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Protein

Probable ubiquitin carboxyl-terminal hydrolase creB

Gene

creB

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641NucleophilePROSITE-ProRule annotation
Active sitei419 – 4191Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.062.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase creB (EC:3.4.19.12)
Alternative name(s):
Carbon catabolite repression protein B
Deubiquitinating enzyme creB
Ubiquitin thioesterase creB
Ubiquitin-hydrolyzing enzyme creB
Ubiquitin-specific-processing protease creB
Gene namesi
Name:creB
ORF Names:ATEG_03173
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_03173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 768768Probable ubiquitin carboxyl-terminal hydrolase creBPRO_0000395683Add
BLAST

Interactioni

Subunit structurei

Interacts with creA, creC and qutD.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 468414USPAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili574 – 63360Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 325Poly-Pro

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000192482.
OrthoDBiEOG7TF7JV.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0CT11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLFRSFRR DAGATAPSVG ATPAKKEPPP PPMTPLEKML QDMGAIREDG
60 70 80 90 100
SDKFFGMENY GNTCYCNSIL QCLYYSVPFR EAVINYPTRT PIESLTAALA
110 120 130 140 150
ETLRYPNPNA HLEAEAQAEK QKAANAQRPG APPNQPQKPE DKDSPEYKKK
160 170 180 190 200
MALQTFPLLE TKNNAPSYGM SESLFTSLKD LFESVVGSQS RIGIVRPQHF
210 220 230 240 250
LDVLRREHEM FRTAMHQDAH EFLNLLLNEV VANVEAEALK QPSLERSLPP
260 270 280 290 300
AESSESVEHS GSSGSKTPNT TRWVHELFEG TLTSETQCLT CEKVSQRDEV
310 320 330 340 350
FLDLSVDLEQ HSSVTSCLRK FSAEEMLCER NKFHCDNCGG LQEAEKRMKI
360 370 380 390 400
KRLPRILALH LKRFKYTEDL QRLQKLFHRV VYPYHLRLFN TTDDAEDPDR
410 420 430 440 450
LYELYAVVVH IGGGPYHGHY VAIIKTQDRG WLLFDDEMVE PVDKNYVRNF
460 470 480 490 500
FGDKPGLACA YVLFYQETTL EAVLREQEQE NMDPALATTE TNDSLKQNGF
510 520 530 540 550
AQSPALGLVH SASQIPSHDE PHRLNSLKRA PTAPSLPTHY EHTDTNSAPS
560 570 580 590 600
IPKPAMAPPV PPIPETHSMP LSPKKSDLQS RKERAKEEKE RKAAEKERER
610 620 630 640 650
QRRKEQEATR KEQEARAREN QRREDAELKA ALEASRASKA DEDRRNQEGQ
660 670 680 690 700
KDRDPGRSGH GLSRLKRGSK SFSHRLSKDK DTRVPSSSNP GVPDPNSPPL
710 720 730 740 750
NNTVVTSEHQ EQEQQPPSDQ QPGASRLSKK HNLNDEERDA NKDPKQDKPG
760
HGKWRSFSLR KKSLGILS
Length:768
Mass (Da):86,786
Last modified:July 13, 2010 - v2
Checksum:i8ED13742A82E7656
GO

Sequence cautioni

The sequence EAU36447.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476597 Genomic DNA. Translation: EAU36447.1. Sequence problems.
RefSeqiXP_001212351.1. XM_001212351.1.

Genome annotation databases

GeneIDi4317779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476597 Genomic DNA. Translation: EAU36447.1. Sequence problems.
RefSeqiXP_001212351.1. XM_001212351.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC19.062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4317779.

Organism-specific databases

EuPathDBiFungiDB:ATEG_03173.

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000192482.
OrthoDBiEOG7TF7JV.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiCREB_ASPTN
AccessioniPrimary (citable) accession number: Q0CT11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: July 22, 2015
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.