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Q0D076

- MNS1B_ASPTN

UniProt

Q0D076 - MNS1B_ASPTN

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Protein
Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B
Gene
mns1B, msdS, ATEG_00658
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 By similarity.

Catalytic activityi

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.

Cofactori

Ca2+. Can also use Mg2+, but with lower efficiency By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei374 – 3741Proton donor By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B (EC:3.2.1.113)
Alternative name(s):
Class I alpha-mannosidase 1B
Man(9)-alpha-mannosidase 1B
Gene namesi
Name:mns1B
Synonyms:msdS
ORF Names:ATEG_00658
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle lumen Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 508487Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B
PRO_0000394822Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi331 ↔ 360 By similarity
Glycosylationi365 – 3651N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi33178.CADATEAP00009571.

Structurei

3D structure databases

ProteinModelPortaliQ0D076.
SMRiQ0D076. Positions 37-507.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG300315.
HOGENOMiHOG000181987.
OMAiYAFPHDS.
OrthoDBiEOG7BP8BH.

Family and domain databases

Gene3Di1.50.10.50. 1 hit.
InterProiIPR001382. Glyco_hydro_47.
[Graphical view]
PANTHERiPTHR11742. PTHR11742. 1 hit.
PfamiPF01532. Glyco_hydro_47. 1 hit.
[Graphical view]
PRINTSiPR00747. GLYHDRLASE47.
SUPFAMiSSF48225. SSF48225. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0D076-1 [UniParc]FASTAAdd to Basket

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MHLPSLSLPL AALTLATPSL AYPYYRTEQP LQNNLAQSRA NTIKEAFSHA    50
WDGYKKYAYP HDELHPVSNG YGDSRNGWGA SAVDALSTAI IMRNATIVNQ 100
ILDHIAQVDY SKTNDTVSLF ETTIRYLGGM LSGYDLLKGP ASGLVRDSKK 150
VDMLLTQSKK LADVLKFAFD TPSGVPYNNI NINTHGNDGA TSNGLAVTGT 200
LVLEWTRLSD LTGDDEYAKL SQKAQSYLLK PQPASSEPFP GLVGSHISIE 250
TGEFTDAQVS WNGGDDSFYE YLIKMYVYDP EAFGEYKDRW EAAAQSSMEH 300
LASHPSTRPD LTFLASYNDG KLGLSSQHLT CFDGGSFLLG GTVLDNDDYI 350
KFGLDLVKGC HETYNATLTG IGPESFAWDP NSVPSNQKAL YEKAGFYIQS 400
GAYILRPEVI ESFYYAYRIT GEEQYREWIW NAFVAINKYC RTSSGFAGLQ 450
DVNAANGGGR YDNQESFLFA EVMKYVYLAH SGDAEWQVQR GNGNKFVFNT 500
EAHPFRVR 508
Length:508
Mass (Da):56,289
Last modified:October 17, 2006 - v1
Checksum:i379FCDF6BCE2EE5B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476594 Genomic DNA. Translation: EAU39304.1.
RefSeqiXP_001210744.1. XM_001210744.1.

Genome annotation databases

EnsemblFungiiCADATEAT00009571; CADATEAP00009571; CADATEAG00009571.
GeneIDi4355413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476594 Genomic DNA. Translation: EAU39304.1 .
RefSeqi XP_001210744.1. XM_001210744.1.

3D structure databases

ProteinModelPortali Q0D076.
SMRi Q0D076. Positions 37-507.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00009571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00009571 ; CADATEAP00009571 ; CADATEAG00009571 .
GeneIDi 4355413.

Phylogenomic databases

eggNOGi NOG300315.
HOGENOMi HOG000181987.
OMAi YAFPHDS.
OrthoDBi EOG7BP8BH.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

Gene3Di 1.50.10.50. 1 hit.
InterProi IPR001382. Glyco_hydro_47.
[Graphical view ]
PANTHERi PTHR11742. PTHR11742. 1 hit.
Pfami PF01532. Glyco_hydro_47. 1 hit.
[Graphical view ]
PRINTSi PR00747. GLYHDRLASE47.
SUPFAMi SSF48225. SSF48225. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiMNS1B_ASPTN
AccessioniPrimary (citable) accession number: Q0D076
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: October 17, 2006
Last modified: November 13, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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