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Q0CXB1

- DAPB_ASPTN

UniProt

Q0CXB1 - DAPB_ASPTN

Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei752 – 7521Charge relay systemPROSITE-ProRule annotation
    Active sitei829 – 8291Charge relay systemPROSITE-ProRule annotation
    Active sitei862 – 8621Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:dapB
    ORF Names:ATEG_01673
    OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
    Taxonomic identifieri341663 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000007963: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 914914Probable dipeptidyl-aminopeptidase BPRO_0000412139Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi638 – 6381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi806 – 8061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi33178.CADATEAP00002893.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0CXB1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8989CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini111 – 914804VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei90 – 11021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000189891.
    OMAiETKFWYQ.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0CXB1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKSEADEDA QFLPMNRPRS SSAASQTSSD SGLSVESALI RNSTYGKTPD    50
    EAYNPAGDPR YRDIEDGEAE SDQPFLPSRK GSGARARRVF WGLLLLCLAG 100
    WVLAFVLFLI QGRSGYSATS EELQQHEADS SAGVTSDGKP VTLKQVLSGD 150
    WLPRSHGIAW IAGPDGEDGL LVEAGEDGGE GFLRVKDIRA RHGDDAGTLK 200
    SRVLMKKSTF YAGQRSILTR LTWPSPDLKK VLVLSDYEKN WRHSYTGLYW 250
    IFDVDSQTAE PLDPDVPEGR VQLASWSPNS DAVVFVRDNN MFLRKLSSDK 300
    VVPITKDGGK DLFYGVPDWV YEEEVLSGNS ATWWSNDAKY VAFLRTNEST 350
    VPEYPVQYFL SRPSGKKPLP GLEDYPDVRQ IKYPKAGAPN PVVNLQFYNV 400
    EKNEVFSVEV PDDFADDDRI IIEVLWAAES NVLVRATNRE SDVLKIFLID 450
    TESRTGKMVR LEDIVGLDGG WVEPSQSTRF IPADPAAGRP NDGYIDTVIH 500
    DGYDHLAYFT PLDNPEPIML TTGEWEVVEA PTAVDLRRGL VYFVATKEAP 550
    TQRHVYQVQL DGSNLKPLTD TSKPGYYHVS FSDGTAYALL SYQGPSIPWQ 600
    AIINTEGDDV VFEETIEENP ELARMVETYA IPSKVFSNIT IDGFTLQMVE 650
    RRPPHFNPHK KYPVLFFLYG GPGSQTVDRK FTIDFQSYVA SNLGYIVVTL 700
    DGRGTGFIGR EARCIIRGNL GYYEAHDQIT AAKMFAEKSY VDESRMAIWG 750
    WSYGGFMTLK TLEQDAGQTF QYGMAVAPVT DWRFYDSIYT ERYMHTPQHN 800
    PSGYDNSSIT DMAALEENVR FLVMHGASDD NVHLQNTLTL IDKLDLSNVQ 850
    NYDVHFYPDS DHSIFFHNAH YMVYERLSNW LVNAFNGEWH RIAAPVPDNS 900
    MWQRFKRALP VFVH 914
    Length:914
    Mass (Da):102,747
    Last modified:October 17, 2006 - v1
    Checksum:i549E8ABBD3DE5314
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476595 Genomic DNA. Translation: EAU38430.1.
    RefSeqiXP_001209038.1. XM_001209038.1.

    Genome annotation databases

    EnsemblFungiiCADATEAT00002893; CADATEAP00002893; CADATEAG00002893.
    GeneIDi4315814.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476595 Genomic DNA. Translation: EAU38430.1 .
    RefSeqi XP_001209038.1. XM_001209038.1.

    3D structure databases

    ProteinModelPortali Q0CXB1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33178.CADATEAP00002893.

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADATEAT00002893 ; CADATEAP00002893 ; CADATEAG00002893 .
    GeneIDi 4315814.

    Phylogenomic databases

    HOGENOMi HOG000189891.
    OMAi ETKFWYQ.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NIH 2624 / FGSC A1156.

    Entry informationi

    Entry nameiDAPB_ASPTN
    AccessioniPrimary (citable) accession number: Q0CXB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3