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Protein
Submitted name:

Down syndrome cell adhesion molecule 1, isoform O

Gene

Dscam1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • antigen binding Source: FlyBase
  • axon guidance receptor activity Source: FlyBase
  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: FlyBase

GO - Biological processi

  • axonal fasciculation Source: FlyBase
  • axon extension involved in axon guidance Source: FlyBase
  • axon guidance Source: FlyBase
  • central nervous system morphogenesis Source: FlyBase
  • dendrite self-avoidance Source: FlyBase
  • detection of mechanical stimulus involved in sensory perception of touch Source: FlyBase
  • detection of molecule of bacterial origin Source: FlyBase
  • mushroom body development Source: FlyBase
  • neuron development Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • phagocytosis Source: FlyBase
  • regulation of axonogenesis Source: FlyBase
  • regulation of dendrite morphogenesis Source: FlyBase
  • ventral cord development Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Down syndrome cell adhesion molecule 1, isoform OImported
Gene namesi
Name:Dscam1Imported
Synonyms:DscamImported
ORF Names:CG17800Imported, Dmel_CG17800Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033159. Dscam1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1625 – 164723HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: FlyBase
  • dendrite Source: FlyBase
  • integral component of plasma membrane Source: FlyBase
  • neuronal cell body Source: FlyBase
  • neuron projection Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 20312003Sequence analysisPRO_5004171242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Combined sourcesCAR_5005389776
Disulfide bondi61 ↔ 117Combined sources
Disulfide bondi160 ↔ 217Combined sources
Disulfide bondi270 ↔ 323Combined sources
Glycosylationi326 – 3261N-linked (GlcNAc...)Combined sourcesCAR_5005389774
Disulfide bondi365 ↔ 406Combined sources
Disulfide bondi451 ↔ 507Combined sources
Disulfide bondi548 ↔ 597Combined sources
Glycosylationi578 – 5781N-linked (GlcNAc...)Combined sourcesCAR_5005389775
Disulfide bondi641 ↔ 694Combined sources
Disulfide bondi736 ↔ 790Combined sources

Proteomic databases

PaxDbiQ0E9I4.
PRIDEiQ0E9I4.

Expressioni

Gene expression databases

BgeeiQ0E9I4.
ExpressionAtlasiQ0E9I4. differential.
GenevisibleiQ0E9I4. DM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-2012532,EBI-2012532

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: FlyBase

Protein-protein interaction databases

STRINGi7227.FBpp0297683.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DMKX-ray4.19A/B/C1-810[»]
ProteinModelPortaliQ0E9I4.
SMRiQ0E9I4. Positions 36-1599.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ0E9I4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 138100Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini153 – 23078Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini247 – 33993Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini343 – 42280Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini429 – 52395Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini528 – 61487Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini619 – 71092Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini715 – 80793Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini812 – 90493Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini913 – 100795Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1012 – 1116105Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1117 – 121397Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1217 – 131094Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1312 – 139483Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini1402 – 149594Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1499 – 159496Fibronectin type-IIIInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQJM. Eukaryota.
ENOG410XQX7. LUCA.
GeneTreeiENSGT00760000118840.

Family and domain databases

Gene3Di2.60.40.10. 15 hits.
InterProiIPR021012. Dscam_C.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF12355. Dscam_C. 1 hit.
PF00041. fn3. 6 hits.
PF07679. I-set. 5 hits.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 10 hits.
SM00408. IGc2. 9 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 10 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0E9I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID
60 70 80 90 100
FSNSTGAEIE CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP
110 120 130 140 150
FRAEDYRQEV HAQVYACLAR NQFGSIISRD VHVRAVVSQH YEEDIHKAFV
160 170 180 190 200
IRGNSAILKC DIPSFVADFV NVISWHSDEK ENFYPGTEYD GKYLVLPSGE
210 220 230 240 250
LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE PIGSKAPSVP
260 270 280 290 300
TGVMVFQQQV PLLSTFAMLC QAQAFPVPVF RWYKFIEGTT RKQAVVLNDR
310 320 330 340 350
VKQVSGTLII KDAVVEDSGK YLCVVNNSVG GESVETVLTV TAPLSAKIDP
360 370 380 390 400
PTQTVDFGRP AVFTCQYTGN PIKTVSWMKD GKAIGHSEPV LRIESVKKED
410 420 430 440 450
KGMYQCFVRN DQESAEASAE LKLGGRFDPP VIRQAFQEET MEPGPSVFLK
460 470 480 490 500
CVAGGNPTPE ISWELDGKKI ANNDRYQVGQ YVTVNGDVVS YLNITSVHAN
510 520 530 540 550
DGGLYKCIAK SKVGVAEHSA KLNVYGLPYI RQMEKKAIVA GETLIVTCPV
560 570 580 590 600
AGYPIDSIVW ERDNRALPIN RKQKVFPNGT LIIENVERNS DQATYTCVAK
610 620 630 640 650
NQEGYSARGS LEVQVMVLPR IIPFAFEEGP AQVGQYLTLH CSVPGGDLPL
660 670 680 690 700
NIDWTLDGQA ISEDLGITTS RVGRRGSVLT IEAVEASHAG NFTCHARNLA
710 720 730 740 750
GHQQFTTPLN VYVPPRWILE PTDKAFAQGS DAKVECKADG FPKPQVTWKK
760 770 780 790 800
AVGDTPGEYK DLKKSDNIRV EEGTLHVDNI QKTNEGYYLC EAINGIGSGL
810 820 830 840 850
SAVIMISVQA PPEFTEKLRN QTARRGEPAV LQCEAKGEKP IGILWNMNNM
860 870 880 890 900
RLDPKNDNRY TIREEILSTG VMSSLSIKRT ERSDSALFTC VATNAFGSDD
910 920 930 940 950
ASINMIVQEV PEMPYALKVL DKSGRSVQLS WAQPYDGNSP LDRYIIEFKR
960 970 980 990 1000
SRASWSEIDR VIVPGHTTEA QVQKLSPATT YNIRIVAENA IGTSQSSEAV
1010 1020 1030 1040 1050
TIITAEEAPS GKPQNIKVEP VNQTTMRVTW KPPPRTEWNG EILGYYVGYK
1060 1070 1080 1090 1100
LSNTNSSYVF ETINFITEEG KEHNLELQNL RVYTQYSVVI QAFNKIGAGP
1110 1120 1130 1140 1150
LSEEEKQFTA EGTPSQPPSD TACTTLTSQT IRVGWVSPPL ESANGVIKTY
1160 1170 1180 1190 1200
KVVYAPSDEW YDETKRHYKK TASSDTVLHG LKKYTNYTMQ VLATTAGGDG
1210 1220 1230 1240 1250
VRSVPIHCQT EPDVPEAPTD VKALVMGNAA ILVSWRPPAQ PNGIITQYTV
1260 1270 1280 1290 1300
YSKAEGAETE TKTQKVPHYQ MSFEATELEK NKPYEFWVTA STTIGEGQQS
1310 1320 1330 1340 1350
KSIVAMPSDQ VPAKIASFDD TFTATFKEDA KMPCLAVGAP QPEITWKIKG
1360 1370 1380 1390 1400
VEFSANDRMR VLPDGSLLIK SVNRQDAGDY SCHAENSIAK DSITHKLIVL
1410 1420 1430 1440 1450
APPQSPHVTL SATTTDALTV KLKPHEGDTA PLHGYTLHYK PEFGEWETSE
1460 1470 1480 1490 1500
VSVDSQKHNI EGLLCGSRYQ VYATGFNNIG AGEASDILNT RTKGQKPKLP
1510 1520 1530 1540 1550
EKPRFIEVSS NSVSLHFKAW KDGGCPMSHF VVESKKRDQI EWNQISNNVK
1560 1570 1580 1590 1600
PDNNYVVLDL EPATWYNLRI TAHNSAGFTV AEYDFATLTV TGGTIAPLDD
1610 1620 1630 1640 1650
GSGHGNVHTR IRLPAWMPEW LDLNFMVPLI ATVVVVAVGI CVVCVALSRR
1660 1670 1680 1690 1700
RADDMRGGQK DVYYDVVYNQ TMGPGATLDK RRPDLRDELG YIAPPNRKLP
1710 1720 1730 1740 1750
PVPGSNYNTC DRIKRGRGGL RSNHSTWDPR RNPNLYEELK APPVPMHGNH
1760 1770 1780 1790 1800
YGHAHGNAEC HYRHPGMEDE ICPYATFHLL GFREEMDPTK AMNFQTFPHQ
1810 1820 1830 1840 1850
NGHAGPVPGH AGTMLPPGHP GHVHSRSGSQ SMPRANRYQR KNSQGGQSSI
1860 1870 1880 1890 1900
YTPAPEYDDP ANCAEEDQYR RYTRVNSQGG SLYSGPGPEY DDPANCAPEE
1910 1920 1930 1940 1950
DQYGSQYGGP YGQPYDHYGS RGSMGRRSIG SARNPGNGSP EPPPPPPRNH
1960 1970 1980 1990 2000
DMSNSSFNDS KESNEISEAE CDRDHGPRGN YGAVKRSPQP KDQRTTEEMR
2010 2020 2030
KLIERNETGP KQLQLQQANG AGFTAYDTMA V
Length:2,031
Mass (Da):224,083
Last modified:October 17, 2006 - v1
Checksum:i1BD3D9E812238969
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: ABI31049.1.
RefSeqiNP_001036498.1. NM_001043033.1.
UniGeneiDm.2832.

Genome annotation databases

EnsemblMetazoaiFBtr0111089; FBpp0110384; FBgn0033159.
GeneIDi35652.
UCSCiCG17800-RO. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: ABI31049.1.
RefSeqiNP_001036498.1. NM_001043033.1.
UniGeneiDm.2832.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DMKX-ray4.19A/B/C1-810[»]
ProteinModelPortaliQ0E9I4.
SMRiQ0E9I4. Positions 36-1599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0297683.

Proteomic databases

PaxDbiQ0E9I4.
PRIDEiQ0E9I4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0111089; FBpp0110384; FBgn0033159.
GeneIDi35652.
UCSCiCG17800-RO. d. melanogaster.

Organism-specific databases

CTDi35652.
FlyBaseiFBgn0033159. Dscam1.

Phylogenomic databases

eggNOGiENOG410IQJM. Eukaryota.
ENOG410XQX7. LUCA.
GeneTreeiENSGT00760000118840.

Miscellaneous databases

EvolutionaryTraceiQ0E9I4.
GenomeRNAii35652.
NextBioi794432.

Gene expression databases

BgeeiQ0E9I4.
ExpressionAtlasiQ0E9I4. differential.
GenevisibleiQ0E9I4. DM.

Family and domain databases

Gene3Di2.60.40.10. 15 hits.
InterProiIPR021012. Dscam_C.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF12355. Dscam_C. 1 hit.
PF00041. fn3. 6 hits.
PF07679. I-set. 5 hits.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 10 hits.
SM00408. IGc2. 9 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 10 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  9. "A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms."
    Sawaya M.R., Wojtowicz W.M., Andre I., Qian B., Wu W., Baker D., Eisenberg D., Zipursky S.L.
    Cell 134:1007-1018(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.19 ANGSTROMS) OF 1-810, GLYCOSYLATION AT ASN-53; ASN-326 AND ASN-578, DISULFIDE BONDS.

Entry informationi

Entry nameiQ0E9I4_DROME
AccessioniPrimary (citable) accession number: Q0E9I4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: May 11, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.