ID   Q0EFB4_HUMAN            Unreviewed;       359 AA.
AC   Q0EFB4;
DT   17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   17-OCT-2006, sequence version 1.
DT   03-MAY-2023, entry version 70.
DE   SubName: Full=MICB antigen {ECO:0000313|EMBL:AFR77728.1};
DE   SubName: Full=MICB protein {ECO:0000313|EMBL:BAF31274.1};
DE   Flags: Fragment;
GN   Name=MICB {ECO:0000313|EMBL:BAF31274.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAF31274.1};
RN   [1] {ECO:0000313|EMBL:BAF31274.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16702430; DOI=10.1534/genetics.106.057034;
RA   Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M.,
RA   Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K.,
RA   Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.,
RA   Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T.,
RA   Inoko H., Bahram S.;
RT   "Rapid evolution of major histocompatibility complex class I genes in
RT   primates generates new disease alleles in humans via hitchhiking
RT   diversity.";
RL   Genetics 173:1555-1570(2006).
RN   [2] {ECO:0000313|EMBL:AFR77728.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zhu F.M., Ying Y.L., He Y.M.;
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AFR77728.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23549730;
RA   Ying Y., He Y., Tao S., Han Z., Wang W., Chen N., He J., Zhang W., He J.,
RA   Zhu F., Lv H.;
RT   "Distribution of MICB diversity in the Zhejiang Han population: PCR
RT   sequence-based typing for exons 2-6 and identification of five novel MICB
RT   alleles.";
RL   Immunogenetics 65:485-492(2013).
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DR   EMBL; JX282181; AFR77728.1; -; Genomic_DNA.
DR   EMBL; JX282182; AFR77729.1; -; Genomic_DNA.
DR   EMBL; JX282184; AFR77731.1; -; Genomic_DNA.
DR   EMBL; AB103613; BAF31274.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0EFB4; -.
DR   SMR; Q0EFB4; -.
DR   PeptideAtlas; Q0EFB4; -.
DR   ChiTaRS; MICB; human.
DR   CDD; cd21017; IgC1_MHC_Ia_MIC-A_MIC-B; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   PANTHER; PTHR16675:SF154; MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE A-RELATED; 1.
DR   PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          183..278
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAF31274.1"
SQ   SEQUENCE   359 AA;  40134 MW;  61E437F858C08985 CRC64;
     PHSLRYNLMV LSQDGSVQSG FLAEGHLDGQ PFLRYDRQKR RAKPQGQWAE DVLGAKTWDT
     ETEDLTENGQ DLRRTLTHIK DQKGGLHSLQ EIRVCEIHED SSTRGSRHFY YDGELFLSQN
     LETQESTVPQ SSRAQTLAMN VTNFWKEDAM KTKTHYRAMQ ADCLQKLQRY LKSGVAIRRT
     VPPMVNVTCS EVSEGNITVT CRASSFYPRN ITLTWRQDGV SLSHNTQQWG DVLPDGNGTY
     QTWVATRIRQ GEEQRFTCYM EHSGNHGTHP VPSGKALVLQ SQRTDFPYVS AAMPCFVIII
     ILCVPCCKKK TSAAEGPELV SLQVLDQHPV GTGDHRDAAQ LGFQPLMSAT GSTGSTEGA
//