SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0CT71

- TRMB_ASPTN

UniProt

Q0CT71 - TRMB_ASPTN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trm8, ATEG_03113
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei224 – 2241S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Active sitei227 – 2271 By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
Transfer RNA methyltransferase 8
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trm8
ORF Names:ATEG_03113
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000370589Add
BLAST

Interactioni

Subunit structurei

Forms a complex with trm82 By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi33178.CADATEAP00008291.

Structurei

3D structure databases

ProteinModelPortaliQ0CT71.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 1252S-adenosyl-L-methionine binding By similarity
Regioni204 – 2052S-adenosyl-L-methionine binding By similarity
Regioni318 – 3203S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000260965.
OMAiHEDESNA.
OrthoDBiEOG708W9T.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0CT71-1 [UniParc]FASTAAdd to Basket

« Hide

MGNSRNKRGK REANRQRTVE ALARAQSGAD TGAALQLPQK KFYRQRAHAN    50
PFSDHQLKYP LSPAHMDWAS HYPAFENPDP AQTNLGGFRK LLKDVEVVDI 100
GCGFGGLLIG LAPLLPETLI VGMEIRIQVL DYVNTRIQAL RTQQRHFKLK 150
SAGGGGSDAA PESPAAPPTP SEAASPDSTT PSEQQAPTTL VPGGFQNISA 200
IRSNTMKFFP NFFGRGQLSK IFICFPDPHF KARKHKMRII SETLNAEYAY 250
ALRPGGLLYT ITDVEEYHHW ILRHFREPEV DGAVPCDDGA DGIKELFERV 300
SDEELQQDPC VEVMREATEE GKKVSRNKGN KYVAVFRRKA DPEWPA 346
Length:346
Mass (Da):38,508
Last modified:October 17, 2006 - v1
Checksum:iC25E452C8D22DCBE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476597 Genomic DNA. Translation: EAU36387.1.
RefSeqiXP_001212291.1. XM_001212291.1.

Genome annotation databases

EnsemblFungiiCADATEAT00008291; CADATEAP00008291; CADATEAG00008291.
GeneIDi4318068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476597 Genomic DNA. Translation: EAU36387.1 .
RefSeqi XP_001212291.1. XM_001212291.1.

3D structure databases

ProteinModelPortali Q0CT71.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00008291.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00008291 ; CADATEAP00008291 ; CADATEAG00008291 .
GeneIDi 4318068.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000260965.
OMAi HEDESNA.
OrthoDBi EOG708W9T.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 3 hits.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 2 hits.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiTRMB_ASPTN
AccessioniPrimary (citable) accession number: Q0CT71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi