ID   EIF3C_ASPTN             Reviewed;         864 AA.
AC   Q0CVT0;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002};
DE            Short=eIF3c {ECO:0000255|HAMAP-Rule:MF_03002};
DE   AltName: Full=Eukaryotic translation initiation factor 3 93 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
DE            Short=eIF3 p93 {ECO:0000255|HAMAP-Rule:MF_03002};
DE   AltName: Full=Translation initiation factor eIF3, p93 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
GN   Name=nip1; ORFNames=ATEG_02204;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03002}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03002}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP-
CC       Rule:MF_03002}.
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DR   EMBL; CH476596; EAU37166.1; -; Genomic_DNA.
DR   RefSeq; XP_001211382.1; XM_001211382.1.
DR   AlphaFoldDB; Q0CVT0; -.
DR   SMR; Q0CVT0; -.
DR   STRING; 341663.Q0CVT0; -.
DR   EnsemblFungi; EAU37166; EAU37166; ATEG_02204.
DR   GeneID; 4316925; -.
DR   VEuPathDB; FungiDB:ATEG_02204; -.
DR   eggNOG; KOG1076; Eukaryota.
DR   HOGENOM; CLU_004304_0_2_1; -.
DR   OMA; FRCGLIK; -.
DR   OrthoDB; 5482362at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR   GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:EnsemblFungi.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_03002; eIF3c; 1.
DR   InterPro; IPR027516; EIF3C.
DR   InterPro; IPR008905; EIF3C_N_dom.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13937; EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED; 1.
DR   PANTHER; PTHR13937:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED; 1.
DR   Pfam; PF05470; eIF-3c_N; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..864
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   C"
FT                   /id="PRO_0000364277"
FT   DOMAIN          602..776
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          1..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          815..864
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..51
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   864 AA;  97317 MW;  D59B6A138A64DAA2 CRC64;
     MSRFFARGGS DSESSSEDEQ ELYSDREEEE QFSDSEEESS EAESSEEESS DDEGAGASRF
     LKNVSESEES EDEERVTVVK SAKDKRLDEL EGIIKAIENA EKINDWAVIS SEFDKLNRQI
     VKVTQAGPTP KIYIQTVADL EDFVNETIAK QKSSNKKMNA SNAKGFNAVK QRIKKNNKEY
     ATLIEKYRAD KDGFMAGGDE EPKPVISAPR ISKVERVEAP VAVTATADDD GFATVGRGGK
     TLQYTPESIL KHLRVIVESR GKKNTDRFEQ IRTMEKLLEV AQNPYQRIRI YLTLISTRFD
     LTSSSSANYM SVDQWKLAQQ EFSTLLSVLE SNREYVVTEG AEEWEDDEKQ PQVAAGETLH
     VPGSIVSYVE RLDDELTRSL QQIDPHTAEY IERLSDEKEL YTNLVRTQVY AEALTTSEKS
     DPRQDSLNRV IMRRLEHIYF KPAQVVTILE EGTWKSLPSN LASDITPRAN SGEVTSLVQT
     LCNYLFRHSD GILRARAMLC QIYFLALHDQ YYRSRDLMLM SHLTENIANF DVSTQILFNR
     TLVQIGLCAF RAGLVYEAQN TLSEVCGSGR QKELLAQGII LQRYSTVSPE QERLERQRQL
     PFHMHINLEL LECIYLTSSM FLEVPLMAQT SSSPEMKRRV ISKTFRRMLD YNERQVFTGP
     AENTRDGVIM SAKFLAAGDW KKAAEMLNSI KIWDLMPQPE KIKEMLSQQI QEEGLRTYLF
     TYAPFYDSVS IATLSNMFEL PEKKIQAIIS RMISHEELAA ALDQVNNAIV FRKGVELSRL
     QSQIVTLADK SMNLLEANEK TLEQRTQGMA NAFQRDQGAG ARGGRGAGRG GQARGGPRFP
     GGQQGRRPGG QQFSGGALGG AIKA
//