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Protein

Serine/threonine-protein phosphatase PP2A-3 catalytic subunit

Gene

PP2A3

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi55 – 551Manganese 1By similarity
Metal bindingi57 – 571Manganese 1By similarity
Metal bindingi83 – 831Manganese 1By similarity
Metal bindingi83 – 831Manganese 2By similarity
Metal bindingi115 – 1151Manganese 2By similarity
Active sitei116 – 1161Proton donorBy similarity
Metal bindingi165 – 1651Manganese 2By similarity
Metal bindingi239 – 2391Manganese 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_296975. Integration of energy metabolism.
REACT_302664. Glycolysis.
REACT_303121. ERKs are inactivated.
REACT_304736. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_320770. PP2A-mediated dephosphorylation of key metabolic factors.
REACT_343002. ERK/MAPK targets.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-3 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A3
Ordered Locus Names:Os02g0217600, LOC_Os02g12580
ORF Names:OsJ_005728, P0027A02.2-1, P0027A02.2-2
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763 Componenti: Chromosome 2

Organism-specific databases

GrameneiQ0E2S4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Serine/threonine-protein phosphatase PP2A-3 catalytic subunitPRO_0000058863Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiQ0E2S4. baseline.

Interactioni

Protein-protein interaction databases

IntActiQ0E2S4. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ0E2S4.
SMRiQ0E2S4. Positions 7-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
InParanoidiQ0E2S4.
KOiK04382.
OMAiDVRTLCD.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0E2S4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSSHGDLDR QIAQLRECKH LAEGEVRALC EQAKAILMEE WNVQPVRCPV
60 70 80 90 100
TVCGDIHGQF YDLIELFRIG GEAPDTNYLF MGDYVDRGYY SVETVSLLVA
110 120 130 140 150
LKVRYRDRIT ILRGNHESRQ ITQVYGFYDE CLRKYGNANV WKYFTDLFDY
160 170 180 190 200
LPLTALIENQ VFCLHGGLSP SLDTLDNIRA LDRIQEVPHE GPMCDLLWSD
210 220 230 240 250
PDDRCGWGIS PRGAGYTFGQ DIAQQFNHTN GLSLISRAHQ LVMEGFNWCQ
260 270 280 290 300
DKNVVTVFSA PNYCYRCGNM AAILEIGENM DQNFLQFDPA PRQIEPDTTR

KTPDYFL
Length:307
Mass (Da):35,145
Last modified:October 17, 2006 - v1
Checksum:i97143563695D0DD6
GO
Isoform 2 (identifier: Q0E2S4-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-80: Missing.

Note: No experimental confirmation available.

Show »
Length:294
Mass (Da):33,710
Checksum:iCDB4E67BCE48D047
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei68 – 8013Missing in isoform 2. 1 PublicationVSP_019124Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004996 Genomic DNA. Translation: BAD17174.1.
AP004996 Genomic DNA. Translation: BAD17175.1.
AP008208 Genomic DNA. Translation: BAF08214.1.
CM000139 Genomic DNA. No translation available.
AK060905 mRNA. No translation available.
AK072676 mRNA. No translation available.
RefSeqiNP_001046300.1. NM_001052835.1. [Q0E2S4-1]
UniGeneiOs.10337.

Genome annotation databases

EnsemblPlantsiOS02T0217600-02; OS02T0217600-02; OS02G0217600. [Q0E2S4-1]
GeneIDi4328734.
KEGGiosa:4328734.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004996 Genomic DNA. Translation: BAD17174.1.
AP004996 Genomic DNA. Translation: BAD17175.1.
AP008208 Genomic DNA. Translation: BAF08214.1.
CM000139 Genomic DNA. No translation available.
AK060905 mRNA. No translation available.
AK072676 mRNA. No translation available.
RefSeqiNP_001046300.1. NM_001052835.1. [Q0E2S4-1]
UniGeneiOs.10337.

3D structure databases

ProteinModelPortaliQ0E2S4.
SMRiQ0E2S4. Positions 7-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ0E2S4. 2 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS02T0217600-02; OS02T0217600-02; OS02G0217600. [Q0E2S4-1]
GeneIDi4328734.
KEGGiosa:4328734.

Organism-specific databases

GrameneiQ0E2S4.

Phylogenomic databases

eggNOGiCOG0639.
InParanoidiQ0E2S4.
KOiK04382.
OMAiDVRTLCD.

Enzyme and pathway databases

ReactomeiREACT_296975. Integration of energy metabolism.
REACT_302664. Glycolysis.
REACT_303121. ERKs are inactivated.
REACT_304736. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_320770. PP2A-mediated dephosphorylation of key metabolic factors.
REACT_343002. ERK/MAPK targets.

Gene expression databases

ExpressionAtlasiQ0E2S4. baseline.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  3. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiPP2A3_ORYSJ
AccessioniPrimary (citable) accession number: Q0E2S4
Secondary accession number(s): Q6Z6L8, Q6Z6L9, Q9XGT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 17, 2006
Last modified: April 1, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.