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Q0E459

- MPK13_ORYSJ

UniProt

Q0E459 - MPK13_ORYSJ

Protein

Mitogen-activated protein kinase 13

Gene

MPK13

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421ATPPROSITE-ProRule annotation
    Active sitei139 – 1391Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 13 (EC:2.7.11.24)
    Short name:
    MAP kinase 13
    Alternative name(s):
    Benzothiadiazole-induced MAP kinase 2
    MAP kinase 2
    OsBIMK2
    OsBWMK2
    OsMAPK2
    OsMPK17-2
    Wound- and blast-induced MAPK 2
    Gene namesi
    Name:MPK13
    Synonyms:BIMK2, BWMK2, MAPK2, MPK17-2
    Ordered Locus Names:Os02g0135200, LOC_Os02g04230
    ORF Names:P0585B01.25
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 2

    Organism-specific databases

    GrameneiQ0E459.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Mitogen-activated protein kinase 13PRO_0000239756Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei175 – 1751PhosphothreonineBy similarity
    Modified residuei177 – 1771PhosphotyrosineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ0E459.

    Expressioni

    Inductioni

    By salicylic acid (SA), ethylene and infection with rice blast fungus (M.grisea).1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ0E459.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 304292Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi175 – 1773TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    OMAiNMRKKPP.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0E459-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFFTEYGEA SQYQIQEVVG KGSYGVVAAA VDTHTGERVA IKKINDVFEH    50
    VSDAIRILRE IKVLRLLRHP DIVVIKHIML PPTRREFRDI YVVFELMESD 100
    LHQVIEANHD LSPEHHRFFL YQLLCALKYI HSANVFHRDL KPKNILANSD 150
    CKLKICDFGL ARVAFNDSPS TIFWTDYVAT RWYRAPELCG SFFSKYTPAI 200
    DIWSIGCIFA EILTGRPLFP GRNVVHQLDL ITDLLGTPSS ETLSRIRNEN 250
    ARGYLTGMQR KHPIPFSHKF HNADPLALRL LERLLAFDPK DRPTAEEALA 300
    DPYFRGISKL SREPSRLPVS KFEFEFERRK LTKDDVREMI YREILEYHPQ 350
    MLQEYIRGGE QISFLYPSGV DRFKRQFAHL EENYSRGERS TPLRRQHASL 400
    PRERVCSSVD SNNQDSDNEE RRAISSIART MISPPRSQEK GKNRASAYPN 450
    GIINLNSNPK IYLKSASISA STCIIRGNKG PKENGISEDM EEVVYELSDN 500
    VTRMLS 506
    Length:506
    Mass (Da):58,281
    Last modified:October 17, 2006 - v1
    Checksum:i7EBCBA768079F972
    GO

    Sequence cautioni

    The sequence AAF23903.1 differs from that shown. Reason: Frameshift at several positions.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF194416 mRNA. Translation: AAF23903.1. Frameshift.
    AY588939 mRNA. Translation: AAT00625.1.
    AP004799 Genomic DNA. Translation: BAD10093.1.
    AP008208 Genomic DNA. Translation: BAF07729.1.
    RefSeqiNP_001045815.1. NM_001052350.1.
    UniGeneiOs.2356.

    Genome annotation databases

    GeneIDi4328223.
    KEGGiosa:4328223.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF194416 mRNA. Translation: AAF23903.1 . Frameshift.
    AY588939 mRNA. Translation: AAT00625.1 .
    AP004799 Genomic DNA. Translation: BAD10093.1 .
    AP008208 Genomic DNA. Translation: BAF07729.1 .
    RefSeqi NP_001045815.1. NM_001052350.1.
    UniGenei Os.2356.

    3D structure databases

    ProteinModelPortali Q0E459.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q0E459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4328223.
    KEGGi osa:4328223.

    Organism-specific databases

    Gramenei Q0E459.

    Phylogenomic databases

    eggNOGi COG0515.
    OMAi NMRKKPP.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel plant MAP kinases phosphorylate defense-related transcription factors."
      Cheong Y.H., Moon B.C., Kim J.K., Cho M.J.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Oryza sativa (japonica cultivar-group) wound and blast induced MAPK (BWMK2) mRNA."
      Wang D.-P., Zhao W.-S., Wang M., Meng X.-B., Lin R.-M., Zhang S.-H., Peng Y.-L.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Aichiasahi.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    4. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    5. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
      Reyna N.S., Yang Y.
      Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, NOMENCLATURE.

    Entry informationi

    Entry nameiMPK13_ORYSJ
    AccessioniPrimary (citable) accession number: Q0E459
    Secondary accession number(s): Q6QUV9, Q6Z831, Q9SE22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3