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Protein

Zinc finger protein 763

Gene

ZNF763

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri144 – 16623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri172 – 19423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. transcription cofactor activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 763
Gene namesi
Name:ZNF763
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:27614. ZNF763.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Zinc finger protein 763PRO_0000330294Add
BLAST

Proteomic databases

PaxDbiQ0D2J5.
PRIDEiQ0D2J5.

PTM databases

PhosphoSiteiQ0D2J5.

Expressioni

Gene expression databases

BgeeiQ0D2J5.
CleanExiHS_ZNF763.
ExpressionAtlasiQ0D2J5. baseline and differential.
GenevestigatoriQ0D2J5.

Organism-specific databases

HPAiHPA047845.

Interactioni

Protein-protein interaction databases

BioGridi129857. 2 interactions.
STRINGi9606.ENSP00000369774.

Structurei

3D structure databases

ProteinModelPortaliQ0D2J5.
SMRiQ0D2J5. Positions 4-53, 142-378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8683KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri144 – 16623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri172 – 19423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG329465.
GeneTreeiENSGT00760000119089.
HOVERGENiHBG018163.
InParanoidiQ0D2J5.
KOiK09228.
PhylomeDBiQ0D2J5.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0D2J5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPVACEDVA VNFTQEEWAL LDISQRKLYR EVMLETFRNL TSIGKKWKDQ
60 70 80 90 100
NIEYEYQNPR RNFRSLIEGN VNEIKEDSHC GETFTQVPDD RLNFQEKKAS
110 120 130 140 150
PEAKSCDNFV CGEVGIGNSS FNMNIRGDIG HKAYEYQDYA PKPYKCQQPK
160 170 180 190 200
KAFRYHPSFR TQERNHTGEK PYACKECGKT FISHSGIRRR MVMHSGDGPY
210 220 230 240 250
KCKFCGKAVH CLRLYLIHER THTGEKPYEC KQCVKSFSYS ATHRIHERTH
260 270 280 290 300
TGEKPYECQQ CGKAFHSSSS FQAHKRTHTG GKPYECKQCG KSFSWCHSFQ
310 320 330 340 350
IHERTHTGEK PCECSKCNKA FRSYRSYLRH KRSHTGEKPY QCKECRKAFT
360 370 380 390
YPSSLRRHER THSAKKPYEC KQCGKALSYK FSNTPKNALW RKTL
Length:394
Mass (Da):46,099
Last modified:April 17, 2007 - v2
Checksum:iC9DA5FBF2D5BB65D
GO
Isoform 2 (identifier: Q0D2J5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMFQ

Note: No experimental confirmation available.

Show »
Length:397
Mass (Da):46,506
Checksum:iD8D1873878D4D26C
GO
Isoform 3 (identifier: Q0D2J5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Note: No experimental confirmation available.

Show »
Length:272
Mass (Da):31,971
Checksum:iB93EEBA226C7F976
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti324 – 3241Y → H.
Corresponds to variant rs7254529 [ dbSNP | Ensembl ].
VAR_057450
Natural varianti327 – 3271Y → H.
Corresponds to variant rs7254529 [ dbSNP | Ensembl ].
VAR_042692

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 122122Missing in isoform 3. 1 PublicationVSP_055970Add
BLAST
Alternative sequencei1 – 11M → MMFQ in isoform 2. 1 PublicationVSP_039173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092240 mRNA. Translation: BAG52505.1.
AK299224 mRNA. Translation: BAG61259.1.
AC008770 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84252.1.
BC105711 mRNA. Translation: AAI05712.2.
BC105712 mRNA. Translation: AAI05713.2.
BC105713 mRNA. Translation: AAI05714.2.
CCDSiCCDS45982.1. [Q0D2J5-2]
RefSeqiNP_001012771.1. NM_001012753.1. [Q0D2J5-2]
UniGeneiHs.646386.

Genome annotation databases

EnsembliENST00000343949; ENSP00000369774; ENSG00000197054. [Q0D2J5-2]
ENST00000358987; ENSP00000402017; ENSG00000197054. [Q0D2J5-1]
GeneIDi284390.
KEGGihsa:284390.
UCSCiuc002msv.3. human. [Q0D2J5-2]
uc002msw.3. human. [Q0D2J5-1]

Polymorphism databases

DMDMi187671927.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092240 mRNA. Translation: BAG52505.1.
AK299224 mRNA. Translation: BAG61259.1.
AC008770 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84252.1.
BC105711 mRNA. Translation: AAI05712.2.
BC105712 mRNA. Translation: AAI05713.2.
BC105713 mRNA. Translation: AAI05714.2.
CCDSiCCDS45982.1. [Q0D2J5-2]
RefSeqiNP_001012771.1. NM_001012753.1. [Q0D2J5-2]
UniGeneiHs.646386.

3D structure databases

ProteinModelPortaliQ0D2J5.
SMRiQ0D2J5. Positions 4-53, 142-378.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129857. 2 interactions.
STRINGi9606.ENSP00000369774.

PTM databases

PhosphoSiteiQ0D2J5.

Polymorphism databases

DMDMi187671927.

Proteomic databases

PaxDbiQ0D2J5.
PRIDEiQ0D2J5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343949; ENSP00000369774; ENSG00000197054. [Q0D2J5-2]
ENST00000358987; ENSP00000402017; ENSG00000197054. [Q0D2J5-1]
GeneIDi284390.
KEGGihsa:284390.
UCSCiuc002msv.3. human. [Q0D2J5-2]
uc002msw.3. human. [Q0D2J5-1]

Organism-specific databases

CTDi284390.
GeneCardsiGC19P012050.
HGNCiHGNC:27614. ZNF763.
HPAiHPA047845.
neXtProtiNX_Q0D2J5.
PharmGKBiPA162410298.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG329465.
GeneTreeiENSGT00760000119089.
HOVERGENiHBG018163.
InParanoidiQ0D2J5.
KOiK09228.
PhylomeDBiQ0D2J5.
TreeFamiTF338854.

Miscellaneous databases

GenomeRNAii284390.
NextBioi35474368.
PROiQ0D2J5.

Gene expression databases

BgeeiQ0D2J5.
CleanExiHS_ZNF763.
ExpressionAtlasiQ0D2J5. baseline and differential.
GenevestigatoriQ0D2J5.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiZN763_HUMAN
AccessioniPrimary (citable) accession number: Q0D2J5
Secondary accession number(s): B3KRU3, B4DRE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 17, 2007
Last modified: March 4, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.