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Q0CYP4

- M2DH_ASPTN

UniProt

Q0CYP4 - M2DH_ASPTN

Protein

Mannitol 2-dehydrogenase

Gene

ATEG_01190

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.By similarity

    Catalytic activityi

    D-mannitol + NAD+ = D-fructose + NADH.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi37 – 4812NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. mannitol 2-dehydrogenase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannitol 2-dehydrogenase (EC:1.1.1.67)
    Short name:
    M2DH
    Short name:
    MDH
    Gene namesi
    ORF Names:ATEG_01190
    OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
    Taxonomic identifieri341663 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000007963: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Mannitol 2-dehydrogenasePRO_0000371543Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi33178.CADATEAP00000339.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0CYP4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mannitol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0246.
    HOGENOMiHOG000202982.
    OMAiPWELMKI.
    OrthoDBiEOG7PCJRT.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view]
    PRINTSiPR00084. MTLDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0CYP4-1 [UniParc]FASTAAdd to Basket

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    MAPLKLNSRN LAQIFAAGKD RVKVPTYQRG SAVKEGIVHV GVGGFHRAHL    50
    AVYVDQLMQN HGVNDYAICG VGLQPFDAAM RDALRSQDHL YTVIERSAKG 100
    SFAHVVGSIN SYLFAPDNRE AVIAKMAHPD THIVSLTITE SGYYYNENTH 150
    ELQAEHPDIQ FDLDPANEKT PRTTFGFLYA ALARRHQQGL RPFTVLSCDN 200
    MQKNGSITRH MLESFARLRN PELAKWIAEQ GAFPNAMVDR ITPQTSPTDK 250
    KALAETIGIE DSWPVVTEPF MQWVLEDQFS DGRPPFEKAG AQVVKNVHDV 300
    EQFEKHKLRL LNGSHSAIGY AGQMAGFEYV HEVMEHPLYN RFVWQMMQEE 350
    VKPLLPEIPG VDIDEYCKTL MERFSNPTIM DQLPRICLNA SGKIPQFIMP 400
    SIAEAIWVTG PFRRLCFVAA AWFRYLNGID DSGKTFNVDD PMREELQAKA 450
    RAGGTNPAEL LNVKSLFGDD LRSDKRFLQE ITTAMEAIAR DGIMKTMPKY 500
    VD 502
    Length:502
    Mass (Da):56,515
    Last modified:October 17, 2006 - v1
    Checksum:iCF961F095B9A5226
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476595 Genomic DNA. Translation: EAU37947.1.
    RefSeqiXP_001208555.1. XM_001208555.1.

    Genome annotation databases

    EnsemblFungiiCADATEAT00000339; CADATEAP00000339; CADATEAG00000339.
    GeneIDi4316123.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476595 Genomic DNA. Translation: EAU37947.1 .
    RefSeqi XP_001208555.1. XM_001208555.1.

    3D structure databases

    ProteinModelPortali Q0CYP4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33178.CADATEAP00000339.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADATEAT00000339 ; CADATEAP00000339 ; CADATEAG00000339 .
    GeneIDi 4316123.

    Phylogenomic databases

    eggNOGi COG0246.
    HOGENOMi HOG000202982.
    OMAi PWELMKI.
    OrthoDBi EOG7PCJRT.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00084. MTLDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NIH 2624 / FGSC A1156.

    Entry informationi

    Entry nameiM2DH_ASPTN
    AccessioniPrimary (citable) accession number: Q0CYP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3