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Protein

Patched domain-containing protein 3

Gene

Ptchd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in sperm development or sperm function.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Patched domain-containing protein 3
Alternative name(s):
RND-type protein RNDEu-3
Gene namesi
Name:Ptchd3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921925. Ptchd3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Transmembranei476 – 496HelicalSequence analysisAdd BLAST21
Transmembranei559 – 579HelicalSequence analysisAdd BLAST21
Transmembranei760 – 780HelicalSequence analysisAdd BLAST21
Transmembranei782 – 802HelicalSequence analysisAdd BLAST21
Transmembranei814 – 834HelicalSequence analysisAdd BLAST21
Transmembranei848 – 868HelicalSequence analysisAdd BLAST21
Transmembranei883 – 903HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • sperm midpiece Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003092631 – 906Patched domain-containing protein 3Add BLAST906

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi148N-linked (GlcNAc...)Sequence analysis1
Glycosylationi235N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ0EEE2.
PRIDEiQ0EEE2.

PTM databases

iPTMnetiQ0EEE2.
PhosphoSitePlusiQ0EEE2.

Expressioni

Tissue specificityi

Expressed in germ cells of the testis (at protein level).1 Publication

Developmental stagei

Expression begins around the pachytene stage of spermatogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000039198.
CleanExiMM_PTCHD3.
GenevisibleiQ0EEE2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035709.

Structurei

3D structure databases

ProteinModelPortaliQ0EEE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini339 – 496SSDPROSITE-ProRule annotationAdd BLAST158

Sequence similaritiesi

Belongs to the patched family.Curated
Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1934. Eukaryota.
ENOG410XRZ4. LUCA.
GeneTreeiENSGT00800000124043.
HOGENOMiHOG000115764.
HOVERGENiHBG082604.
InParanoidiQ0EEE2.
OMAiEKCEIPL.
OrthoDBiEOG091G01KV.
PhylomeDBiQ0EEE2.
TreeFamiTF331806.

Family and domain databases

InterProiIPR003392. Ptc/Disp.
IPR000731. SSD.
[Graphical view]
PfamiPF02460. Patched. 1 hit.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0EEE2-1) [UniParc]FASTAAdd to basket
Also known as: Ptchd3b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISSKVAPGE EEQGESPSKV ELGEAEEQRE APLEGQLEAV PLDEAGPSWT
60 70 80 90 100
TGPPLERLPP LGQEAPPPRR CHTNCLEAPL SRGFQRFGAT VGANPWLFLL
110 120 130 140 150
GPALLTASLG TGLIFLPKEK ENLEEQYTPI GSPAKAERRF VQGHFSTNDT
160 170 180 190 200
YRFSASRTSS ETNFASILVV SLANSLLEPE IFKEVSKLDQ AVQALKVVQE
210 220 230 240 250
NGTQILYQEV CAKYKTLCVP PNPLLFSWQH NSSLNLSDLT FPIHNTPTQL
260 270 280 290 300
IYLAGFFGGN VLGQMTGKSQ RLVESRAMRL LYYLKTEDPE DSERSQAWLT
310 320 330 340 350
HFLDHFNDMK SSLTLEEIEV VYFSSLSRQL EFEATSKTVI PLFHLAYILI
360 370 380 390 400
ILFAVVSCSR LDCIRNKMCV AVFGVFSVAM SVVSGFGLML HLGVPFVIIV
410 420 430 440 450
ANSPFLILGV GVDDMFIMIS AWQKTSLSES IRERLSNSYS KVAVSITITT
460 470 480 490 500
ITNVLAFYTG ITSSFRSVQY FCIYTGTTLL FCYFYSITCF GAVMALDGKR
510 520 530 540 550
EVAWSRWLEK PDQKYSSLKK SCCVPFGSLI DKHGEDNHPM NLFFRDYFGP
560 570 580 590 600
FLTTSKAKFI VVLLYIFYII SSIYGCFQVQ EGLDLRNLAS DDSYITPYFN
610 620 630 640 650
VEEDYFSDYG PRVMVIVTES VNYWDNDVRQ KLDKCMTQFE ENEYVDKNLT
660 670 680 690 700
EFWLEAYMQY MNSSGNNPND KNTFMNNIAG FLQFFPIFTY DINISSSNEI
710 720 730 740 750
TSSRGFIQIV DVSSSSNKKR MLLKLRSIAE NCEVPLMVYN QAFIYFDQYA
760 770 780 790 800
AIIENTVRNV MIASTAMFIV SLLLIPHPVC SLWVTFAIAS VIVGVTGFMA
810 820 830 840 850
FWNVNLDSIS MINLVICIGF SFDFSAHISY AFVSSTEPSV NKKSIEALYL
860 870 880 890 900
LGYPVLQSAI STIIGVCVLS AAKAYIFRTF FKIMFLVMFF GAAHGLIFIP

VFLTFF
Length:906
Mass (Da):101,813
Last modified:October 17, 2006 - v1
Checksum:iDFCB9B3497766E5B
GO
Isoform 2 (identifier: Q0EEE2-2) [UniParc]FASTAAdd to basket
Also known as: Ptchd3a

The sequence of this isoform differs from the canonical sequence as follows:
     410-410: V → E
     411-906: Missing.

Note: No experimental confirmation available.
Show »
Length:410
Mass (Da):45,329
Checksum:iF8FE3A6C01168F94
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029100410V → E in isoform 2. 1 Publication1
Alternative sequenceiVSP_029101411 – 906Missing in isoform 2. 1 PublicationAdd BLAST496

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB235902 mRNA. Translation: BAF32146.1.
AK015440 mRNA. Translation: BAB29848.1.
AK017136 mRNA. Translation: BAB30614.1.
AL663041 Genomic DNA. Translation: CAM21595.2.
CCDSiCCDS49014.1. [Q0EEE2-1]
RefSeqiNP_083325.1. NM_029049.1. [Q0EEE2-1]
UniGeneiMm.61213.

Genome annotation databases

EnsembliENSMUST00000036690; ENSMUSP00000035709; ENSMUSG00000039198. [Q0EEE2-1]
GeneIDi74675.
KEGGimmu:74675.
UCSCiuc007mwf.2. mouse. [Q0EEE2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB235902 mRNA. Translation: BAF32146.1.
AK015440 mRNA. Translation: BAB29848.1.
AK017136 mRNA. Translation: BAB30614.1.
AL663041 Genomic DNA. Translation: CAM21595.2.
CCDSiCCDS49014.1. [Q0EEE2-1]
RefSeqiNP_083325.1. NM_029049.1. [Q0EEE2-1]
UniGeneiMm.61213.

3D structure databases

ProteinModelPortaliQ0EEE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035709.

PTM databases

iPTMnetiQ0EEE2.
PhosphoSitePlusiQ0EEE2.

Proteomic databases

PaxDbiQ0EEE2.
PRIDEiQ0EEE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036690; ENSMUSP00000035709; ENSMUSG00000039198. [Q0EEE2-1]
GeneIDi74675.
KEGGimmu:74675.
UCSCiuc007mwf.2. mouse. [Q0EEE2-1]

Organism-specific databases

CTDi374308.
MGIiMGI:1921925. Ptchd3.

Phylogenomic databases

eggNOGiKOG1934. Eukaryota.
ENOG410XRZ4. LUCA.
GeneTreeiENSGT00800000124043.
HOGENOMiHOG000115764.
HOVERGENiHBG082604.
InParanoidiQ0EEE2.
OMAiEKCEIPL.
OrthoDBiEOG091G01KV.
PhylomeDBiQ0EEE2.
TreeFamiTF331806.

Miscellaneous databases

PROiQ0EEE2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039198.
CleanExiMM_PTCHD3.
GenevisibleiQ0EEE2. MM.

Family and domain databases

InterProiIPR003392. Ptc/Disp.
IPR000731. SSD.
[Graphical view]
PfamiPF02460. Patched. 1 hit.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTHD3_MOUSE
AccessioniPrimary (citable) accession number: Q0EEE2
Secondary accession number(s): A2AC39, Q9CUM1, Q9D3R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.