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Q0D2L3

- SPEB_RAT

UniProt

Q0D2L3 - SPEB_RAT

Protein

Agmatinase, mitochondrial

Gene

Agmat

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Agmatine + H2O = putrescine + urea.

    Cofactori

    Manganese.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi163 – 1631Manganese 1PROSITE-ProRule annotation
    Metal bindingi188 – 1881Manganese 2PROSITE-ProRule annotation
    Metal bindingi279 – 2791Manganese 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. agmatinase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
    2. spermidine biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Putrescine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00534; UER00287.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Agmatinase, mitochondrial (EC:3.5.3.11)
    Alternative name(s):
    Agmatine ureohydrolase
    Short name:
    AUH
    Gene namesi
    Name:Agmat
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi1308424. Agmat.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
    BLAST
    Chaini34 – 353320Agmatinase, mitochondrialPRO_0000320073Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei194 – 1941N6-acetyllysineBy similarity
    Modified residuei218 – 2181N6-acetyllysine; alternateBy similarity
    Modified residuei218 – 2181N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ0D2L3.
    PRIDEiQ0D2L3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ0D2L3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000016646.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0D2L3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the arginase family. Agmatinase subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0010.
    GeneTreeiENSGT00530000063082.
    HOGENOMiHOG000204320.
    HOVERGENiHBG023165.
    InParanoidiQ5BK25.
    KOiK01480.
    OMAiGATFRRC.
    OrthoDBiEOG7M98GH.
    PhylomeDBiQ0D2L3.
    TreeFamiTF328612.

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    InterProiIPR005925. Agmatinase-rel.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    PRINTSiPR00116. ARGINASE.
    TIGRFAMsiTIGR01230. agmatinase. 1 hit.
    PROSITEiPS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0D2L3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQLLKSSWV RSAGSGVVTW RASAGLFCPG TRQASDTSDT LHHPSPSSES    50
    QVQPVRVCSM MHLPLQSSPE GLDAAFVGVP LDTGTSNRPG ARFGPRRIRE 100
    ESLMLGTVNP STGALPFQSL RVADLGNVNV NLYNLQDSCR LIREAYQNIL 150
    ATGCIPLTLG GDHTITYPIL QAVAKEHGPV GLVHVGAHSN TSDKPLEDKV 200
    YHRTPFRRSV DEGLLDSKRV VQIGIRGSSR TLDPYRYSRS QGFRVVLAED 250
    CWMKSLVPLM AEIRQQMGGV PLYISFAIDA LDPAYAPGTG TPEIAGLTPS 300
    QALEIIRGCQ GLNVVGCDLV EVSPPYDLSG NTALLAANLL FEMLCALPKV 350
    TTV 353
    Length:353
    Mass (Da):37,987
    Last modified:October 17, 2006 - v1
    Checksum:iE59BC1FECE84735A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC091231 mRNA. Translation: AAH91231.1.
    BC105628 mRNA. Translation: AAI05629.1.
    RefSeqiNP_001041650.1. NM_001048185.1.
    UniGeneiRn.7880.

    Genome annotation databases

    EnsembliENSRNOT00000016648; ENSRNOP00000016646; ENSRNOG00000012315.
    GeneIDi298607.
    KEGGirno:298607.
    UCSCiRGD:1308424. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC091231 mRNA. Translation: AAH91231.1 .
    BC105628 mRNA. Translation: AAI05629.1 .
    RefSeqi NP_001041650.1. NM_001048185.1.
    UniGenei Rn.7880.

    3D structure databases

    ProteinModelPortali Q0D2L3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000016646.

    Proteomic databases

    PaxDbi Q0D2L3.
    PRIDEi Q0D2L3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000016648 ; ENSRNOP00000016646 ; ENSRNOG00000012315 .
    GeneIDi 298607.
    KEGGi rno:298607.
    UCSCi RGD:1308424. rat.

    Organism-specific databases

    CTDi 79814.
    RGDi 1308424. Agmat.

    Phylogenomic databases

    eggNOGi COG0010.
    GeneTreei ENSGT00530000063082.
    HOGENOMi HOG000204320.
    HOVERGENi HBG023165.
    InParanoidi Q5BK25.
    KOi K01480.
    OMAi GATFRRC.
    OrthoDBi EOG7M98GH.
    PhylomeDBi Q0D2L3.
    TreeFami TF328612.

    Enzyme and pathway databases

    UniPathwayi UPA00534 ; UER00287 .

    Miscellaneous databases

    NextBioi 644061.
    PROi Q0D2L3.

    Gene expression databases

    Genevestigatori Q0D2L3.

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    InterProi IPR005925. Agmatinase-rel.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    PRINTSi PR00116. ARGINASE.
    TIGRFAMsi TIGR01230. agmatinase. 1 hit.
    PROSITEi PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiSPEB_RAT
    AccessioniPrimary (citable) accession number: Q0D2L3
    Secondary accession number(s): Q5BK25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    May have little or no activity due to the lack of several residues essential for manganese binding and catalytic activity.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3