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Q0CSD3

- CBPYA_ASPTN

UniProt

Q0CSD3 - CBPYA_ASPTN

Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei280 – 2801PROSITE-ProRule annotation
    Active sitei472 – 4721PROSITE-ProRule annotation
    Active sitei534 – 5341PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:cpyA
    ORF Names:ATEG_03401
    OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
    Taxonomic identifieri341663 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000007963: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 138121By similarityPRO_0000407439Add
    BLAST
    Chaini139 – 557419Carboxypeptidase Y homolog APRO_0000407440Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi193 ↔ 433By similarity
    Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi327 ↔ 341By similarity
    Disulfide bondi351 ↔ 374By similarity
    Disulfide bondi358 ↔ 367By similarity
    Disulfide bondi396 ↔ 403By similarity
    Glycosylationi523 – 5231N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Interactioni

    Protein-protein interaction databases

    STRINGi33178.CADATEAP00006792.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0CSD3.
    SMRiQ0CSD3. Positions 138-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2939.
    HOGENOMiHOG000198296.
    OMAiWPGQKEY.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0CSD3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVLPATLLV GAATAAVPPF QQQFQQVLGI PQEEVEQAAP VAPSAPTTPK    50
    PLQIFQDQLK SLSDEARKLW DEVSNFFPDS MDHNPVFSLP KKHTRRPDSH 100
    WDHIVRGSDV QGVWVTGADG EKQREVDGKL EAYDLRVKKT DPSALGIDPG 150
    VKQYTGYLDD NENDKHLFYW FFESRNDPEN DPVVLWLNGG PGCSSLTGLF 200
    MELGPSSINE KIKPVYNEYS WNSNASVIFL DQPVNVGYSY SGSAVSDTVA 250
    AGKDVYALLT LFFKQFPEYA KQDFHIAGES YAGHYIPVFA SEILSHKKRN 300
    INLQSVLIGN GLTDGYTQYE YYRPMGCGEG GYPAVLDKGT CQSMDNALPR 350
    CQSMIKSCYE SESSWVCIPA SIYCNNALIG PYQRTGQNVY DVRGKCEDES 400
    NLCYKGMGYV SEYLNKAEVR QAVGAEVDGY DSCNFDINRN FLFHGDWMKP 450
    YHRLVPGLLE QIPVLIYAGD ADYICNWLGN KAWTEALEWP GQKEYASAEM 500
    EDLVIEQNAN TGKKIGQVKS HGNFTFMRIY GGGHMVPMDQ PESGLEFFNR 550
    WLGGEWF 557
    Length:557
    Mass (Da):62,443
    Last modified:October 17, 2006 - v1
    Checksum:i5789C84F886F2EB9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476597 Genomic DNA. Translation: EAU36675.1.
    RefSeqiXP_001212579.1. XM_001212579.1.

    Genome annotation databases

    EnsemblFungiiCADATEAT00006792; CADATEAP00006792; CADATEAG00006792.
    GeneIDi4317774.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476597 Genomic DNA. Translation: EAU36675.1 .
    RefSeqi XP_001212579.1. XM_001212579.1.

    3D structure databases

    ProteinModelPortali Q0CSD3.
    SMRi Q0CSD3. Positions 138-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33178.CADATEAP00006792.

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADATEAT00006792 ; CADATEAP00006792 ; CADATEAG00006792 .
    GeneIDi 4317774.

    Phylogenomic databases

    eggNOGi COG2939.
    HOGENOMi HOG000198296.
    OMAi WPGQKEY.
    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NIH 2624 / FGSC A1156.

    Entry informationi

    Entry nameiCBPYA_ASPTN
    AccessioniPrimary (citable) accession number: Q0CSD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3