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Protein
Submitted name:

CD22 antigen

Gene

CD22

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Names & Taxonomyi

Protein namesi
Submitted name:
CD22 antigenImported
Submitted name:
CD22 moleculeImported
Gene namesi
Name:CD22Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000012124.14

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei688 – 708HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26201

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501430673220 – 847Sequence analysisAdd BLAST828

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ0EAF5

Expressioni

Gene expression databases

BgeeiENSG00000012124
ExpressionAtlasiQ0EAF5 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ0EAF5, 2 interactors

Structurei

3D structure databases

SMRiQ0EAF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 235Ig-likeInterPro annotationAdd BLAST93
Domaini242 – 326Ig-likeInterPro annotationAdd BLAST85
Domaini331 – 416Ig-likeInterPro annotationAdd BLAST86
Domaini419 – 500Ig-likeInterPro annotationAdd BLAST82
Domaini505 – 582Ig-likeInterPro annotationAdd BLAST78
Domaini593 – 676Ig-likeInterPro annotationAdd BLAST84

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IUGI Eukaryota
ENOG410YH8H LUCA
HOVERGENiHBG005272
KOiK06467
OMAiPTNYTWY
OrthoDBiEOG091G0FT0

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 7 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 6 hits

Sequencei

Sequence statusi: Complete.

Q0EAF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLLGPWLLL LVLEYLAFSD SSKWVFEHPE TLYAWEGACV WIPCTYRALD
60 70 80 90 100
GDLESFILFH NPEYNKNTSK FDGTRLYEST KDGKVPSEQK RVQFLGDKNK
110 120 130 140 150
NCTLSIHPVH LNDSGQLGLR MESKTEKWME RIHLNVSERP FPPHIQLPPE
160 170 180 190 200
IQESQEVTLT CLLNFSCYGY PIQLQWLLEG VPMRQAAVTS TSLTIKSVFT
210 220 230 240 250
RSELKFSPQW SHHGKIVTCQ LQDADGKFLS NDTVQLNVKH TPKLEIKVTP
260 270 280 290 300
SDAIVREGDS VTMTCEVSSS NPEYTTVSWL KDGTSLKKQN TFTLNLREVT
310 320 330 340 350
KDQSGKYCCQ VSNDVGPGRS EEVFLQVQYA PEPSTVQILH SPAVEGSQVE
360 370 380 390 400
FLCMSLANPL PTNYTWYHNG KEMQGRTEEK VHIPKILPWH AGTYSCVAEN
410 420 430 440 450
ILGTGQRGPG AELDVQYPPK KVTTVIQNPM PIREGDTVTL SCNYNSSNPS
460 470 480 490 500
VTRYEWKPHG AWEEPSLGVL KIQNVGWDNT TIACAACNSW CSWASPVALN
510 520 530 540 550
VQYAPRDVRV RKIKPLSEIH SGNSVSLQCD FSSSHPKEVQ FFWEKNGRLL
560 570 580 590 600
GKESQLNFDS ISPEDAGSYS CWVNNSIGQT ASKAWTLEVL YAPRRLRVSM
610 620 630 640 650
SPGDQVMEGK SATLTCESDA NPPVSHYTWF DWNNQSLPYH SQKLRLEPVK
660 670 680 690 700
VQHSGAYWCQ GTNSVGKGRS PLSTLTVYYS PETIGRRVAV GLGSCLAILI
710 720 730 740 750
LAICGLKLQR RWKRTQSQQG LQENSSGQSF FVRNKKVRRA PLSEGPHSLG
760 770 780 790 800
CYNPMMEDGI SYTTLRFPEM NIPRTGDAES SEMQRPPPDC DDTVTYSALH
810 820 830 840
KRQVGDYENV IPDFPEDEGI HYSELIQFGV GERPQAQENV DYVILKH
Length:847
Mass (Da):95,348
Last modified:October 17, 2006 - v1
Checksum:i38EB0BE4220ACA2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF064756 Genomic DNA Translation: ABK41939.1
AB253793 Genomic DNA Translation: BAF32756.1
AB253794 Genomic DNA Translation: BAF32757.1
AB253795 Genomic DNA Translation: BAF32758.1
RefSeqiNP_001762.2, NM_001771.3
UniGeneiHs.579691

Genome annotation databases

GeneIDi933
KEGGihsa:933
UCSCiuc010edt.5 human

Similar proteinsi

Entry informationi

Entry nameiQ0EAF5_HUMAN
AccessioniPrimary (citable) accession number: Q0EAF5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Main funding by: National Institutes of Health