Q0D2L3 (SPEB_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Agmatinase, mitochondrial
EC=3.5.3.11

Alternative name(s):
Agmatine ureohydrolase
Short name=AUH

Gene names

Name:

Agmat

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Agmatine + H2O = putrescine + urea.
Cofactor	Manganese Potential.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the arginase family. Agmatinase subfamily.

Ontologies

Keywords
Biological process	Putrescine biosynthesis Spermidine biosynthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	putrescine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW spermidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	agmatinase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 353		Agmatinase, mitochondrial		PRO_0000320073
Sites
	Metal binding	163	1	Manganese 1 By similarity
	Metal binding	188	1	Manganese 2 By similarity
	Metal binding	279	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0D2L3 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: E59BC1FECE84735A	FASTA	353	37,987
	10 20 30 40 50 60 MLQLLKSSWV RSAGSGVVTW RASAGLFCPG TRQASDTSDT LHHPSPSSES QVQPVRVCSM 70 80 90 100 110 120 MHLPLQSSPE GLDAAFVGVP LDTGTSNRPG ARFGPRRIRE ESLMLGTVNP STGALPFQSL 130 140 150 160 170 180 RVADLGNVNV NLYNLQDSCR LIREAYQNIL ATGCIPLTLG GDHTITYPIL QAVAKEHGPV 190 200 210 220 230 240 GLVHVGAHSN TSDKPLEDKV YHRTPFRRSV DEGLLDSKRV VQIGIRGSSR TLDPYRYSRS 250 260 270 280 290 300 QGFRVVLAED CWMKSLVPLM AEIRQQMGGV PLYISFAIDA LDPAYAPGTG TPEIAGLTPS 310 320 330 340 350 QALEIIRGCQ GLNVVGCDLV EVSPPYDLSG NTALLAANLL FEMLCALPKV TTV

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC091231 mRNA. Translation: AAH91231.1. BC105628 mRNA. Translation: AAI05629.1.
IPI	IPI00365297.
RefSeq	NP_001041650.1. NM_001048185.1.
UniGene	Rn.7880.
3D structure databases
ProteinModelPortal	Q0D2L3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0D2L3.
Proteomic databases
PRIDE	Q0D2L3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000016648; ENSRNOP00000016646; ENSRNOG00000012315.
GeneID	298607.
KEGG	rno:298607.
Organism-specific databases
CTD	79814.
RGD	1308424. Agmat.
Phylogenomic databases
eggNOG	roNOG14712.
GeneTree	ENSGT00530000063082.
HOVERGEN	HBG023165.
InParanoid	Q0D2L3.
OMA	GCVPLTL.
OrthoDB	EOG43R3MX.
PhylomeDB	Q0D2L3.
Gene expression databases
ArrayExpress	Q0D2L3.
Genevestigator	Q0D2L3.
Family and domain databases
InterPro	IPR005925. Agmatinase-rel. IPR006035. Ureohydrolase. IPR023696. Ureohydrolase_domain. [Graphical view]
Gene3D	G3DSA:3.40.800.10. Ureohydrolase. 1 hit.
KO	K01480.
PANTHER	PTHR11358. Ureohydrolase. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
PIRSF	PIRSF036979. Arginase. 1 hit.
PRINTS	PR00116. ARGINASE.
TIGRFAMs	TIGR01230. Agmatinase. 1 hit.
PROSITE	PS01053. ARGINASE_1. False negative. PS51409. ARGINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	644061.

Entry information

Entry name

SPEB_RAT

Accession

Primary (citable) accession number: Q0D2L3
Secondary accession number(s): Q5BK25

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 17, 2006
Last modified:	November 16, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program