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Q0CUG5

- MANA2_ASPTN

UniProt

Q0CUG5 - MANA2_ASPTN

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Protein

Probable mannan endo-1,4-beta-mannosidase A-2

Gene
manA-2, man1-2, ATEG_02669
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans By similarity.

Catalytic activityi

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei213 – 2131Proton donor By similarity
Active sitei321 – 3211Nucleophile By similarity

GO - Molecular functioni

  1. mannan endo-1,4-beta-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannan endo-1,4-beta-mannosidase A-2 (EC:3.2.1.78)
Alternative name(s):
Endo-beta-1,4-mannanase A-2
Gene namesi
Name:manA-2
Synonyms:man1-2
ORF Names:ATEG_02669
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 396375Probable mannan endo-1,4-beta-mannosidase A-2PRO_0000393704Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi270 – 2701N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ0CUG5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3934.
HOGENOMiHOG000169951.
OMAiLWITSHA.
OrthoDBiEOG7M3J90.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CUG5-1 [UniParc]FASTAAdd to Basket

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MKVPRLLLAL GGLASIHIAS ALPQGAVERD MHATSAVVHG GNVKTKFPST    50
TGLKFTIDGE TGYFAGSNSY WIGFLTNNAD VDLVFQHMKE SGLKILRVWG 100
FNDVNTKPAT GTVWYQLHAN GTSTINTGPD GLQRLDYVVH SAERHGIKLI 150
INFVNNWNDY GGINSYLQAY GGASNEDFYN SEPMQKAYRA YIKEVVSRYI 200
DSPAVFAWEL ANEPRCKGCD TSVLHSWIEK TSRYIKSLDK KHMVTTGEEG 250
FGLDLMSDGS YPFTYVEGGN FTDTLSIPTI DFGTFHLYPS SWGTTNDWGN 300
LWVEAHGAAC KAAGKPRLFE EYGVTADHCA LEKPWQTTAL KTKGVSGDLY 350
WQYGDTLSTG PSPDDGNTFY YGTDEFDCLV SDHVAAIDEM EKHGRH 396
Length:396
Mass (Da):43,756
Last modified:April 20, 2010 - v2
Checksum:iD326B27A4DADC65C
GO

Sequence cautioni

The sequence EAU37631.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476596 Genomic DNA. Translation: EAU37631.1. Different initiation.
RefSeqiXP_001211847.1. XM_001211847.1.

Genome annotation databases

GeneIDi4317245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476596 Genomic DNA. Translation: EAU37631.1 . Different initiation.
RefSeqi XP_001211847.1. XM_001211847.1.

3D structure databases

ProteinModelPortali Q0CUG5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4317245.

Phylogenomic databases

eggNOGi COG3934.
HOGENOMi HOG000169951.
OMAi LWITSHA.
OrthoDBi EOG7M3J90.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiMANA2_ASPTN
AccessioniPrimary (citable) accession number: Q0CUG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 19, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi