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Protein

Probable ubiquitin carboxyl-terminal hydrolase creB

Gene

creB

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64NucleophilePROSITE-ProRule annotation1
Active sitei419Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC19.062.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase creB (EC:3.4.19.12)
Alternative name(s):
Carbon catabolite repression protein B
Deubiquitinating enzyme creB
Ubiquitin thioesterase creB
Ubiquitin-hydrolyzing enzyme creB
Ubiquitin-specific-processing protease creB
Gene namesi
Name:creB
ORF Names:ATEG_03173
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_03173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003956831 – 768Probable ubiquitin carboxyl-terminal hydrolase creBAdd BLAST768

Interactioni

Subunit structurei

Interacts with creA, creC and qutD.By similarity

Protein-protein interaction databases

STRINGi33178.CADATEAP00006518.

Structurei

3D structure databases

SMRiQ0CT11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 468USPAdd BLAST414

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili574 – 633Sequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 32Poly-Pro5

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000192482.
OrthoDBiEOG092C0UAA.

Family and domain databases

InterProiView protein in InterPro
IPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
PfamiView protein in Pfam
PF00443. UCH. 1 hit.
PROSITEiView protein in PROSITE
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0CT11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLFRSFRR DAGATAPSVG ATPAKKEPPP PPMTPLEKML QDMGAIREDG
60 70 80 90 100
SDKFFGMENY GNTCYCNSIL QCLYYSVPFR EAVINYPTRT PIESLTAALA
110 120 130 140 150
ETLRYPNPNA HLEAEAQAEK QKAANAQRPG APPNQPQKPE DKDSPEYKKK
160 170 180 190 200
MALQTFPLLE TKNNAPSYGM SESLFTSLKD LFESVVGSQS RIGIVRPQHF
210 220 230 240 250
LDVLRREHEM FRTAMHQDAH EFLNLLLNEV VANVEAEALK QPSLERSLPP
260 270 280 290 300
AESSESVEHS GSSGSKTPNT TRWVHELFEG TLTSETQCLT CEKVSQRDEV
310 320 330 340 350
FLDLSVDLEQ HSSVTSCLRK FSAEEMLCER NKFHCDNCGG LQEAEKRMKI
360 370 380 390 400
KRLPRILALH LKRFKYTEDL QRLQKLFHRV VYPYHLRLFN TTDDAEDPDR
410 420 430 440 450
LYELYAVVVH IGGGPYHGHY VAIIKTQDRG WLLFDDEMVE PVDKNYVRNF
460 470 480 490 500
FGDKPGLACA YVLFYQETTL EAVLREQEQE NMDPALATTE TNDSLKQNGF
510 520 530 540 550
AQSPALGLVH SASQIPSHDE PHRLNSLKRA PTAPSLPTHY EHTDTNSAPS
560 570 580 590 600
IPKPAMAPPV PPIPETHSMP LSPKKSDLQS RKERAKEEKE RKAAEKERER
610 620 630 640 650
QRRKEQEATR KEQEARAREN QRREDAELKA ALEASRASKA DEDRRNQEGQ
660 670 680 690 700
KDRDPGRSGH GLSRLKRGSK SFSHRLSKDK DTRVPSSSNP GVPDPNSPPL
710 720 730 740 750
NNTVVTSEHQ EQEQQPPSDQ QPGASRLSKK HNLNDEERDA NKDPKQDKPG
760
HGKWRSFSLR KKSLGILS
Length:768
Mass (Da):86,786
Last modified:July 13, 2010 - v2
Checksum:i8ED13742A82E7656
GO

Sequence cautioni

The sequence EAU36447 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476597 Genomic DNA. Translation: EAU36447.1. Sequence problems.
RefSeqiXP_001212351.1. XM_001212351.1.

Genome annotation databases

GeneIDi4317779.

Similar proteinsi

Entry informationi

Entry nameiCREB_ASPTN
AccessioniPrimary (citable) accession number: Q0CT11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: August 30, 2017
This is version 43 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families