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Q0D2I5 (IFFO1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Intermediate filament family orphan 1
Alternative name(s):
Tumor antigen HOM-TES-103
Gene names
Name:IFFO1
Synonyms:IFFO
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Ubiquitously expressed. Ref.3

Sequence similarities

Belongs to the intermediate filament family.

Sequence caution

The sequence AF124432 differs from that shown. Reason: Frameshift at positions 119, 226 and 384.

The sequence AF124432 differs from that shown. Reason: Frameshift at positions 121, 227 and 385.

Ontologies

Keywords
   Cellular componentIntermediate filament
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q0D2I5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q0D2I5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-360: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q0D2I5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     259-264: WEEEYT → CFYRVK
     265-559: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 4 (identifier: Q0D2I5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     357-357: Q → QKKL
Note: No experimental confirmation available.
Isoform 5 (identifier: Q0D2I5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     357-357: Q → QKKL
     451-451: Q → QQ
Isoform 6 (identifier: Q0D2I5-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-360: Missing.
     451-451: Q → QQ
Isoform 7 (identifier: Q0D2I5-7)

The sequence of this isoform differs from the canonical sequence as follows:
     357-357: Q → QKL
     451-451: Q → QQ
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 559559Intermediate filament family orphan 1
PRO_0000316794

Regions

Coiled coil85 – 11733 Potential
Coiled coil237 – 30165 Potential
Coiled coil455 – 50147 Potential
Compositional bias173 – 18210Poly-Ser
Compositional bias538 – 5425Poly-Pro

Natural variations

Alternative sequence1 – 360360Missing in isoform 2 and isoform 6.
VSP_030781
Alternative sequence259 – 2646WEEEYT → CFYRVK in isoform 3.
VSP_030782
Alternative sequence265 – 559295Missing in isoform 3.
VSP_030783
Alternative sequence3571Q → QKKL in isoform 4 and isoform 5.
VSP_030784
Alternative sequence3571Q → QKL in isoform 7.
VSP_039709
Alternative sequence4511Q → QQ in isoform 5, isoform 6 and isoform 7.
VSP_038240

Experimental info

Sequence conflict152 – 1532SA → LE in AF124432. Ref.3
Sequence conflict2851A → V in AF124432. Ref.3
Sequence conflict3581V → F in AAI10388. Ref.2
Sequence conflict3871P → A in AF124432. Ref.3
Sequence conflict4711K → M in AF124432. Ref.3
Sequence conflict4741Q → H in AF124432. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: 050FCFFB4953CBD8

FASTA55961,979
        10         20         30         40         50         60 
MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA YSPPGPGPAP 

        70         80         90        100        110        120 
PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL LEKQLQQALE EGKQGRRGLG 

       130        140        150        160        170        180 
RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS PSARVLGSPA RSPAGPLAPS AASLSSSSTS 

       190        200        210        220        230        240 
TSTTYSSSAR FMPGTIWSFS HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA 

       250        260        270        280        290        300 
LYNVLAKVKR ERDEYKRRWE EEYTVRIQLQ DRVNELQEEA QEADACQEEL ALKVEQLKAE 

       310        320        330        340        350        360 
LVVFKGLMSN NLSELDTKIQ EKAMKVDMDI CRRIDITAKL CDVAQQRNCE DMIQMFQVPS 

       370        380        390        400        410        420 
MGGRKRERKA AVEEDTSLSE SEGPRQPDGD EEESTALSIN EEMQRMLNQL REYDFEDDCD 

       430        440        450        460        470        480 
SLTWEETEET LLLWEDFSGY AMAAAEAQGE QEDSLEKVIK DTESLFKTRE KEYQETIDQI 

       490        500        510        520        530        540 
ELELATAKND MNRHLHEYME MCSMKRGLDV QMETCRRLIT QSGDRKSPAF TAVPLSDPPP 

       550 
PPSEAEDSDR DVSSDSSMR 

« Hide

Isoform 2 [UniParc].

Checksum: 85B455C4F759C047
Show »

FASTA19922,790
Isoform 3 [UniParc].

Checksum: 5FC1FFA8036C1478
Show »

FASTA26428,128
Isoform 4 [UniParc].

Checksum: A23759D144A4F602
Show »

FASTA56262,348
Isoform 5 [UniParc].

Checksum: FD057A78376C2486
Show »

FASTA56362,476
Isoform 6 [UniParc].

Checksum: 9652F97422DFD9B0
Show »

FASTA20022,918
Isoform 7 [UniParc].

Checksum: 540FFA923014FCA3
Show »

FASTA56262,348

References

« Hide 'large scale' references
[1]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 5; 6 AND 7).
Tissue: Brain, Placenta and Skin.
[3]"A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing."
Tuereci O., Sahin U., Koslowski M., Buss B., Bell C., Ballweber P., Zwick C., Eberle T., Zuber M., Villena-Heinsen C., Seitz G., Pfreundschuh M.
Oncogene 21:3879-3888(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 102-559 (ISOFORM 4), TISSUE SPECIFICITY.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH471116 Genomic DNA. Translation: EAW88781.1.
CH471116 Genomic DNA. Translation: EAW88783.1.
BC002857 mRNA. Translation: AAH02857.2.
BC004384 mRNA. Translation: AAH04384.2.
BC010431 mRNA. No translation available.
BC071170 mRNA. Translation: AAH71170.1.
BC103817 mRNA. Translation: AAI03818.1.
BC103818 mRNA. Translation: AAI03819.1.
BC110387 mRNA. Translation: AAI10388.1.
BC113848 mRNA. Translation: AAI13849.1.
BC114454 mRNA. Translation: AAI14455.1.
AF124432 mRNA. No translation available.
CCDSCCDS41741.1. [Q0D2I5-5]
CCDS8550.2. [Q0D2I5-4]
RefSeqNP_001034759.1. NM_001039670.2. [Q0D2I5-5]
NP_542768.2. NM_080730.4. [Q0D2I5-4]
XP_006719038.1. XM_006718975.1. [Q0D2I5-7]
XP_006719040.1. XM_006718977.1. [Q0D2I5-1]
UniGeneHs.15243.

3D structure databases

ProteinModelPortalQ0D2I5.
SMRQ0D2I5. Positions 453-519.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117407. 7 interactions.
IntActQ0D2I5. 3 interactions.
STRING9606.ENSP00000349364.

PTM databases

PhosphoSiteQ0D2I5.

Polymorphism databases

DMDM259016254.

Proteomic databases

MaxQBQ0D2I5.
PaxDbQ0D2I5.
PRIDEQ0D2I5.

Protocols and materials databases

DNASU25900.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000336604; ENSP00000337593; ENSG00000010295. [Q0D2I5-4]
ENST00000356896; ENSP00000349364; ENSG00000010295. [Q0D2I5-5]
ENST00000396840; ENSP00000380052; ENSG00000010295. [Q0D2I5-1]
ENST00000487279; ENSP00000432493; ENSG00000010295. [Q0D2I5-3]
GeneID25900.
KEGGhsa:25900.
UCSCuc001qoz.2. human. [Q0D2I5-6]
uc001qpa.2. human. [Q0D2I5-2]
uc001qpc.2. human. [Q0D2I5-5]
uc001qpf.2. human. [Q0D2I5-4]

Organism-specific databases

CTD25900.
GeneCardsGC12M006648.
HGNCHGNC:24970. IFFO1.
MIM610495. gene.
neXtProtNX_Q0D2I5.
PharmGKBPA164720809.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45260.
HOGENOMHOG000049269.
HOVERGENHBG100545.
InParanoidQ0D2I5.
OMAAVCTPSA.
OrthoDBEOG79CXZD.
PhylomeDBQ0D2I5.
TreeFamTF331217.

Gene expression databases

ArrayExpressQ0D2I5.
BgeeQ0D2I5.
CleanExHS_IFFO1.
GenevestigatorQ0D2I5.

Family and domain databases

InterProIPR026665. Iffo1/2.
[Graphical view]
PANTHERPTHR14516. PTHR14516. 1 hit.
ProtoNetSearch...

Other

ChiTaRSIFFO1. human.
GenomeRNAi25900.
NextBio47359.
PROQ0D2I5.
SOURCESearch...

Entry information

Entry nameIFFO1_HUMAN
AccessionPrimary (citable) accession number: Q0D2I5
Secondary accession number(s): Q24JT6 expand/collapse secondary AC list , Q7L5J9, Q7Z5X4, Q9BQ46
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM