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Protein
Submitted name:

CD22 antigen

Gene

CD22

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Names & Taxonomyi

Protein namesi
Submitted name:
CD22 antigenImported
Submitted name:
CD22 moleculeImported
Gene namesi
Name:CD22Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei688 – 70821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26201.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 847828Sequence analysisPRO_5007698422Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ0EAF5.

Expressioni

Gene expression databases

BgeeiENSG00000012124.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000085219.

Structurei

3D structure databases

SMRiQ0EAF5. Positions 36-677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 23593Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini242 – 32685Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini331 – 41686Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini419 – 50082Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini505 – 58278Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini593 – 67684Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IUGI. Eukaryota.
ENOG410YH8H. LUCA.
HOVERGENiHBG005272.
KOiK06467.
OMAiPTNYTWY.
OrthoDBiEOG091G0FT0.
PhylomeDBiQ0EAF5.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 7 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
PROSITEiPS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0EAF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLLGPWLLL LVLEYLAFSD SSKWVFEHPE TLYAWEGACV WIPCTYRALD
60 70 80 90 100
GDLESFILFH NPEYNKNTSK FDGTRLYEST KDGKVPSEQK RVQFLGDKNK
110 120 130 140 150
NCTLSIHPVH LNDSGQLGLR MESKTEKWME RIHLNVSERP FPPHIQLPPE
160 170 180 190 200
IQESQEVTLT CLLNFSCYGY PIQLQWLLEG VPMRQAAVTS TSLTIKSVFT
210 220 230 240 250
RSELKFSPQW SHHGKIVTCQ LQDADGKFLS NDTVQLNVKH TPKLEIKVTP
260 270 280 290 300
SDAIVREGDS VTMTCEVSSS NPEYTTVSWL KDGTSLKKQN TFTLNLREVT
310 320 330 340 350
KDQSGKYCCQ VSNDVGPGRS EEVFLQVQYA PEPSTVQILH SPAVEGSQVE
360 370 380 390 400
FLCMSLANPL PTNYTWYHNG KEMQGRTEEK VHIPKILPWH AGTYSCVAEN
410 420 430 440 450
ILGTGQRGPG AELDVQYPPK KVTTVIQNPM PIREGDTVTL SCNYNSSNPS
460 470 480 490 500
VTRYEWKPHG AWEEPSLGVL KIQNVGWDNT TIACAACNSW CSWASPVALN
510 520 530 540 550
VQYAPRDVRV RKIKPLSEIH SGNSVSLQCD FSSSHPKEVQ FFWEKNGRLL
560 570 580 590 600
GKESQLNFDS ISPEDAGSYS CWVNNSIGQT ASKAWTLEVL YAPRRLRVSM
610 620 630 640 650
SPGDQVMEGK SATLTCESDA NPPVSHYTWF DWNNQSLPYH SQKLRLEPVK
660 670 680 690 700
VQHSGAYWCQ GTNSVGKGRS PLSTLTVYYS PETIGRRVAV GLGSCLAILI
710 720 730 740 750
LAICGLKLQR RWKRTQSQQG LQENSSGQSF FVRNKKVRRA PLSEGPHSLG
760 770 780 790 800
CYNPMMEDGI SYTTLRFPEM NIPRTGDAES SEMQRPPPDC DDTVTYSALH
810 820 830 840
KRQVGDYENV IPDFPEDEGI HYSELIQFGV GERPQAQENV DYVILKH
Length:847
Mass (Da):95,348
Last modified:October 17, 2006 - v1
Checksum:i38EB0BE4220ACA2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF064756 Genomic DNA. Translation: ABK41939.1.
AB253793 Genomic DNA. Translation: BAF32756.1.
AB253794 Genomic DNA. Translation: BAF32757.1.
AB253795 Genomic DNA. Translation: BAF32758.1.
RefSeqiNP_001762.2. NM_001771.3.
UniGeneiHs.579691.

Genome annotation databases

GeneIDi933.
KEGGihsa:933.
UCSCiuc010edt.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF064756 Genomic DNA. Translation: ABK41939.1.
AB253793 Genomic DNA. Translation: BAF32756.1.
AB253794 Genomic DNA. Translation: BAF32757.1.
AB253795 Genomic DNA. Translation: BAF32758.1.
RefSeqiNP_001762.2. NM_001771.3.
UniGeneiHs.579691.

3D structure databases

SMRiQ0EAF5. Positions 36-677.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000085219.

Proteomic databases

MaxQBiQ0EAF5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi933.
KEGGihsa:933.
UCSCiuc010edt.5. human.

Organism-specific databases

CTDi933.
PharmGKBiPA26201.

Phylogenomic databases

eggNOGiENOG410IUGI. Eukaryota.
ENOG410YH8H. LUCA.
HOVERGENiHBG005272.
KOiK06467.
OMAiPTNYTWY.
OrthoDBiEOG091G0FT0.
PhylomeDBiQ0EAF5.

Miscellaneous databases

GenomeRNAii933.

Gene expression databases

BgeeiENSG00000012124.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 7 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
PROSITEiPS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ0EAF5_HUMAN
AccessioniPrimary (citable) accession number: Q0EAF5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.