVSLKPE IIVDQYEYKY PAIKDLKKPC ITLGKAPDLN    50
    KAYKSVLSGM NAAKLDPDDV CSYLAAAMQF FEGTCPEDWT SYGILIARKG 100
    DRITPNPLVE IKRTDVEGNW ALTGGMELTR DPTVSEHASL VGLLLSLYRL 150
    SKISGQNTGN YKTNIADRIE QIFETAPFVK IVEHHTLMTT HKMCANWSTI 200
    PNFRFLAGTY DMFFSRIEHL YSAIRVGTVV TAYEDCSGLV SFTGFIKQIN 250
    LTAREAILYF FHKNFEEEIR RMFEPGQETA VPHSYFIHFR SLGLSGKSPY 300
    SSNAVGHVFN LIHFVGCYMG QVRSLNATVI AACAPHEMSV LGGYLGEEFF 350
    GKGTFERRFF RDEKELQEYE AAELTKSDVA LADDGTVNSD DEDYFSGETR 400
    SPEAVYTRIM MNGGRLKRSH IRRYVSVSSN HQARPNSFAE FLNKTYSNDS 450
    Length:450
    Mass (Da):50,744
    Last modified:October 3, 2006 - v1
    Checksum:i6D7911DAA222A86A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ875050 Genomic RNA. Translation: ABI47937.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ875050 Genomic RNA. Translation: ABI47937.1 .

    3D structure databases

    ProteinModelPortali Q0GBY4.
    SMRi Q0GBY4. Positions 5-448.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.3570.10. 1 hit.
    1.10.3610.10. 1 hit.
    InterProi IPR000448. Rhabdo_ncapsid.
    IPR023331. Rhabdovirus_ncapsid_C.
    IPR023330. Rhabdovirus_ncapsid_N.
    [Graphical view ]
    Pfami PF00945. Rhabdo_ncap. 1 hit.
    [Graphical view ]
    ProDomi PD002087. Rhabd_nucleocap. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF140809. SSF140809. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Zhao Y.J., Guo L., Huang Y., Qian A.D.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiNCAP_RABVR
    AccessioniPrimary (citable) accession number: Q0GBY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Displays a superantigen activity in human and mouse, activating mostly V-beta-8 subtypes of T-cell receptor.By similarity

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3