Guanine nucleotide-binding protein alpha-1 subunit - Oryza sativa subsp. japonica (Rice)

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Q0DJ33 (GPA1_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein alpha-1 subunit
Short name=GP-alpha-1

Alternative name(s):
Protein Dwarf1

Gene names

Name:	GPA1
Synonyms:	D1, GA1, RGA1
Ordered Locus Names:	Os05g0333200, LOC_Os05g26890
ORF Names:	OJ1005_D04.15, OSJNBa0049D13.1

Organism

Oryza sativa subsp. japonica (Rice) [Reference proteome]

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza ›

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Subunit structure	G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Domain	The helical domain (69-189) is required for self-activation By similarity.
Sequence similarities	Belongs to the G-alpha family.
Sequence caution	The sequence BAF17140.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Ligand	GTP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Transducer
PTM	Lipoprotein Myristate Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	heterotrimeric G-protein complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	G-protein beta/gamma-subunit complex binding Inferred from Biological aspect of Ancestor. Source: RefGenome G-protein coupled receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from Biological aspect of Ancestor. Source: RefGenome GTPase inhibitor activity Inferred from Biological aspect of Ancestor. Source: RefGenome channel regulator activity Inferred from Biological aspect of Ancestor. Source: RefGenome metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW signal transducer activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LOC_Os03g46650	Q40687	2	EBI-1100098,EBI-1100119

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 380

379

Guanine nucleotide-binding protein alpha-1 subunit

PRO_0000203622

Regions

Nucleotide binding

46 – 53

GTP By similarity

Nucleotide binding

188 – 194

GTP By similarity

Nucleotide binding

219 – 223

GTP By similarity

Nucleotide binding

288 – 291

GTP By similarity

Sites

Metal binding

Magnesium By similarity

Metal binding

194

Magnesium By similarity

Binding site

356

GTP; via amide nitrogen By similarity

Amino acid modifications

Lipidation

N-myristoyl glycine By similarity

Lipidation

S-palmitoyl cysteine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q0DJ33 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: 4EEFAEDAB4463612
Show »

FASTA

380

44,206

        10         20         30         40         50         60 
MGSSCSRSHS LSEAETTKNA KSADIDRRIL QETKAEQHIH KLLLLGAGES GKSTIFKQIK 

        70         80         90        100        110        120 
LLFQTGFDEA ELRSYTSVIH ANVYQTIKIL YEGAKELSQV ESDSSKYVIS PDNQEIGEKL 

       130        140        150        160        170        180 
SDIDGRLDYP LLNKELVLDV KRLWQDPAIQ ETYLRGSILQ LPDCAQYFME NLDRLAEAGY 

       190        200        210        220        230        240 
VPTKEDVLYA RVRTNGVVQI QFSPVGENKR GGEVYRLYDV GGQRNERRKW IHLFEGVNAV 

       250        260        270        280        290        300 
IFCAAISEYD QMLFEDETKN RMMETKELFD WVLKQRCFEK TSFILFLNKF DIFEKKIQKV 

       310        320        330        340        350        360 
PLSVCEWFKD YQPIAPGKQE VEHAYEFVKK KFEELYFQSS KPDRVDRVFK IYRTTALDQK 

       370        380 
LVKKTFKLID ESMRRSREGT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a cDNA for the alpha subunit of a G protein from rice." Ishikawa A., Tsubouchi H., Iwasaki Y., Asahi T. Plant Cell Physiol. 36:353-359(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Nipponbare. Tissue: Leaf.
[2]	"A fine physical map of the rice chromosome 5." Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J., Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F., Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y. Mol. Genet. Genomics 274:337-345(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[4]	"The rice annotation project database (RAP-DB): 2008 update." The rice annotation project (RAP) Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D38232 mRNA. Translation: BAA07405.1. AC117264 Genomic DNA. Translation: AAV43839.1. AC144739 Genomic DNA. Translation: AAW57778.2. AP008211 Genomic DNA. Translation: BAF17140.1. Different initiation.
RefSeq	NP_001055226.1. NM_001061761.1.
UniGene	Os.5302.
3D structure databases
ProteinModelPortal	Q0DJ33.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
IntAct	Q0DJ33. 1 interaction.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4338448.
KEGG	osa:4338448.
Organism-specific databases
Gramene	Q0DJ33.
Phylogenomic databases
eggNOG	NOG322962.
KO	K04640.
ProtClustDB	CLSN2683295.
Gene expression databases
ArrayExpress	Q0DJ33.
Family and domain databases
Gene3D	1.10.400.10. 1 hit.
InterPro	IPR001019. Gprotein_alpha_su. IPR011025. GproteinA_insert. IPR027417. P-loop_NTPase. IPR002976. Plant_Gprotein_alpha. [Graphical view]
PANTHER	PTHR10218. PTHR10218. 1 hit. PTHR10218:SF25. PTHR10218:SF25. 1 hit.
Pfam	PF00503. G-alpha. 1 hit. [Graphical view]
PRINTS	PR00318. GPROTEINA. PR01242. GPROTEINAPLT.
SMART	SM00275. G_alpha. 1 hit. [Graphical view]
SUPFAM	SSF47895. SSF47895. 1 hit. SSF52540. SSF52540. 2 hits.
ProtoNet	Search...

Entry information

Entry name

GPA1_ORYSJ

Accession

Primary (citable) accession number: Q0DJ33
Secondary accession number(s): P49083

Q5W732

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	February 19, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents