UniProtKB - Q0DJ33 (GPA1_ORYSJ)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Guanine nucleotide-binding protein alpha-1 subunit
Gene
GPA1
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (Probable). May function in a signal transduction pathway required for normal growth and development of internodes, leaves, panicles and seeds (PubMed:10377457). Involved in gibberellin signal transduction (PubMed:10468600, PubMed:11027362). Involved in R gene-mediated disease resistance. Functions upstream of the small GTPase RAC1 in the early steps of signaling (PubMed:12237405). Involved in brassinosteroid (BR) response. May not be a signaling molecule in BRI1-meditated perception or transduction (PubMed:17117160, PubMed:19036785). Acts together with the E3 ubiquitin ligase TUD1 to mediate a BR signaling pathway that affects plant growth and development (PubMed:23526892).Curated7 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 53 | MagnesiumBy similarity | 1 | |
Metal bindingi | 194 | MagnesiumBy similarity | 1 | |
Binding sitei | 356 | GTP; via amide nitrogenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 46 – 53 | GTPBy similarity | 8 | |
Nucleotide bindingi | 188 – 194 | GTPBy similarity | 7 | |
Nucleotide bindingi | 219 – 223 | GTPBy similarity | 5 | |
Nucleotide bindingi | 288 – 291 | GTPBy similarity | 4 |
GO - Molecular functioni
- channel regulator activity Source: GO_Central
- G-protein beta/gamma-subunit complex binding Source: GO_Central
- G-protein coupled receptor binding Source: GO_Central
- GTPase activity Source: GO_Central
- GTPase inhibitor activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- signal transducer activity Source: GO_Central
GO - Biological processi
- abscisic acid-activated signaling pathway Source: EnsemblPlants
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: GO_Central
- blue light signaling pathway Source: EnsemblPlants
- brassinosteroid mediated signaling pathway Source: UniProtKB
- cell death Source: EnsemblPlants
- defense response Source: UniProtKB-KW
- defense response signaling pathway, resistance gene-dependent Source: UniProtKB
- gibberellic acid mediated signaling pathway Source: EnsemblPlants
- gibberellin mediated signaling pathway Source: UniProtKB
- G-protein coupled receptor signaling pathway, coupled to S1P second messenger Source: EnsemblPlants
- L-phenylalanine biosynthetic process Source: EnsemblPlants
- negative regulation of abscisic acid-activated signaling pathway Source: EnsemblPlants
- positive regulation of abscisic acid-activated signaling pathway Source: EnsemblPlants
- positive regulation of developmental growth Source: UniProtKB
- reactive oxygen species metabolic process Source: EnsemblPlants
- regulation of cell proliferation Source: EnsemblPlants
- regulation of stomatal movement Source: EnsemblPlants
- response to glucose Source: EnsemblPlants
- response to low fluence blue light stimulus by blue low-fluence system Source: EnsemblPlants
- seed germination Source: EnsemblPlants
- thylakoid membrane organization Source: EnsemblPlants
- tyrosine biosynthetic process Source: EnsemblPlants
Keywordsi
Molecular function | Transducer |
Biological process | Plant defense |
Ligand | GTP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-OSA-112043. PLC beta mediated events. R-OSA-202040. G-protein activation. R-OSA-2514859. Inactivation, recovery and regulation of the phototransduction cascade. R-OSA-399997. Acetylcholine regulates insulin secretion. R-OSA-416476. G alpha (q) signalling events. R-OSA-416482. G alpha (12/13) signalling events. R-OSA-418555. G alpha (s) signalling events. R-OSA-434316. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion. |
Names & Taxonomyi
Protein namesi | Recommended name: Guanine nucleotide-binding protein alpha-1 subunitShort name: GP-alpha-1 Alternative name(s): Protein Daikoku dwarf1 Publication Protein Dwarf1 |
Gene namesi | Name:GPA1Curated Synonyms:D11 Publication, GA1, RGA11 Publication Ordered Locus Names:Os05g0333200Imported, LOC_Os05g26890Curated ORF Names:OJ1005_D04.15, OSJNBa0049D13.1 |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Dwarf plants and small seeds (PubMed:10377457, PubMed:10468600). Short internodes, leaves and panicles (PubMed:10377457).2 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 223 | Q → L: Constitutively active. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000203622 | 2 – 380 | Guanine nucleotide-binding protein alpha-1 subunitAdd BLAST | 379 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycineBy similarity | 1 | |
Lipidationi | 5 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Myristate, PalmitateProteomic databases
PaxDbi | Q0DJ33. |
Expressioni
Tissue specificityi
Highly expressed in young internodes. Expressed in the base of the stamen, pistil, lemma, and palea before flowering and in the pericarp of the ovary after fertilization.1 Publication
Inductioni
By infection with an avirulent race of rice blast fungus (M.grisea) and sphingolipid elicitors (PubMed:12237405). Down-regulated by a virulent race of rice blast fungus (M.grisea) (PubMed:12237405). Down-regulated by 24-epi-brassinolide (PubMed:17117160).2 Publications
Gene expression databases
ExpressionAtlasi | Q0DJ33. baseline and differential. |
Genevisiblei | Q0DJ33. OS. |
Interactioni
Subunit structurei
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site (PubMed:15078334). Interacts with COLD1 (PubMed:25728666). Interacts with TUD1 (PubMed:23526892).3 Publications
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
RGB1 | Q40687 | 2 | EBI-1100098,EBI-1100119 |
GO - Molecular functioni
- G-protein beta/gamma-subunit complex binding Source: GO_Central
- G-protein coupled receptor binding Source: GO_Central
Protein-protein interaction databases
IntActi | Q0DJ33. 1 interactor. |
STRINGi | 39947.LOC_Os05g26890.1. |
Structurei
3D structure databases
ProteinModelPortali | Q0DJ33. |
SMRi | Q0DJ33. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domaini
The helical domain (69-189) is required for self-activation.By similarity
Sequence similaritiesi
Belongs to the G-alpha family.Curated
Phylogenomic databases
eggNOGi | KOG0082. Eukaryota. ENOG410XNVQ. LUCA. |
InParanoidi | Q0DJ33. |
KOi | K19729. |
OrthoDBi | EOG09360CLR. |
Family and domain databases
CDDi | cd00066. G-alpha. 1 hit. |
Gene3Di | 1.10.400.10. 1 hit. |
InterProi | View protein in InterPro IPR001019. Gprotein_alpha_su. IPR011025. GproteinA_insert. IPR027417. P-loop_NTPase. IPR002976. Plant_Gprotein_alpha. |
PANTHERi | PTHR10218. PTHR10218. 1 hit. PTHR10218:SF224. PTHR10218:SF224. 1 hit. |
Pfami | View protein in Pfam PF00503. G-alpha. 1 hit. |
PRINTSi | PR00318. GPROTEINA. PR01242. GPROTEINAPLT. |
SMARTi | View protein in SMART SM00275. G_alpha. 1 hit. |
SUPFAMi | SSF47895. SSF47895. 1 hit. SSF52540. SSF52540. 2 hits. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q0DJ33-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSSCSRSHS LSEAETTKNA KSADIDRRIL QETKAEQHIH KLLLLGAGES
60 70 80 90 100
GKSTIFKQIK LLFQTGFDEA ELRSYTSVIH ANVYQTIKIL YEGAKELSQV
110 120 130 140 150
ESDSSKYVIS PDNQEIGEKL SDIDGRLDYP LLNKELVLDV KRLWQDPAIQ
160 170 180 190 200
ETYLRGSILQ LPDCAQYFME NLDRLAEAGY VPTKEDVLYA RVRTNGVVQI
210 220 230 240 250
QFSPVGENKR GGEVYRLYDV GGQRNERRKW IHLFEGVNAV IFCAAISEYD
260 270 280 290 300
QMLFEDETKN RMMETKELFD WVLKQRCFEK TSFILFLNKF DIFEKKIQKV
310 320 330 340 350
PLSVCEWFKD YQPIAPGKQE VEHAYEFVKK KFEELYFQSS KPDRVDRVFK
360 370 380
IYRTTALDQK LVKKTFKLID ESMRRSREGT
Sequence cautioni
The sequence BAF17140 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D38232 mRNA. Translation: BAA07405.1. AC117264 Genomic DNA. Translation: AAV43839.1. AC144739 Genomic DNA. Translation: AAW57778.2. AP008211 Genomic DNA. Translation: BAF17140.1. Different initiation. AP014961 Genomic DNA. No translation available. |
RefSeqi | XP_015639183.1. XM_015783697.1. |
UniGenei | Os.5302. |
Genome annotation databases
EnsemblPlantsi | Os05t0333200-00; Os05t0333200-00; Os05g0333200. |
GeneIDi | 4338448. |
Gramenei | Os05t0333200-00; Os05t0333200-00; Os05g0333200. |
KEGGi | osa:4338448. |
Similar proteinsi
Entry informationi
Entry namei | GPA1_ORYSJ | |
Accessioni | Q0DJ33Primary (citable) accession number: Q0DJ33 Secondary accession number(s): P49083 Q5W732 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | February 28, 2018 | |
This is version 93 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |