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Q0CYP4

- M2DH_ASPTN

UniProt

Q0CYP4 - M2DH_ASPTN

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Protein

Mannitol 2-dehydrogenase

Gene

ATEG_01190

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.By similarity

Catalytic activityi

D-mannitol + NAD+ = D-fructose + NADH.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 4812NADBy similarityAdd
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. mannitol 2-dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Mannitol 2-dehydrogenase (EC:1.1.1.67)
Short name:
M2DH
Short name:
MDH
Gene namesi
ORF Names:ATEG_01190
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Mannitol 2-dehydrogenasePRO_0000371543Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi33178.CADATEAP00000339.

Structurei

3D structure databases

ProteinModelPortaliQ0CYP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannitol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0246.
HOGENOMiHOG000202982.
OMAiPWELMKI.
OrthoDBiEOG7PCJRT.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0CYP4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPLKLNSRN LAQIFAAGKD RVKVPTYQRG SAVKEGIVHV GVGGFHRAHL
60 70 80 90 100
AVYVDQLMQN HGVNDYAICG VGLQPFDAAM RDALRSQDHL YTVIERSAKG
110 120 130 140 150
SFAHVVGSIN SYLFAPDNRE AVIAKMAHPD THIVSLTITE SGYYYNENTH
160 170 180 190 200
ELQAEHPDIQ FDLDPANEKT PRTTFGFLYA ALARRHQQGL RPFTVLSCDN
210 220 230 240 250
MQKNGSITRH MLESFARLRN PELAKWIAEQ GAFPNAMVDR ITPQTSPTDK
260 270 280 290 300
KALAETIGIE DSWPVVTEPF MQWVLEDQFS DGRPPFEKAG AQVVKNVHDV
310 320 330 340 350
EQFEKHKLRL LNGSHSAIGY AGQMAGFEYV HEVMEHPLYN RFVWQMMQEE
360 370 380 390 400
VKPLLPEIPG VDIDEYCKTL MERFSNPTIM DQLPRICLNA SGKIPQFIMP
410 420 430 440 450
SIAEAIWVTG PFRRLCFVAA AWFRYLNGID DSGKTFNVDD PMREELQAKA
460 470 480 490 500
RAGGTNPAEL LNVKSLFGDD LRSDKRFLQE ITTAMEAIAR DGIMKTMPKY

VD
Length:502
Mass (Da):56,515
Last modified:October 17, 2006 - v1
Checksum:iCF961F095B9A5226
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476595 Genomic DNA. Translation: EAU37947.1.
RefSeqiXP_001208555.1. XM_001208555.1.

Genome annotation databases

EnsemblFungiiCADATEAT00000339; CADATEAP00000339; CADATEAG00000339.
GeneIDi4316123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476595 Genomic DNA. Translation: EAU37947.1 .
RefSeqi XP_001208555.1. XM_001208555.1.

3D structure databases

ProteinModelPortali Q0CYP4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00000339.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00000339 ; CADATEAP00000339 ; CADATEAG00000339 .
GeneIDi 4316123.

Phylogenomic databases

eggNOGi COG0246.
HOGENOMi HOG000202982.
OMAi PWELMKI.
OrthoDBi EOG7PCJRT.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view ]
PRINTSi PR00084. MTLDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiM2DH_ASPTN
AccessioniPrimary (citable) accession number: Q0CYP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 17, 2006
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3