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Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei280 – 2801PROSITE-ProRule annotation
Active sitei472 – 4721PROSITE-ProRule annotation
Active sitei534 – 5341PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:ATEG_03401
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_03401.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 138121By similarityPRO_0000407439Add
BLAST
Chaini139 – 557419Carboxypeptidase Y homolog APRO_0000407440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi193 ↔ 433By similarity
Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi327 ↔ 341By similarity
Disulfide bondi351 ↔ 374By similarity
Disulfide bondi358 ↔ 367By similarity
Disulfide bondi396 ↔ 403By similarity
Glycosylationi523 – 5231N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00006792.

Structurei

3D structure databases

ProteinModelPortaliQ0CSD3.
SMRiQ0CSD3. Positions 138-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000198296.
OMAiGQKEYAS.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CSD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLPATLLV GAATAAVPPF QQQFQQVLGI PQEEVEQAAP VAPSAPTTPK
60 70 80 90 100
PLQIFQDQLK SLSDEARKLW DEVSNFFPDS MDHNPVFSLP KKHTRRPDSH
110 120 130 140 150
WDHIVRGSDV QGVWVTGADG EKQREVDGKL EAYDLRVKKT DPSALGIDPG
160 170 180 190 200
VKQYTGYLDD NENDKHLFYW FFESRNDPEN DPVVLWLNGG PGCSSLTGLF
210 220 230 240 250
MELGPSSINE KIKPVYNEYS WNSNASVIFL DQPVNVGYSY SGSAVSDTVA
260 270 280 290 300
AGKDVYALLT LFFKQFPEYA KQDFHIAGES YAGHYIPVFA SEILSHKKRN
310 320 330 340 350
INLQSVLIGN GLTDGYTQYE YYRPMGCGEG GYPAVLDKGT CQSMDNALPR
360 370 380 390 400
CQSMIKSCYE SESSWVCIPA SIYCNNALIG PYQRTGQNVY DVRGKCEDES
410 420 430 440 450
NLCYKGMGYV SEYLNKAEVR QAVGAEVDGY DSCNFDINRN FLFHGDWMKP
460 470 480 490 500
YHRLVPGLLE QIPVLIYAGD ADYICNWLGN KAWTEALEWP GQKEYASAEM
510 520 530 540 550
EDLVIEQNAN TGKKIGQVKS HGNFTFMRIY GGGHMVPMDQ PESGLEFFNR

WLGGEWF
Length:557
Mass (Da):62,443
Last modified:October 17, 2006 - v1
Checksum:i5789C84F886F2EB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476597 Genomic DNA. Translation: EAU36675.1.
RefSeqiXP_001212579.1. XM_001212579.1.

Genome annotation databases

EnsemblFungiiCADATEAT00006792; CADATEAP00006792; CADATEAG00006792.
GeneIDi4317774.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476597 Genomic DNA. Translation: EAU36675.1.
RefSeqiXP_001212579.1. XM_001212579.1.

3D structure databases

ProteinModelPortaliQ0CSD3.
SMRiQ0CSD3. Positions 138-554.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi33178.CADATEAP00006792.

Protein family/group databases

MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADATEAT00006792; CADATEAP00006792; CADATEAG00006792.
GeneIDi4317774.

Organism-specific databases

EuPathDBiFungiDB:ATEG_03401.

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000198296.
OMAiGQKEYAS.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiCBPYA_ASPTN
AccessioniPrimary (citable) accession number: Q0CSD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: October 17, 2006
Last modified: May 27, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.