Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0D2I5

- IFFO1_HUMAN

UniProt

Q0D2I5 - IFFO1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Intermediate filament family orphan 1

Gene

IFFO1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate filament family orphan 1
Alternative name(s):
Tumor antigen HOM-TES-103
Gene namesi
Name:IFFO1
Synonyms:IFFO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:24970. IFFO1.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720809.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Intermediate filament family orphan 1PRO_0000316794Add
BLAST

Proteomic databases

MaxQBiQ0D2I5.
PaxDbiQ0D2I5.
PRIDEiQ0D2I5.

PTM databases

PhosphoSiteiQ0D2I5.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ0D2I5.
CleanExiHS_IFFO1.
ExpressionAtlasiQ0D2I5. baseline and differential.
GenevestigatoriQ0D2I5.

Interactioni

Protein-protein interaction databases

BioGridi117407. 9 interactions.
IntActiQ0D2I5. 3 interactions.
STRINGi9606.ENSP00000349364.

Structurei

3D structure databases

ProteinModelPortaliQ0D2I5.
SMRiQ0D2I5. Positions 453-519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili85 – 11733Sequence AnalysisAdd
BLAST
Coiled coili237 – 30165Sequence AnalysisAdd
BLAST
Coiled coili455 – 50147Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi173 – 18210Poly-Ser
Compositional biasi538 – 5425Poly-Pro

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG45260.
GeneTreeiENSGT00510000046803.
HOGENOMiHOG000049269.
HOVERGENiHBG100545.
InParanoidiQ0D2I5.
OMAiAVCTPSA.
OrthoDBiEOG79CXZD.
PhylomeDBiQ0D2I5.
TreeFamiTF331217.

Family and domain databases

InterProiIPR026665. Iffo1/2.
[Graphical view]
PANTHERiPTHR14516. PTHR14516. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q0D2I5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA
60 70 80 90 100
YSPPGPGPAP PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL
110 120 130 140 150
LEKQLQQALE EGKQGRRGLG RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS
160 170 180 190 200
PSARVLGSPA RSPAGPLAPS AASLSSSSTS TSTTYSSSAR FMPGTIWSFS
210 220 230 240 250
HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA LYNVLAKVKR
260 270 280 290 300
ERDEYKRRWE EEYTVRIQLQ DRVNELQEEA QEADACQEEL ALKVEQLKAE
310 320 330 340 350
LVVFKGLMSN NLSELDTKIQ EKAMKVDMDI CRRIDITAKL CDVAQQRNCE
360 370 380 390 400
DMIQMFQVPS MGGRKRERKA AVEEDTSLSE SEGPRQPDGD EEESTALSIN
410 420 430 440 450
EEMQRMLNQL REYDFEDDCD SLTWEETEET LLLWEDFSGY AMAAAEAQGE
460 470 480 490 500
QEDSLEKVIK DTESLFKTRE KEYQETIDQI ELELATAKND MNRHLHEYME
510 520 530 540 550
MCSMKRGLDV QMETCRRLIT QSGDRKSPAF TAVPLSDPPP PPSEAEDSDR

DVSSDSSMR
Length:559
Mass (Da):61,979
Last modified:September 22, 2009 - v2
Checksum:i050FCFFB4953CBD8
GO
Isoform 2 (identifier: Q0D2I5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-360: Missing.

Note: No experimental confirmation available.

Show »
Length:199
Mass (Da):22,790
Checksum:i85B455C4F759C047
GO
Isoform 3 (identifier: Q0D2I5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-264: WEEEYT → CFYRVK
     265-559: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:264
Mass (Da):28,128
Checksum:i5FC1FFA8036C1478
GO
Isoform 4 (identifier: Q0D2I5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-357: Q → QKKL

Note: No experimental confirmation available.

Show »
Length:562
Mass (Da):62,348
Checksum:iA23759D144A4F602
GO
Isoform 5 (identifier: Q0D2I5-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-357: Q → QKKL
     451-451: Q → QQ

Show »
Length:563
Mass (Da):62,476
Checksum:iFD057A78376C2486
GO
Isoform 6 (identifier: Q0D2I5-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-360: Missing.
     451-451: Q → QQ

Show »
Length:200
Mass (Da):22,918
Checksum:i9652F97422DFD9B0
GO
Isoform 7 (identifier: Q0D2I5-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-357: Q → QKL
     451-451: Q → QQ

Note: No experimental confirmation available.

Show »
Length:562
Mass (Da):62,348
Checksum:i540FFA923014FCA3
GO

Sequence cautioni

The sequence AF124432 differs from that shown. Reason: Frameshift at positions 119, 226 and 384. Curated
The sequence AF124432 differs from that shown. Reason: Frameshift at positions 121, 227 and 385. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1532SA → LE in AF124432. (PubMed:12032826)Curated
Sequence conflicti285 – 2851A → V in AF124432. (PubMed:12032826)Curated
Sequence conflicti358 – 3581V → F in AAI10388. (PubMed:15489334)Curated
Sequence conflicti387 – 3871P → A in AF124432. (PubMed:12032826)Curated
Sequence conflicti471 – 4711K → M in AF124432. (PubMed:12032826)Curated
Sequence conflicti474 – 4741Q → H in AF124432. (PubMed:12032826)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 360360Missing in isoform 2 and isoform 6. 1 PublicationVSP_030781Add
BLAST
Alternative sequencei259 – 2646WEEEYT → CFYRVK in isoform 3. 1 PublicationVSP_030782
Alternative sequencei265 – 559295Missing in isoform 3. 1 PublicationVSP_030783Add
BLAST
Alternative sequencei357 – 3571Q → QKKL in isoform 4 and isoform 5. 2 PublicationsVSP_030784
Alternative sequencei357 – 3571Q → QKL in isoform 7. 1 PublicationVSP_039709
Alternative sequencei451 – 4511Q → QQ in isoform 5, isoform 6 and isoform 7. 1 PublicationVSP_038240

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471116 Genomic DNA. Translation: EAW88781.1.
CH471116 Genomic DNA. Translation: EAW88783.1.
BC002857 mRNA. Translation: AAH02857.2.
BC004384 mRNA. Translation: AAH04384.2.
BC010431 mRNA. No translation available.
BC071170 mRNA. Translation: AAH71170.1.
BC103817 mRNA. Translation: AAI03818.1.
BC103818 mRNA. Translation: AAI03819.1.
BC110387 mRNA. Translation: AAI10388.1.
BC113848 mRNA. Translation: AAI13849.1.
BC114454 mRNA. Translation: AAI14455.1.
AF124432 mRNA. No translation available.
CCDSiCCDS41741.1. [Q0D2I5-5]
CCDS8550.2. [Q0D2I5-4]
RefSeqiNP_001034759.1. NM_001039670.2. [Q0D2I5-5]
NP_542768.2. NM_080730.4. [Q0D2I5-4]
XP_006719038.1. XM_006718975.1. [Q0D2I5-7]
XP_006719040.1. XM_006718977.1. [Q0D2I5-1]
UniGeneiHs.15243.

Genome annotation databases

EnsembliENST00000336604; ENSP00000337593; ENSG00000010295. [Q0D2I5-4]
ENST00000356896; ENSP00000349364; ENSG00000010295. [Q0D2I5-5]
ENST00000396840; ENSP00000380052; ENSG00000010295. [Q0D2I5-1]
ENST00000487279; ENSP00000432493; ENSG00000010295. [Q0D2I5-3]
GeneIDi25900.
KEGGihsa:25900.
UCSCiuc001qoz.2. human. [Q0D2I5-6]
uc001qpa.2. human. [Q0D2I5-2]
uc001qpc.2. human. [Q0D2I5-5]
uc001qpf.2. human. [Q0D2I5-4]

Polymorphism databases

DMDMi259016254.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471116 Genomic DNA. Translation: EAW88781.1 .
CH471116 Genomic DNA. Translation: EAW88783.1 .
BC002857 mRNA. Translation: AAH02857.2 .
BC004384 mRNA. Translation: AAH04384.2 .
BC010431 mRNA. No translation available.
BC071170 mRNA. Translation: AAH71170.1 .
BC103817 mRNA. Translation: AAI03818.1 .
BC103818 mRNA. Translation: AAI03819.1 .
BC110387 mRNA. Translation: AAI10388.1 .
BC113848 mRNA. Translation: AAI13849.1 .
BC114454 mRNA. Translation: AAI14455.1 .
AF124432 mRNA. No translation available.
CCDSi CCDS41741.1. [Q0D2I5-5 ]
CCDS8550.2. [Q0D2I5-4 ]
RefSeqi NP_001034759.1. NM_001039670.2. [Q0D2I5-5 ]
NP_542768.2. NM_080730.4. [Q0D2I5-4 ]
XP_006719038.1. XM_006718975.1. [Q0D2I5-7 ]
XP_006719040.1. XM_006718977.1. [Q0D2I5-1 ]
UniGenei Hs.15243.

3D structure databases

ProteinModelPortali Q0D2I5.
SMRi Q0D2I5. Positions 453-519.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117407. 9 interactions.
IntActi Q0D2I5. 3 interactions.
STRINGi 9606.ENSP00000349364.

PTM databases

PhosphoSitei Q0D2I5.

Polymorphism databases

DMDMi 259016254.

Proteomic databases

MaxQBi Q0D2I5.
PaxDbi Q0D2I5.
PRIDEi Q0D2I5.

Protocols and materials databases

DNASUi 25900.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336604 ; ENSP00000337593 ; ENSG00000010295 . [Q0D2I5-4 ]
ENST00000356896 ; ENSP00000349364 ; ENSG00000010295 . [Q0D2I5-5 ]
ENST00000396840 ; ENSP00000380052 ; ENSG00000010295 . [Q0D2I5-1 ]
ENST00000487279 ; ENSP00000432493 ; ENSG00000010295 . [Q0D2I5-3 ]
GeneIDi 25900.
KEGGi hsa:25900.
UCSCi uc001qoz.2. human. [Q0D2I5-6 ]
uc001qpa.2. human. [Q0D2I5-2 ]
uc001qpc.2. human. [Q0D2I5-5 ]
uc001qpf.2. human. [Q0D2I5-4 ]

Organism-specific databases

CTDi 25900.
GeneCardsi GC12M006648.
HGNCi HGNC:24970. IFFO1.
MIMi 610495. gene.
neXtProti NX_Q0D2I5.
PharmGKBi PA164720809.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45260.
GeneTreei ENSGT00510000046803.
HOGENOMi HOG000049269.
HOVERGENi HBG100545.
InParanoidi Q0D2I5.
OMAi AVCTPSA.
OrthoDBi EOG79CXZD.
PhylomeDBi Q0D2I5.
TreeFami TF331217.

Miscellaneous databases

ChiTaRSi IFFO1. human.
GenomeRNAii 25900.
NextBioi 47359.
PROi Q0D2I5.
SOURCEi Search...

Gene expression databases

Bgeei Q0D2I5.
CleanExi HS_IFFO1.
ExpressionAtlasi Q0D2I5. baseline and differential.
Genevestigatori Q0D2I5.

Family and domain databases

InterProi IPR026665. Iffo1/2.
[Graphical view ]
PANTHERi PTHR14516. PTHR14516. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 5; 6 AND 7).
    Tissue: Brain, Placenta and Skin.
  3. "A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing."
    Tuereci O., Sahin U., Koslowski M., Buss B., Bell C., Ballweber P., Zwick C., Eberle T., Zuber M., Villena-Heinsen C., Seitz G., Pfreundschuh M.
    Oncogene 21:3879-3888(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 102-559 (ISOFORM 4), TISSUE SPECIFICITY.
    Tissue: Testis.

Entry informationi

Entry nameiIFFO1_HUMAN
AccessioniPrimary (citable) accession number: Q0D2I5
Secondary accession number(s): Q24JT6
, Q7L5J9, Q7Z5X4, Q9BQ46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 22, 2009
Last modified: November 26, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3