ID PAL2_ORYSJ Reviewed; 713 AA. AC Q0DZE0; P53443; Q6K6P7; DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot. DT 17-OCT-2006, sequence version 1. DT 16-JUN-2009, entry version 21. DE RecName: Full=Phenylalanine ammonia-lyase; DE EC=4.3.1.24; GN Name=ZB8; OrderedLocusNames=Os02g0627100, LOC_Os02g41680; GN ORFNames=P0042D01.10, OsJ_007359; OS Oryza sativa subsp. japonica (Rice). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade; OC Ehrhartoideae; Oryzeae; Oryza. OX NCBI_TaxID=39947; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nipponbare; RX PubMed=16100779; DOI=10.1038/nature03895; RG International rice genome sequencing project (IRGSP); RT "The map-based sequence of the rice genome."; RL Nature 436:793-800(2005). RN [2] RP GENOME REANNOTATION. RC STRAIN=cv. Nipponbare; RX PubMed=17210932; DOI=10.1101/gr.5509507; RG The rice annotation project (RAP); RT "Curated genome annotation of Oryza sativa ssp. japonica and RT comparative genome analysis with Arabidopsis thaliana."; RL Genome Res. 17:175-183(2007). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nipponbare; RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038; RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., RA Cong L., Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., RA Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., RA Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., RA Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., RA Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., RA Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., RA Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., RA Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., RA Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., RA Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., RA Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., RA Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., RA Samudrala R., Wang J., Wong G.K.-S., Yang H.; RT "The genomes of Oryza sativa: a history of duplications."; RL PLoS Biol. 3:266-281(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Nipponbare; RX MEDLINE=22752273; PubMed=12869764; DOI=10.1126/science.1081288; RG The rice full-length cDNA consortium; RT "Collection, mapping, and annotation of over 28,000 cDNA clones from RT japonica rice."; RL Science 301:376-379(2003). CC -!- FUNCTION: This is a key enzyme of plant metabolism catalyzing the CC first reaction in the biosynthesis from L-phenylalanine of a wide CC variety of natural products based on the phenylpropane skeleton. CC -!- CATALYTIC ACTIVITY: L-phenylalanine = trans-cinnamate + ammonia. CC -!- PATHWAY: Phenylpropanoid metabolism; cinnamic acid biosynthesis; CC trans-cinnamic acid from L-phenylalanine: step 1/1. CC -!- SUBCELLULAR LOCATION: Cytoplasm (Probable). CC -!- PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO), CC which is formed autocatalytically by cyclization and dehydration CC of residues Ala-Ser-Gly (By similarity). CC -!- SIMILARITY: Belongs to the PAL/histidase family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AP005000; BAD23155.1; -; Genomic_DNA. DR EMBL; AP008208; BAF09398.1; -; Genomic_DNA. DR EMBL; CM000139; EAZ23876.1; -; Genomic_DNA. DR EMBL; AK068993; -; NOT_ANNOTATED_CDS; mRNA. DR RefSeq; NP_001047484.1; -. DR UniGene; Os.25687; -. DR HSSP; P21310; 1GKM. DR SMR; Q0DZE0; 24-713. DR GeneID; 4330040; -. DR KEGG; osa:4330040; -. DR Gramene; P53443; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0016211; F:ammonia ligase activity; IEA:InterPro. DR GO; GO:0016841; F:ammonia-lyase activity; IEA:InterPro. DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro. DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:InterPro. DR GO; GO:0009698; P:phenylpropanoid metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR001106; Phe/His_NH3-lyase. DR InterPro; IPR005922; Phe_NH3-lyase. DR Pfam; PF00221; PAL; 1. DR TIGRFAMs; TIGR01226; phe_am_lyase; 1. DR PROSITE; PS00488; PAL_HISTIDASE; 1. PE 2: Evidence at transcript level; KW Cytoplasm; Lyase; Phenylpropanoid metabolism. FT CHAIN 1 713 Phenylalanine ammonia-lyase. FT /FTId=PRO_0000215402. FT MOD_RES 200 200 2,3-didehydroalanine (Ser) (By FT similarity). FT CROSSLNK 199 201 5-imidazolinone (Ala-Gly) (By FT similarity). SQ SEQUENCE 713 AA; 76981 MW; 774C6D2B9B77348A CRC64; MECENGRVSA NGMSGLCVAA PRADPLNWGK ATEEMTGSHL DEVKRMVAEY RQPLVKIEGA SLRIAQVAAV AAAGEARVEL DESARERVKA SSDWVMNSMM NGTDSYGVTT GFGATSHRRT KEGGALQREL IRFLNAGAFG TGTDGHVLPA EATRAAMLVR INTLLQGYSG IRFEILEAIA KLLNANVTPC LPLRGTITAS GDLVPLSYIA GLVTGRENAV AVAPDGSKVN AAEAFKIAGI QGGFFELQPK EGLAMVNGTA VGSGLASTVL FEANILAILA EVLSAVFCEV MNGKPEYTDH LTHKLKHHPG QIEAAAIMEH ILEGSSYMKH AKKLGELDPL MKPKQDRYAL RTSPQWLGPQ IEVIRAATKS IEREINSVND NPLIDVSRGK ALHGGNFQGT PIGVSMDNTR LAIAAIGKLM FAQFSELVND FYNNGLPSNL SGGRNPSLDY GFKGAEIAMA SYCSELQFLG NPVTNHVQSA EQHNQDVNSL GLISSRKTDE AIDILKLMSS TFLIALCQAV DLRHIEENVK SAVKSCVMTV AKKTLSTNST GDLHVARFCE KDLLKEIDRE AVFAYADDPC SHNYPLMKKL RNVLVERALA NGAAEFNADT SVFAKVAQFE EELRATLPGA IEAARAAVEN GTAAIPSRIT ECRSYPLYRF VREELGTKYL TGEKTRSPGE ELNKVLVAIN EGKHIDPLLE CLKEWNGEPL PIC //