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Q0CZX6

- KYNU2_ASPTN

UniProt

Q0CZX6 - KYNU2_ASPTN

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Protein
Kynureninase 2
Gene
bna5-2, ATEG_00758
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei134 – 1341Pyridoxal phosphate; via amide nitrogen By similarity
Binding sitei135 – 1351Pyridoxal phosphate By similarity
Binding sitei247 – 2471Pyridoxal phosphate By similarity
Binding sitei250 – 2501Pyridoxal phosphate By similarity
Binding sitei272 – 2721Pyridoxal phosphate By similarity
Binding sitei312 – 3121Pyridoxal phosphate By similarity
Binding sitei340 – 3401Pyridoxal phosphate By similarity

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynureninase 2 (EC:3.7.1.3)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5-2
L-kynurenine hydrolase 2
Gene namesi
Name:bna5-2
ORF Names:ATEG_00758
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Kynureninase 2UniRule annotation
PRO_0000356972Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi33178.CADATEAP00007194.

Structurei

3D structure databases

ProteinModelPortaliQ0CZX6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni162 – 1654Pyridoxal phosphate binding By similarity

Sequence similaritiesi

Belongs to the kynureninase family.

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242438.
OMAiGWYGGDK.
OrthoDBiEOG7V1G0J.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0CZX6-1 [UniParc]FASTAAdd to Basket

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MSENNCSKPS FPDNAASKEY AASLDAADPL ASFRDQFIIP SKANIACKRL    50
AKPNLSPEPC IYFCGNSLGI QPKATAKYLE AQLDTWSSIG VCGHFTNLED 100
SPMKSWQLLA EQAAESMSKI VGADPAEVAA MGTLTANLHL LMASFYKPTA 150
TKHKILMDWK AFPSDHYAIE SHIAWHNLDP KESMVLIGPD EGEYEISTDK 200
ILSYIDQHAE DAALLLLPGI QYYTGQLFDI PKITEYAKSR NLVVGWDLAH 250
AYGNVELKLH DWNVDFAAWC TYKYGNAGPG AMAGLFVHDK HGQVDYSQGE 300
DSPKFRHRLT GWYGGDRSVR FKMDNKFKPI PGAGGFQISN PSAIDLSCLC 350
AALSVFDQTS VSELRRKSLK LTAYLEYLLL KDTTEDSRPF RIITPTNPEA 400
RGAQLSLLLK PGLLQGVSER LQDAGIICDK REPGVVRVAP VPLYNTYSEV 450
WEFVQQFRAA LQL 463
Length:463
Mass (Da):51,310
Last modified:October 17, 2006 - v1
Checksum:i402C2BC2BD9A167A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476594 Genomic DNA. Translation: EAU39404.1.
RefSeqiXP_001210844.1. XM_001210844.1.

Genome annotation databases

EnsemblFungiiCADATEAT00007194; CADATEAP00007194; CADATEAG00007194.
GeneIDi4355513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476594 Genomic DNA. Translation: EAU39404.1 .
RefSeqi XP_001210844.1. XM_001210844.1.

3D structure databases

ProteinModelPortali Q0CZX6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00007194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00007194 ; CADATEAP00007194 ; CADATEAG00007194 .
GeneIDi 4355513.

Phylogenomic databases

eggNOGi COG3844.
HOGENOMi HOG000242438.
OMAi GWYGGDK.
OrthoDBi EOG7V1G0J.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiKYNU2_ASPTN
AccessioniPrimary (citable) accession number: Q0CZX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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