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Protein
Submitted name:

Valyl-tRNA synthetase, isoform A

Gene

ValRS

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • aminoacyl-tRNA editing activity Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • glutamate-tRNA ligase activity Source: FlyBase
  • valine-tRNA ligase activity Source: FlyBase

GO - Biological processi

  • photoreceptor cell maintenance Source: FlyBase
  • phototransduction Source: FlyBase
  • valyl-tRNA aminoacylation Source: FlyBase

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Valyl-tRNA synthetase, isoform AImported
Submitted name:
Valyl-tRNA synthetase, isoform BImported (EC:6.1.1.17Imported, EC:6.1.1.9Imported)
Gene namesi
Name:ValRSImported
Synonyms:Aats-valImported, CG4062Imported
ORF Names:Dmel_CG4062Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0027079. ValRS.

Subcellular locationi

Expressioni

Gene expression databases

BgeeiFBgn0027079.
ExpressionAtlasiQ0E993. differential.

Interactioni

Protein-protein interaction databases

IntActiQ0E993. 7 interactors.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 731tRNA-synt_1InterPro annotationAdd BLAST630
Domaini776 – 925Anticodon_1InterPro annotationAdd BLAST150

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0432. Eukaryota.
COG0525. LUCA.
GeneTreeiENSGT00550000074727.
OrthoDBiEOG091G01XH.

Family and domain databases

CDDicd07962. Anticodon_Ia_Val. 1 hit.
Gene3Di1.10.287.380. 1 hit.
1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_02004. Val_tRNA_synth_type1. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR033705. Anticodon_Ia_Val.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR037118. Val-tRNA_synth_C_sf.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0E993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEAEQQNDA NAPAGAGGDP PKTAKQLEKE RLKAEKLAKL QAKLDKKAAA
60 70 80 90 100
APAAGEKKEK PEKRTKEVKE AAVYTAQTAP GEKKDLSGAL PDAYSPRYVE
110 120 130 140 150
AQWYSWWEKE GFFTPEYGRA SIDAPNPNGK FVMIIPPPNV TGSLHLGHAL
160 170 180 190 200
TNAIEDAITR YHRMKGRTTL WVPGCDHAGI ATQVVVEKLL WRDEKLSRHD
210 220 230 240 250
LGREKFIERI WDWRREKGGR IYEQLKSLGS SYDWTRVAFT MDPKLCRAVT
260 270 280 290 300
EAFVRLHEEG SIYRSSRLVN WSCTLRSAIS DIEVDKVEIP GRTFLSIPGY
310 320 330 340 350
EDKVEFGVLI KFAYKVEGSD EEIIVATTRI ETMLGDTAVA VHPQDDRYKH
360 370 380 390 400
LHGKFVVHPF STRRLPIVCD EFVDMAFGTG AVKITPAHDP NDYEVGKRCN
410 420 430 440 450
LPFITIFNDD GYIIGDYGEF TGMKRFECRK KILEKLKALN LYRETLNNPM
460 470 480 490 500
VVPICSRSKD VVEPLIKPQW YVSCSDMAAS ATEAVRSGEL KIIPEHHTKT
510 520 530 540 550
WYHWMDGIRD WCVSRQLWWG HRIPAYHVSF TDPSLQTGSN DDEQYWIVAR
560 570 580 590 600
SEAEALTKAA ERFGVDASKI VLKQDEDVLD TWFSSGIFPF SVFGWPDQTK
610 620 630 640 650
DLQTFYPTSL LETGHDILFF WVARMVFFGQ KLLGKLPFKE VYLHPMVRDA
660 670 680 690 700
HGRKMSKSLG NVIDPMDVIR GITLEGLHAQ LVGSNLDPRE IEKAKAGQKQ
710 720 730 740 750
DYPQGIPECG SDALRFALCA YITQARDINL DINRVLGYRF FCNKLWNATK
760 770 780 790 800
FALLYFTGSE KFDTELSASA AINQMDAWIL SRLAAAIEAC NTGFESYDFA
810 820 830 840 850
AATSACYAFW LYDLCDVYLE CLKPIFQSGS EEQQTAARRT LYVCLDYGLR
860 870 880 890 900
LLSPFMPFIT EELYQRLPRA NPAPSICVAS YPSNTSWRST KIESDVEFVQ
910 920 930 940 950
KAARIIRSAR SDYNLPNKVK TEVYIVCTDS VPSEILKRYA SDLATISYCS
960 970 980 990 1000
NVVFDSPAPQ GCAILTVTGQ CEVHLLLKGL VEADKEIAKL QKKSDQLVQT
1010 1020 1030 1040
VGKLTQAIQA ADYATKVPAE VQEANETKLC ESRAEIERIA AAIETLKLM
Length:1,049
Mass (Da):118,254
Last modified:October 17, 2006 - v1
Checksum:i13A513ABF69E8EEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58412.1.
AE013599 Genomic DNA. Translation: AAM68598.1.
RefSeqiNP_524838.1. NM_080099.3.
NP_725259.1. NM_165970.2.
UniGeneiDm.1791.

Genome annotation databases

EnsemblMetazoaiFBtr0087734; FBpp0086847; FBgn0027079.
FBtr0087735; FBpp0086848; FBgn0027079.
GeneIDi45783.
UCSCiCG4062-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ0E993_DROME
AccessioniPrimary (citable) accession number: Q0E993
Entry historyiIntegrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: October 25, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported