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Q0CSD3 (CBPYA_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase Y homolog A

EC=3.4.16.5
Gene names
Name:cpyA
ORF Names:ATEG_03401
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 138121 By similarity
PRO_0000407439
Chain139 – 557419Carboxypeptidase Y homolog A
PRO_0000407440

Sites

Active site2801 By similarity
Active site4721 By similarity
Active site5341 By similarity

Amino acid modifications

Glycosylation2241N-linked (GlcNAc...) Potential
Glycosylation5231N-linked (GlcNAc...) Potential
Disulfide bond193 ↔ 433 By similarity
Disulfide bond327 ↔ 341 By similarity
Disulfide bond351 ↔ 374 By similarity
Disulfide bond358 ↔ 367 By similarity
Disulfide bond396 ↔ 403 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0CSD3 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 5789C84F886F2EB9

FASTA55762,443
        10         20         30         40         50         60 
MRVLPATLLV GAATAAVPPF QQQFQQVLGI PQEEVEQAAP VAPSAPTTPK PLQIFQDQLK 

        70         80         90        100        110        120 
SLSDEARKLW DEVSNFFPDS MDHNPVFSLP KKHTRRPDSH WDHIVRGSDV QGVWVTGADG 

       130        140        150        160        170        180 
EKQREVDGKL EAYDLRVKKT DPSALGIDPG VKQYTGYLDD NENDKHLFYW FFESRNDPEN 

       190        200        210        220        230        240 
DPVVLWLNGG PGCSSLTGLF MELGPSSINE KIKPVYNEYS WNSNASVIFL DQPVNVGYSY 

       250        260        270        280        290        300 
SGSAVSDTVA AGKDVYALLT LFFKQFPEYA KQDFHIAGES YAGHYIPVFA SEILSHKKRN 

       310        320        330        340        350        360 
INLQSVLIGN GLTDGYTQYE YYRPMGCGEG GYPAVLDKGT CQSMDNALPR CQSMIKSCYE 

       370        380        390        400        410        420 
SESSWVCIPA SIYCNNALIG PYQRTGQNVY DVRGKCEDES NLCYKGMGYV SEYLNKAEVR 

       430        440        450        460        470        480 
QAVGAEVDGY DSCNFDINRN FLFHGDWMKP YHRLVPGLLE QIPVLIYAGD ADYICNWLGN 

       490        500        510        520        530        540 
KAWTEALEWP GQKEYASAEM EDLVIEQNAN TGKKIGQVKS HGNFTFMRIY GGGHMVPMDQ 

       550 
PESGLEFFNR WLGGEWF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476597 Genomic DNA. Translation: EAU36675.1.
RefSeqXP_001212579.1. XM_001212579.1.

3D structure databases

ProteinModelPortalQ0CSD3.
SMRQ0CSD3. Positions 138-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33178.CADATEAP00006792.

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADATEAT00006792; CADATEAP00006792; CADATEAG00006792.
GeneID4317774.

Phylogenomic databases

eggNOGCOG2939.
HOGENOMHOG000198296.
OMALEWEHGD.
OrthoDBEOG7XDBR1.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_ASPTN
AccessionPrimary (citable) accession number: Q0CSD3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: October 17, 2006
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries