Q0CXB1 (DAPB_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable dipeptidyl-aminopeptidase B
Short name=DPAP B
EC=3.4.14.5

Gene names

Name:	dapB
ORF Names:	ATEG_01673

Organism

Aspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]

Taxonomic identifier

341663 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Aspergillus terreus

Protein attributes

Sequence length	914 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.
Catalytic activity	Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Subcellular location	Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.
Sequence similarities	Belongs to the peptidase S9B family.

Ontologies

Keywords
Cellular component	Membrane Vacuole
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Aminopeptidase Hydrolase Protease Serine protease
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW vacuolar membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 914	914	Probable dipeptidyl-aminopeptidase B		PRO_0000412139
Regions
	Topological domain	1 – 89	89	Cytoplasmic Potential
	Transmembrane	90 – 110	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	111 – 914	804	Vacuolar Potential
Sites
	Active site	752	1	Charge relay system By similarity
	Active site	829	1	Charge relay system By similarity
	Active site	862	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	347	1	N-linked (GlcNAc...) Potential
	Glycosylation	638	1	N-linked (GlcNAc...) Potential
	Glycosylation	806	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0CXB1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 549E8ABBD3DE5314	FASTA	914	102,747
	10 20 30 40 50 60 MGKSEADEDA QFLPMNRPRS SSAASQTSSD SGLSVESALI RNSTYGKTPD EAYNPAGDPR 70 80 90 100 110 120 YRDIEDGEAE SDQPFLPSRK GSGARARRVF WGLLLLCLAG WVLAFVLFLI QGRSGYSATS 130 140 150 160 170 180 EELQQHEADS SAGVTSDGKP VTLKQVLSGD WLPRSHGIAW IAGPDGEDGL LVEAGEDGGE 190 200 210 220 230 240 GFLRVKDIRA RHGDDAGTLK SRVLMKKSTF YAGQRSILTR LTWPSPDLKK VLVLSDYEKN 250 260 270 280 290 300 WRHSYTGLYW IFDVDSQTAE PLDPDVPEGR VQLASWSPNS DAVVFVRDNN MFLRKLSSDK 310 320 330 340 350 360 VVPITKDGGK DLFYGVPDWV YEEEVLSGNS ATWWSNDAKY VAFLRTNEST VPEYPVQYFL 370 380 390 400 410 420 SRPSGKKPLP GLEDYPDVRQ IKYPKAGAPN PVVNLQFYNV EKNEVFSVEV PDDFADDDRI 430 440 450 460 470 480 IIEVLWAAES NVLVRATNRE SDVLKIFLID TESRTGKMVR LEDIVGLDGG WVEPSQSTRF 490 500 510 520 530 540 IPADPAAGRP NDGYIDTVIH DGYDHLAYFT PLDNPEPIML TTGEWEVVEA PTAVDLRRGL 550 560 570 580 590 600 VYFVATKEAP TQRHVYQVQL DGSNLKPLTD TSKPGYYHVS FSDGTAYALL SYQGPSIPWQ 610 620 630 640 650 660 AIINTEGDDV VFEETIEENP ELARMVETYA IPSKVFSNIT IDGFTLQMVE RRPPHFNPHK 670 680 690 700 710 720 KYPVLFFLYG GPGSQTVDRK FTIDFQSYVA SNLGYIVVTL DGRGTGFIGR EARCIIRGNL 730 740 750 760 770 780 GYYEAHDQIT AAKMFAEKSY VDESRMAIWG WSYGGFMTLK TLEQDAGQTF QYGMAVAPVT 790 800 810 820 830 840 DWRFYDSIYT ERYMHTPQHN PSGYDNSSIT DMAALEENVR FLVMHGASDD NVHLQNTLTL 850 860 870 880 890 900 IDKLDLSNVQ NYDVHFYPDS DHSIFFHNAH YMVYERLSNW LVNAFNGEWH RIAAPVPDNS 910 MWQRFKRALP VFVH

References

[1]

"Annotation of the Aspergillus terreus NIH2624 genome." Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K. , Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J., Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W., Nierman W.C., Milne T., Madden K. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NIH 2624 / FGSC A1156.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH476595 Genomic DNA. Translation: EAU38430.1.
RefSeq	XP_001209038.1. XM_001209038.1.
3D structure databases
ProteinModelPortal	Q0CXB1.
ModBase	Search...
Protein-protein interaction databases
STRING	33178.CADATEAP00002893.
Protein family/group databases
MEROPS	S09.006.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADATEAT00002893; CADATEAP00002893; CADATEAG00002893.
GeneID	4315814.
Phylogenomic databases
HOGENOM	HOG000189891.
OrthoDB	EOG4Q885J.
Family and domain databases
InterPro	IPR002471. Pept_S9_AS. IPR001375. Peptidase_S9. IPR002469. Peptidase_S9B. [Graphical view]
Pfam	PF00930. DPPIV_N. 1 hit. PF00326. Peptidase_S9. 1 hit. [Graphical view]
PROSITE	PS00708. PRO_ENDOPEP_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_ASPTN

Accession

Primary (citable) accession number: Q0CXB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	October 17, 2006
Last modified:	April 3, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program