Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0D2L3

- SPEB_RAT

UniProt

Q0D2L3 - SPEB_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Agmatinase, mitochondrial

Gene

Agmat

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Agmatine + H2O = putrescine + urea.

Cofactori

Manganese.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi163 – 1631Manganese 1PROSITE-ProRule annotation
Metal bindingi188 – 1881Manganese 2PROSITE-ProRule annotation
Metal bindingi279 – 2791Manganese 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. agmatinase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
  2. spermidine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00534; UER00287.

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase, mitochondrial (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:Agmat
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi1308424. Agmat.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
BLAST
Chaini34 – 353320Agmatinase, mitochondrialPRO_0000320073Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei194 – 1941N6-acetyllysineBy similarity
Modified residuei218 – 2181N6-acetyllysine; alternateBy similarity
Modified residuei218 – 2181N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ0D2L3.
PRIDEiQ0D2L3.

Expressioni

Gene expression databases

GenevestigatoriQ0D2L3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016646.

Structurei

3D structure databases

ProteinModelPortaliQ0D2L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0010.
GeneTreeiENSGT00530000063082.
HOGENOMiHOG000204320.
HOVERGENiHBG023165.
InParanoidiQ0D2L3.
KOiK01480.
OMAiGATFRRC.
OrthoDBiEOG7M98GH.
PhylomeDBiQ0D2L3.
TreeFamiTF328612.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0D2L3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQLLKSSWV RSAGSGVVTW RASAGLFCPG TRQASDTSDT LHHPSPSSES
60 70 80 90 100
QVQPVRVCSM MHLPLQSSPE GLDAAFVGVP LDTGTSNRPG ARFGPRRIRE
110 120 130 140 150
ESLMLGTVNP STGALPFQSL RVADLGNVNV NLYNLQDSCR LIREAYQNIL
160 170 180 190 200
ATGCIPLTLG GDHTITYPIL QAVAKEHGPV GLVHVGAHSN TSDKPLEDKV
210 220 230 240 250
YHRTPFRRSV DEGLLDSKRV VQIGIRGSSR TLDPYRYSRS QGFRVVLAED
260 270 280 290 300
CWMKSLVPLM AEIRQQMGGV PLYISFAIDA LDPAYAPGTG TPEIAGLTPS
310 320 330 340 350
QALEIIRGCQ GLNVVGCDLV EVSPPYDLSG NTALLAANLL FEMLCALPKV

TTV
Length:353
Mass (Da):37,987
Last modified:October 17, 2006 - v1
Checksum:iE59BC1FECE84735A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC091231 mRNA. Translation: AAH91231.1.
BC105628 mRNA. Translation: AAI05629.1.
RefSeqiNP_001041650.1. NM_001048185.1.
UniGeneiRn.7880.

Genome annotation databases

EnsembliENSRNOT00000016648; ENSRNOP00000016646; ENSRNOG00000012315.
GeneIDi298607.
KEGGirno:298607.
UCSCiRGD:1308424. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC091231 mRNA. Translation: AAH91231.1 .
BC105628 mRNA. Translation: AAI05629.1 .
RefSeqi NP_001041650.1. NM_001048185.1.
UniGenei Rn.7880.

3D structure databases

ProteinModelPortali Q0D2L3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016646.

Proteomic databases

PaxDbi Q0D2L3.
PRIDEi Q0D2L3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000016648 ; ENSRNOP00000016646 ; ENSRNOG00000012315 .
GeneIDi 298607.
KEGGi rno:298607.
UCSCi RGD:1308424. rat.

Organism-specific databases

CTDi 79814.
RGDi 1308424. Agmat.

Phylogenomic databases

eggNOGi COG0010.
GeneTreei ENSGT00530000063082.
HOGENOMi HOG000204320.
HOVERGENi HBG023165.
InParanoidi Q0D2L3.
KOi K01480.
OMAi GATFRRC.
OrthoDBi EOG7M98GH.
PhylomeDBi Q0D2L3.
TreeFami TF328612.

Enzyme and pathway databases

UniPathwayi UPA00534 ; UER00287 .

Miscellaneous databases

NextBioi 644061.
PROi Q0D2L3.

Gene expression databases

Genevestigatori Q0D2L3.

Family and domain databases

Gene3Di 3.40.800.10. 1 hit.
InterProi IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
[Graphical view ]
PANTHERi PTHR11358. PTHR11358. 1 hit.
Pfami PF00491. Arginase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036979. Arginase. 1 hit.
PRINTSi PR00116. ARGINASE.
TIGRFAMsi TIGR01230. agmatinase. 1 hit.
PROSITEi PS51409. ARGINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiSPEB_RAT
AccessioniPrimary (citable) accession number: Q0D2L3
Secondary accession number(s): Q5BK25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

May have little or no activity due to the lack of several residues essential for manganese binding and catalytic activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3