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Q0D2I5

- IFFO1_HUMAN

UniProt

Q0D2I5 - IFFO1_HUMAN

Protein

Intermediate filament family orphan 1

Gene

IFFO1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (22 Sep 2009)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intermediate filament family orphan 1
    Alternative name(s):
    Tumor antigen HOM-TES-103
    Gene namesi
    Name:IFFO1
    Synonyms:IFFO
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24970. IFFO1.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Intermediate filament

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164720809.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Intermediate filament family orphan 1PRO_0000316794Add
    BLAST

    Proteomic databases

    MaxQBiQ0D2I5.
    PaxDbiQ0D2I5.
    PRIDEiQ0D2I5.

    PTM databases

    PhosphoSiteiQ0D2I5.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ0D2I5.
    BgeeiQ0D2I5.
    CleanExiHS_IFFO1.
    GenevestigatoriQ0D2I5.

    Interactioni

    Protein-protein interaction databases

    BioGridi117407. 7 interactions.
    IntActiQ0D2I5. 3 interactions.
    STRINGi9606.ENSP00000349364.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0D2I5.
    SMRiQ0D2I5. Positions 453-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili85 – 11733Sequence AnalysisAdd
    BLAST
    Coiled coili237 – 30165Sequence AnalysisAdd
    BLAST
    Coiled coili455 – 50147Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi173 – 18210Poly-Ser
    Compositional biasi538 – 5425Poly-Pro

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG45260.
    HOGENOMiHOG000049269.
    HOVERGENiHBG100545.
    InParanoidiQ0D2I5.
    OMAiAVCTPSA.
    OrthoDBiEOG79CXZD.
    PhylomeDBiQ0D2I5.
    TreeFamiTF331217.

    Family and domain databases

    InterProiIPR026665. Iffo1/2.
    [Graphical view]
    PANTHERiPTHR14516. PTHR14516. 1 hit.

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q0D2I5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA    50
    YSPPGPGPAP PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL 100
    LEKQLQQALE EGKQGRRGLG RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS 150
    PSARVLGSPA RSPAGPLAPS AASLSSSSTS TSTTYSSSAR FMPGTIWSFS 200
    HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA LYNVLAKVKR 250
    ERDEYKRRWE EEYTVRIQLQ DRVNELQEEA QEADACQEEL ALKVEQLKAE 300
    LVVFKGLMSN NLSELDTKIQ EKAMKVDMDI CRRIDITAKL CDVAQQRNCE 350
    DMIQMFQVPS MGGRKRERKA AVEEDTSLSE SEGPRQPDGD EEESTALSIN 400
    EEMQRMLNQL REYDFEDDCD SLTWEETEET LLLWEDFSGY AMAAAEAQGE 450
    QEDSLEKVIK DTESLFKTRE KEYQETIDQI ELELATAKND MNRHLHEYME 500
    MCSMKRGLDV QMETCRRLIT QSGDRKSPAF TAVPLSDPPP PPSEAEDSDR 550
    DVSSDSSMR 559
    Length:559
    Mass (Da):61,979
    Last modified:September 22, 2009 - v2
    Checksum:i050FCFFB4953CBD8
    GO
    Isoform 2 (identifier: Q0D2I5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-360: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:199
    Mass (Da):22,790
    Checksum:i85B455C4F759C047
    GO
    Isoform 3 (identifier: Q0D2I5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         259-264: WEEEYT → CFYRVK
         265-559: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:264
    Mass (Da):28,128
    Checksum:i5FC1FFA8036C1478
    GO
    Isoform 4 (identifier: Q0D2I5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         357-357: Q → QKKL

    Note: No experimental confirmation available.

    Show »
    Length:562
    Mass (Da):62,348
    Checksum:iA23759D144A4F602
    GO
    Isoform 5 (identifier: Q0D2I5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         357-357: Q → QKKL
         451-451: Q → QQ

    Show »
    Length:563
    Mass (Da):62,476
    Checksum:iFD057A78376C2486
    GO
    Isoform 6 (identifier: Q0D2I5-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-360: Missing.
         451-451: Q → QQ

    Show »
    Length:200
    Mass (Da):22,918
    Checksum:i9652F97422DFD9B0
    GO
    Isoform 7 (identifier: Q0D2I5-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         357-357: Q → QKL
         451-451: Q → QQ

    Note: No experimental confirmation available.

    Show »
    Length:562
    Mass (Da):62,348
    Checksum:i540FFA923014FCA3
    GO

    Sequence cautioni

    The sequence AF124432 differs from that shown. Reason: Frameshift at positions 119, 226 and 384.
    The sequence AF124432 differs from that shown. Reason: Frameshift at positions 121, 227 and 385.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti152 – 1532SA → LE in AF124432. (PubMed:12032826)Curated
    Sequence conflicti285 – 2851A → V in AF124432. (PubMed:12032826)Curated
    Sequence conflicti358 – 3581V → F in AAI10388. (PubMed:15489334)Curated
    Sequence conflicti387 – 3871P → A in AF124432. (PubMed:12032826)Curated
    Sequence conflicti471 – 4711K → M in AF124432. (PubMed:12032826)Curated
    Sequence conflicti474 – 4741Q → H in AF124432. (PubMed:12032826)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 360360Missing in isoform 2 and isoform 6. 1 PublicationVSP_030781Add
    BLAST
    Alternative sequencei259 – 2646WEEEYT → CFYRVK in isoform 3. 1 PublicationVSP_030782
    Alternative sequencei265 – 559295Missing in isoform 3. 1 PublicationVSP_030783Add
    BLAST
    Alternative sequencei357 – 3571Q → QKKL in isoform 4 and isoform 5. 2 PublicationsVSP_030784
    Alternative sequencei357 – 3571Q → QKL in isoform 7. 1 PublicationVSP_039709
    Alternative sequencei451 – 4511Q → QQ in isoform 5, isoform 6 and isoform 7. 1 PublicationVSP_038240

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471116 Genomic DNA. Translation: EAW88781.1.
    CH471116 Genomic DNA. Translation: EAW88783.1.
    BC002857 mRNA. Translation: AAH02857.2.
    BC004384 mRNA. Translation: AAH04384.2.
    BC010431 mRNA. No translation available.
    BC071170 mRNA. Translation: AAH71170.1.
    BC103817 mRNA. Translation: AAI03818.1.
    BC103818 mRNA. Translation: AAI03819.1.
    BC110387 mRNA. Translation: AAI10388.1.
    BC113848 mRNA. Translation: AAI13849.1.
    BC114454 mRNA. Translation: AAI14455.1.
    AF124432 mRNA. No translation available.
    CCDSiCCDS41741.1. [Q0D2I5-5]
    CCDS8550.2. [Q0D2I5-4]
    RefSeqiNP_001034759.1. NM_001039670.2. [Q0D2I5-5]
    NP_542768.2. NM_080730.4. [Q0D2I5-4]
    XP_006719038.1. XM_006718975.1. [Q0D2I5-7]
    XP_006719040.1. XM_006718977.1. [Q0D2I5-1]
    UniGeneiHs.15243.

    Genome annotation databases

    EnsembliENST00000336604; ENSP00000337593; ENSG00000010295. [Q0D2I5-4]
    ENST00000356896; ENSP00000349364; ENSG00000010295. [Q0D2I5-5]
    ENST00000396840; ENSP00000380052; ENSG00000010295. [Q0D2I5-1]
    ENST00000487279; ENSP00000432493; ENSG00000010295. [Q0D2I5-3]
    GeneIDi25900.
    KEGGihsa:25900.
    UCSCiuc001qoz.2. human. [Q0D2I5-6]
    uc001qpa.2. human. [Q0D2I5-2]
    uc001qpc.2. human. [Q0D2I5-5]
    uc001qpf.2. human. [Q0D2I5-4]

    Polymorphism databases

    DMDMi259016254.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471116 Genomic DNA. Translation: EAW88781.1 .
    CH471116 Genomic DNA. Translation: EAW88783.1 .
    BC002857 mRNA. Translation: AAH02857.2 .
    BC004384 mRNA. Translation: AAH04384.2 .
    BC010431 mRNA. No translation available.
    BC071170 mRNA. Translation: AAH71170.1 .
    BC103817 mRNA. Translation: AAI03818.1 .
    BC103818 mRNA. Translation: AAI03819.1 .
    BC110387 mRNA. Translation: AAI10388.1 .
    BC113848 mRNA. Translation: AAI13849.1 .
    BC114454 mRNA. Translation: AAI14455.1 .
    AF124432 mRNA. No translation available.
    CCDSi CCDS41741.1. [Q0D2I5-5 ]
    CCDS8550.2. [Q0D2I5-4 ]
    RefSeqi NP_001034759.1. NM_001039670.2. [Q0D2I5-5 ]
    NP_542768.2. NM_080730.4. [Q0D2I5-4 ]
    XP_006719038.1. XM_006718975.1. [Q0D2I5-7 ]
    XP_006719040.1. XM_006718977.1. [Q0D2I5-1 ]
    UniGenei Hs.15243.

    3D structure databases

    ProteinModelPortali Q0D2I5.
    SMRi Q0D2I5. Positions 453-519.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117407. 7 interactions.
    IntActi Q0D2I5. 3 interactions.
    STRINGi 9606.ENSP00000349364.

    PTM databases

    PhosphoSitei Q0D2I5.

    Polymorphism databases

    DMDMi 259016254.

    Proteomic databases

    MaxQBi Q0D2I5.
    PaxDbi Q0D2I5.
    PRIDEi Q0D2I5.

    Protocols and materials databases

    DNASUi 25900.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336604 ; ENSP00000337593 ; ENSG00000010295 . [Q0D2I5-4 ]
    ENST00000356896 ; ENSP00000349364 ; ENSG00000010295 . [Q0D2I5-5 ]
    ENST00000396840 ; ENSP00000380052 ; ENSG00000010295 . [Q0D2I5-1 ]
    ENST00000487279 ; ENSP00000432493 ; ENSG00000010295 . [Q0D2I5-3 ]
    GeneIDi 25900.
    KEGGi hsa:25900.
    UCSCi uc001qoz.2. human. [Q0D2I5-6 ]
    uc001qpa.2. human. [Q0D2I5-2 ]
    uc001qpc.2. human. [Q0D2I5-5 ]
    uc001qpf.2. human. [Q0D2I5-4 ]

    Organism-specific databases

    CTDi 25900.
    GeneCardsi GC12M006648.
    HGNCi HGNC:24970. IFFO1.
    MIMi 610495. gene.
    neXtProti NX_Q0D2I5.
    PharmGKBi PA164720809.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45260.
    HOGENOMi HOG000049269.
    HOVERGENi HBG100545.
    InParanoidi Q0D2I5.
    OMAi AVCTPSA.
    OrthoDBi EOG79CXZD.
    PhylomeDBi Q0D2I5.
    TreeFami TF331217.

    Miscellaneous databases

    ChiTaRSi IFFO1. human.
    GenomeRNAii 25900.
    NextBioi 47359.
    PROi Q0D2I5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q0D2I5.
    Bgeei Q0D2I5.
    CleanExi HS_IFFO1.
    Genevestigatori Q0D2I5.

    Family and domain databases

    InterProi IPR026665. Iffo1/2.
    [Graphical view ]
    PANTHERi PTHR14516. PTHR14516. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 5; 6 AND 7).
      Tissue: Brain, Placenta and Skin.
    3. "A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing."
      Tuereci O., Sahin U., Koslowski M., Buss B., Bell C., Ballweber P., Zwick C., Eberle T., Zuber M., Villena-Heinsen C., Seitz G., Pfreundschuh M.
      Oncogene 21:3879-3888(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 102-559 (ISOFORM 4), TISSUE SPECIFICITY.
      Tissue: Testis.

    Entry informationi

    Entry nameiIFFO1_HUMAN
    AccessioniPrimary (citable) accession number: Q0D2I5
    Secondary accession number(s): Q24JT6
    , Q7L5J9, Q7Z5X4, Q9BQ46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3