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Q0D076

- MNS1B_ASPTN

UniProt

Q0D076 - MNS1B_ASPTN

Protein

Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B

Gene

mns1B

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 By similarity.By similarity

    Catalytic activityi

    Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.

    Cofactori

    Ca2+. Can also use Mg2+, but with lower efficiency By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei374 – 3741Proton donorBy similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B (EC:3.2.1.113)
    Alternative name(s):
    Class I alpha-mannosidase 1B
    Man(9)-alpha-mannosidase 1B
    Gene namesi
    Name:mns1B
    Synonyms:msdS
    ORF Names:ATEG_00658
    OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
    Taxonomic identifieri341663 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000007963: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle lumen Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 508487Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1BPRO_0000394822Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi331 ↔ 360By similarity
    Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi33178.CADATEAP00009571.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0D076.
    SMRiQ0D076. Positions 37-507.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 47 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG300315.
    HOGENOMiHOG000181987.
    OMAiYAFPHDS.
    OrthoDBiEOG7BP8BH.

    Family and domain databases

    Gene3Di1.50.10.50. 1 hit.
    InterProiIPR001382. Glyco_hydro_47.
    [Graphical view]
    PANTHERiPTHR11742. PTHR11742. 1 hit.
    PfamiPF01532. Glyco_hydro_47. 1 hit.
    [Graphical view]
    PRINTSiPR00747. GLYHDRLASE47.
    SUPFAMiSSF48225. SSF48225. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0D076-1 [UniParc]FASTAAdd to Basket

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    MHLPSLSLPL AALTLATPSL AYPYYRTEQP LQNNLAQSRA NTIKEAFSHA    50
    WDGYKKYAYP HDELHPVSNG YGDSRNGWGA SAVDALSTAI IMRNATIVNQ 100
    ILDHIAQVDY SKTNDTVSLF ETTIRYLGGM LSGYDLLKGP ASGLVRDSKK 150
    VDMLLTQSKK LADVLKFAFD TPSGVPYNNI NINTHGNDGA TSNGLAVTGT 200
    LVLEWTRLSD LTGDDEYAKL SQKAQSYLLK PQPASSEPFP GLVGSHISIE 250
    TGEFTDAQVS WNGGDDSFYE YLIKMYVYDP EAFGEYKDRW EAAAQSSMEH 300
    LASHPSTRPD LTFLASYNDG KLGLSSQHLT CFDGGSFLLG GTVLDNDDYI 350
    KFGLDLVKGC HETYNATLTG IGPESFAWDP NSVPSNQKAL YEKAGFYIQS 400
    GAYILRPEVI ESFYYAYRIT GEEQYREWIW NAFVAINKYC RTSSGFAGLQ 450
    DVNAANGGGR YDNQESFLFA EVMKYVYLAH SGDAEWQVQR GNGNKFVFNT 500
    EAHPFRVR 508
    Length:508
    Mass (Da):56,289
    Last modified:October 17, 2006 - v1
    Checksum:i379FCDF6BCE2EE5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476594 Genomic DNA. Translation: EAU39304.1.
    RefSeqiXP_001210744.1. XM_001210744.1.

    Genome annotation databases

    EnsemblFungiiCADATEAT00009571; CADATEAP00009571; CADATEAG00009571.
    GeneIDi4355413.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476594 Genomic DNA. Translation: EAU39304.1 .
    RefSeqi XP_001210744.1. XM_001210744.1.

    3D structure databases

    ProteinModelPortali Q0D076.
    SMRi Q0D076. Positions 37-507.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33178.CADATEAP00009571.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADATEAT00009571 ; CADATEAP00009571 ; CADATEAG00009571 .
    GeneIDi 4355413.

    Phylogenomic databases

    eggNOGi NOG300315.
    HOGENOMi HOG000181987.
    OMAi YAFPHDS.
    OrthoDBi EOG7BP8BH.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Family and domain databases

    Gene3Di 1.50.10.50. 1 hit.
    InterProi IPR001382. Glyco_hydro_47.
    [Graphical view ]
    PANTHERi PTHR11742. PTHR11742. 1 hit.
    Pfami PF01532. Glyco_hydro_47. 1 hit.
    [Graphical view ]
    PRINTSi PR00747. GLYHDRLASE47.
    SUPFAMi SSF48225. SSF48225. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NIH 2624 / FGSC A1156.

    Entry informationi

    Entry nameiMNS1B_ASPTN
    AccessioniPrimary (citable) accession number: Q0D076
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3