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Protein

Laccase-12/13

Gene

LAC12

more
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi85 – 851Copper 1By similarity
Metal bindingi87 – 871Copper 2By similarity
Metal bindingi130 – 1301Copper 2By similarity
Metal bindingi132 – 1321Copper 3By similarity
Metal bindingi475 – 4751Copper 4By similarity
Metal bindingi478 – 4781Copper 1By similarity
Metal bindingi480 – 4801Copper 3By similarity
Metal bindingi537 – 5371Copper 3By similarity
Metal bindingi538 – 5381Copper 4By similarity
Metal bindingi539 – 5391Copper 2By similarity
Metal bindingi543 – 5431Copper 4By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-12/13 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 12/13
Diphenol oxidase 12/13
Urishiol oxidase 12/13
Gene namesi
Name:LAC12
Ordered Locus Names:Os05g0458500, LOC_Os05g38410
ORF Names:OJ1362_D02.9, OsJ_018046
AND
Name:LAC13
Ordered Locus Names:Os05g0458600, LOC_Os05g38420
ORF Names:OJ1362_D02.10
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 5

Organism-specific databases

GrameneiQ0DHL2.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 574547Laccase-12/13PRO_0000291897Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi388 – 3881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi398 – 3981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi447 – 4471N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ0DHL2.

Expressioni

Gene expression databases

ExpressionAtlasiQ0DHL2. baseline.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 151117Plastocyanin-like 1Add
BLAST
Domaini161 – 314154Plastocyanin-like 2Add
BLAST
Domaini424 – 558135Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ0DHL2.
OMAiTHPCAPG.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0DHL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAASSVLRC CLLVAALMTL SAMGAEAITR QYLFDVQTTS VTRLCSTKSI
60 70 80 90 100
VTVNGQYPGP TLFAREGDHV EVTVVNHSPY NMSIHWHGIR QLLSGWADGP
110 120 130 140 150
SYITQCPIQP GGSYVYRFTI TGQRGTLWWH AHISWLRATV HGPMVILPPA
160 170 180 190 200
GVGYPFPAPH EEVPIMFGEW WNNDTEAVIS QALQTGGGPN ISDAYTLNGL
210 220 230 240 250
PGPLYNCSAQ DTFKLKVKPG KTYMLRLINA ALNDELFFSI ANHTLTVVDV
260 270 280 290 300
DALYVKPFTV DTLIIAPGQT SNVLLTAKPT YPGASYYMLA RPYTTTQGTF
310 320 330 340 350
DNTTVAGVLE YDDPCPTTAA GKIVPIFSPT LPQINDTNAV SNFTAKLRSL
360 370 380 390 400
ASAGYPAAVP QQVDHRFFFT VGLGTHPCAV NGTCQGPNGS RFAASINNVS
410 420 430 440 450
FVLPATALLQ SHFAGKSKGV YASNFPYYPL NPFNYTGTPP NNTNVMNGTK
460 470 480 490 500
VLVLPYGANV ELVMQDTSIL GAESHPLHLH GFNFFVVGQG FGNFDPINDP
510 520 530 540 550
AKFNLYDPVE RNTVGVPAGG WVAIRFHADN PGVWFMHCHL EVHMSWGLKM
560 570
AWLVLDGSRP DQKLPPPPLD LPKC
Length:574
Mass (Da):62,348
Last modified:October 17, 2006 - v1
Checksum:i27DD915DD4F41C13
GO

Sequence cautioni

The sequence AAU44018.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAU44019.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AK068047 differs from that shown. Reason: Frameshift at position 77. Curated
The sequence BAF17660.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EAZ34563.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105770 Genomic DNA. Translation: AAU44018.1. Sequence problems.
AC105770 Genomic DNA. Translation: AAU44019.1. Sequence problems.
AP008211 Genomic DNA. Translation: BAF17660.1. Sequence problems.
AP008211 Genomic DNA. Translation: BAF17661.1.
CM000142 Genomic DNA. Translation: EAZ34563.1. Sequence problems.
AK068047 mRNA. No translation available.
RefSeqiNP_001055746.1. NM_001062281.1.
NP_001055747.1. NM_001062282.1.
UniGeneiOs.51049.

Genome annotation databases

EnsemblPlantsiOS05T0458500-00; OS05T0458500-00; OS05G0458500.
OS05T0458600-01; OS05T0458600-01; OS05G0458600.
GeneIDi4339003.
4339004.
KEGGiosa:4339003.
osa:4339004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105770 Genomic DNA. Translation: AAU44018.1. Sequence problems.
AC105770 Genomic DNA. Translation: AAU44019.1. Sequence problems.
AP008211 Genomic DNA. Translation: BAF17660.1. Sequence problems.
AP008211 Genomic DNA. Translation: BAF17661.1.
CM000142 Genomic DNA. Translation: EAZ34563.1. Sequence problems.
AK068047 mRNA. No translation available.
RefSeqiNP_001055746.1. NM_001062281.1.
NP_001055747.1. NM_001062282.1.
UniGeneiOs.51049.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ0DHL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS05T0458500-00; OS05T0458500-00; OS05G0458500.
OS05T0458600-01; OS05T0458600-01; OS05G0458600.
GeneIDi4339003.
4339004.
KEGGiosa:4339003.
osa:4339004.

Organism-specific databases

GrameneiQ0DHL2.

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ0DHL2.
OMAiTHPCAPG.

Gene expression databases

ExpressionAtlasiQ0DHL2. baseline.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (OS05G0458500 AND OS05G0458600).
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (OS05G0458500 AND OS05G0458600).
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (OS05G0458500 AND OS05G0458600).
    Strain: cv. Nipponbare.
  5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (OS05G0458600).
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiLAC12_ORYSJ
AccessioniPrimary (citable) accession number: Q0DHL2
Secondary accession number(s): Q0DHL3, Q65XF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 17, 2006
Last modified: January 7, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.