Reviewed, UniProtKB/Swiss-Prot Q0D2I5 (IFFO1_HUMAN)

Names and origin

Protein names

Recommended name:
    Intermediate filament family orphan 1
Alternative name(s):
    HOM-TES-103 tumor antigen

Gene names

Name:	IFFO1
Synonyms:	IFFO

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	563 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Ubiquitously expressed. Ref.3
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Gene Ontology (GO)
Cellular component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q0D2I5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q0D2I5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-363: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q0D2I5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     259-264: WEEEYT → CFYRVK
     265-563: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q0D2I5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     359-361: KLF → LV

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 563	563	Intermediate filament family orphan 1		PRO_0000316794
Regions
	Coiled coil	85 – 117	33	Potential
	Coiled coil	237 – 301	65	Potential
	Coiled coil	445 – 505	61	Potential
	Compositional bias	173 – 182	10	Poly-Ser
	Compositional bias	542 – 546	5	Poly-Pro
Natural variations
	Alternative sequence	1 – 363	363	Missing in isoform 2.		VSP_030781
	Alternative sequence	259 – 264	6	WEEEYT → CFYRVK in isoform 3.		VSP_030782
	Alternative sequence	265 – 563	299	Missing in isoform 3.		VSP_030783
	Alternative sequence	359 – 361	3	KLF → LV in isoform 4.		VSP_030784
Experimental info
	Sequence conflict	152 – 153	2	SA → LE Ref.3
	Sequence conflict	285	1	A → V in AF124432. Ref.3
	Sequence conflict	361	1	F → V in AF124432. Ref.3
	Sequence conflict	387	1	P → A Ref.3
	Sequence conflict	455	1	Missing Ref.3
	Sequence conflict	475	1	K → M Ref.3
	Sequence conflict	478	1	Q → H Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 8A18C48B6E969A75	FASTA	563	62,524
	10 20 30 40 50 60 MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA YSPPGPGPAP 70 80 90 100 110 120 PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL LEKQLQQALE EGKQGRRGLG 130 140 150 160 170 180 RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS PSARVLGSPA RSPAGPLAPS AASLSSSSTS 190 200 210 220 230 240 TSTTYSSSAR FMPGTIWSFS HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA 250 260 270 280 290 300 LYNVLAKVKR ERDEYKRRWE EEYTVRIQLQ DRVNELQEEA QEADACQEEL ALKVEQLKAE 310 320 330 340 350 360 LVVFKGLMSN NLSELDTKIQ EKAMKVDMDI CRRIDITAKL CDVAQQRNCE DMIQMFQKKL 370 380 390 400 410 420 FPSMGGRKRE RKAAVEEDTS LSESEGPRQP DGDEEESTAL SINEEMQRML NQLREYDFED 430 440 450 460 470 480 DCDSLTWEET EETLLLWEDF SGYAMAAAEA QGEQQEDSLE KVIKDTESLF KTREKEYQET 490 500 510 520 530 540 IDQIELELAT AKNDMNRHLH EYMEMCSMKR GLDVQMETCR RLITQSGDRK SPAFTAVPLS 550 560 DPPPPPSEAE DSDRDVSSDS SMR
	Isoform 2. Checksum: 9652F97422DFD9B0	FASTA	200	22,918
	10 20 30 40 50 60 MGGRKRERKA AVEEDTSLSE SEGPRQPDGD EEESTALSIN EEMQRMLNQL REYDFEDDCD 70 80 90 100 110 120 SLTWEETEET LLLWEDFSGY AMAAAEAQGE QQEDSLEKVI KDTESLFKTR EKEYQETIDQ 130 140 150 160 170 180 IELELATAKN DMNRHLHEYM EMCSMKRGLD VQMETCRRLI TQSGDRKSPA FTAVPLSDPP 190 200 PPPSEAEDSD RDVSSDSSMR
	Isoform 3. Checksum: 5FC1FFA8036C1478	FASTA	264	28,128
	10 20 30 40 50 60 MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA YSPPGPGPAP 70 80 90 100 110 120 PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL LEKQLQQALE EGKQGRRGLG 130 140 150 160 170 180 RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS PSARVLGSPA RSPAGPLAPS AASLSSSSTS 190 200 210 220 230 240 TSTTYSSSAR FMPGTIWSFS HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA 250 260 LYNVLAKVKR ERDEYKRRCF YRVK
	Isoform 4. Checksum: 540FFA923014FCA3	FASTA	562	62,348
	10 20 30 40 50 60 MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA YSPPGPGPAP 70 80 90 100 110 120 PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL LEKQLQQALE EGKQGRRGLG 130 140 150 160 170 180 RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS PSARVLGSPA RSPAGPLAPS AASLSSSSTS 190 200 210 220 230 240 TSTTYSSSAR FMPGTIWSFS HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA 250 260 270 280 290 300 LYNVLAKVKR ERDEYKRRWE EEYTVRIQLQ DRVNELQEEA QEADACQEEL ALKVEQLKAE 310 320 330 340 350 360 LVVFKGLMSN NLSELDTKIQ EKAMKVDMDI CRRIDITAKL CDVAQQRNCE DMIQMFQKLV 370 380 390 400 410 420 PSMGGRKRER KAAVEEDTSL SESEGPRQPD GDEEESTALS INEEMQRMLN QLREYDFEDD 430 440 450 460 470 480 CDSLTWEETE ETLLLWEDFS GYAMAAAEAQ GEQQEDSLEK VIKDTESLFK TREKEYQETI 490 500 510 520 530 540 DQIELELATA KNDMNRHLHE YMEMCSMKRG LDVQMETCRR LITQSGDRKS PAFTAVPLSD 550 560 PPPPPSEAED SDRDVSSDSS MR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4). Tissue: Brain, Colon, Placenta and Skin.
[3]	"A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing." Tuereci O., Sahin U., Koslowski M., Buss B., Bell C., Ballweber P., Zwick C., Eberle T., Zuber M., Villena-Heinsen C., Seitz G., Pfreundschuh M. Oncogene 21:3879-3888(2002) [PubMed: 12032826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 102-563 (ISOFORM 1), TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CH471116 Genomic DNA. Translation: EAW88785.1. BC002857 mRNA. Translation: AAH02857.2. BC004384 mRNA. Translation: AAH04384.1. BC010431 mRNA. Translation: AAH10431.1. BC071170 mRNA. Translation: AAH71170.1. BC103817 mRNA. Translation: AAI03818.1. BC103818 mRNA. Translation: AAI03819.1. BC110387 mRNA. Translation: AAI10388.1. BC113848 mRNA. Translation: AAI13849.1. AF124432 mRNA. No translation available.
IPI	IPI00449478. IPI00787448. IPI00792474. IPI00884887.
UniGene	Hs.15243 Hs.544577
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q0D2I5. 3 interactions.
Genome annotation databases
Ensembl	ENSG00000010295. Homo sapiens. [Contig view]
Organism-specific databases
GeneCards	GC12M006521.
HGNC	HGNC:24970. IFFO1.
MIM	610495. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q0D2I5.
Gene expression databases
ArrayExpress	Q0D2I5.
Bgee	Q0D2I5.
CleanEx	HS_IFFO1.
Family and domain databases
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

IFFO1_HUMAN

Accession

Primary (citable) accession number: Q0D2I5
Secondary accession number(s): Q7L5J9, Q7Z5X4, Q9BQ46

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 17, 2006
Last modified:	April 14, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)