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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611MannoseCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160SAAS annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cell membrane SAAS annotation; Peripheral membrane protein SAAS annotation
  • Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4122HelicalSequence analysisAdd
BLAST
Transmembranei506 – 52924HelicalSequence analysisAdd
BLAST
Transmembranei672 – 69928HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinSAAS annotation, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 73Combined sources
Glycosylationi87 – 871N-linked (GlcNAc...)Combined sourcesCAR_5007922606
Disulfide bondi118 ↔ 207Combined sources
Glycosylationi160 – 1601N-linked (GlcNAc...)Combined sourcesCAR_5007922622
Glycosylationi188 – 1881N-linked (GlcNAc...)Combined sourcesCAR_5007922611
Disulfide bondi220 ↔ 249Combined sources
Disulfide bondi230 ↔ 241Combined sources
Glycosylationi236 – 2361N-linked (GlcNAc...)Combined sourcesCAR_5007922614
Glycosylationi243 – 2431N-linked (GlcNAc...)Combined sourcesCAR_5007922619
Glycosylationi264 – 2641N-linked (GlcNAc...)Combined sourcesCAR_5007922603
Glycosylationi278 – 2781N-linked (GlcNAc...)Combined sourcesCAR_5007922620
Glycosylationi291 – 2911N-linked (GlcNAc...)Combined sourcesCAR_5007922608
Glycosylationi297 – 2971N-linked (GlcNAc...)Combined sourcesCAR_5007922604
Disulfide bondi298 ↔ 332Combined sources
Disulfide bondi332 ↔ 412Combined sources
Disulfide bondi332 ↔ 385Combined sources
Glycosylationi335 – 3351N-linked (GlcNAc...)Combined sourcesCAR_5007922607
Glycosylationi356 – 3561N-linked (GlcNAc...)Combined sourcesCAR_5007922605
Disulfide bondi378 ↔ 439Combined sources
Disulfide bondi385 ↔ 412Combined sources
Glycosylationi386 – 3861N-linked (GlcNAc...)Combined sourcesCAR_5007922615
Glycosylationi392 – 3921N-linked (GlcNAc...)Combined sourcesCAR_5007922617
Disulfide bondi395 ↔ 404Combined sources
Glycosylationi442 – 4421N-linked (GlcNAc...)Combined sourcesCAR_5007922609

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NGBX-ray2.68A/D/G/I43-122[»]
A/D/G/I201-303[»]
A/D/G/I325-486[»]
3SE8X-ray1.90G43-486[»]
3SE9X-ray2.00G43-486[»]
3TGTX-ray1.90A43-486[»]
3U7YX-ray2.45G43-122[»]
G201-303[»]
G325-486[»]
4DKOX-ray1.98A/C43-486[»]
4DKPX-ray1.80A/C43-486[»]
4DKQX-ray1.89A43-486[»]
4DKRX-ray1.80A/C43-486[»]
4DKUX-ray2.49A/B43-122[»]
A/B201-303[»]
A/B325-486[»]
4DKVX-ray2.18A/B43-122[»]
A/B201-303[»]
A/B325-486[»]
4DVSX-ray2.10A/B43-122[»]
A/B201-302[»]
A/B202-303[»]
A/B325-486[»]
4DVTX-ray2.40A/B88-122[»]
A/B201-433[»]
A/B457-486[»]
4DVVX-ray1.94A/B88-122[»]
A/B201-341[»]
A/B457-486[»]
4DVWX-ray2.20A/B88-122[»]
A/B201-293[»]
A/B457-486[»]
4DVXX-ray2.40A/B88-122[»]
A/B201-241[»]
A/B293-433[»]
A/B457-486[»]
4H8WX-ray1.85G43-486[»]
4I54X-ray2.50A/B43-486[»]
4JB9X-ray2.60G43-486[»]
4JDTX-ray3.26G43-486[»]
4JKPX-ray2.82G43-486[»]
4JPVX-ray2.83G43-486[»]
4JPWX-ray2.90G43-486[»]
4LSPX-ray2.15G43-486[»]
4LSQX-ray2.25G43-486[»]
4LSRX-ray2.28G43-486[»]
4LSUX-ray2.30G43-486[»]
4OLUX-ray2.20G43-122[»]
G201-303[»]
G325-486[»]
4OLVX-ray2.50G43-122[»]
G201-303[»]
G325-486[»]
4OLWX-ray2.71G43-122[»]
G201-303[»]
G325-486[»]
4OLXX-ray2.20G43-122[»]
G201-303[»]
G325-486[»]
4OLYX-ray2.35G43-122[»]
G201-303[»]
G325-486[»]
4OLZX-ray2.10G43-122[»]
G201-303[»]
G325-486[»]
4OM0X-ray2.29G43-122[»]
G201-303[»]
G325-486[»]
4OM1X-ray2.13G43-122[»]
G201-303[»]
G325-486[»]
4P9HX-ray3.00G43-122[»]
G201-303[»]
G325-486[»]
4RFNX-ray3.21A/G43-486[»]
4RFOX-ray3.20G43-486[»]
4RZ8X-ray1.90A/B/C/D43-122[»]
A/B/C/D201-303[»]
A/B/C/D325-486[»]
4XNZX-ray3.39A/D/G43-122[»]
A/D/G201-303[»]
A/D/G325-486[»]
4XVTX-ray1.69G43-486[»]
4YDJX-ray2.31G/I43-122[»]
G/I201-303[»]
G/I325-486[»]
4YDKX-ray2.05G43-122[»]
G201-303[»]
G325-486[»]
4YDLX-ray1.80A/G43-122[»]
A/G201-303[»]
A/G325-486[»]
4YFLX-ray3.39E/G43-122[»]
E/G201-303[»]
E/G325-486[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 140108GP120InterPro annotationAdd
BLAST
Domaini141 – 505365GP120InterPro annotationAdd
BLAST
Domaini524 – 715192GP41InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiIPR000328. GP41-like.
IPR000777. HIV1_GP160.
[Graphical view]
PfamiPF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Q0ED31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVKETQMNW PNLWKWGTLI LGLVIICSAS DNLWVTVYYG VPVWKDADTT
60 70 80 90 100
LFCASDAKAH ETEVHNVWAT HACVPTDPNP QEIHLENVTE NFNMWKNNMV
110 120 130 140 150
EQMQEDVISL WDQSLQPCVK LTPLCVTLHC TTAKLTNVTN ITNVPNIGNI
160 170 180 190 200
TDEVRNCSFN MTTEIRDKKQ KVHALFYKLD IVQIEDKNDS SKYRLINCNT
210 220 230 240 250
SVIKQACPKI SFDPIPIHYC TPAGYVILKC NDKNFNGTGP CKNVSSVQCT
260 270 280 290 300
HGIKPVVSTQ LLLNGSLAEE EIIIRSENLT NNAKTIIVHL NKSVEINCTR
310 320 330 340 350
PSNNMRTSMR IGPGQVFYRT GSITGDIRKA YCEINGTKWN KVLKQVTEKL
360 370 380 390 400
KEHFNNKTII FQPPSGGDLE ITMHHFNCRG EFFYCNTTQL FNNTCIGNET
410 420 430 440 450
MKGCNGTITL PCKIKQIINM WQGTGQAMYA PPIDGKINCV SNITGILLTR
460 470 480 490 500
DGGANNTSNE TFRPGGGNIK DNWRSELYKY KVVQIEPLGI APTRAKRRVV
510 520 530 540 550
EREKRAVGIG AMIFGFLGAA GSTMGAASIT LTVQARQLLS GIVQQQSNLL
560 570 580 590 600
RAIEAQQHLL QLTVWGIKQL QARVLAVERY LKDQKFLGLW GCSGKIICTT
610 620 630 640 650
AVPWNSTWSN KSFEEIWNNM TWIEWEREIS NYTNQIYEIL TESQNQQDRN
660 670 680 690 700
EKDLLELDKW ASLWNWFDIT NWLWYIKIFI MIVGGLIGLR IIFAVLSIVN
710 720 730 740 750
RVRQGYSPLS FQTPIHHQRE PDRPERIEEG GGEQGRDRSV RLVSGFLSLA
760 770 780 790 800
WDDLRSLCLF SYHRLRDFIL IATRTVELLG HSSLKGLRRG WEGLKYLGNL
810 820 830 840 850
LLYWGQELKI SAISLLNTTA IAVAGWTDRV IEVAQGAWRA ILHIPRRIRQ

GLERTLL
Length:857
Mass (Da):97,310
Last modified:October 17, 2006 - v1
Checksum:iAA83C4FF189CCD0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB253424 Genomic DNA. Translation: BAF31367.1.
AB253425 Genomic DNA. Translation: BAF31376.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB253424 Genomic DNA. Translation: BAF31367.1.
AB253425 Genomic DNA. Translation: BAF31376.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NGBX-ray2.68A/D/G/I43-122[»]
A/D/G/I201-303[»]
A/D/G/I325-486[»]
3SE8X-ray1.90G43-486[»]
3SE9X-ray2.00G43-486[»]
3TGTX-ray1.90A43-486[»]
3U7YX-ray2.45G43-122[»]
G201-303[»]
G325-486[»]
4DKOX-ray1.98A/C43-486[»]
4DKPX-ray1.80A/C43-486[»]
4DKQX-ray1.89A43-486[»]
4DKRX-ray1.80A/C43-486[»]
4DKUX-ray2.49A/B43-122[»]
A/B201-303[»]
A/B325-486[»]
4DKVX-ray2.18A/B43-122[»]
A/B201-303[»]
A/B325-486[»]
4DVSX-ray2.10A/B43-122[»]
A/B201-302[»]
A/B202-303[»]
A/B325-486[»]
4DVTX-ray2.40A/B88-122[»]
A/B201-433[»]
A/B457-486[»]
4DVVX-ray1.94A/B88-122[»]
A/B201-341[»]
A/B457-486[»]
4DVWX-ray2.20A/B88-122[»]
A/B201-293[»]
A/B457-486[»]
4DVXX-ray2.40A/B88-122[»]
A/B201-241[»]
A/B293-433[»]
A/B457-486[»]
4H8WX-ray1.85G43-486[»]
4I54X-ray2.50A/B43-486[»]
4JB9X-ray2.60G43-486[»]
4JDTX-ray3.26G43-486[»]
4JKPX-ray2.82G43-486[»]
4JPVX-ray2.83G43-486[»]
4JPWX-ray2.90G43-486[»]
4LSPX-ray2.15G43-486[»]
4LSQX-ray2.25G43-486[»]
4LSRX-ray2.28G43-486[»]
4LSUX-ray2.30G43-486[»]
4OLUX-ray2.20G43-122[»]
G201-303[»]
G325-486[»]
4OLVX-ray2.50G43-122[»]
G201-303[»]
G325-486[»]
4OLWX-ray2.71G43-122[»]
G201-303[»]
G325-486[»]
4OLXX-ray2.20G43-122[»]
G201-303[»]
G325-486[»]
4OLYX-ray2.35G43-122[»]
G201-303[»]
G325-486[»]
4OLZX-ray2.10G43-122[»]
G201-303[»]
G325-486[»]
4OM0X-ray2.29G43-122[»]
G201-303[»]
G325-486[»]
4OM1X-ray2.13G43-122[»]
G201-303[»]
G325-486[»]
4P9HX-ray3.00G43-122[»]
G201-303[»]
G325-486[»]
4RFNX-ray3.21A/G43-486[»]
4RFOX-ray3.20G43-486[»]
4RZ8X-ray1.90A/B/C/D43-122[»]
A/B/C/D201-303[»]
A/B/C/D325-486[»]
4XNZX-ray3.39A/D/G43-122[»]
A/D/G201-303[»]
A/D/G325-486[»]
4XVTX-ray1.69G43-486[»]
4YDJX-ray2.31G/I43-122[»]
G/I201-303[»]
G/I325-486[»]
4YDKX-ray2.05G43-122[»]
G201-303[»]
G325-486[»]
4YDLX-ray1.80A/G43-122[»]
A/G201-303[»]
A/G325-486[»]
4YFLX-ray3.39E/G43-122[»]
E/G201-303[»]
E/G325-486[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiIPR000328. GP41-like.
IPR000777. HIV1_GP160.
[Graphical view]
PfamiPF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ0ED31_9HIV1
AccessioniPrimary (citable) accession number: Q0ED31
Entry historyi
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.