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Q0E459

- MPK13_ORYSJ

UniProt

Q0E459 - MPK13_ORYSJ

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Protein

Mitogen-activated protein kinase 13

Gene

MPK13

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATPPROSITE-ProRule annotation
Active sitei139 – 1391Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 13 (EC:2.7.11.24)
Short name:
MAP kinase 13
Alternative name(s):
Benzothiadiazole-induced MAP kinase 2
MAP kinase 2
OsBIMK2
OsBWMK2
OsMAPK2
OsMPK17-2
Wound- and blast-induced MAPK 2
Gene namesi
Name:MPK13
Synonyms:BIMK2, BWMK2, MAPK2, MPK17-2
Ordered Locus Names:Os02g0135200, LOC_Os02g04230
ORF Names:P0585B01.25
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 2

Organism-specific databases

GrameneiQ0E459.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Mitogen-activated protein kinase 13PRO_0000239756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751PhosphothreonineBy similarity
Modified residuei177 – 1771PhosphotyrosineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ0E459.

Expressioni

Inductioni

By salicylic acid (SA), ethylene and infection with rice blast fungus (M.grisea).1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ0E459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 304292Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi175 – 1773TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ0E459.
OMAiNMRKKPP.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0E459-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFFTEYGEA SQYQIQEVVG KGSYGVVAAA VDTHTGERVA IKKINDVFEH
60 70 80 90 100
VSDAIRILRE IKVLRLLRHP DIVVIKHIML PPTRREFRDI YVVFELMESD
110 120 130 140 150
LHQVIEANHD LSPEHHRFFL YQLLCALKYI HSANVFHRDL KPKNILANSD
160 170 180 190 200
CKLKICDFGL ARVAFNDSPS TIFWTDYVAT RWYRAPELCG SFFSKYTPAI
210 220 230 240 250
DIWSIGCIFA EILTGRPLFP GRNVVHQLDL ITDLLGTPSS ETLSRIRNEN
260 270 280 290 300
ARGYLTGMQR KHPIPFSHKF HNADPLALRL LERLLAFDPK DRPTAEEALA
310 320 330 340 350
DPYFRGISKL SREPSRLPVS KFEFEFERRK LTKDDVREMI YREILEYHPQ
360 370 380 390 400
MLQEYIRGGE QISFLYPSGV DRFKRQFAHL EENYSRGERS TPLRRQHASL
410 420 430 440 450
PRERVCSSVD SNNQDSDNEE RRAISSIART MISPPRSQEK GKNRASAYPN
460 470 480 490 500
GIINLNSNPK IYLKSASISA STCIIRGNKG PKENGISEDM EEVVYELSDN

VTRMLS
Length:506
Mass (Da):58,281
Last modified:October 17, 2006 - v1
Checksum:i7EBCBA768079F972
GO

Sequence cautioni

The sequence AAF23903.1 differs from that shown. Reason: Frameshift at several positions.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF194416 mRNA. Translation: AAF23903.1. Frameshift.
AY588939 mRNA. Translation: AAT00625.1.
AP004799 Genomic DNA. Translation: BAD10093.1.
AP008208 Genomic DNA. Translation: BAF07729.1.
RefSeqiNP_001045815.1. NM_001052350.1.
UniGeneiOs.2356.

Genome annotation databases

GeneIDi4328223.
KEGGiosa:4328223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF194416 mRNA. Translation: AAF23903.1 . Frameshift.
AY588939 mRNA. Translation: AAT00625.1 .
AP004799 Genomic DNA. Translation: BAD10093.1 .
AP008208 Genomic DNA. Translation: BAF07729.1 .
RefSeqi NP_001045815.1. NM_001052350.1.
UniGenei Os.2356.

3D structure databases

ProteinModelPortali Q0E459.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q0E459.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4328223.
KEGGi osa:4328223.

Organism-specific databases

Gramenei Q0E459.

Phylogenomic databases

eggNOGi COG0515.
InParanoidi Q0E459.
OMAi NMRKKPP.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel plant MAP kinases phosphorylate defense-related transcription factors."
    Cheong Y.H., Moon B.C., Kim J.K., Cho M.J.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Oryza sativa (japonica cultivar-group) wound and blast induced MAPK (BWMK2) mRNA."
    Wang D.-P., Zhao W.-S., Wang M., Meng X.-B., Lin R.-M., Zhang S.-H., Peng Y.-L.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Aichiasahi.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  5. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
    Reyna N.S., Yang Y.
    Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, NOMENCLATURE.

Entry informationi

Entry nameiMPK13_ORYSJ
AccessioniPrimary (citable) accession number: Q0E459
Secondary accession number(s): Q6QUV9, Q6Z831, Q9SE22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3