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Reviewed, UniProtKB/Swiss-Prot Q0EFA0 (GPX1_PANTR)

Last modified February 9, 2010. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glutathione peroxidase 1
      Short name=GSHPx-1
      Short name=GPx-1
    EC=1.11.1.9
Alternative name(s):
    Cellular glutathione peroxidase
Gene names
Name: GPX1
OrganismPan troglodytes (Chimpanzee)
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Protects the hemoglobin in erythrocytes from oxidative breakdown By similarity.

Catalytic activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the glutathione peroxidase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversitySelenocysteine
   LigandSelenium
   Molecular functionOxidoreductase
Peroxidase
   PTMAcetylation
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionglutathione peroxidase activity

Inferred from electronic annotation. Source: EC

selenium binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201Glutathione peroxidase 1
PRO_0000274127

Sites

Active site471 By similarity

Amino acid modifications

Non-standard residue471Selenocysteine
Modified residue1461N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0EFA0-1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: F2E192F83439811B

FASTA20121,950
        10         20         30         40         50         60 
MCAARLAAAA AQSVYAFSAR PLAGGEPVSL GSLRGKVLLI ENVASLUGTT VRDYTQMNEL 

        70         80         90        100        110        120 
QRRLGPRGLV VLGFPCNQFG HQENAKNEEI LNSLKYVRPG GGFEPNFMLF EKCEVNGAGA 

       130        140        150        160        170        180 
HTLFAFLREA LPAPSDDATA LMTDPKLITW SPVCRNDVAW NFEKFLVGPD GVPLRRYSRR 

       190        200 
FQTIDIEPDI EALLSQGPSC A 

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References

[1]"Molecular evolution of primate glutathione peroxidases."
Fukuhara R., Kageyama T.
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB120996 mRNA. Translation: BAF31850.1.
RefSeqNP_001070980.2.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ0EFA0.

Protein family/group databases

PeroxiBase1358. PtroGPx01.

Genome annotation databases

EnsemblENSPTRT00000027928; ENSPTRP00000051383; ENSPTRG00000014921; Pan troglodytes. [Genome view]
GeneID461015.
KEGGptr:461015.

Organism-specific databases

CTD461015.

Phylogenomic databases

eggNOGprNOG12554.
HOVERGENQ0EFA0.
InParanoidQ0EFA0.

Enzyme and pathway databases

BRENDA1.11.1.9. 264977.

Family and domain databases

InterProIPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHERPTHR11592. Glut_peroxidase. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
PROSITEPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPX1_PANTR
AccessionPrimary (citable) accession number: Q0EFA0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: February 26, 2008
Last modified: February 9, 2010
This is version 29 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents