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Q0D076 (MNS1B_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B

EC=3.2.1.113
Alternative name(s):
Class I alpha-mannosidase 1B
Man(9)-alpha-mannosidase 1B
Gene names
Name:mns1B
Synonyms:msdS
ORF Names:ATEG_00658
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 By similarity.

Catalytic activity

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.

Cofactor

Ca2+. Can also use Mg2+, but with lower efficiency By similarity.

Pathway

Protein modification; protein glycosylation.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasmic vesicle lumen By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 47 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasmic vesicle
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein glycosylation

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasmic membrane-bounded vesicle lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 508487Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B
PRO_0000394822

Sites

Active site3741Proton donor By similarity

Amino acid modifications

Glycosylation941N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation3651N-linked (GlcNAc...) Potential
Disulfide bond331 ↔ 360 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0D076 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 379FCDF6BCE2EE5B

FASTA50856,289
        10         20         30         40         50         60 
MHLPSLSLPL AALTLATPSL AYPYYRTEQP LQNNLAQSRA NTIKEAFSHA WDGYKKYAYP 

        70         80         90        100        110        120 
HDELHPVSNG YGDSRNGWGA SAVDALSTAI IMRNATIVNQ ILDHIAQVDY SKTNDTVSLF 

       130        140        150        160        170        180 
ETTIRYLGGM LSGYDLLKGP ASGLVRDSKK VDMLLTQSKK LADVLKFAFD TPSGVPYNNI 

       190        200        210        220        230        240 
NINTHGNDGA TSNGLAVTGT LVLEWTRLSD LTGDDEYAKL SQKAQSYLLK PQPASSEPFP 

       250        260        270        280        290        300 
GLVGSHISIE TGEFTDAQVS WNGGDDSFYE YLIKMYVYDP EAFGEYKDRW EAAAQSSMEH 

       310        320        330        340        350        360 
LASHPSTRPD LTFLASYNDG KLGLSSQHLT CFDGGSFLLG GTVLDNDDYI KFGLDLVKGC 

       370        380        390        400        410        420 
HETYNATLTG IGPESFAWDP NSVPSNQKAL YEKAGFYIQS GAYILRPEVI ESFYYAYRIT 

       430        440        450        460        470        480 
GEEQYREWIW NAFVAINKYC RTSSGFAGLQ DVNAANGGGR YDNQESFLFA EVMKYVYLAH 

       490        500 
SGDAEWQVQR GNGNKFVFNT EAHPFRVR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476594 Genomic DNA. Translation: EAU39304.1.
RefSeqXP_001210744.1. XM_001210744.1.

3D structure databases

ProteinModelPortalQ0D076.
SMRQ0D076. Positions 37-507.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33178.CADATEAP00009571.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADATEAT00009571; CADATEAP00009571; CADATEAG00009571.
GeneID4355413.

Phylogenomic databases

eggNOGNOG300315.
HOGENOMHOG000181987.
OMAYAFPHDS.
OrthoDBEOG7BP8BH.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

Gene3D1.50.10.50. 1 hit.
InterProIPR001382. Glyco_hydro_47.
[Graphical view]
PANTHERPTHR11742. PTHR11742. 1 hit.
PfamPF01532. Glyco_hydro_47. 1 hit.
[Graphical view]
PRINTSPR00747. GLYHDRLASE47.
SUPFAMSSF48225. SSF48225. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMNS1B_ASPTN
AccessionPrimary (citable) accession number: Q0D076
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: October 17, 2006
Last modified: November 13, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries