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Q0CXB1

- DAPB_ASPTN

UniProt

Q0CXB1 - DAPB_ASPTN

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Protein

Probable dipeptidyl-aminopeptidase B

Gene
dapB, ATEG_01673
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei752 – 7521Charge relay system By similarity
Active sitei829 – 8291Charge relay system By similarity
Active sitei862 – 8621Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:ATEG_01673
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8989Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei90 – 11021Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini111 – 914804Vacuolar Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 914914Probable dipeptidyl-aminopeptidase BPRO_0000412139Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi347 – 3471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi638 – 6381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi806 – 8061N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00002893.

Structurei

3D structure databases

ProteinModelPortaliQ0CXB1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891.
OMAiETKFWYQ.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0CXB1-1 [UniParc]FASTAAdd to Basket

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MGKSEADEDA QFLPMNRPRS SSAASQTSSD SGLSVESALI RNSTYGKTPD    50
EAYNPAGDPR YRDIEDGEAE SDQPFLPSRK GSGARARRVF WGLLLLCLAG 100
WVLAFVLFLI QGRSGYSATS EELQQHEADS SAGVTSDGKP VTLKQVLSGD 150
WLPRSHGIAW IAGPDGEDGL LVEAGEDGGE GFLRVKDIRA RHGDDAGTLK 200
SRVLMKKSTF YAGQRSILTR LTWPSPDLKK VLVLSDYEKN WRHSYTGLYW 250
IFDVDSQTAE PLDPDVPEGR VQLASWSPNS DAVVFVRDNN MFLRKLSSDK 300
VVPITKDGGK DLFYGVPDWV YEEEVLSGNS ATWWSNDAKY VAFLRTNEST 350
VPEYPVQYFL SRPSGKKPLP GLEDYPDVRQ IKYPKAGAPN PVVNLQFYNV 400
EKNEVFSVEV PDDFADDDRI IIEVLWAAES NVLVRATNRE SDVLKIFLID 450
TESRTGKMVR LEDIVGLDGG WVEPSQSTRF IPADPAAGRP NDGYIDTVIH 500
DGYDHLAYFT PLDNPEPIML TTGEWEVVEA PTAVDLRRGL VYFVATKEAP 550
TQRHVYQVQL DGSNLKPLTD TSKPGYYHVS FSDGTAYALL SYQGPSIPWQ 600
AIINTEGDDV VFEETIEENP ELARMVETYA IPSKVFSNIT IDGFTLQMVE 650
RRPPHFNPHK KYPVLFFLYG GPGSQTVDRK FTIDFQSYVA SNLGYIVVTL 700
DGRGTGFIGR EARCIIRGNL GYYEAHDQIT AAKMFAEKSY VDESRMAIWG 750
WSYGGFMTLK TLEQDAGQTF QYGMAVAPVT DWRFYDSIYT ERYMHTPQHN 800
PSGYDNSSIT DMAALEENVR FLVMHGASDD NVHLQNTLTL IDKLDLSNVQ 850
NYDVHFYPDS DHSIFFHNAH YMVYERLSNW LVNAFNGEWH RIAAPVPDNS 900
MWQRFKRALP VFVH 914
Length:914
Mass (Da):102,747
Last modified:October 17, 2006 - v1
Checksum:i549E8ABBD3DE5314
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476595 Genomic DNA. Translation: EAU38430.1.
RefSeqiXP_001209038.1. XM_001209038.1.

Genome annotation databases

EnsemblFungiiCADATEAT00002893; CADATEAP00002893; CADATEAG00002893.
GeneIDi4315814.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476595 Genomic DNA. Translation: EAU38430.1 .
RefSeqi XP_001209038.1. XM_001209038.1.

3D structure databases

ProteinModelPortali Q0CXB1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00002893.

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00002893 ; CADATEAP00002893 ; CADATEAG00002893 .
GeneIDi 4315814.

Phylogenomic databases

HOGENOMi HOG000189891.
OMAi ETKFWYQ.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiDAPB_ASPTN
AccessioniPrimary (citable) accession number: Q0CXB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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