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Q0CXB1

- DAPB_ASPTN

UniProt

Q0CXB1 - DAPB_ASPTN

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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei752 – 7521Charge relay systemPROSITE-ProRule annotation
Active sitei829 – 8291Charge relay systemPROSITE-ProRule annotation
Active sitei862 – 8621Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:ATEG_01673
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8989CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei90 – 11021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini111 – 914804VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 914914Probable dipeptidyl-aminopeptidase BPRO_0000412139Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi638 – 6381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi806 – 8061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00002893.

Structurei

3D structure databases

ProteinModelPortaliQ0CXB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891.
OMAiETKFWYQ.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0CXB1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKSEADEDA QFLPMNRPRS SSAASQTSSD SGLSVESALI RNSTYGKTPD
60 70 80 90 100
EAYNPAGDPR YRDIEDGEAE SDQPFLPSRK GSGARARRVF WGLLLLCLAG
110 120 130 140 150
WVLAFVLFLI QGRSGYSATS EELQQHEADS SAGVTSDGKP VTLKQVLSGD
160 170 180 190 200
WLPRSHGIAW IAGPDGEDGL LVEAGEDGGE GFLRVKDIRA RHGDDAGTLK
210 220 230 240 250
SRVLMKKSTF YAGQRSILTR LTWPSPDLKK VLVLSDYEKN WRHSYTGLYW
260 270 280 290 300
IFDVDSQTAE PLDPDVPEGR VQLASWSPNS DAVVFVRDNN MFLRKLSSDK
310 320 330 340 350
VVPITKDGGK DLFYGVPDWV YEEEVLSGNS ATWWSNDAKY VAFLRTNEST
360 370 380 390 400
VPEYPVQYFL SRPSGKKPLP GLEDYPDVRQ IKYPKAGAPN PVVNLQFYNV
410 420 430 440 450
EKNEVFSVEV PDDFADDDRI IIEVLWAAES NVLVRATNRE SDVLKIFLID
460 470 480 490 500
TESRTGKMVR LEDIVGLDGG WVEPSQSTRF IPADPAAGRP NDGYIDTVIH
510 520 530 540 550
DGYDHLAYFT PLDNPEPIML TTGEWEVVEA PTAVDLRRGL VYFVATKEAP
560 570 580 590 600
TQRHVYQVQL DGSNLKPLTD TSKPGYYHVS FSDGTAYALL SYQGPSIPWQ
610 620 630 640 650
AIINTEGDDV VFEETIEENP ELARMVETYA IPSKVFSNIT IDGFTLQMVE
660 670 680 690 700
RRPPHFNPHK KYPVLFFLYG GPGSQTVDRK FTIDFQSYVA SNLGYIVVTL
710 720 730 740 750
DGRGTGFIGR EARCIIRGNL GYYEAHDQIT AAKMFAEKSY VDESRMAIWG
760 770 780 790 800
WSYGGFMTLK TLEQDAGQTF QYGMAVAPVT DWRFYDSIYT ERYMHTPQHN
810 820 830 840 850
PSGYDNSSIT DMAALEENVR FLVMHGASDD NVHLQNTLTL IDKLDLSNVQ
860 870 880 890 900
NYDVHFYPDS DHSIFFHNAH YMVYERLSNW LVNAFNGEWH RIAAPVPDNS
910
MWQRFKRALP VFVH
Length:914
Mass (Da):102,747
Last modified:October 17, 2006 - v1
Checksum:i549E8ABBD3DE5314
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476595 Genomic DNA. Translation: EAU38430.1.
RefSeqiXP_001209038.1. XM_001209038.1.

Genome annotation databases

EnsemblFungiiCADATEAT00002893; CADATEAP00002893; CADATEAG00002893.
GeneIDi4315814.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476595 Genomic DNA. Translation: EAU38430.1 .
RefSeqi XP_001209038.1. XM_001209038.1.

3D structure databases

ProteinModelPortali Q0CXB1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00002893.

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00002893 ; CADATEAP00002893 ; CADATEAG00002893 .
GeneIDi 4315814.

Phylogenomic databases

HOGENOMi HOG000189891.
OMAi ETKFWYQ.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiDAPB_ASPTN
AccessioniPrimary (citable) accession number: Q0CXB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3