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Q0E0Q3 (PARP3_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Poly [ADP-ribose] polymerase 3
Short name=PARP-3
EC=2.4.2.30
Alternative name(s):
NAD(+) ADP-ribosyltransferase 3
Short name=ADPRT-3
Poly[ADP-ribose] synthase 3
Gene names
Name:PARP3
Ordered Locus Names:Os02g0530600, LOC_Os02g32860
ORF Names:P0476H10.38
OrganismOryza sativa subsp. japonica (Rice)
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length831 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks By similarity.

Catalytic activity

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 1 BRCT domain.

Contains 1 PARP alpha-helical domain.

Contains 1 PARP catalytic domain.

Sequence caution

The sequence BAD25449.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentNucleus
   LigandNAD
   Molecular functionGlycosyltransferase
Transferase
   PTMADP-ribosylation
Gene Ontology (GO)
   Biological processprotein ADP-ribosylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD+ ADP-ribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 831831Poly [ADP-ribose] polymerase 3
PRO_0000260505

Regions

Domain198 – 29093BRCT
Domain466 – 585120PARP alpha-helical
Domain594 – 827234PARP catalytic

Sequences

Sequence LengthMass (Da)Tools
Q0E0Q3 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 448C932D3F97173E

FASTA83192,404
        10         20         30         40         50         60 
MVHETRSRTL AASQEEGKAA PKKQKTESKE QEGGQQAPSK NKKTADNEEH DGEQEPSKNK 

        70         80         90        100        110        120 
KLKAEESDLN GKATAVKEFS EFCKAIREHL TIEDMRKILQ GNEQDASGSE DAVVPRCEDV 

       130        140        150        160        170        180 
MFYGPLDKCP VCGGQLECKG LKYNCTGTHS EWACCSFSTN NPSRRGGPIK VPDDVKNDFV 

       190        200        210        220        230        240 
RKWLKQQEGN KYPKRNLDDE GIFSGMMIAL SGRMSRSHGY FKEQIMKHGG KVNNSVIGVT 

       250        260        270        280        290        300 
CVVASPAERH QGGSGGFAEA LERGTPVVSE NWIIDSVQKK EKQPLAAYDI ASDVVPEGRG 

       310        320        330        340        350        360 
LPLGNLDPTE EAIETLAAEL KLAGKRAVHK DSKLEKDGGH IYEKDGIIYN CAFSVCDLGG 

       370        380        390        400        410        420 
DINQLCIMQL IMVPENHLHL YYKKGPIGHD QMAEERVEDF GSRFNDAIKE FVRLFEEVTG 

       430        440        450        460        470        480 
NEFEPWEREK KFKKKCMKMY PLDMDDGVDV RHGGVALRQL GAAAAHCKLD PSVTFIMKQL 

       490        500        510        520        530        540 
CSQEIYRYAL TEMGHDVPDL PIGMLTDLHL KRGEETLLEW KQDVESAPES GPAADAFWME 

       550        560        570        580        590        600 
ISNKWFTLFP TTRPYTMKGY EQIADNVASG LETVRDINVA SRLIGDVFGS TLDDPLSQCY 

       610        620        630        640        650        660 
KKLGCSINRV VEDSEDYKMI LKYLEKTYEP VKVGDVVYSA TVERIYAVES SALPSYDEIK 

       670        680        690        700        710        720 
KLPNKVLLWC GTRSSNLLRH LRDGFVPAVC HIPVPGYMFG KAIVCSDAAA EAALYGFTAV 

       730        740        750        760        770        780 
DRPEGYLVLA VASLGKEIQE ITGTPGSEDV KRMEEKKMGV KGVGRKTTDP SEHFTWRDGV 

       790        800        810        820        830 
TVPCGKLVPS TNKDGPLEYN EYAVYDPKQV SIAFLVGVKY EEQNMEVVPD E

« Hide

References

« Hide 'large scale' references
[1]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed: 16100779] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"The rice annotation project database (RAP-DB): 2008 update."
The rice annotation project (RAP)
Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed: 18089549] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: cv. Nipponbare.
[3]"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
The rice full-length cDNA consortium
Science 301:376-379(2003) [PubMed: 12869764] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP004790 Genomic DNA. Translation: BAD25449.1. Sequence problems.
AP008208 Genomic DNA. Translation: BAF08935.1.
AK102681 mRNA. No translation available.
RefSeqNP_001047021.1. NM_001053556.1.
UniGeneOs.54236.

3D structure databases

ProteinModelPortalQ0E0Q3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsLOC_Os02g32860.1; LOC_Os02g32860.1; LOC_Os02g32860.
GeneID4329546.
KEGGosa:4329546.

Organism-specific databases

GrameneQ6H750.

Phylogenomic databases

GeneTreeEPGT00070000030699.
HOGENOMHBG592687.
OMAYAVYDPK.
PhylomeDBQ0E0Q3.
ProtClustDBPLN03122.

Family and domain databases

InterProIPR001357. BRCT.
IPR012982. PADR1.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004102. Poly(ADP-ribose)pol_reg_dom.
IPR008893. WGR_domain.
[Graphical view]
Gene3DG3DSA:1.20.142.10. PARP_reg. 1 hit.
PfamPF00533. BRCT. 1 hit.
PF08063. PADR1. 1 hit.
PF00644. PARP. 1 hit.
PF02877. PARP_reg. 1 hit.
PF05406. WGR. 1 hit.
[Graphical view]
SMARTSM00292. BRCT. 1 hit.
SM00773. WGR. 1 hit.
[Graphical view]
SUPFAMSSF52113. BRCT. 1 hit.
SSF47587. PARP_reg. 1 hit.
SSF142921. SSF142921. 1 hit.
PROSITEPS50172. BRCT. 1 hit.
PS51060. PARP_ALPHA_HD. 1 hit.
PS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePARP3_ORYSJ
AccessionPrimary (citable) accession number: Q0E0Q3
Secondary accession number(s): Q6H750
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 17, 2006
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

SIMILARITY comments

Index of protein domains and families

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