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Q0CXB1 (DAPB_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:dapB
ORF Names:ATEG_01673
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length914 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 914914Probable dipeptidyl-aminopeptidase B
PRO_0000412139

Regions

Topological domain1 – 8989Cytoplasmic Potential
Transmembrane90 – 11021Helical; Signal-anchor for type II membrane protein; Potential
Topological domain111 – 914804Vacuolar Potential

Sites

Active site7521Charge relay system By similarity
Active site8291Charge relay system By similarity
Active site8621Charge relay system By similarity

Amino acid modifications

Glycosylation3471N-linked (GlcNAc...) Potential
Glycosylation6381N-linked (GlcNAc...) Potential
Glycosylation8061N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q0CXB1 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 549E8ABBD3DE5314

FASTA914102,747
        10         20         30         40         50         60 
MGKSEADEDA QFLPMNRPRS SSAASQTSSD SGLSVESALI RNSTYGKTPD EAYNPAGDPR 

        70         80         90        100        110        120 
YRDIEDGEAE SDQPFLPSRK GSGARARRVF WGLLLLCLAG WVLAFVLFLI QGRSGYSATS 

       130        140        150        160        170        180 
EELQQHEADS SAGVTSDGKP VTLKQVLSGD WLPRSHGIAW IAGPDGEDGL LVEAGEDGGE 

       190        200        210        220        230        240 
GFLRVKDIRA RHGDDAGTLK SRVLMKKSTF YAGQRSILTR LTWPSPDLKK VLVLSDYEKN 

       250        260        270        280        290        300 
WRHSYTGLYW IFDVDSQTAE PLDPDVPEGR VQLASWSPNS DAVVFVRDNN MFLRKLSSDK 

       310        320        330        340        350        360 
VVPITKDGGK DLFYGVPDWV YEEEVLSGNS ATWWSNDAKY VAFLRTNEST VPEYPVQYFL 

       370        380        390        400        410        420 
SRPSGKKPLP GLEDYPDVRQ IKYPKAGAPN PVVNLQFYNV EKNEVFSVEV PDDFADDDRI 

       430        440        450        460        470        480 
IIEVLWAAES NVLVRATNRE SDVLKIFLID TESRTGKMVR LEDIVGLDGG WVEPSQSTRF 

       490        500        510        520        530        540 
IPADPAAGRP NDGYIDTVIH DGYDHLAYFT PLDNPEPIML TTGEWEVVEA PTAVDLRRGL 

       550        560        570        580        590        600 
VYFVATKEAP TQRHVYQVQL DGSNLKPLTD TSKPGYYHVS FSDGTAYALL SYQGPSIPWQ 

       610        620        630        640        650        660 
AIINTEGDDV VFEETIEENP ELARMVETYA IPSKVFSNIT IDGFTLQMVE RRPPHFNPHK 

       670        680        690        700        710        720 
KYPVLFFLYG GPGSQTVDRK FTIDFQSYVA SNLGYIVVTL DGRGTGFIGR EARCIIRGNL 

       730        740        750        760        770        780 
GYYEAHDQIT AAKMFAEKSY VDESRMAIWG WSYGGFMTLK TLEQDAGQTF QYGMAVAPVT 

       790        800        810        820        830        840 
DWRFYDSIYT ERYMHTPQHN PSGYDNSSIT DMAALEENVR FLVMHGASDD NVHLQNTLTL 

       850        860        870        880        890        900 
IDKLDLSNVQ NYDVHFYPDS DHSIFFHNAH YMVYERLSNW LVNAFNGEWH RIAAPVPDNS 

       910 
MWQRFKRALP VFVH 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476595 Genomic DNA. Translation: EAU38430.1.
RefSeqXP_001209038.1. XM_001209038.1.

3D structure databases

ProteinModelPortalQ0CXB1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33178.CADATEAP00002893.

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADATEAT00002893; CADATEAP00002893; CADATEAG00002893.
GeneID4315814.

Phylogenomic databases

HOGENOMHOG000189891.
OMAETKFWYQ.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
PROSITEPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_ASPTN
AccessionPrimary (citable) accession number: Q0CXB1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries