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Protein

Mitochondrial glycine transporter

Gene

ATEG_03118

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:ATEG_03118
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_03118

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 50Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei78 – 104Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei136 – 161Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei189 – 212Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei236 – 262Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei291 – 309Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789291 – 329Mitochondrial glycine transporterAdd BLAST329

Proteomic databases

PRIDEiQ0CT66

Structurei

3D structure databases

ProteinModelPortaliQ0CT66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati19 – 103Solcar 1UniRule annotationAdd BLAST85
Repeati130 – 214Solcar 2UniRule annotationAdd BLAST85
Repeati232 – 316Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000006978
OMAiTVYEQMM
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 1 hit
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q0CT66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNAAYLAP QVKTTSTSSK TTFHFAAGLC SGLTSSILLQ PADLLKTRVQ
60 70 80 90 100
QSQQTAALLP TLKTILSSPH PIRSLWRGTL PSALRTGFGS ALYFTTLNAL
110 120 130 140 150
RQPLAQSAVL TGSNGSANKG TKSSSALPKL SNWANLGTGA VARVAAGFVM
160 170 180 190 200
MPVTVIKVRY ESDYYAYRSL YGAGRDIVRT EGFRGLFSGF GATAARDAPY
210 220 230 240 250
AGLYVLFYEQ LKRHLAGLKH SGTADQPLAA TSSSSINFIS GGLAAGLATT
260 270 280 290 300
ITNPFDAVKT RLQLMPGKYG NMMRAVKLMI QEDGVRSLFG GLGLRITRKA
310 320
LSSALAWTVY EELILRAEIR WAEKAHAHV
Length:329
Mass (Da):35,183
Last modified:October 17, 2006 - v1
Checksum:i95836351E73A9280
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476597 Genomic DNA Translation: EAU36392.1
RefSeqiXP_001212296.1, XM_001212296.1

Genome annotation databases

EnsemblFungiiCADATEAT00008296; CADATEAP00008296; CADATEAG00008296
GeneIDi4317801

Similar proteinsi

Entry informationi

Entry nameiS2538_ASPTN
AccessioniPrimary (citable) accession number: Q0CT66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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