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Q0CT71 (TRMB_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA (guanine-N(7)-)-methyltransferase

EC=2.1.1.33
Alternative name(s):
Transfer RNA methyltransferase 8
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene names
Name:trm8
ORF Names:ATEG_03113
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity. HAMAP-Rule MF_03055

Catalytic activity

S-adenosyl-L-methionine + guanine46 in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine46 in tRNA. HAMAP-Rule MF_03055

Pathway

tRNA modification; N(7)-methylguanine-tRNA biosynthesis. HAMAP-Rule MF_03055

Subunit structure

Forms a complex with trm82 By similarity. HAMAP-Rule MF_03055

Subcellular location

Nucleus By similarity HAMAP-Rule MF_03055.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentNucleus
   LigandRNA-binding
S-adenosyl-L-methionine
tRNA-binding
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346tRNA (guanine-N(7)-)-methyltransferase HAMAP-Rule MF_03055
PRO_0000370589

Regions

Region124 – 1252S-adenosyl-L-methionine binding By similarity
Region204 – 2052S-adenosyl-L-methionine binding By similarity
Region318 – 3203S-adenosyl-L-methionine binding By similarity

Sites

Active site2271 By similarity
Binding site1011S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site2241S-adenosyl-L-methionine; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0CT71 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: C25E452C8D22DCBE

FASTA34638,508
        10         20         30         40         50         60 
MGNSRNKRGK REANRQRTVE ALARAQSGAD TGAALQLPQK KFYRQRAHAN PFSDHQLKYP 

        70         80         90        100        110        120 
LSPAHMDWAS HYPAFENPDP AQTNLGGFRK LLKDVEVVDI GCGFGGLLIG LAPLLPETLI 

       130        140        150        160        170        180 
VGMEIRIQVL DYVNTRIQAL RTQQRHFKLK SAGGGGSDAA PESPAAPPTP SEAASPDSTT 

       190        200        210        220        230        240 
PSEQQAPTTL VPGGFQNISA IRSNTMKFFP NFFGRGQLSK IFICFPDPHF KARKHKMRII 

       250        260        270        280        290        300 
SETLNAEYAY ALRPGGLLYT ITDVEEYHHW ILRHFREPEV DGAVPCDDGA DGIKELFERV 

       310        320        330        340 
SDEELQQDPC VEVMREATEE GKKVSRNKGN KYVAVFRRKA DPEWPA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476597 Genomic DNA. Translation: EAU36387.1.
RefSeqXP_001212291.1. XM_001212291.1.

3D structure databases

ProteinModelPortalQ0CT71.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33178.CADATEAP00008291.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADATEAT00008291; CADATEAP00008291; CADATEAG00008291.
GeneID4318068.

Phylogenomic databases

eggNOGCOG0220.
HOGENOMHOG000260965.
OMARAHSNPI.
OrthoDBEOG708W9T.

Enzyme and pathway databases

UniPathwayUPA00989.

Family and domain databases

HAMAPMF_03055. tRNA_methyltr_TrmB_euk.
InterProIPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamPF02390. Methyltransf_4. 2 hits.
[Graphical view]
PROSITEPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRMB_ASPTN
AccessionPrimary (citable) accession number: Q0CT71
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways