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Q0D2J5

- ZN763_HUMAN

UniProt

Q0D2J5 - ZN763_HUMAN

Protein

Zinc finger protein 763

Gene

ZNF763

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri144 – 16623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri172 – 19423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 33423C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 763
    Gene namesi
    Name:ZNF763
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:27614. ZNF763.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410298.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Zinc finger protein 763PRO_0000330294Add
    BLAST

    Proteomic databases

    PaxDbiQ0D2J5.
    PRIDEiQ0D2J5.

    PTM databases

    PhosphoSiteiQ0D2J5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ0D2J5.
    BgeeiQ0D2J5.
    CleanExiHS_ZNF763.
    GenevestigatoriQ0D2J5.

    Organism-specific databases

    HPAiHPA047845.

    Interactioni

    Protein-protein interaction databases

    BioGridi129857. 1 interaction.
    STRINGi9606.ENSP00000369774.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0D2J5.
    SMRiQ0D2J5. Positions 4-53, 105-392.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 8683KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri144 – 16623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri172 – 19423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 33423C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG329465.
    HOVERGENiHBG018163.
    InParanoidiQ0D2J5.
    KOiK09228.
    PhylomeDBiQ0D2J5.
    TreeFamiTF338854.

    Family and domain databases

    Gene3Di3.30.160.60. 9 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 7 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q0D2J5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPVACEDVA VNFTQEEWAL LDISQRKLYR EVMLETFRNL TSIGKKWKDQ    50
    NIEYEYQNPR RNFRSLIEGN VNEIKEDSHC GETFTQVPDD RLNFQEKKAS 100
    PEAKSCDNFV CGEVGIGNSS FNMNIRGDIG HKAYEYQDYA PKPYKCQQPK 150
    KAFRYHPSFR TQERNHTGEK PYACKECGKT FISHSGIRRR MVMHSGDGPY 200
    KCKFCGKAVH CLRLYLIHER THTGEKPYEC KQCVKSFSYS ATHRIHERTH 250
    TGEKPYECQQ CGKAFHSSSS FQAHKRTHTG GKPYECKQCG KSFSWCHSFQ 300
    IHERTHTGEK PCECSKCNKA FRSYRSYLRH KRSHTGEKPY QCKECRKAFT 350
    YPSSLRRHER THSAKKPYEC KQCGKALSYK FSNTPKNALW RKTL 394
    Length:394
    Mass (Da):46,099
    Last modified:April 17, 2007 - v2
    Checksum:iC9DA5FBF2D5BB65D
    GO
    Isoform 2 (identifier: Q0D2J5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MMFQ

    Note: No experimental confirmation available.

    Show »
    Length:397
    Mass (Da):46,506
    Checksum:iD8D1873878D4D26C
    GO
    Isoform 3 (identifier: Q0D2J5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-122: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:272
    Mass (Da):31,971
    Checksum:iB93EEBA226C7F976
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti324 – 3241Y → H.
    Corresponds to variant rs7254529 [ dbSNP | Ensembl ].
    VAR_057450
    Natural varianti327 – 3271Y → H.
    Corresponds to variant rs7254529 [ dbSNP | Ensembl ].
    VAR_042692

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 122122Missing in isoform 3. 1 PublicationVSP_055970Add
    BLAST
    Alternative sequencei1 – 11M → MMFQ in isoform 2. 1 PublicationVSP_039173

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK092240 mRNA. Translation: BAG52505.1.
    AK299224 mRNA. Translation: BAG61259.1.
    AC008770 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84252.1.
    BC105711 mRNA. Translation: AAI05712.2.
    BC105712 mRNA. Translation: AAI05713.2.
    BC105713 mRNA. Translation: AAI05714.2.
    CCDSiCCDS45982.1. [Q0D2J5-2]
    RefSeqiNP_001012771.1. NM_001012753.1. [Q0D2J5-2]
    UniGeneiHs.646386.

    Genome annotation databases

    EnsembliENST00000343949; ENSP00000369774; ENSG00000197054. [Q0D2J5-2]
    ENST00000358987; ENSP00000402017; ENSG00000197054. [Q0D2J5-1]
    ENST00000545530; ENSP00000446166; ENSG00000197054.
    GeneIDi284390.
    KEGGihsa:284390.
    UCSCiuc002msv.3. human. [Q0D2J5-2]
    uc002msw.3. human. [Q0D2J5-1]

    Polymorphism databases

    DMDMi187671927.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK092240 mRNA. Translation: BAG52505.1 .
    AK299224 mRNA. Translation: BAG61259.1 .
    AC008770 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84252.1 .
    BC105711 mRNA. Translation: AAI05712.2 .
    BC105712 mRNA. Translation: AAI05713.2 .
    BC105713 mRNA. Translation: AAI05714.2 .
    CCDSi CCDS45982.1. [Q0D2J5-2 ]
    RefSeqi NP_001012771.1. NM_001012753.1. [Q0D2J5-2 ]
    UniGenei Hs.646386.

    3D structure databases

    ProteinModelPortali Q0D2J5.
    SMRi Q0D2J5. Positions 4-53, 105-392.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129857. 1 interaction.
    STRINGi 9606.ENSP00000369774.

    PTM databases

    PhosphoSitei Q0D2J5.

    Polymorphism databases

    DMDMi 187671927.

    Proteomic databases

    PaxDbi Q0D2J5.
    PRIDEi Q0D2J5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343949 ; ENSP00000369774 ; ENSG00000197054 . [Q0D2J5-2 ]
    ENST00000358987 ; ENSP00000402017 ; ENSG00000197054 . [Q0D2J5-1 ]
    ENST00000545530 ; ENSP00000446166 ; ENSG00000197054 .
    GeneIDi 284390.
    KEGGi hsa:284390.
    UCSCi uc002msv.3. human. [Q0D2J5-2 ]
    uc002msw.3. human. [Q0D2J5-1 ]

    Organism-specific databases

    CTDi 284390.
    GeneCardsi GC19P012050.
    HGNCi HGNC:27614. ZNF763.
    HPAi HPA047845.
    neXtProti NX_Q0D2J5.
    PharmGKBi PA162410298.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG329465.
    HOVERGENi HBG018163.
    InParanoidi Q0D2J5.
    KOi K09228.
    PhylomeDBi Q0D2J5.
    TreeFami TF338854.

    Miscellaneous databases

    GenomeRNAii 284390.
    NextBioi 94818.
    PROi Q0D2J5.

    Gene expression databases

    ArrayExpressi Q0D2J5.
    Bgeei Q0D2J5.
    CleanExi HS_ZNF763.
    Genevestigatori Q0D2J5.

    Family and domain databases

    Gene3Di 3.30.160.60. 9 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 7 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

    Entry informationi

    Entry nameiZN763_HUMAN
    AccessioniPrimary (citable) accession number: Q0D2J5
    Secondary accession number(s): B3KRU3, B4DRE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3