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Protein

Zinc finger protein 763

Gene

ZNF763

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 166C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 763
Gene namesi
Name:ZNF763
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197054.11
HGNCiHGNC:27614 ZNF763
neXtProtiNX_Q0D2J5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi284390
OpenTargetsiENSG00000197054
PharmGKBiPA162410298

Polymorphism and mutation databases

BioMutaiZNF763
DMDMi187671927

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003302941 – 394Zinc finger protein 763Add BLAST394

Proteomic databases

PaxDbiQ0D2J5
PeptideAtlasiQ0D2J5
PRIDEiQ0D2J5

PTM databases

iPTMnetiQ0D2J5
PhosphoSitePlusiQ0D2J5

Expressioni

Gene expression databases

BgeeiENSG00000197054
CleanExiHS_ZNF763
ExpressionAtlasiQ0D2J5 baseline and differential
GenevisibleiQ0D2J5 HS

Organism-specific databases

HPAiHPA047845

Interactioni

Protein-protein interaction databases

BioGridi129857, 2 interactors
IntActiQ0D2J5, 1 interactor
STRINGi9606.ENSP00000467286

Structurei

3D structure databases

ProteinModelPortaliQ0D2J5
SMRiQ0D2J5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 86KRABPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 166C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ0D2J5
KOiK09228
OrthoDBiEOG091G02KC
PhylomeDBiQ0D2J5
TreeFamiTF338854

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0D2J5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPVACEDVA VNFTQEEWAL LDISQRKLYR EVMLETFRNL TSIGKKWKDQ
60 70 80 90 100
NIEYEYQNPR RNFRSLIEGN VNEIKEDSHC GETFTQVPDD RLNFQEKKAS
110 120 130 140 150
PEAKSCDNFV CGEVGIGNSS FNMNIRGDIG HKAYEYQDYA PKPYKCQQPK
160 170 180 190 200
KAFRYHPSFR TQERNHTGEK PYACKECGKT FISHSGIRRR MVMHSGDGPY
210 220 230 240 250
KCKFCGKAVH CLRLYLIHER THTGEKPYEC KQCVKSFSYS ATHRIHERTH
260 270 280 290 300
TGEKPYECQQ CGKAFHSSSS FQAHKRTHTG GKPYECKQCG KSFSWCHSFQ
310 320 330 340 350
IHERTHTGEK PCECSKCNKA FRSYRSYLRH KRSHTGEKPY QCKECRKAFT
360 370 380 390
YPSSLRRHER THSAKKPYEC KQCGKALSYK FSNTPKNALW RKTL
Length:394
Mass (Da):46,099
Last modified:April 17, 2007 - v2
Checksum:iC9DA5FBF2D5BB65D
GO
Isoform 2 (identifier: Q0D2J5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMFQ

Note: No experimental confirmation available.
Show »
Length:397
Mass (Da):46,506
Checksum:iD8D1873878D4D26C
GO
Isoform 3 (identifier: Q0D2J5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):31,971
Checksum:iB93EEBA226C7F976
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057450324Y → H. Corresponds to variant dbSNP:rs7254529Ensembl.1
Natural variantiVAR_042692327Y → H. Corresponds to variant dbSNP:rs7254529Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559701 – 122Missing in isoform 3. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_0391731M → MMFQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092240 mRNA Translation: BAG52505.1
AK299224 mRNA Translation: BAG61259.1
AC008770 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84252.1
BC105711 mRNA Translation: AAI05712.2
BC105712 mRNA Translation: AAI05713.2
BC105713 mRNA Translation: AAI05714.2
CCDSiCCDS45982.1 [Q0D2J5-2]
RefSeqiNP_001012771.1, NM_001012753.1 [Q0D2J5-2]
UniGeneiHs.646386

Genome annotation databases

EnsembliENST00000343949; ENSP00000369774; ENSG00000197054 [Q0D2J5-2]
ENST00000358987; ENSP00000402017; ENSG00000197054 [Q0D2J5-1]
GeneIDi284390
KEGGihsa:284390
UCSCiuc002msv.4 human [Q0D2J5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN763_HUMAN
AccessioniPrimary (citable) accession number: Q0D2J5
Secondary accession number(s): B3KRU3, B4DRE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health