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Q0CYP4 (M2DH_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannitol 2-dehydrogenase

Short name=M2DH
Short name=MDH
EC=1.1.1.67
Gene names
ORF Names:ATEG_01190
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway By similarity.

Catalytic activity

D-mannitol + NAD+ = D-fructose + NADH.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol 2-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502Mannitol 2-dehydrogenase
PRO_0000371543

Regions

Nucleotide binding37 – 4812NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0CYP4 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: CF961F095B9A5226

FASTA50256,515
        10         20         30         40         50         60 
MAPLKLNSRN LAQIFAAGKD RVKVPTYQRG SAVKEGIVHV GVGGFHRAHL AVYVDQLMQN 

        70         80         90        100        110        120 
HGVNDYAICG VGLQPFDAAM RDALRSQDHL YTVIERSAKG SFAHVVGSIN SYLFAPDNRE 

       130        140        150        160        170        180 
AVIAKMAHPD THIVSLTITE SGYYYNENTH ELQAEHPDIQ FDLDPANEKT PRTTFGFLYA 

       190        200        210        220        230        240 
ALARRHQQGL RPFTVLSCDN MQKNGSITRH MLESFARLRN PELAKWIAEQ GAFPNAMVDR 

       250        260        270        280        290        300 
ITPQTSPTDK KALAETIGIE DSWPVVTEPF MQWVLEDQFS DGRPPFEKAG AQVVKNVHDV 

       310        320        330        340        350        360 
EQFEKHKLRL LNGSHSAIGY AGQMAGFEYV HEVMEHPLYN RFVWQMMQEE VKPLLPEIPG 

       370        380        390        400        410        420 
VDIDEYCKTL MERFSNPTIM DQLPRICLNA SGKIPQFIMP SIAEAIWVTG PFRRLCFVAA 

       430        440        450        460        470        480 
AWFRYLNGID DSGKTFNVDD PMREELQAKA RAGGTNPAEL LNVKSLFGDD LRSDKRFLQE 

       490        500 
ITTAMEAIAR DGIMKTMPKY VD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476595 Genomic DNA. Translation: EAU37947.1.
RefSeqXP_001208555.1. XM_001208555.1.

3D structure databases

ProteinModelPortalQ0CYP4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33178.CADATEAP00000339.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADATEAT00000339; CADATEAP00000339; CADATEAG00000339.
GeneID4316123.

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHOG000202982.
OMAPWELMKI.
OrthoDBEOG7PCJRT.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
ProtoNetSearch...

Entry information

Entry nameM2DH_ASPTN
AccessionPrimary (citable) accession number: Q0CYP4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families