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Protein
Submitted name:

Down syndrome cell adhesion molecule 1, isoform AX

Gene

Dscam1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • antigen binding Source: FlyBase
  • axon guidance receptor activity Source: FlyBase
  • identical protein binding Source: FlyBase
  • protein homodimerization activity Source: FlyBase

GO - Biological processi

  • axonal fasciculation Source: FlyBase
  • axon extension involved in axon guidance Source: FlyBase
  • axon guidance Source: FlyBase
  • central nervous system morphogenesis Source: FlyBase
  • dendrite self-avoidance Source: FlyBase
  • detection of mechanical stimulus involved in sensory perception of touch Source: FlyBase
  • detection of molecule of bacterial origin Source: FlyBase
  • mushroom body development Source: FlyBase
  • neuron development Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • phagocytosis Source: FlyBase
  • regulation of axonogenesis Source: FlyBase
  • regulation of dendrite morphogenesis Source: FlyBase
  • ventral cord development Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-376172 DSCAM interactions

Names & Taxonomyi

Protein namesi
Submitted name:
Down syndrome cell adhesion molecule 1, isoform AXImported
Gene namesi
Name:Dscam1Imported
Synonyms:DscamImported
ORF Names:CG17800Imported, Dmel_CG17800Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033159 Dscam1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1622 – 1643HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500417118829 – 2019Sequence analysisAdd BLAST1991

Proteomic databases

PRIDEiQ0E9L8

Expressioni

Gene expression databases

BgeeiFBgn0033159
ExpressionAtlasiQ0E9L8 differential
GenevisibleiQ0E9L8 DM

Interactioni

GO - Molecular functioni

  • identical protein binding Source: FlyBase
  • protein homodimerization activity Source: FlyBase

Structurei

3D structure databases

ProteinModelPortaliQ0E9L8
SMRiQ0E9L8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 134Ig-likeInterPro annotationAdd BLAST96
Domaini250 – 342Ig-likeInterPro annotationAdd BLAST93
Domaini346 – 425Ig-likeInterPro annotationAdd BLAST80
Domaini432 – 526Ig-likeInterPro annotationAdd BLAST95
Domaini531 – 617Ig-likeInterPro annotationAdd BLAST87
Domaini622 – 713Ig-likeInterPro annotationAdd BLAST92
Domaini718 – 810Ig-likeInterPro annotationAdd BLAST93
Domaini815 – 907Ig-likeInterPro annotationAdd BLAST93
Domaini916 – 1010Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini1015 – 1119Fibronectin type-IIIInterPro annotationAdd BLAST105
Domaini1120 – 1216Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini1220 – 1313Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1315 – 1397Ig-likeInterPro annotationAdd BLAST83
Domaini1405 – 1498Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1502 – 1597Fibronectin type-IIIInterPro annotationAdd BLAST96

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

OrthoDBiEOG091G005W

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 16 hits
InterProiView protein in InterPro
IPR021012 Dscam_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF12355 Dscam_C, 1 hit
PF00041 fn3, 6 hits
PF07679 I-set, 5 hits
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 10 hits
SM00408 IGc2, 9 hits
SUPFAMiSSF48726 SSF48726, 9 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 9 hits

Sequencei

Sequence statusi: Complete.

Q0E9L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID
60 70 80 90 100
FSNSTGAEIE CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP
110 120 130 140 150
FRAEDYRQEV HAQVYACLAR NQFGSIISRD VHVRAVVHQF YQTRVIDEFV
160 170 180 190 200
LRGNSATLKC LVPSFVADFI DVEGWIDEEG VEILRPLPDD SVDGKYLVLP
210 220 230 240 250
SGELHIREVG PEDGYKSYQC RTKHRLTGET RLSATKGRLV ITEPIGARAP
260 270 280 290 300
TFSTDSNSFS YTRSVGQSFA LLCQAQAYPV PIMRWYKFIE GTTRKQAVVL
310 320 330 340 350
NDRVKQVSGT LIIKDAVVED SGKYLCVVNN SVGGESVETV LTVTAPLSAK
360 370 380 390 400
IDPPTQTVDF GRPAVFTCQY TGNPIKTVSW MKDGKAIGHS EPVLRIESVK
410 420 430 440 450
KEDKGMYQCF VRNDQESAEA SAELKLGGRF DPPVIRQAFQ EETMEPGPSV
460 470 480 490 500
FLKCVAGGNP TPEISWELDG KKIANNDRYQ VGQYVTVNGD VVSYLNITSV
510 520 530 540 550
HANDGGLYKC IAKSKVGVAE HSAKLNVYGL PYIRQMEKKA IVAGETLIVT
560 570 580 590 600
CPVAGYPIDS IVWERDNRAL PINRKQKVFP NGTLIIENVE RNSDQATYTC
610 620 630 640 650
VAKNQEGYSA RGSLEVQVMV PPKITPFDFG DAPTNVEDSV SVMCLISNGD
660 670 680 690 700
LPIDIEWFFN DYGISSYSGI NVVKGGKRNS MLSIDSVQAR HAGKYSCRAK
710 720 730 740 750
NHAAAVNYTT ELIVNVPPRW ILEPTDKAFA QGSDAKVECK ADGFPKPQVT
760 770 780 790 800
WKKAVGDTPG EYKDLKKSDN IRVEEGTLHV DNIQKTNEGY YLCEAINGIG
810 820 830 840 850
SGLSAVIMIS VQAPPEFTEK LRNQTARRGE PAVLQCEAKG EKPIGILWNM
860 870 880 890 900
NNMRLDPKND NRYTIREEIL STGVMSSLSI KRTERSDSAL FTCVATNAFG
910 920 930 940 950
SDDASINMIV QEVPEMPYAL KVLDKSGRSV QLSWAQPYDG NSPLDRYIIE
960 970 980 990 1000
FKRSRASWSE IDRVIVPGHT TEAQVQKLSP ATTYNIRIVA ENAIGTSQSS
1010 1020 1030 1040 1050
EAVTIITAEE APSGKPQNIK VEPVNQTTMR VTWKPPPRTE WNGEILGYYV
1060 1070 1080 1090 1100
GYKLSNTNSS YVFETINFIT EEGKEHNLEL QNLRVYTQYS VVIQAFNKIG
1110 1120 1130 1140 1150
AGPLSEEEKQ FTAEGTPSQP PSDTACTTLT SQTIRVGWVS PPLESANGVI
1160 1170 1180 1190 1200
KTYKVVYAPS DEWYDETKRH YKKTASSDTV LHGLKKYTNY TMQVLATTAG
1210 1220 1230 1240 1250
GDGVRSVPIH CQTEPDVPEA PTDVKALVMG NAAILVSWRP PAQPNGIITQ
1260 1270 1280 1290 1300
YTVYSKAEGA ETETKTQKVP HYQMSFEATE LEKNKPYEFW VTASTTIGEG
1310 1320 1330 1340 1350
QQSKSIVAMP SDQVPAKIAS FDDTFTATFK EDAKMPCLAV GAPQPEITWK
1360 1370 1380 1390 1400
IKGVEFSAND RMRVLPDGSL LIKSVNRQDA GDYSCHAENS IAKDSITHKL
1410 1420 1430 1440 1450
IVLAPPQSPH VTLSATTTDA LTVKLKPHEG DTAPLHGYTL HYKPEFGEWE
1460 1470 1480 1490 1500
TSEVSVDSQK HNIEGLLCGS RYQVYATGFN NIGAGEASDI LNTRTKGQKP
1510 1520 1530 1540 1550
KLPEKPRFIE VSSNSVSLHF KAWKDGGCPM SHFVVESKKR DQIEWNQISN
1560 1570 1580 1590 1600
NVKPDNNYVV LDLEPATWYN LRITAHNSAG FTVAEYDFAT LTVTGGTIAP
1610 1620 1630 1640 1650
SRDLPELSAE DTIRIILSNL NLVVPVVAAL LVIIIAIIVI CILRSKGNHH
1660 1670 1680 1690 1700
KDDVVYNQTM GPGATLDKRR PDLRDELGYI APPNRKLPPV PGSNYNTCDR
1710 1720 1730 1740 1750
IKRGRGGLRS NHSTWDPRRN PNLYEELKAP PVPMHGNHYG HAHGNAECHY
1760 1770 1780 1790 1800
RHPGMEDEIC PYATFHLLGF REEMDPTKAM NFQTFPHQNG HAGPVPGHAG
1810 1820 1830 1840 1850
TMLPPGHPGH VHSRSGSQSM PRANRYQRKN SQGGQSSIYT PAPEYDDPAN
1860 1870 1880 1890 1900
CAEEDQYRRY TRVNSQGGSL YSGPGPEYDD PANCAPEEDQ YGSQYGGPYG
1910 1920 1930 1940 1950
QPYDHYGSRG SMGRRSIGSA RNPGNGSPEP PPPPPRNHDM SNSSFNDSKE
1960 1970 1980 1990 2000
SNEISEAECD RDHGPRGNYG AVKRSPQPKD QRTTEEMRKL IERNETGPKQ
2010
LQLQQANGAG FTAYDTMAV
Length:2,019
Mass (Da):222,704
Last modified:October 17, 2006 - v1
Checksum:iCBF64678D71CA8B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: ABI31031.1
RefSeqiNP_001036480.1, NM_001043015.1
UniGeneiDm.2832

Genome annotation databases

EnsemblMetazoaiFBtr0111070; FBpp0110364; FBgn0033159
GeneIDi35652
UCSCiCG17800-RAX d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ0E9L8_DROME
AccessioniPrimary (citable) accession number: Q0E9L8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health