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Protein

Patched domain-containing protein 3

Gene

Ptchd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in sperm development or sperm function.1 Publication

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Patched domain-containing protein 3
Alternative name(s):
RND-type protein RNDEu-3
Gene namesi
Name:Ptchd3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921925. Ptchd3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei338 – 35821HelicalSequence analysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence analysisAdd
BLAST
Transmembranei392 – 41221HelicalSequence analysisAdd
BLAST
Transmembranei442 – 46221HelicalSequence analysisAdd
BLAST
Transmembranei476 – 49621HelicalSequence analysisAdd
BLAST
Transmembranei559 – 57921HelicalSequence analysisAdd
BLAST
Transmembranei760 – 78021HelicalSequence analysisAdd
BLAST
Transmembranei782 – 80221HelicalSequence analysisAdd
BLAST
Transmembranei814 – 83421HelicalSequence analysisAdd
BLAST
Transmembranei848 – 86821HelicalSequence analysisAdd
BLAST
Transmembranei883 – 90321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • sperm midpiece Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 906906Patched domain-containing protein 3PRO_0000309263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ0EEE2.
PRIDEiQ0EEE2.

PTM databases

PhosphoSiteiQ0EEE2.

Expressioni

Tissue specificityi

Expressed in germ cells of the testis (at protein level).1 Publication

Developmental stagei

Expression begins around the pachytene stage of spermatogenesis.1 Publication

Gene expression databases

BgeeiQ0EEE2.
CleanExiMM_PTCHD3.
GenevisibleiQ0EEE2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035709.

Structurei

3D structure databases

ProteinModelPortaliQ0EEE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini339 – 496158SSDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the patched family.Curated
Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1934. Eukaryota.
ENOG410XRZ4. LUCA.
GeneTreeiENSGT00800000124043.
HOGENOMiHOG000115764.
HOVERGENiHBG082604.
InParanoidiQ0EEE2.
OMAiDQYLVIV.
OrthoDBiEOG7QK0B6.
PhylomeDBiQ0EEE2.
TreeFamiTF331806.

Family and domain databases

InterProiIPR003392. Patched.
IPR000731. SSD.
[Graphical view]
PfamiPF02460. Patched. 1 hit.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0EEE2-1) [UniParc]FASTAAdd to basket

Also known as: Ptchd3b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISSKVAPGE EEQGESPSKV ELGEAEEQRE APLEGQLEAV PLDEAGPSWT
60 70 80 90 100
TGPPLERLPP LGQEAPPPRR CHTNCLEAPL SRGFQRFGAT VGANPWLFLL
110 120 130 140 150
GPALLTASLG TGLIFLPKEK ENLEEQYTPI GSPAKAERRF VQGHFSTNDT
160 170 180 190 200
YRFSASRTSS ETNFASILVV SLANSLLEPE IFKEVSKLDQ AVQALKVVQE
210 220 230 240 250
NGTQILYQEV CAKYKTLCVP PNPLLFSWQH NSSLNLSDLT FPIHNTPTQL
260 270 280 290 300
IYLAGFFGGN VLGQMTGKSQ RLVESRAMRL LYYLKTEDPE DSERSQAWLT
310 320 330 340 350
HFLDHFNDMK SSLTLEEIEV VYFSSLSRQL EFEATSKTVI PLFHLAYILI
360 370 380 390 400
ILFAVVSCSR LDCIRNKMCV AVFGVFSVAM SVVSGFGLML HLGVPFVIIV
410 420 430 440 450
ANSPFLILGV GVDDMFIMIS AWQKTSLSES IRERLSNSYS KVAVSITITT
460 470 480 490 500
ITNVLAFYTG ITSSFRSVQY FCIYTGTTLL FCYFYSITCF GAVMALDGKR
510 520 530 540 550
EVAWSRWLEK PDQKYSSLKK SCCVPFGSLI DKHGEDNHPM NLFFRDYFGP
560 570 580 590 600
FLTTSKAKFI VVLLYIFYII SSIYGCFQVQ EGLDLRNLAS DDSYITPYFN
610 620 630 640 650
VEEDYFSDYG PRVMVIVTES VNYWDNDVRQ KLDKCMTQFE ENEYVDKNLT
660 670 680 690 700
EFWLEAYMQY MNSSGNNPND KNTFMNNIAG FLQFFPIFTY DINISSSNEI
710 720 730 740 750
TSSRGFIQIV DVSSSSNKKR MLLKLRSIAE NCEVPLMVYN QAFIYFDQYA
760 770 780 790 800
AIIENTVRNV MIASTAMFIV SLLLIPHPVC SLWVTFAIAS VIVGVTGFMA
810 820 830 840 850
FWNVNLDSIS MINLVICIGF SFDFSAHISY AFVSSTEPSV NKKSIEALYL
860 870 880 890 900
LGYPVLQSAI STIIGVCVLS AAKAYIFRTF FKIMFLVMFF GAAHGLIFIP

VFLTFF
Length:906
Mass (Da):101,813
Last modified:October 17, 2006 - v1
Checksum:iDFCB9B3497766E5B
GO
Isoform 2 (identifier: Q0EEE2-2) [UniParc]FASTAAdd to basket

Also known as: Ptchd3a

The sequence of this isoform differs from the canonical sequence as follows:
     410-410: V → E
     411-906: Missing.

Note: No experimental confirmation available.
Show »
Length:410
Mass (Da):45,329
Checksum:iF8FE3A6C01168F94
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei410 – 4101V → E in isoform 2. 1 PublicationVSP_029100
Alternative sequencei411 – 906496Missing in isoform 2. 1 PublicationVSP_029101Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB235902 mRNA. Translation: BAF32146.1.
AK015440 mRNA. Translation: BAB29848.1.
AK017136 mRNA. Translation: BAB30614.1.
AL663041 Genomic DNA. Translation: CAM21595.2.
CCDSiCCDS49014.1. [Q0EEE2-1]
RefSeqiNP_083325.1. NM_029049.1. [Q0EEE2-1]
UniGeneiMm.61213.

Genome annotation databases

EnsembliENSMUST00000036690; ENSMUSP00000035709; ENSMUSG00000039198. [Q0EEE2-1]
GeneIDi74675.
KEGGimmu:74675.
UCSCiuc007mwf.2. mouse. [Q0EEE2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB235902 mRNA. Translation: BAF32146.1.
AK015440 mRNA. Translation: BAB29848.1.
AK017136 mRNA. Translation: BAB30614.1.
AL663041 Genomic DNA. Translation: CAM21595.2.
CCDSiCCDS49014.1. [Q0EEE2-1]
RefSeqiNP_083325.1. NM_029049.1. [Q0EEE2-1]
UniGeneiMm.61213.

3D structure databases

ProteinModelPortaliQ0EEE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035709.

PTM databases

PhosphoSiteiQ0EEE2.

Proteomic databases

PaxDbiQ0EEE2.
PRIDEiQ0EEE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036690; ENSMUSP00000035709; ENSMUSG00000039198. [Q0EEE2-1]
GeneIDi74675.
KEGGimmu:74675.
UCSCiuc007mwf.2. mouse. [Q0EEE2-1]

Organism-specific databases

CTDi374308.
MGIiMGI:1921925. Ptchd3.

Phylogenomic databases

eggNOGiKOG1934. Eukaryota.
ENOG410XRZ4. LUCA.
GeneTreeiENSGT00800000124043.
HOGENOMiHOG000115764.
HOVERGENiHBG082604.
InParanoidiQ0EEE2.
OMAiDQYLVIV.
OrthoDBiEOG7QK0B6.
PhylomeDBiQ0EEE2.
TreeFamiTF331806.

Miscellaneous databases

NextBioi341360.
PROiQ0EEE2.
SOURCEiSearch...

Gene expression databases

BgeeiQ0EEE2.
CleanExiMM_PTCHD3.
GenevisibleiQ0EEE2. MM.

Family and domain databases

InterProiIPR003392. Patched.
IPR000731. SSD.
[Graphical view]
PfamiPF02460. Patched. 1 hit.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the novel RND-type protein in mice."
    Hashimoto S., Yamaguchi A.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-729 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Male germ cell-specific expression of a novel patched-domain containing gene Ptchd3."
    Fan J., Akabane H., Zheng X., Zhou X., Zhang L., Liu Q., Zhang Y.-L., Yang J., Zhu G.-Z.
    Biochem. Biophys. Res. Commun. 363:757-761(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPTHD3_MOUSE
AccessioniPrimary (citable) accession number: Q0EEE2
Secondary accession number(s): A2AC39, Q9CUM1, Q9D3R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 17, 2006
Last modified: November 11, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.