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Protein

Eukaryotic translation initiation factor 3 subunit C

Gene

nip1

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit CUniRule annotation
Short name:
eIF3cUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 93 kDa subunit homologUniRule annotation
Short name:
eIF3 p93UniRule annotation
Translation initiation factor eIF3, p93 subunit homologUniRule annotation
Gene namesi
Name:nip1
ORF Names:ATEG_02204
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_02204

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003642771 – 864Eukaryotic translation initiation factor 3 subunit CAdd BLAST864

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00000001

Structurei

3D structure databases

ProteinModelPortaliQ0CVT0
SMRiQ0CVT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini602 – 776PCIPROSITE-ProRule annotationAdd BLAST175

Sequence similaritiesi

Belongs to the eIF-3 subunit C family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000029414
OMAiVVMHRSE
OrthoDBiEOG092C17F5

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_03002 eIF3c, 1 hit
InterProiView protein in InterPro
IPR027516 EIF3C
IPR008905 EIF3C_N_dom
IPR000717 PCI_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05470 eIF-3c_N, 1 hit
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

Q0CVT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFFARGGS DSESSSEDEQ ELYSDREEEE QFSDSEEESS EAESSEEESS
60 70 80 90 100
DDEGAGASRF LKNVSESEES EDEERVTVVK SAKDKRLDEL EGIIKAIENA
110 120 130 140 150
EKINDWAVIS SEFDKLNRQI VKVTQAGPTP KIYIQTVADL EDFVNETIAK
160 170 180 190 200
QKSSNKKMNA SNAKGFNAVK QRIKKNNKEY ATLIEKYRAD KDGFMAGGDE
210 220 230 240 250
EPKPVISAPR ISKVERVEAP VAVTATADDD GFATVGRGGK TLQYTPESIL
260 270 280 290 300
KHLRVIVESR GKKNTDRFEQ IRTMEKLLEV AQNPYQRIRI YLTLISTRFD
310 320 330 340 350
LTSSSSANYM SVDQWKLAQQ EFSTLLSVLE SNREYVVTEG AEEWEDDEKQ
360 370 380 390 400
PQVAAGETLH VPGSIVSYVE RLDDELTRSL QQIDPHTAEY IERLSDEKEL
410 420 430 440 450
YTNLVRTQVY AEALTTSEKS DPRQDSLNRV IMRRLEHIYF KPAQVVTILE
460 470 480 490 500
EGTWKSLPSN LASDITPRAN SGEVTSLVQT LCNYLFRHSD GILRARAMLC
510 520 530 540 550
QIYFLALHDQ YYRSRDLMLM SHLTENIANF DVSTQILFNR TLVQIGLCAF
560 570 580 590 600
RAGLVYEAQN TLSEVCGSGR QKELLAQGII LQRYSTVSPE QERLERQRQL
610 620 630 640 650
PFHMHINLEL LECIYLTSSM FLEVPLMAQT SSSPEMKRRV ISKTFRRMLD
660 670 680 690 700
YNERQVFTGP AENTRDGVIM SAKFLAAGDW KKAAEMLNSI KIWDLMPQPE
710 720 730 740 750
KIKEMLSQQI QEEGLRTYLF TYAPFYDSVS IATLSNMFEL PEKKIQAIIS
760 770 780 790 800
RMISHEELAA ALDQVNNAIV FRKGVELSRL QSQIVTLADK SMNLLEANEK
810 820 830 840 850
TLEQRTQGMA NAFQRDQGAG ARGGRGAGRG GQARGGPRFP GGQQGRRPGG
860
QQFSGGALGG AIKA
Length:864
Mass (Da):97,317
Last modified:October 17, 2006 - v1
Checksum:iD59B6A138A64DAA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476596 Genomic DNA Translation: EAU37166.1
RefSeqiXP_001211382.1, XM_001211382.1

Genome annotation databases

EnsemblFungiiCADATEAT00000001; CADATEAP00000001; CADATEAG00000001
GeneIDi4316925

Similar proteinsi

Entry informationi

Entry nameiEIF3C_ASPTN
AccessioniPrimary (citable) accession number: Q0CVT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health