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Protein

Eukaryotic translation initiation factor 3 subunit B

Gene

eIF3b

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

  • mRNA binding Source: FlyBase
  • translation initiation factor activity Source: UniProtKB
  • translation initiation factor binding Source: InterPro

GO - Biological processi

  • ovarian follicle cell development Source: FlyBase
  • regulation of translational initiation Source: UniProtKB
  • translational initiation Source: FlyBase

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit BUniRule annotation
Short name:
eIF3bUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 9UniRule annotation
Gene namesi
Name:eIF3bUniRule annotation
Synonyms:eIF3-S9UniRule annotation
ORF Names:CG4878Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034237. eIF3b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003637971 – 690Eukaryotic translation initiation factor 3 subunit BAdd BLAST690

Proteomic databases

PaxDbiQ0E940.
PRIDEiQ0E940.

Expressioni

Gene expression databases

BgeeiFBgn0034237.
ExpressionAtlasiQ0E940. differential.
GenevisibleiQ0E940. DM.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix (PubMed:17392269). Interacts with mxt (PubMed:23716590).UniRule annotation2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi62670. 29 interactors.
IntActiQ0E940. 13 interactors.
STRINGi7227.FBpp0086098.

Structurei

3D structure databases

ProteinModelPortaliQ0E940.
SMRiQ0E940.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 141RRMUniRule annotationAdd BLAST85
Repeati207 – 246WD 1Add BLAST40
Repeati293 – 331WD 2Add BLAST39
Repeati334 – 369WD 3Add BLAST36
Repeati442 – 484WD 4Add BLAST43
Repeati530 – 575WD 5Add BLAST46

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili595 – 645UniRule annotationAdd BLAST51

Sequence similaritiesi

Belongs to the eIF-3 subunit B family.UniRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2314. Eukaryota.
COG5354. LUCA.
GeneTreeiENSGT00550000074913.
InParanoidiQ0E940.
KOiK03253.
OMAiNFAWEPK.
OrthoDBiEOG091G02V5.
PhylomeDBiQ0E940.

Family and domain databases

CDDicd12278. RRM_eIF3B. 1 hit.
Gene3Di2.130.10.10. 2 hits.
HAMAPiMF_03001. eIF3b. 1 hit.
InterProiView protein in InterPro
IPR011400. EIF3B.
IPR034363. eIF3B_RRM.
IPR000504. RRM_dom.
IPR013979. TIF_beta_prop-like.
IPR015943. WD40/YVTN_repeat-like_dom.
PANTHERiPTHR14068. PTHR14068. 1 hit.
PfamiView protein in Pfam
PF08662. eIF2A. 1 hit.
PF00076. RRM_1. 1 hit.
PIRSFiPIRSF036424. eIF3b. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 1 hit.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0E940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKKSEEHS GTDANDSDYQ EEPNFDDPPG FVDNISDEDL LGDMLAQRPS
60 70 80 90 100
EADGVESVVV VDNIPKVEPV RLEKLKLVIN KLFSNYGEIV NVVYPVDEEG
110 120 130 140 150
KTKGYAFMEY KQARQAEEAV KKLNNHRLDK NHTFAVNLFT DFQKYENIPE
160 170 180 190 200
KWEPPTVQTF KVQSDLYNFI NDPDTYDQYC VAAETAPNCV QVGFWQNVLP
210 220 230 240 250
EPFELETRER FTDTFVKWSP LGTYVVTFHK PGVAIWGGSS FQKIQKFPHP
260 270 280 290 300
GTQFVEFSPC ENYLVTYGPT PTGQKIIIWD IRTGAEKRSF VADGMSVLSM
310 320 330 340 350
FRWSHDDKFV ARMGENSIHI YETPSFYLLD LKSIKIPGIR GFSWSPTDNV
360 370 380 390 400
IAYWVEEQNQ IPARVTLMEI PKKREIRNKN LFHVADCKLH WQKSGDYLCV
410 420 430 440 450
KVDRYSKLKK DKKDLDVKFL GMFYNFEIFH MREKEIPVDS VEIRELILAF
460 470 480 490 500
AWEPVGNKFS IIHGETNSSN VSFYEVNKGV KPSLVKRLEK KSCTHLFWSP
510 520 530 540 550
RGQFIVMANL TMGTFEFVDS TNDYIITASP DHFRASEVEW DPTGRYVVTG
560 570 580 590 600
VSSWKVKEDT GFNMYTFQGR IIKRTILKNF VQFLWRPRPP TLLSEEKQKE
610 620 630 640 650
IKKNLKKYYA AFEQKDRLRL TRASKELLEK RSQLRETFME YRNKRIAEWA
660 670 680 690
EQKSRRIMLR GHVDTDNLET DEVDEEIVEF LVKEEVTLLE
Length:690
Mass (Da):80,441
Last modified:October 17, 2006 - v1
Checksum:iD7536C21C931D778
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12T → A in AAM52578 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57842.1.
AY122066 mRNA. Translation: AAM52578.1.
BT072816 mRNA. Translation: ACN62419.1.
RefSeqiNP_611228.1. NM_137384.3.
NP_725691.1. NM_166239.4.
UniGeneiDm.7152.

Genome annotation databases

EnsemblMetazoaiFBtr0086941; FBpp0086097; FBgn0034237.
FBtr0086942; FBpp0086098; FBgn0034237.
GeneIDi36981.
KEGGidme:Dmel_CG4878.
UCSCiCG4878-RA. d. melanogaster.
CG4878-RB. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiEIF3B_DROME
AccessioniPrimary (citable) accession number: Q0E940
Secondary accession number(s): C0PUW0, Q8MR84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 17, 2006
Last modified: September 27, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families