Unreviewed, UniProtKB/TrEMBL Q0E965 (Q0E965_DROME)

Names and origin

Protein names

Submitted name:
    SRPK, isoform A EMBL AAF58140.2
    EC=2.7.11.-

Gene names

Name:	SRPK FlyBase FBgn0026370
ORF Names:	Dmel_CG8174 EMBL AAF58140.2

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	764 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. RuleBase RU000305V3

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304V2 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305V3 Transferase
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0E965-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: C7E01E78FB96993D	FASTA	764	85,131
	10 20 30 40 50 60 MNKADVNRRV LAIQAKKKRH KNRKRGKQNG TNPQEQSNSS QNQNPKPSSN PIPEPNRSSE 70 80 90 100 110 120 NLQAPDNANN SHLNAPSSAA FSKATATATA STSSGGSAGT PDQYQPPKKT QAKAKPNTQK 130 140 150 160 170 180 EHQQQPPRSS SNESYESETF SDNEDQELME DYCKGGYHPV NIGDLFHDRY HVIRKLGWGH 190 200 210 220 230 240 FSTVWLCWDL QAMGYVAIKI VKSAPHFAET ARDEIKILKT VRETDPSNPR RHKTVQMLDD 250 260 270 280 290 300 FKITGVNGTH ICMVFEVLGD NLLKLIRKSN YRGIPLANVK TITRQVLEGL DYLHTCCKII 310 320 330 340 350 360 HTDIKPENVL LCVDEPHVRS LATEATQLYC MNSKMYPSLV SRAPKEYREP PITGKMSKNR 370 380 390 400 410 420 KKKLKKKAKK RMELFKQQRD YLEQADGQGA INPNEVQNGD AGISDADEYF DANSVEDNVH 430 440 450 460 470 480 VAAGQPSRKQ REERKAPPEQ SEEAQEQDPL TEGTDKAKKK KKKKNKNKSN QSKGQQPPQL 490 500 510 520 530 540 ENSTSSAESS SALKSQQANG SNSTTNNKSN TNSSGTLKGQ SNGKKMPLRP KQEKQGSNHQ 550 560 570 580 590 600 LNNNNSKPNS NSDSKISSGS VENTSSATNG PHSNSTLPTP PPPPQAKHKA KKDPALDECN 610 620 630 640 650 660 VHVKIADLGN ACWVDRHFTE DIQTRQYRSL EVIIGAGYNT SADIWSTACM VFELATGDYL 670 680 690 700 710 720 FEPHSGESYT RDEDHLAHII ELLGPIPREI LLNGTYAAKS FTRSCELRNI SGLKPWGLMD 730 740 750 760 VLLEKYEWSQ KDAASFASFL TPMLEFDPNK RATAAECLQH PWLR

References

[1]

"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.

[2]

"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013599 Genomic DNA. Translation: AAF58140.2.
RefSeq	NP_611034.2. NP_725458.1.
UniGene	Dm.21378
3D structure databases
SMR	Q0E965. Positions 155-326, 601-763.
ModBase	Search...
Proteomic databases
PRIDE	Q0E965.
Genome annotation databases
Ensembl	FBgn0026370. Drosophila melanogaster. [Contig view]
GeneID	36706.
KEGG	dme:Dmel_CG8174.
Organism-specific databases
FlyBase	FBgn0026370. SRPK.
Phylogenomic databases
OMA	Q0E965. DANSVED.
Gene expression databases
ArrayExpress	Q0E965.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 2 hits. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	799974.

Entry information

Entry name

Q0E965_DROME

Accession

Primary (citable) accession number: Q0E965

Entry history

Integrated into UniProtKB/TrEMBL:	October 17, 2006
Last sequence update:	October 17, 2006
Last modified:	July 7, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)