Q0GBX6 (VGLG_RABVD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycoprotein G

Gene names

Name:

G

Organism

Rabies virus (strain China/DRV) (RABV) [Complete proteome]

Taxonomic identifier

445792 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA negative-strand viruses › Mononegavirales › Rhabdoviridae › Lyssavirus › Rabies virus

Virus host

Homo sapiens (Human) [TaxID: 9606]
Mammalia [TaxID: 40674]

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein G and thereby facilitate rabies virus entry into cells By similarity.
Subunit structure	Homotrimer. Interacts with matrix protein By similarity.
Subcellular location	Virion membrane; Single-pass type I membrane protein Potential.
Post-translational modification	Glycosylated and palmitoylated by host. Glycosylation is crucial for glycoprotein export at the cell surface By similarity.
Biotechnological use	Primary surface antigen capable of inducing and reacting with virus-neutralizing antibodies. Almost all human and veterinary vaccines are based on the functional aspects of the G protein.
Miscellaneous	Arg-352 is highly involved in rabies virus pathogenicity. Its mutation dramatically attenuates the virus By similarity.
Sequence similarities	Belongs to the lyssavirus glycoprotein family.

Ontologies

Keywords
Cellular component	Membrane Viral envelope protein Virion
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 524	505	Glycoprotein G		PRO_0000295800
Regions
	Topological domain	20 – 459	440	Virion surface Potential
	Transmembrane	460 – 480	21	Helical; Potential
	Topological domain	481 – 524	44	Intravirion Potential
Amino acid modifications
	Lipidation	480	1	S-palmitoyl cysteine; by host By similarity
	Glycosylation	56	1	N-linked (GlcNAc...); by host By similarity
	Glycosylation	266	1	N-linked (GlcNAc...); by host By similarity
	Glycosylation	338	1	N-linked (GlcNAc...); by host By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0GBX6 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 345C31B9FE59A242	FASTA	524	58,356
	10 20 30 40 50 60 MVPQALLLVP LLGFSLCFGK FPIYTIPTKL GPWSPIDIHH LSCPNNLVVE DEGCTNLSGF 70 80 90 100 110 120 SYMELKVGRI SAIKVNGFTC TGVVTEAETY TNFVGYVTTT FKRKHFRPMP GCMYSRVQLE 130 140 150 160 170 180 DGRSPQIEES LHNPYPDYHW LRTVRTTKES LIIISPSVTD LDPYDKSLHS RVFPGRKCSG 190 200 210 220 230 240 ITVSSTYCST NHDYTVWMPE ILRLGTSCDI FTNSRGKRAS KGSKTCGFVD ERGLYKSLKG 250 260 270 280 290 300 ACKLKLCGVP GLRLMDGTWV AMQTSNETKW CPPGQLVNLH DLHSDEIEHL VVEELVKKRE 310 320 330 340 350 360 ECLDALESIT TTKSVSFRRL SHLRKLVPGF GKAYTIFNKT LMEAEAHYKS VRTWNEIIPS 370 380 390 400 410 420 KGCLRVGGGC HPHVNGVFFN GIILGPDGHV LIPEMQSSLL QQHIELLESS VIPLMHPLAD 430 440 450 460 470 480 PFTVFKDGDE IEDFVEVHLP DVHEQVSGVD LGLPNWGEYV LLSAGTLIAL MLIIFLITCC 490 500 510 520 KRVDRPESTQ RSLRGTGRNV SVTSQSGKFI PSRESYKSGG ETGL

References

[1]	Zhao Y.J., Guo L., Huang Y., Qian A.D. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ875051 Other RNA. Translation: ABI47945.1.
3D structure databases
ProteinModelPortal	Q0GBX6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001903. Rhabd_glycop. [Graphical view]
Pfam	PF00974. Rhabdo_glycop. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VGLG_RABVD

Accession

Primary (citable) accession number: Q0GBX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	October 3, 2006
Last modified:	January 9, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program