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Protein

Serine/threonine-protein phosphatase 2B catalytic subunit

Gene

tax-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-dependent, calmodulin-stimulated protein phosphatase (PubMed:12221132, PubMed:16481400, PubMed:22300764, PubMed:23805378). Dephosphorylates arrd-17 (PubMed:22300764). Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation (PubMed:23805378). Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534' (PubMed:16481400). Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium (PubMed:16481400). Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons and sensitivity to CO2 levels (PubMed:18524955, PubMed:11879652). Plays a role in egg-laying, body-size, fertility, growth, movement and cuticle development (PubMed:12684004, PubMed:15522306, PubMed:17113567, PubMed:22300764). Negatively regulates lifespan (PubMed:19279398). Promotes transcription activator crtc-1 nuclear localization, probably by dephosphorylating crtc-1 and thereby negatively regulates lifespan (PubMed:21331044). Regulates expression of chemoreceptor srt-2 in AWC neurons probably downstream of Ser/Thr kinase kin-29 (PubMed:17113567). Regulates expression of tax-6 inhibitor rcn-1 (PubMed:12684004). Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine (PubMed:15990870). Plays a role in several endocytic processes including in coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle recycling (PubMed:20803083, PubMed:21345307). May negatively regulate excitatory GABA receptor exp-1 during enteric muscle contraction (PubMed:16084527). May negatively regulate autophagy (PubMed:19279398).15 Publications

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation4 Publications

Cofactori

Protein has several cofactor binding sites:
  • Fe3+CuratedNote: Binds 1 Fe3+ ion per subunit.Curated
  • Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Enzyme regulationi

Inhibited by immunosuppressant cyclosporin A (CsA).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi115 – 1151IronBy similarity
Metal bindingi117 – 1171IronBy similarity
Metal bindingi143 – 1431IronBy similarity
Metal bindingi143 – 1431ZincBy similarity
Metal bindingi175 – 1751ZincBy similarity
Active sitei176 – 1761Proton donorBy similarity
Metal bindingi224 – 2241ZincBy similarity
Metal bindingi306 – 3061ZincBy similarity

GO - Molecular functioni

  • calcium ion binding Source: WormBase
  • calmodulin-dependent protein phosphatase activity Source: WormBase
  • phosphoprotein phosphatase activity Source: WormBase

GO - Biological processi

  • calcium-mediated signaling Source: UniProtKB
  • chemosensory behavior Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • dauer larval development Source: WormBase
  • determination of adult lifespan Source: WormBase
  • hyperosmotic response Source: WormBase
  • olfactory behavior Source: WormBase
  • olfactory learning Source: WormBase
  • peptidyl-serine dephosphorylation Source: WormBase
  • positive regulation of growth rate Source: WormBase
  • positive regulation of multicellular organism growth Source: WormBase
  • protein dephosphorylation Source: WormBase
  • protein localization to nonmotile primary cilium Source: WormBase
  • regulation of gene expression Source: WormBase
  • response to alkaline pH Source: UniProtKB
  • response to hermaphrodite contact Source: WormBase
  • thermosensory behavior Source: WormBase
  • thermotaxis Source: WormBase
  • vulval location Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Behavior, Chemotaxis, Endocytosis

Keywords - Ligandi

Calcium, Iron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-2871809. FCERI mediated Ca+2 mobilization.
R-CEL-4086398. Ca2+ pathway.
R-CEL-5607763. CLEC7A (Dectin-1) induces NFAT activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2B catalytic subunitCurated (EC:3.1.3.16UniRule annotation4 Publications)
Alternative name(s):
Abnormal chemotaxis protein 6Imported
Calmodulin-dependent calcineurin subunit A1 Publication
Gene namesi
Name:tax-6Imported
Synonyms:cna-1Imported
ORF Names:C02F4.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC02F4.2a; CE07853; WBGene00006527; tax-6.
C02F4.2b; CE46805; WBGene00006527; tax-6.
C02F4.2c; CE46586; WBGene00006527; tax-6.

Subcellular locationi

Isoform a :
  • Perikaryon 1 Publication
  • Cell projectiondendrite 1 Publication
  • Cell projectionaxon 1 Publication
  • Cell projectioncilium 1 Publication
  • Cytoplasm 1 Publication

GO - Cellular componenti

  • axon Source: WormBase
  • cytoplasm Source: WormBase
  • dendrite Source: WormBase
  • neuronal cell body Source: WormBase
  • nonmotile primary cilium Source: WormBase
  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in an increase in lifespan (PubMed:21331044, PubMed:23805378). Also causes nuclear exclusion of crtc-1 (PubMed:21331044).2 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi259 – 2591D → N in p675; impaired thermotaxis and chemotaxis towards NaCl, hypersensitivity to low osmotic conditions, enhanced olfactory adaptation to isoamyl alcohol. Slow growth rate and body is smaller and slender with a transparent appearance resulting from a thinner cuticle. Reduced brood size associated with egg retention. Partially resistant to serotonin-induced egg laying. Increased susceptibility to nicotine-mediated paralysis. Impaired mating behavior and reduced localization of pkd-2 to neuronal cilium. Impaired CO2 avoidance. Impaired coelomocyte endocytosis, apical endocytosis in intestine and recycling of synaptic vesicles at synapses. 7 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Serine/threonine-protein phosphatase 2B catalytic subunitCuratedPRO_0000436904Add
BLAST

Proteomic databases

EPDiQ0G819.
PaxDbiQ0G819.
Q86MD4.
Q95002.
PRIDEiQ95002.

Expressioni

Tissue specificityi

Expressed in head and tail neurons, ventral nerve cord, body wall and vulva muscles, sperm and spermatheca (PubMed:12221132). Expressed in hypodermal seam cells (PubMed:15522306). Expressed in intestinal and anal depressor muscles (PubMed:16084527). In male, expressed in CEM, HOB and ray RnB neurons (PubMed:16481400). Isoform a: Expressed in thermosensory ADF neurons, chemosensory ASE, AWA and AWC neurons, osmosensory ASH neurons and AIY and AIZ interneurons (PubMed:11879652). Expressed in body wall, vulva and pharyngeal muscles (PubMed:11879652).5 Publications

Developmental stagei

Expressed in embryos and at all larval stages.1 Publication

Gene expression databases

ExpressionAtlasiQ0G819. baseline.

Interactioni

Subunit structurei

Forms a complex composed of a catalytic subunit tax-6 and a regulatory subunit cnb-1 which confers calcium sensitivity (PubMed:12221132). Interacts with rcn-1; the interaction is calcium-dependent and inhibits tax-6 catalytic activity (PubMed:12684004). Interacts with exp-1; the interaction is calcium and cnb-1-independent (PubMed:16084527). Interacts with arrd-17 (PubMed:22300764). Interacts with kin-29 (PubMed:17113567). Interacts with cnp-2 (PubMed:18593529). Interacts with daf-16 (PubMed:23805378). Interacts with dyn-1 (PubMed:20803083).8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
kin-29Q210173EBI-2412118,EBI-2893174
rcn-1P538064EBI-2412118,EBI-323055

Protein-protein interaction databases

IntActiQ0G819. 3 interactions.
MINTiMINT-1093406.
STRINGi6239.C02F4.2c.

Structurei

3D structure databases

ProteinModelPortaliQ0G819.
SMRiQ0G819. Positions 35-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni38 – 326289CatalyticCuratedAdd
BLAST
Regioni272 – 2787Calcineurin B binding-site 1Curated
Regioni321 – 3266Calcineurin B binding-site 2Curated
Regioni418 – 44023Calmodulin-bindingCuratedAdd
BLAST
Regioni490 – 51223Inhibitory domainCuratedAdd
BLAST

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2B subfamily.Curated

Phylogenomic databases

eggNOGiKOG0375. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00530000063087.
HOGENOMiHOG000172699.
InParanoidiQ0G819.
KOiK04348.
OMAiRRIDRFK.
OrthoDBiEOG7BZVSC.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform cImported (identifier: Q0G819-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTSAGQNS AAKPDTTNTT TTASNNNRER ERDLKQFTER FVKTVQFPVS
60 70 80 90 100
ERLTVDQVYD RRTGKPRHEV LRDHFIKEGR IEEEAAIRVI QECSSLFRNE
110 120 130 140 150
KTMLEIEAPV TVCGDIHGQF YDLMKLFEVG GSPATTKYLF LGDYVDRGYF
160 170 180 190 200
SIECVLYLWA LKICYPTTLF LLRGNHECRH LTEYFTFKQE CKIKYSERVY
210 220 230 240 250
DVCMESFDAL PLAALMNQQF LCVHGGLSPE IHTLEDIRRI DRFKEPPAFG
260 270 280 290 300
PMCDLLWSDP LEDFGNERNS EQFSHNSVRG CSYFYSYAAC CDFLQHNNLL
310 320 330 340 350
SIIRAHEAQD AGYRMYRKSQ ATGFPSLITI FSAPNYLDVY NNKAAILKYE
360 370 380 390 400
NNVMNIRQFN CSPHPYWLPN FMDVFTWSLP FVGEKVTEML VHILNICSDD
410 420 430 440 450
ELMAECDDTF EGGVGSARKE VIRHKIRAIG KMARAFSVLR HESESVLQLK
460 470 480 490 500
GLNAGGKLPQ GALSEGRTGL NAAYRIEQSV AAESGCDSGH LIQSFEEARR
510 520 530 540
LDKINERMPP TMATPPAQSP SQSPIPSRQT TPQPPQNGPS NS
Note: No experimental confirmation available.Curated
Length:542
Mass (Da):61,505
Last modified:January 25, 2012 - v2
Checksum:i60983B8A0C504883
GO
Isoform aImported (identifier: Q0G819-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     441-441: H → E
     448-479: QLKGLNAGGKLPQGALSEGRTGLNAAYRIEQS → ALKGLTPTGALPMGTLQGGSRGVRE

Show »
Length:535
Mass (Da):60,666
Checksum:iFC0363809D04103E
GO
Isoform bImported (identifier: Q0G819-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     413-450: GVGSARKEVI...HESESVLQLK → ADGKWIFPYP...IFYQTFFGTP
     451-542: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:450
Mass (Da):52,057
Checksum:iEC01B58E6C8F3E43
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei413 – 45038GVGSA…VLQLK → ADGKWIFPYPPHTGDVCLTI RFSFIFSLIFYQTFFGTP in isoform b. VSP_058441Add
BLAST
Alternative sequencei441 – 4411H → E in isoform a. CuratedVSP_058442
Alternative sequencei448 – 47932QLKGL…RIEQS → ALKGLTPTGALPMGTLQGGS RGVRE in isoform a. VSP_058443Add
BLAST
Alternative sequencei451 – 54292Missing in isoform b. CuratedVSP_058444Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAB02719.1.
BX284604 Genomic DNA. Translation: CAD88213.2.
BX284604 Genomic DNA. Translation: CAL36491.2.
PIRiT18864.
RefSeqiNP_001076658.2. NM_001083189.4.
UniGeneiCel.13613.

Genome annotation databases

EnsemblMetazoaiC02F4.2c; C02F4.2c; WBGene00006527.
GeneIDi177943.
KEGGicel:CELE_C02F4.2.
UCSCiC02F4.2c. c. elegans.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAB02719.1.
BX284604 Genomic DNA. Translation: CAD88213.2.
BX284604 Genomic DNA. Translation: CAL36491.2.
PIRiT18864.
RefSeqiNP_001076658.2. NM_001083189.4.
UniGeneiCel.13613.

3D structure databases

ProteinModelPortaliQ0G819.
SMRiQ0G819. Positions 35-511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ0G819. 3 interactions.
MINTiMINT-1093406.
STRINGi6239.C02F4.2c.

Proteomic databases

EPDiQ0G819.
PaxDbiQ0G819.
Q86MD4.
Q95002.
PRIDEiQ95002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC02F4.2c; C02F4.2c; WBGene00006527.
GeneIDi177943.
KEGGicel:CELE_C02F4.2.
UCSCiC02F4.2c. c. elegans.

Organism-specific databases

CTDi177943.
WormBaseiC02F4.2a; CE07853; WBGene00006527; tax-6.
C02F4.2b; CE46805; WBGene00006527; tax-6.
C02F4.2c; CE46586; WBGene00006527; tax-6.

Phylogenomic databases

eggNOGiKOG0375. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00530000063087.
HOGENOMiHOG000172699.
InParanoidiQ0G819.
KOiK04348.
OMAiRRIDRFK.
OrthoDBiEOG7BZVSC.

Enzyme and pathway databases

ReactomeiR-CEL-2871809. FCERI mediated Ca+2 mobilization.
R-CEL-4086398. Ca2+ pathway.
R-CEL-5607763. CLEC7A (Dectin-1) induces NFAT activation.

Gene expression databases

ExpressionAtlasiQ0G819. baseline.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  2. "Calcineurin, a calcium/calmodulin-dependent protein phosphatase, is involved in movement, fertility, egg laying, and growth in Caenorhabditis elegans."
    Bandyopadhyay J., Lee J., Lee J., Lee J.I., Yu J.-R., Jee C., Cho J.-H., Jung S., Lee M.H., Zannoni S., Singson A., Kim D., Koo H.-S., Ahnn J.
    Mol. Biol. Cell 13:3281-3293(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, INTERACTION WITH CNB-1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. "Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6."
    Kuhara A., Inada H., Katsura I., Mori I.
    Neuron 33:751-763(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF ASP-259.
  4. "The Caenorhabditis elegans homologue of Down syndrome critical region 1, RCN-1, inhibits multiple functions of the phosphatase calcineurin."
    Lee J.I., Dhakal B.K., Lee J., Bandyopadhyay J., Jeong S.Y., Eom S.H., Kim D.H., Ahnn J.
    J. Mol. Biol. 328:147-156(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RCN-1, MUTAGENESIS OF ASP-259.
  5. "Opposing functions of calcineurin and CaMKII regulate G-protein signaling in egg-laying behavior of C.elegans."
    Lee J., Jee C., Song H.O., Bandyopadhyay J., Lee J.I., Yu J.R., Lee J., Park B.J., Ahnn J.
    J. Mol. Biol. 344:585-595(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  6. "Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans."
    Gottschalk A., Almedom R.B., Schedletzky T., Anderson S.D., Yates J.R. III, Schafer W.R.
    EMBO J. 24:2566-2578(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF ASP-259.
  7. "Calcineurin regulates enteric muscle contraction through EXP-1, excitatory GABA-gated channel, in C. elegans."
    Lee J., Song H.O., Jee C., Vanoaica L., Ahnn J.
    J. Mol. Biol. 352:313-318(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EXP-1, TISSUE SPECIFICITY.
  8. "Casein kinase II and calcineurin modulate TRPP function and ciliary localization."
    Hu J., Bae Y.-K., Knobel K.M., Barr M.M.
    Mol. Biol. Cell 17:2200-2211(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF ASP-259.
  9. "Calcineurin interacts with KIN-29, a Ser/Thr kinase, in Caenorhabditis elegans."
    Singaravelu G., Song H.O., Ji Y.J., Jee C., Park B.J., Ahnn J.
    Biochem. Biophys. Res. Commun. 352:29-35(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH KIN-29.
  10. "Novel calcineurin interacting protein-2: the functional characterization of CNP-2 in Caenorhabditis elegans."
    Xianglan C., Ko K.M., Singaravelu G., Ahnn J.
    BMB Rep. 41:455-460(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNP-2.
  11. "Acute carbon dioxide avoidance in Caenorhabditis elegans."
    Hallem E.A., Sternberg P.W.
    Proc. Natl. Acad. Sci. U.S.A. 105:8038-8043(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF ASP-259.
  12. "Autophagy genes mediate the effect of calcineurin on life span in C. elegans."
    Dwivedi M., Song H.O., Ahnn J.
    Autophagy 5:604-607(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Calcineurin regulates coelomocyte endocytosis via DYN-1 and CUP-4 in Caenorhabditis elegans."
    Song H.O., Lee J., Ji Y.J., Dwivedi M., Cho J.H., Park B.J., Ahnn J.
    Mol. Cells 30:255-262(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DYN-1, MUTAGENESIS OF ASP-259.
  14. "Calcineurin may regulate multiple endocytic processes in C. elegans."
    Song H.O., Ahnn J.
    BMB Rep. 44:96-101(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF ASP-259.
  15. "Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB."
    Mair W., Morantte I., Rodrigues A.P., Manning G., Montminy M., Shaw R.J., Dillin A.
    Nature 470:404-408(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  16. "CNP-1 (ARRD-17), a novel substrate of calcineurin, is critical for modulation of egg-laying and locomotion in response to food and lysine sensation in Caenorhabditis elegans."
    Jee C., Choi T.W., Kalichamy K., Yee J.Z., Song H.O., Ji Y.J., Lee J., Lee J.I., L'Etoile N.D., Ahnn J., Lee S.K.
    J. Mol. Biol. 417:165-178(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH ARRD-17.
  17. "CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16."
    Tao L., Xie Q., Ding Y.H., Li S.T., Peng S., Zhang Y.P., Tan D., Yuan Z., Dong M.Q.
    Elife 2:E00518-E00518(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH DAF-16, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiPP2B_CAEEL
AccessioniPrimary (citable) accession number: Q0G819
Secondary accession number(s): Q86MD4, Q95002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 6, 2016
Last sequence update: January 25, 2012
Last modified: July 6, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.