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Q0CUG5 (MANA2_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable mannan endo-1,4-beta-mannosidase A-2

EC=3.2.1.78
Alternative name(s):
Endo-beta-1,4-mannanase A-2
Gene names
Name:manA-2
Synonyms:man1-2
ORF Names:ATEG_02669
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans By similarity.

Catalytic activity

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 5 (cellulase A) family.

Sequence caution

The sequence EAU37631.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmannan endo-1,4-beta-mannosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 396375Probable mannan endo-1,4-beta-mannosidase A-2
PRO_0000393704

Sites

Active site2131Proton donor By similarity
Active site3211Nucleophile By similarity

Amino acid modifications

Glycosylation1201N-linked (GlcNAc...) Potential
Glycosylation2701N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q0CUG5 [UniParc].

Last modified April 20, 2010. Version 2.
Checksum: D326B27A4DADC65C

FASTA39643,756
        10         20         30         40         50         60 
MKVPRLLLAL GGLASIHIAS ALPQGAVERD MHATSAVVHG GNVKTKFPST TGLKFTIDGE 

        70         80         90        100        110        120 
TGYFAGSNSY WIGFLTNNAD VDLVFQHMKE SGLKILRVWG FNDVNTKPAT GTVWYQLHAN 

       130        140        150        160        170        180 
GTSTINTGPD GLQRLDYVVH SAERHGIKLI INFVNNWNDY GGINSYLQAY GGASNEDFYN 

       190        200        210        220        230        240 
SEPMQKAYRA YIKEVVSRYI DSPAVFAWEL ANEPRCKGCD TSVLHSWIEK TSRYIKSLDK 

       250        260        270        280        290        300 
KHMVTTGEEG FGLDLMSDGS YPFTYVEGGN FTDTLSIPTI DFGTFHLYPS SWGTTNDWGN 

       310        320        330        340        350        360 
LWVEAHGAAC KAAGKPRLFE EYGVTADHCA LEKPWQTTAL KTKGVSGDLY WQYGDTLSTG 

       370        380        390 
PSPDDGNTFY YGTDEFDCLV SDHVAAIDEM EKHGRH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476596 Genomic DNA. Translation: EAU37631.1. Different initiation.
RefSeqXP_001211847.1. XM_001211847.1.

3D structure databases

ProteinModelPortalQ0CUG5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4317245.

Phylogenomic databases

eggNOGCOG3934.
HOGENOMHOG000169951.
OMALWITSHA.
OrthoDBEOG7M3J90.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMANA2_ASPTN
AccessionPrimary (citable) accession number: Q0CUG5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 19, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries