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Protein

Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

Gene

PP2A1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Manganese 1By similarity1
Metal bindingi56Manganese 1By similarity1
Metal bindingi82Manganese 1By similarity1
Metal bindingi82Manganese 2By similarity1
Metal bindingi114Manganese 2By similarity1
Active sitei115Proton donorBy similarity1
Metal bindingi164Manganese 2By similarity1
Metal bindingi238Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A1
Ordered Locus Names:Os06g0574500, LOC_Os06g37660
ORF Names:OsJ_020918, OSJNBa0006A22.44
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588611 – 306Serine/threonine-protein phosphatase PP2A-1 catalytic subunitAdd BLAST306

Proteomic databases

PaxDbiQ0DBD3
PRIDEiQ0DBD3

Expressioni

Gene expression databases

ExpressionAtlasiQ0DBD3 differential
GenevisibleiQ0DBD3 OS

Interactioni

Protein-protein interaction databases

IntActiQ0DBD3, 1 interactor
STRINGi39947.LOC_Os06g37660.1

Structurei

3D structure databases

ProteinModelPortaliQ0DBD3
SMRiQ0DBD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiKOG0371 Eukaryota
COG0639 LUCA
InParanoidiQ0DBD3
KOiK04382
OMAiNWGHDKN
OrthoDBiEOG09360EXD

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q0DBD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSHADLDRQ ISQLRECKFL GEAEVRALCE QAKAILMEEW NVQPVRCPVT
60 70 80 90 100
VCGDIHGQFY DLIELFRIGG DSPDTNYLFM GDYVDRGYYS VETVTLLVAL
110 120 130 140 150
KVRYRDRITI LRGNHESRQI TQVYGFYDEC LRKYGNANVW KYFTDLFDYL
160 170 180 190 200
PLTALVENQV FCLHGGLSPS LDTLDNIRAL DRIQEVPHEG PMCDLLWSDP
210 220 230 240 250
DDRCGWGISP RGAGYTFGQD IAQQFNHTNG LTLISRAHQL VMEGFNWCQD
260 270 280 290 300
KNVVTVFSAP NYCYRCGNMA AILEIGENMD QNFLQFDPAP RQIEPDTTRK

TPDYFL
Length:306
Mass (Da):35,114
Last modified:October 17, 2006 - v1
Checksum:iF95722F8A638FF31
GO

Sequence cautioni

The sequence AK071838 differs from that shown. Reason: Frameshift at position 236.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004729 Genomic DNA Translation: BAD61854.1
AP008212 Genomic DNA Translation: BAF19840.1
AP014962 Genomic DNA Translation: BAS98342.1
CM000143 Genomic DNA Translation: EAZ37435.1
AK071838 mRNA No translation available.
RefSeqiXP_015643067.1, XM_015787581.1
UniGeneiOs.49858

Genome annotation databases

EnsemblPlantsiOs06t0574500-01; Os06t0574500-01; Os06g0574500
GeneIDi4341364
GrameneiOs06t0574500-01; Os06t0574500-01; Os06g0574500
KEGGiosa:4341364

Similar proteinsi

Entry informationi

Entry nameiPP2A1_ORYSJ
AccessioniPrimary (citable) accession number: Q0DBD3
Secondary accession number(s): A0A0P0WY45
, Q42981, Q5Z7K2, Q9ZSS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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