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Protein

Kelch-like protein 30

Gene

KLHL30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 30
Gene namesi
Name:KLHL30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24770. KLHL30.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393522.

Polymorphism and mutation databases

BioMutaiKLHL30.
DMDMi327478576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578Kelch-like protein 30PRO_0000274594Add
BLAST

Proteomic databases

PaxDbiQ0D2K2.
PRIDEiQ0D2K2.

PTM databases

iPTMnetiQ0D2K2.

Expressioni

Gene expression databases

BgeeiQ0D2K2.
CleanExiHS_KLHL30.

Organism-specific databases

HPAiHPA045926.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386389.

Structurei

3D structure databases

ProteinModelPortaliQ0D2K2.
SMRiQ0D2K2. Positions 9-248, 269-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 10068BTBPROSITE-ProRule annotationAdd
BLAST
Domaini153 – 255103BACKAdd
BLAST
Repeati270 – 32657Kelch 1Add
BLAST
Repeati327 – 37751Kelch 2Add
BLAST
Repeati378 – 42245Kelch 3Add
BLAST
Repeati424 – 47148Kelch 4Add
BLAST
Repeati473 – 51341Kelch 5Add
BLAST
Repeati514 – 56350Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129689.
HOGENOMiHOG000261671.
HOVERGENiHBG101644.
InParanoidiQ0D2K2.
KOiK10466.
OMAiCAFYNTK.
OrthoDBiEOG7X0VGP.
PhylomeDBiQ0D2K2.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030582. KLHL30.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF9. PTHR24412:SF9. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0D2K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRNVDDLDF HLPSHAQDML DGLQRLRSQP KLADVTLLVG GRELPCHRGL
60 70 80 90 100
LALSSPYFHA MFAGDFAESF SARVELRDVE PAVVGQLVDF VYTGRLTITQ
110 120 130 140 150
GNVEALTRTA ARLHFPSVQK VCGRYLQQQL DAANCLGICE FGEQQGLLGV
160 170 180 190 200
AAKAWAFLRE NFEAVAREDE FLQLPRERLV TCLAGDLLQV QPEQSRLEAL
210 220 230 240 250
MRWVRHDPQA RAAHLPELLS LVHLDAVPRP CVQQLLASEP LIQESEACRA
260 270 280 290 300
ALSQGHDGAP LALQQKLEEV LVVVGGQALE EEEAGEEPTP GLGNFAFYNS
310 320 330 340 350
KAKRWMALPD FPDYHKWGFS LAALNNNIYV TGGSRGTKTD TWSTTQAWCF
360 370 380 390 400
PLKEASWKPV APMLKPRTNH ASAALNGEIY VIGGTTLDVV EVESYDPYTD
410 420 430 440 450
SWTPVSPALK YVSNFSAAGC RGRLYLVGSS ACKYNALALQ CYNPVTDAWS
460 470 480 490 500
VIASPFLPKY LSSPRCAALH GELYLIGDNT KKVYVYDPGA NLWQKVQSQH
510 520 530 540 550
SLHENGALVP LGDALYVTGG RWQGMEGDYH VEMEAYDTVR DTWTRHGALP
560 570
RLWLYHGAST VFLDVSKWTQ PSGPTQEH
Length:578
Mass (Da):63,976
Last modified:April 5, 2011 - v3
Checksum:iE6C55A0D9DC2E07A
GO

Sequence cautioni

The sequence BAC86148.1 differs from that shown. Reason: Erroneous termination at position 317. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491G → S in AAI05697 (PubMed:15489334).Curated
Sequence conflicti178 – 1781R → Q in AAI05697 (PubMed:15489334).Curated
Sequence conflicti195 – 1951S → G in BAC86148 (PubMed:14702039).Curated
Sequence conflicti213 – 2131A → V in BAC86148 (PubMed:14702039).Curated
Sequence conflicti213 – 2131A → V in AAI05697 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016757 Genomic DNA. No translation available.
BX280405 mRNA. No translation available.
AK125364 mRNA. Translation: BAC86148.1. Sequence problems.
BC105696 mRNA. Translation: AAI05697.1.
CCDSiCCDS46555.2.
RefSeqiNP_940984.3. NM_198582.3.
UniGeneiHs.591595.

Genome annotation databases

EnsembliENST00000409223; ENSP00000386389; ENSG00000168427.
GeneIDi377007.
KEGGihsa:377007.
UCSCiuc002vxr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016757 Genomic DNA. No translation available.
BX280405 mRNA. No translation available.
AK125364 mRNA. Translation: BAC86148.1. Sequence problems.
BC105696 mRNA. Translation: AAI05697.1.
CCDSiCCDS46555.2.
RefSeqiNP_940984.3. NM_198582.3.
UniGeneiHs.591595.

3D structure databases

ProteinModelPortaliQ0D2K2.
SMRiQ0D2K2. Positions 9-248, 269-544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386389.

PTM databases

iPTMnetiQ0D2K2.

Polymorphism and mutation databases

BioMutaiKLHL30.
DMDMi327478576.

Proteomic databases

PaxDbiQ0D2K2.
PRIDEiQ0D2K2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409223; ENSP00000386389; ENSG00000168427.
GeneIDi377007.
KEGGihsa:377007.
UCSCiuc002vxr.3. human.

Organism-specific databases

CTDi377007.
GeneCardsiKLHL30.
HGNCiHGNC:24770. KLHL30.
HPAiHPA045926.
neXtProtiNX_Q0D2K2.
PharmGKBiPA162393522.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129689.
HOGENOMiHOG000261671.
HOVERGENiHBG101644.
InParanoidiQ0D2K2.
KOiK10466.
OMAiCAFYNTK.
OrthoDBiEOG7X0VGP.
PhylomeDBiQ0D2K2.
TreeFamiTF329218.

Miscellaneous databases

GenomeRNAii377007.
PROiQ0D2K2.

Gene expression databases

BgeeiQ0D2K2.
CleanExiHS_KLHL30.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR030582. KLHL30.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF9. PTHR24412:SF9. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ebert L., Heil O., Hennig S., Neubert P., Partsch E., Peters M., Radelof U., Schneider D., Korn B.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-121.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-578.
    Tissue: Tongue.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-394.

Entry informationi

Entry nameiKLH30_HUMAN
AccessioniPrimary (citable) accession number: Q0D2K2
Secondary accession number(s): Q6ZUS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: April 5, 2011
Last modified: July 6, 2016
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.