Q0D2I5 (IFFO1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Intermediate filament family orphan 1

Alternative name(s):
Tumor antigen HOM-TES-103

Gene names

Name:	IFFO1
Synonyms:	IFFO

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Ubiquitously expressed. Ref.3
Sequence similarities	Belongs to the intermediate filament family.
Sequence caution	The sequence AF124432 differs from that shown. Reason: Frameshift at positions 119, 226 and 384. The sequence AF124432 differs from that shown. Reason: Frameshift at positions 121, 227 and 385.

Ontologies

Keywords
Cellular component	Intermediate filament
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q0D2I5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q0D2I5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-360: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q0D2I5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     259-264: WEEEYT → CFYRVK
     265-559: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 4 (identifier: Q0D2I5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     357-357: Q → QKKL

Note: No experimental confirmation available.

Isoform 5 (identifier: Q0D2I5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     357-357: Q → QKKL
     451-451: Q → QQ

Isoform 6 (identifier: Q0D2I5-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-360: Missing.
     451-451: Q → QQ

Isoform 7 (identifier: Q0D2I5-7)

The sequence of this isoform differs from the canonical sequence as follows:
     357-357: Q → QKL
     451-451: Q → QQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 559	559	Intermediate filament family orphan 1		PRO_0000316794
Regions
	Coiled coil	85 – 117	33	Potential
	Coiled coil	237 – 301	65	Potential
	Coiled coil	455 – 501	47	Potential
	Compositional bias	173 – 182	10	Poly-Ser
	Compositional bias	538 – 542	5	Poly-Pro
Natural variations
	Alternative sequence	1 – 360	360	Missing in isoform 2 and isoform 6.		VSP_030781
	Alternative sequence	259 – 264	6	WEEEYT → CFYRVK in isoform 3.		VSP_030782
	Alternative sequence	265 – 559	295	Missing in isoform 3.		VSP_030783
	Alternative sequence	357	1	Q → QKKL in isoform 4 and isoform 5.		VSP_030784
	Alternative sequence	357	1	Q → QKL in isoform 7.		VSP_039709
	Alternative sequence	451	1	Q → QQ in isoform 5, isoform 6 and isoform 7.		VSP_038240
Experimental info
	Sequence conflict	152 – 153	2	SA → LE in AF124432. Ref.3
	Sequence conflict	285	1	A → V in AF124432. Ref.3
	Sequence conflict	358	1	V → F in AAI10388. Ref.2
	Sequence conflict	387	1	P → A in AF124432. Ref.3
	Sequence conflict	471	1	K → M in AF124432. Ref.3
	Sequence conflict	474	1	Q → H in AF124432. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 22, 2009. Version 2. Checksum: 050FCFFB4953CBD8	FASTA	559	61,979
	10 20 30 40 50 60 MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA YSPPGPGPAP 70 80 90 100 110 120 PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL LEKQLQQALE EGKQGRRGLG 130 140 150 160 170 180 RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS PSARVLGSPA RSPAGPLAPS AASLSSSSTS 190 200 210 220 230 240 TSTTYSSSAR FMPGTIWSFS HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA 250 260 270 280 290 300 LYNVLAKVKR ERDEYKRRWE EEYTVRIQLQ DRVNELQEEA QEADACQEEL ALKVEQLKAE 310 320 330 340 350 360 LVVFKGLMSN NLSELDTKIQ EKAMKVDMDI CRRIDITAKL CDVAQQRNCE DMIQMFQVPS 370 380 390 400 410 420 MGGRKRERKA AVEEDTSLSE SEGPRQPDGD EEESTALSIN EEMQRMLNQL REYDFEDDCD 430 440 450 460 470 480 SLTWEETEET LLLWEDFSGY AMAAAEAQGE QEDSLEKVIK DTESLFKTRE KEYQETIDQI 490 500 510 520 530 540 ELELATAKND MNRHLHEYME MCSMKRGLDV QMETCRRLIT QSGDRKSPAF TAVPLSDPPP 550 PPSEAEDSDR DVSSDSSMR
	Isoform 2 [UniParc]. Checksum: 85B455C4F759C047	FASTA	199	22,790
	10 20 30 40 50 60 MGGRKRERKA AVEEDTSLSE SEGPRQPDGD EEESTALSIN EEMQRMLNQL REYDFEDDCD 70 80 90 100 110 120 SLTWEETEET LLLWEDFSGY AMAAAEAQGE QEDSLEKVIK DTESLFKTRE KEYQETIDQI 130 140 150 160 170 180 ELELATAKND MNRHLHEYME MCSMKRGLDV QMETCRRLIT QSGDRKSPAF TAVPLSDPPP 190 PPSEAEDSDR DVSSDSSMR
	Isoform 3 [UniParc]. Checksum: 5FC1FFA8036C1478	FASTA	264	28,128
	10 20 30 40 50 60 MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA YSPPGPGPAP 70 80 90 100 110 120 PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL LEKQLQQALE EGKQGRRGLG 130 140 150 160 170 180 RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS PSARVLGSPA RSPAGPLAPS AASLSSSSTS 190 200 210 220 230 240 TSTTYSSSAR FMPGTIWSFS HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA 250 260 LYNVLAKVKR ERDEYKRRCF YRVK
	Isoform 4 [UniParc]. Checksum: A23759D144A4F602	FASTA	562	62,348
	10 20 30 40 50 60 MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA YSPPGPGPAP 70 80 90 100 110 120 PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL LEKQLQQALE EGKQGRRGLG 130 140 150 160 170 180 RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS PSARVLGSPA RSPAGPLAPS AASLSSSSTS 190 200 210 220 230 240 TSTTYSSSAR FMPGTIWSFS HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA 250 260 270 280 290 300 LYNVLAKVKR ERDEYKRRWE EEYTVRIQLQ DRVNELQEEA QEADACQEEL ALKVEQLKAE 310 320 330 340 350 360 LVVFKGLMSN NLSELDTKIQ EKAMKVDMDI CRRIDITAKL CDVAQQRNCE DMIQMFQKKL 370 380 390 400 410 420 VPSMGGRKRE RKAAVEEDTS LSESEGPRQP DGDEEESTAL SINEEMQRML NQLREYDFED 430 440 450 460 470 480 DCDSLTWEET EETLLLWEDF SGYAMAAAEA QGEQEDSLEK VIKDTESLFK TREKEYQETI 490 500 510 520 530 540 DQIELELATA KNDMNRHLHE YMEMCSMKRG LDVQMETCRR LITQSGDRKS PAFTAVPLSD 550 560 PPPPPSEAED SDRDVSSDSS MR
	Isoform 5 [UniParc]. Checksum: FD057A78376C2486	FASTA	563	62,476
	10 20 30 40 50 60 MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA YSPPGPGPAP 70 80 90 100 110 120 PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL LEKQLQQALE EGKQGRRGLG 130 140 150 160 170 180 RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS PSARVLGSPA RSPAGPLAPS AASLSSSSTS 190 200 210 220 230 240 TSTTYSSSAR FMPGTIWSFS HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA 250 260 270 280 290 300 LYNVLAKVKR ERDEYKRRWE EEYTVRIQLQ DRVNELQEEA QEADACQEEL ALKVEQLKAE 310 320 330 340 350 360 LVVFKGLMSN NLSELDTKIQ EKAMKVDMDI CRRIDITAKL CDVAQQRNCE DMIQMFQKKL 370 380 390 400 410 420 VPSMGGRKRE RKAAVEEDTS LSESEGPRQP DGDEEESTAL SINEEMQRML NQLREYDFED 430 440 450 460 470 480 DCDSLTWEET EETLLLWEDF SGYAMAAAEA QGEQQEDSLE KVIKDTESLF KTREKEYQET 490 500 510 520 530 540 IDQIELELAT AKNDMNRHLH EYMEMCSMKR GLDVQMETCR RLITQSGDRK SPAFTAVPLS 550 560 DPPPPPSEAE DSDRDVSSDS SMR
	Isoform 6 [UniParc]. Checksum: 9652F97422DFD9B0	FASTA	200	22,918
	10 20 30 40 50 60 MGGRKRERKA AVEEDTSLSE SEGPRQPDGD EEESTALSIN EEMQRMLNQL REYDFEDDCD 70 80 90 100 110 120 SLTWEETEET LLLWEDFSGY AMAAAEAQGE QQEDSLEKVI KDTESLFKTR EKEYQETIDQ 130 140 150 160 170 180 IELELATAKN DMNRHLHEYM EMCSMKRGLD VQMETCRRLI TQSGDRKSPA FTAVPLSDPP 190 200 PPPSEAEDSD RDVSSDSSMR
	Isoform 7 [UniParc]. Checksum: 540FFA923014FCA3	FASTA	562	62,348
	10 20 30 40 50 60 MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA YSPPGPGPAP 70 80 90 100 110 120 PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL LEKQLQQALE EGKQGRRGLG 130 140 150 160 170 180 RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS PSARVLGSPA RSPAGPLAPS AASLSSSSTS 190 200 210 220 230 240 TSTTYSSSAR FMPGTIWSFS HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA 250 260 270 280 290 300 LYNVLAKVKR ERDEYKRRWE EEYTVRIQLQ DRVNELQEEA QEADACQEEL ALKVEQLKAE 310 320 330 340 350 360 LVVFKGLMSN NLSELDTKIQ EKAMKVDMDI CRRIDITAKL CDVAQQRNCE DMIQMFQKLV 370 380 390 400 410 420 PSMGGRKRER KAAVEEDTSL SESEGPRQPD GDEEESTALS INEEMQRMLN QLREYDFEDD 430 440 450 460 470 480 CDSLTWEETE ETLLLWEDFS GYAMAAAEAQ GEQQEDSLEK VIKDTESLFK TREKEYQETI 490 500 510 520 530 540 DQIELELATA KNDMNRHLHE YMEMCSMKRG LDVQMETCRR LITQSGDRKS PAFTAVPLSD 550 560 PPPPPSEAED SDRDVSSDSS MR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 5; 6 AND 7). Tissue: Brain, Placenta and Skin.
[3]	"A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing." Tuereci O., Sahin U., Koslowski M., Buss B., Bell C., Ballweber P., Zwick C., Eberle T., Zuber M., Villena-Heinsen C., Seitz G., Pfreundschuh M. Oncogene 21:3879-3888(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 102-559 (ISOFORM 4), TISSUE SPECIFICITY. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH471116 Genomic DNA. Translation: EAW88781.1. CH471116 Genomic DNA. Translation: EAW88783.1. BC002857 mRNA. Translation: AAH02857.2. BC004384 mRNA. Translation: AAH04384.2. BC010431 mRNA. No translation available. BC071170 mRNA. Translation: AAH71170.1. BC103817 mRNA. Translation: AAI03818.1. BC103818 mRNA. Translation: AAI03819.1. BC110387 mRNA. Translation: AAI10388.1. BC113848 mRNA. Translation: AAI13849.1. BC114454 mRNA. Translation: AAI14455.1. AF124432 mRNA. No translation available.
IPI	IPI00022868. IPI00449478. IPI00787448. IPI00884887. IPI00944478. IPI00944656. IPI00977955.
RefSeq	NP_001034759.1. NM_001039670.2. NP_542768.2. NM_080730.4.
UniGene	Hs.15243.
3D structure databases
ProteinModelPortal	Q0D2I5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q0D2I5. 3 interactions.
STRING	9606.ENSP00000349364.
PTM databases
PhosphoSite	Q0D2I5.
Polymorphism databases
DMDM	259016254.
Proteomic databases
PaxDb	Q0D2I5.
PRIDE	Q0D2I5.
Protocols and materials databases
DNASU	25900.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000336604; ENSP00000337593; ENSG00000010295. ENST00000356896; ENSP00000349364; ENSG00000010295. ENST00000396840; ENSP00000380052; ENSG00000010295. ENST00000487279; ENSP00000432493; ENSG00000010295.
GeneID	25900.
KEGG	hsa:25900.
UCSC	uc001qoz.2. human. uc001qpa.2. human. uc001qpc.2. human. uc001qpf.2. human.
Organism-specific databases
CTD	25900.
GeneCards	GC12M006648.
HGNC	HGNC:24970. IFFO1.
MIM	610495. gene.
neXtProt	NX_Q0D2I5.
PharmGKB	PA164720809.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45260.
HOGENOM	HOG000049269.
HOVERGEN	HBG100545.
InParanoid	Q0D2I5.
OMA	LAPSAAC.
PhylomeDB	Q0D2I5.
Gene expression databases
ArrayExpress	Q0D2I5.
Bgee	Q0D2I5.
CleanEx	HS_IFFO1.
Genevestigator	Q0D2I5.
Family and domain databases
InterPro	IPR026665. Iffo1/2. [Graphical view]
PANTHER	PTHR14516. PTHR14516. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	IFFO1. human.
GenomeRNAi	25900.
NextBio	47359.
SOURCE	Search...

Entry information

Entry name

IFFO1_HUMAN

Accession

Primary (citable) accession number: Q0D2I5
Secondary accession number(s): Q24JT6 , Q7L5J9, Q7Z5X4, Q9BQ46

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 22, 2009
Last modified:	May 1, 2013
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.