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Q0DJ33

- GPA1_ORYSJ

UniProt

Q0DJ33 - GPA1_ORYSJ

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Protein

Guanine nucleotide-binding protein alpha-1 subunit

Gene
GPA1, D1, GA1, RGA1, Os05g0333200, LOC_Os05g26890, OJ1005_D04.15, OSJNBa0049D13.1
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Magnesium By similarity
Metal bindingi194 – 1941Magnesium By similarity
Binding sitei356 – 3561GTP; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 538GTP By similarity
Nucleotide bindingi188 – 1947GTP By similarity
Nucleotide bindingi219 – 2235GTP By similarity
Nucleotide bindingi288 – 2914GTP By similarity

GO - Molecular functioni

  1. channel regulator activity Source: RefGenome
  2. G-protein beta/gamma-subunit complex binding Source: RefGenome
  3. G-protein coupled receptor binding Source: RefGenome
  4. GTPase activity Source: RefGenome
  5. GTPase inhibitor activity Source: RefGenome
  6. GTP binding Source: UniProtKB-KW
  7. metal ion binding Source: UniProtKB-KW
  8. protein binding Source: IntAct
  9. signal transducer activity Source: RefGenome

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RefGenome
  2. blue light signaling pathway Source: EnsemblPlants/Gramene
  3. cell death Source: EnsemblPlants/Gramene
  4. cellular response to abscisic acid stimulus Source: EnsemblPlants/Gramene
  5. gibberellic acid mediated signaling pathway Source: EnsemblPlants/Gramene
  6. G-protein coupled receptor signaling pathway, coupled to S1P second messenger Source: EnsemblPlants/Gramene
  7. L-phenylalanine biosynthetic process Source: EnsemblPlants/Gramene
  8. negative regulation of abscisic acid-activated signaling pathway Source: EnsemblPlants/Gramene
  9. negative regulation of catalytic activity Source: GOC
  10. positive regulation of abscisic acid-activated signaling pathway Source: EnsemblPlants/Gramene
  11. reactive oxygen species metabolic process Source: EnsemblPlants/Gramene
  12. regulation of cell proliferation Source: EnsemblPlants/Gramene
  13. response to glucose Source: EnsemblPlants/Gramene
  14. response to low fluence blue light stimulus by blue low-fluence system Source: EnsemblPlants/Gramene
  15. seed germination Source: EnsemblPlants/Gramene
  16. thylakoid membrane organization Source: EnsemblPlants/Gramene
  17. tyrosine biosynthetic process Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein alpha-1 subunit
Short name:
GP-alpha-1
Alternative name(s):
Protein Dwarf1
Gene namesi
Name:GPA1
Synonyms:D1, GA1, RGA1
Ordered Locus Names:Os05g0333200, LOC_Os05g26890
ORF Names:OJ1005_D04.15, OSJNBa0049D13.1
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 5

Organism-specific databases

GrameneiQ0DJ33.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: EnsemblPlants/Gramene
  2. extrinsic component of cytoplasmic side of plasma membrane Source: RefGenome
  3. heterotrimeric G-protein complex Source: RefGenome
  4. plasmodesma Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 380379Guanine nucleotide-binding protein alpha-1 subunitPRO_0000203622Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity
Lipidationi5 – 51S-palmitoyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Binary interactionsi

WithEntry#Exp.IntActNotes
LOC_Os03g46650Q406872EBI-1100098,EBI-1100119

Protein-protein interaction databases

IntActiQ0DJ33. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ0DJ33.

Family & Domainsi

Domaini

The helical domain (69-189) is required for self-activation By similarity.

Sequence similaritiesi

Belongs to the G-alpha family.

Phylogenomic databases

eggNOGiNOG322962.
KOiK04640.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
IPR002976. Plant_Gprotein_alpha.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR01242. GPROTEINAPLT.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0DJ33-1 [UniParc]FASTAAdd to Basket

« Hide

MGSSCSRSHS LSEAETTKNA KSADIDRRIL QETKAEQHIH KLLLLGAGES    50
GKSTIFKQIK LLFQTGFDEA ELRSYTSVIH ANVYQTIKIL YEGAKELSQV 100
ESDSSKYVIS PDNQEIGEKL SDIDGRLDYP LLNKELVLDV KRLWQDPAIQ 150
ETYLRGSILQ LPDCAQYFME NLDRLAEAGY VPTKEDVLYA RVRTNGVVQI 200
QFSPVGENKR GGEVYRLYDV GGQRNERRKW IHLFEGVNAV IFCAAISEYD 250
QMLFEDETKN RMMETKELFD WVLKQRCFEK TSFILFLNKF DIFEKKIQKV 300
PLSVCEWFKD YQPIAPGKQE VEHAYEFVKK KFEELYFQSS KPDRVDRVFK 350
IYRTTALDQK LVKKTFKLID ESMRRSREGT 380
Length:380
Mass (Da):44,206
Last modified:July 24, 2007 - v2
Checksum:i4EEFAEDAB4463612
GO

Sequence cautioni

The sequence BAF17140.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38232 mRNA. Translation: BAA07405.1.
AC117264 Genomic DNA. Translation: AAV43839.1.
AC144739 Genomic DNA. Translation: AAW57778.2.
AP008211 Genomic DNA. Translation: BAF17140.1. Different initiation.
RefSeqiNP_001055226.1. NM_001061761.1.
UniGeneiOs.5302.

Genome annotation databases

GeneIDi4338448.
KEGGiosa:4338448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38232 mRNA. Translation: BAA07405.1 .
AC117264 Genomic DNA. Translation: AAV43839.1 .
AC144739 Genomic DNA. Translation: AAW57778.2 .
AP008211 Genomic DNA. Translation: BAF17140.1 . Different initiation.
RefSeqi NP_001055226.1. NM_001061761.1.
UniGenei Os.5302.

3D structure databases

ProteinModelPortali Q0DJ33.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q0DJ33. 1 interaction.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4338448.
KEGGi osa:4338448.

Organism-specific databases

Gramenei Q0DJ33.

Phylogenomic databases

eggNOGi NOG322962.
KOi K04640.

Family and domain databases

Gene3Di 1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
IPR002976. Plant_Gprotein_alpha.
[Graphical view ]
PANTHERi PTHR10218. PTHR10218. 1 hit.
Pfami PF00503. G-alpha. 1 hit.
[Graphical view ]
PRINTSi PR00318. GPROTEINA.
PR01242. GPROTEINAPLT.
SMARTi SM00275. G_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a cDNA for the alpha subunit of a G protein from rice."
    Ishikawa A., Tsubouchi H., Iwasaki Y., Asahi T.
    Plant Cell Physiol. 36:353-359(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Nipponbare.
    Tissue: Leaf.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiGPA1_ORYSJ
AccessioniPrimary (citable) accession number: Q0DJ33
Secondary accession number(s): P49083
, Q2HNY6, Q43604, Q5KQF9, Q5W732
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: June 11, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi