Q0CXS6 (MTLD_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase
Short name=M1PDH
Short name=MPD
Short name=MPDH
EC=1.1.1.17

Gene names

Name:	mpdA
ORF Names:	ATEG_01508

Organism

Aspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]

Taxonomic identifier

341663 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.
Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000371524
Regions
	Nucleotide binding	5 – 16	12	NAD By similarity
Sites
	Active site	213	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0CXS6 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: F9A1A47CE4A697AC	FASTA	388	42,864
	10 20 30 40 50 60 MGKKAIQFGG GNIGRGFVAE FLHEAGYEVV FVDVMDAVVS ALQTTPSYNV TEVSKDGENT 70 80 90 100 110 120 KTISNYRAIN SKTNESDAVK EIATADVVTC AVGPNILKFI APLIAKGIDA RTESKPVAVI 130 140 150 160 170 180 ACENAIGATD TLHGFIKEHT PKDRLDTLYD RARFANSAID RIVPNQPPNS GLNVRIEKFY 190 200 210 220 230 240 EWAVEQTPFG SFGHPDIPAI HWVDNLEPYI ERKLFTVNTG HATTAYYGHL RGKKMIADAL 250 260 270 280 290 300 ADDEIRSMVH KVLDETASLI VSKHGIPEDE QKEYVDTIIG RMSNPYLEDN IERVGRAPLR 310 320 330 340 350 360 KLSRKERFIG PASQLAERGQ KFDALVDAIE MALRFQNVPG DQESADLAQI LKQKSSEDAT 370 380 SELTGLEKDH PLYSPVLERV AKVQQDTK

References

[1]

"Annotation of the Aspergillus terreus NIH2624 genome." Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K. , Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J., Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W., Nierman W.C., Milne T., Madden K. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NIH 2624 / FGSC A1156.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH476595 Genomic DNA. Translation: EAU38265.1.
RefSeq	XP_001208873.1. XM_001208873.1.
3D structure databases
ProteinModelPortal	Q0CXS6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADATEAT00002661; CADATEAP00002661; CADATEAG00002661.
GeneID	4315529.
Phylogenomic databases
GeneTree	EFGT00050000004394.
OrthoDB	EOG469V3C.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_ASPTN

Accession

Primary (citable) accession number: Q0CXS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	October 17, 2006
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program