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Q0CT11

- CREB_ASPTN

UniProt

Q0CT11 - CREB_ASPTN

Protein

Probable ubiquitin carboxyl-terminal hydrolase creB

Gene

creB

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 2 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei64 – 641NucleophilePROSITE-ProRule annotation
    Active sitei419 – 4191Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. carbon catabolite repression of transcription Source: UniProtKB
    2. ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase creB (EC:3.4.19.12)
    Alternative name(s):
    Carbon catabolite repression protein B
    Deubiquitinating enzyme creB
    Ubiquitin thioesterase creB
    Ubiquitin-hydrolyzing enzyme creB
    Ubiquitin-specific-processing protease creB
    Gene namesi
    Name:creB
    ORF Names:ATEG_03173
    OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
    Taxonomic identifieri341663 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000007963: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 768768Probable ubiquitin carboxyl-terminal hydrolase creBPRO_0000395683Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with creA, creC and qutD.By similarity

    Protein-protein interaction databases

    STRINGi33178.CADATEAP00006518.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 468414USPAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili574 – 63360Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi28 – 325Poly-Pro

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5533.
    HOGENOMiHOG000192482.
    OrthoDBiEOG7TF7JV.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0CT11-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSLFRSFRR DAGATAPSVG ATPAKKEPPP PPMTPLEKML QDMGAIREDG    50
    SDKFFGMENY GNTCYCNSIL QCLYYSVPFR EAVINYPTRT PIESLTAALA 100
    ETLRYPNPNA HLEAEAQAEK QKAANAQRPG APPNQPQKPE DKDSPEYKKK 150
    MALQTFPLLE TKNNAPSYGM SESLFTSLKD LFESVVGSQS RIGIVRPQHF 200
    LDVLRREHEM FRTAMHQDAH EFLNLLLNEV VANVEAEALK QPSLERSLPP 250
    AESSESVEHS GSSGSKTPNT TRWVHELFEG TLTSETQCLT CEKVSQRDEV 300
    FLDLSVDLEQ HSSVTSCLRK FSAEEMLCER NKFHCDNCGG LQEAEKRMKI 350
    KRLPRILALH LKRFKYTEDL QRLQKLFHRV VYPYHLRLFN TTDDAEDPDR 400
    LYELYAVVVH IGGGPYHGHY VAIIKTQDRG WLLFDDEMVE PVDKNYVRNF 450
    FGDKPGLACA YVLFYQETTL EAVLREQEQE NMDPALATTE TNDSLKQNGF 500
    AQSPALGLVH SASQIPSHDE PHRLNSLKRA PTAPSLPTHY EHTDTNSAPS 550
    IPKPAMAPPV PPIPETHSMP LSPKKSDLQS RKERAKEEKE RKAAEKERER 600
    QRRKEQEATR KEQEARAREN QRREDAELKA ALEASRASKA DEDRRNQEGQ 650
    KDRDPGRSGH GLSRLKRGSK SFSHRLSKDK DTRVPSSSNP GVPDPNSPPL 700
    NNTVVTSEHQ EQEQQPPSDQ QPGASRLSKK HNLNDEERDA NKDPKQDKPG 750
    HGKWRSFSLR KKSLGILS 768
    Length:768
    Mass (Da):86,786
    Last modified:July 13, 2010 - v2
    Checksum:i8ED13742A82E7656
    GO

    Sequence cautioni

    The sequence EAU36447.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476597 Genomic DNA. Translation: EAU36447.1. Sequence problems.
    RefSeqiXP_001212351.1. XM_001212351.1.

    Genome annotation databases

    GeneIDi4317779.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476597 Genomic DNA. Translation: EAU36447.1 . Sequence problems.
    RefSeqi XP_001212351.1. XM_001212351.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33178.CADATEAP00006518.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4317779.

    Phylogenomic databases

    eggNOGi COG5533.
    HOGENOMi HOG000192482.
    OrthoDBi EOG7TF7JV.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NIH 2624 / FGSC A1156.

    Entry informationi

    Entry nameiCREB_ASPTN
    AccessioniPrimary (citable) accession number: Q0CT11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 31 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3