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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61MannoseCombined sources1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ApoptosisUniRule annotationSAAS annotation, Fusion of virus membrane with host membraneUniRule annotationSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Cleaved into the following 2 chains:
Surface protein gp120UniRule annotation
Short name:
SUUniRule annotation
Alternative name(s):
Glycoprotein 120UniRule annotation
Short name:
gp120UniRule annotation
Transmembrane protein gp41UniRule annotation
Short name:
TMUniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 41HelicalUniRule annotationAdd BLAST22
Transmembranei506 – 529HelicalUniRule annotationAdd BLAST24
Transmembranei672 – 699HelicalUniRule annotationAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host endosomeUniRule annotationSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 73Combined sources
GlycosylationiCAR_500845195687N-linked (GlcNAc...)Combined sources1
Disulfide bondi118 ↔ 207Combined sources
GlycosylationiCAR_5008451953160N-linked (GlcNAc...)Combined sources1
GlycosylationiCAR_5008451963188N-linked (GlcNAc...)Combined sources1
Disulfide bondi220 ↔ 249Combined sources
Disulfide bondi230 ↔ 241Combined sources
GlycosylationiCAR_5008451952236N-linked (GlcNAc...)Combined sources1
GlycosylationiCAR_5008451951243N-linked (GlcNAc...)Combined sources1
GlycosylationiCAR_5008451957264N-linked (GlcNAc...)Combined sources1
GlycosylationiCAR_5008451955278N-linked (GlcNAc...)Combined sources1
GlycosylationiCAR_5008451961291N-linked (GlcNAc...)Combined sources1
GlycosylationiCAR_5008451960297N-linked (GlcNAc...)Combined sources1
Disulfide bondi298 ↔ 332Combined sources
Disulfide bondi332 ↔ 412Combined sources
Disulfide bondi332 ↔ 385Combined sources
GlycosylationiCAR_5008451958335N-linked (GlcNAc...)Combined sources1
GlycosylationiCAR_5008451954356N-linked (GlcNAc...)Combined sources1
Disulfide bondi378 ↔ 439Combined sources
Disulfide bondi385 ↔ 412Combined sources
GlycosylationiCAR_5008451950386N-linked (GlcNAc...)Combined sources1
GlycosylationiCAR_5008451962392N-linked (GlcNAc...)Combined sources1
Disulfide bondi395 ↔ 404Combined sources
GlycosylationiCAR_5008451959442N-linked (GlcNAc...)Combined sources1

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Interactioni

Subunit structurei

The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NGBX-ray2.68A/D/G/I43-122[»]
A/D/G/I201-303[»]
A/D/G/I325-486[»]
3SE9X-ray2.00G43-486[»]
3TGTX-ray1.90A43-486[»]
3U7YX-ray2.45G43-122[»]
G201-303[»]
G325-486[»]
4DKOX-ray1.98A/C43-486[»]
4DKPX-ray1.80A/C43-486[»]
4DKQX-ray1.89A43-486[»]
4DKRX-ray1.80A/C43-486[»]
4DKUX-ray2.49A/B43-122[»]
A/B201-303[»]
A/B325-486[»]
4DKVX-ray2.18A/B43-122[»]
A/B201-303[»]
A/B325-486[»]
4DVSX-ray2.10A/B43-122[»]
A/B201-302[»]
A/B325-486[»]
4DVTX-ray2.40A/B88-122[»]
A/B201-293[»]
A/B341-433[»]
A/B457-486[»]
4DVVX-ray1.94A/B88-122[»]
A/B201-341[»]
A/B457-486[»]
4DVWX-ray2.20A/B88-122[»]
A/B201-293[»]
A/B341-433[»]
A/B457-486[»]
4DVXX-ray2.40A/B88-122[»]
A/B201-293[»]
A/B341-433[»]
A/B457-486[»]
4H8WX-ray1.85G43-486[»]
4I54X-ray2.50A/B43-486[»]
4JB9X-ray2.60G43-486[»]
4JDTX-ray3.26G43-486[»]
4JKPX-ray2.82G43-486[»]
4JPVX-ray2.83G43-486[»]
4JPWX-ray2.90G43-486[»]
4LSPX-ray2.15G43-486[»]
4LSQX-ray2.25G43-486[»]
4LSRX-ray2.28G43-486[»]
4LSUX-ray2.30G43-486[»]
4OLUX-ray2.20G43-122[»]
G201-303[»]
G325-486[»]
4OLVX-ray2.50G43-122[»]
G201-303[»]
G325-486[»]
4OLWX-ray2.71G43-122[»]
G201-303[»]
G325-486[»]
4OLXX-ray2.20G43-122[»]
G201-303[»]
G325-486[»]
4OLYX-ray2.35G43-122[»]
G201-303[»]
G325-486[»]
4OLZX-ray2.10G43-122[»]
G201-303[»]
G325-486[»]
4OM0X-ray2.29G43-122[»]
G201-303[»]
G325-486[»]
4OM1X-ray2.13G43-122[»]
G201-303[»]
G325-486[»]
4P9HX-ray3.00G43-122[»]
G201-303[»]
G325-486[»]
4RFNX-ray3.21A/G43-486[»]
4RFOX-ray3.20G43-486[»]
4RZ8X-ray1.90A/B/C/D43-122[»]
A/B/C/D201-303[»]
A/B/C/D325-486[»]
4XNZX-ray3.39A/D/G43-122[»]
A/D/G201-303[»]
A/D/G325-486[»]
4XVTX-ray1.69G43-486[»]
4YDJX-ray2.31G/I43-122[»]
G/I201-303[»]
G/I325-486[»]
4YDKX-ray2.05G43-122[»]
G201-303[»]
G325-486[»]
4YDLX-ray1.80A/G43-122[»]
A/G201-303[»]
A/G325-486[»]
4YFLX-ray3.39E/G43-122[»]
E/G201-303[»]
E/G325-486[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 140GP120InterPro annotationAdd BLAST108
Domaini141 – 505GP120InterPro annotationAdd BLAST365
Domaini524 – 715GP41InterPro annotationAdd BLAST192

Domaini

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiIPR000328. GP41-like.
IPR000777. HIV1_GP160.
[Graphical view]
PfamiPF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0ED31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVKETQMNW PNLWKWGTLI LGLVIICSAS DNLWVTVYYG VPVWKDADTT
60 70 80 90 100
LFCASDAKAH ETEVHNVWAT HACVPTDPNP QEIHLENVTE NFNMWKNNMV
110 120 130 140 150
EQMQEDVISL WDQSLQPCVK LTPLCVTLHC TTAKLTNVTN ITNVPNIGNI
160 170 180 190 200
TDEVRNCSFN MTTEIRDKKQ KVHALFYKLD IVQIEDKNDS SKYRLINCNT
210 220 230 240 250
SVIKQACPKI SFDPIPIHYC TPAGYVILKC NDKNFNGTGP CKNVSSVQCT
260 270 280 290 300
HGIKPVVSTQ LLLNGSLAEE EIIIRSENLT NNAKTIIVHL NKSVEINCTR
310 320 330 340 350
PSNNMRTSMR IGPGQVFYRT GSITGDIRKA YCEINGTKWN KVLKQVTEKL
360 370 380 390 400
KEHFNNKTII FQPPSGGDLE ITMHHFNCRG EFFYCNTTQL FNNTCIGNET
410 420 430 440 450
MKGCNGTITL PCKIKQIINM WQGTGQAMYA PPIDGKINCV SNITGILLTR
460 470 480 490 500
DGGANNTSNE TFRPGGGNIK DNWRSELYKY KVVQIEPLGI APTRAKRRVV
510 520 530 540 550
EREKRAVGIG AMIFGFLGAA GSTMGAASIT LTVQARQLLS GIVQQQSNLL
560 570 580 590 600
RAIEAQQHLL QLTVWGIKQL QARVLAVERY LKDQKFLGLW GCSGKIICTT
610 620 630 640 650
AVPWNSTWSN KSFEEIWNNM TWIEWEREIS NYTNQIYEIL TESQNQQDRN
660 670 680 690 700
EKDLLELDKW ASLWNWFDIT NWLWYIKIFI MIVGGLIGLR IIFAVLSIVN
710 720 730 740 750
RVRQGYSPLS FQTPIHHQRE PDRPERIEEG GGEQGRDRSV RLVSGFLSLA
760 770 780 790 800
WDDLRSLCLF SYHRLRDFIL IATRTVELLG HSSLKGLRRG WEGLKYLGNL
810 820 830 840 850
LLYWGQELKI SAISLLNTTA IAVAGWTDRV IEVAQGAWRA ILHIPRRIRQ

GLERTLL
Length:857
Mass (Da):97,310
Last modified:October 17, 2006 - v1
Checksum:iAA83C4FF189CCD0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB253424 Genomic DNA. Translation: BAF31367.1.
AB253425 Genomic DNA. Translation: BAF31376.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB253424 Genomic DNA. Translation: BAF31367.1.
AB253425 Genomic DNA. Translation: BAF31376.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NGBX-ray2.68A/D/G/I43-122[»]
A/D/G/I201-303[»]
A/D/G/I325-486[»]
3SE9X-ray2.00G43-486[»]
3TGTX-ray1.90A43-486[»]
3U7YX-ray2.45G43-122[»]
G201-303[»]
G325-486[»]
4DKOX-ray1.98A/C43-486[»]
4DKPX-ray1.80A/C43-486[»]
4DKQX-ray1.89A43-486[»]
4DKRX-ray1.80A/C43-486[»]
4DKUX-ray2.49A/B43-122[»]
A/B201-303[»]
A/B325-486[»]
4DKVX-ray2.18A/B43-122[»]
A/B201-303[»]
A/B325-486[»]
4DVSX-ray2.10A/B43-122[»]
A/B201-302[»]
A/B325-486[»]
4DVTX-ray2.40A/B88-122[»]
A/B201-293[»]
A/B341-433[»]
A/B457-486[»]
4DVVX-ray1.94A/B88-122[»]
A/B201-341[»]
A/B457-486[»]
4DVWX-ray2.20A/B88-122[»]
A/B201-293[»]
A/B341-433[»]
A/B457-486[»]
4DVXX-ray2.40A/B88-122[»]
A/B201-293[»]
A/B341-433[»]
A/B457-486[»]
4H8WX-ray1.85G43-486[»]
4I54X-ray2.50A/B43-486[»]
4JB9X-ray2.60G43-486[»]
4JDTX-ray3.26G43-486[»]
4JKPX-ray2.82G43-486[»]
4JPVX-ray2.83G43-486[»]
4JPWX-ray2.90G43-486[»]
4LSPX-ray2.15G43-486[»]
4LSQX-ray2.25G43-486[»]
4LSRX-ray2.28G43-486[»]
4LSUX-ray2.30G43-486[»]
4OLUX-ray2.20G43-122[»]
G201-303[»]
G325-486[»]
4OLVX-ray2.50G43-122[»]
G201-303[»]
G325-486[»]
4OLWX-ray2.71G43-122[»]
G201-303[»]
G325-486[»]
4OLXX-ray2.20G43-122[»]
G201-303[»]
G325-486[»]
4OLYX-ray2.35G43-122[»]
G201-303[»]
G325-486[»]
4OLZX-ray2.10G43-122[»]
G201-303[»]
G325-486[»]
4OM0X-ray2.29G43-122[»]
G201-303[»]
G325-486[»]
4OM1X-ray2.13G43-122[»]
G201-303[»]
G325-486[»]
4P9HX-ray3.00G43-122[»]
G201-303[»]
G325-486[»]
4RFNX-ray3.21A/G43-486[»]
4RFOX-ray3.20G43-486[»]
4RZ8X-ray1.90A/B/C/D43-122[»]
A/B/C/D201-303[»]
A/B/C/D325-486[»]
4XNZX-ray3.39A/D/G43-122[»]
A/D/G201-303[»]
A/D/G325-486[»]
4XVTX-ray1.69G43-486[»]
4YDJX-ray2.31G/I43-122[»]
G/I201-303[»]
G/I325-486[»]
4YDKX-ray2.05G43-122[»]
G201-303[»]
G325-486[»]
4YDLX-ray1.80A/G43-122[»]
A/G201-303[»]
A/G325-486[»]
4YFLX-ray3.39E/G43-122[»]
E/G201-303[»]
E/G325-486[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiIPR000328. GP41-like.
IPR000777. HIV1_GP160.
[Graphical view]
PfamiPF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ0ED31_9HIV1
AccessioniPrimary (citable) accession number: Q0ED31
Entry historyi
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.