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Q0CSD3

- CBPYA_ASPTN

UniProt

Q0CSD3 - CBPYA_ASPTN

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Protein
Carboxypeptidase Y homolog A
Gene
cpyA, ATEG_03401
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei280 – 2801 By similarity
Active sitei472 – 4721 By similarity
Active sitei534 – 5341 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:ATEG_03401
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Propeptidei18 – 138121 By similarity
PRO_0000407439Add
BLAST
Chaini139 – 557419Carboxypeptidase Y homolog A
PRO_0000407440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi193 ↔ 433 By similarity
Glycosylationi224 – 2241N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi327 ↔ 341 By similarity
Disulfide bondi351 ↔ 374 By similarity
Disulfide bondi358 ↔ 367 By similarity
Disulfide bondi396 ↔ 403 By similarity
Glycosylationi523 – 5231N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00006792.

Structurei

3D structure databases

ProteinModelPortaliQ0CSD3.
SMRiQ0CSD3. Positions 138-554.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000198296.
OMAiWPGQKEY.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CSD3-1 [UniParc]FASTAAdd to Basket

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MRVLPATLLV GAATAAVPPF QQQFQQVLGI PQEEVEQAAP VAPSAPTTPK    50
PLQIFQDQLK SLSDEARKLW DEVSNFFPDS MDHNPVFSLP KKHTRRPDSH 100
WDHIVRGSDV QGVWVTGADG EKQREVDGKL EAYDLRVKKT DPSALGIDPG 150
VKQYTGYLDD NENDKHLFYW FFESRNDPEN DPVVLWLNGG PGCSSLTGLF 200
MELGPSSINE KIKPVYNEYS WNSNASVIFL DQPVNVGYSY SGSAVSDTVA 250
AGKDVYALLT LFFKQFPEYA KQDFHIAGES YAGHYIPVFA SEILSHKKRN 300
INLQSVLIGN GLTDGYTQYE YYRPMGCGEG GYPAVLDKGT CQSMDNALPR 350
CQSMIKSCYE SESSWVCIPA SIYCNNALIG PYQRTGQNVY DVRGKCEDES 400
NLCYKGMGYV SEYLNKAEVR QAVGAEVDGY DSCNFDINRN FLFHGDWMKP 450
YHRLVPGLLE QIPVLIYAGD ADYICNWLGN KAWTEALEWP GQKEYASAEM 500
EDLVIEQNAN TGKKIGQVKS HGNFTFMRIY GGGHMVPMDQ PESGLEFFNR 550
WLGGEWF 557
Length:557
Mass (Da):62,443
Last modified:October 17, 2006 - v1
Checksum:i5789C84F886F2EB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476597 Genomic DNA. Translation: EAU36675.1.
RefSeqiXP_001212579.1. XM_001212579.1.

Genome annotation databases

EnsemblFungiiCADATEAT00006792; CADATEAP00006792; CADATEAG00006792.
GeneIDi4317774.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476597 Genomic DNA. Translation: EAU36675.1 .
RefSeqi XP_001212579.1. XM_001212579.1.

3D structure databases

ProteinModelPortali Q0CSD3.
SMRi Q0CSD3. Positions 138-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00006792.

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00006792 ; CADATEAP00006792 ; CADATEAG00006792 .
GeneIDi 4317774.

Phylogenomic databases

eggNOGi COG2939.
HOGENOMi HOG000198296.
OMAi WPGQKEY.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiCBPYA_ASPTN
AccessioniPrimary (citable) accession number: Q0CSD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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