Q0CRI5 (KMO_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine 3-monooxygenase
EC=1.14.13.9

Alternative name(s):
Biosynthesis of nicotinic acid protein 4
Kynurenine 3-hydroxylase

Gene names

Name:	bna4
ORF Names:	ATEG_03699

Organism

Aspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]

Taxonomic identifier

341663 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Mitochondrion
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Kynurenine 3-monooxygenase		PRO_0000361923

Sequences

	Sequence		Length	Mass (Da)
	Q0CRI5 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 766B7A6D64BE7FAF	FASTA	500	56,617
	10 20 30 40 50 60 MAQSTKQKVV IVGAGPVGSL AALYAAARGD EVEVYELRGD LRDPSTIPLN FTKSINLALS 70 80 90 100 110 120 ERGINAMRHS NREEMIHKVL EEAIPMHGRM IHGRDDGKLW EAAQAYDVHG RYINAADRST 130 140 150 160 170 180 LNNALLDELE RTPNVNLFFN HKLTGADFRA NKAWFERRIP GESTSDRVEI QVNFDYLIGA 190 200 210 220 230 240 DGAHSASRYH MMKYARVDYQ QEYIDTLWCE FRIPPTDDGD FRISPNHLHI WPGKEFMFIA 250 260 270 280 290 300 LPSADKSFTC TLFAPAGHYA RLKSSPQNLL ESFDTHFPGV CPELITPKDL QEQFETNPHL 310 320 330 340 350 360 PLISIKCKPH HFDSSVVIVG DAAHAVLPFY GQGLNAGLED IRVLFEIMDK HGVYNPDISP 370 380 390 400 410 420 EMRTLSRQAA FQAYTDQRIA DAHAINDLSK QNYLEMRWGV KLPLYKLRKS IEETLDRYVP 430 440 450 460 470 480 SLGWQTQYAR VSFSNQRYSE VIKAVRRQGR LLGFGFISAI VSGVAVVGIL AWKRPREASV 490 500 LSVLKSSARQ LGDVWRSKFR

References

[1]

"Annotation of the Aspergillus terreus NIH2624 genome." Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K. , Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J., Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W., Nierman W.C., Milne T., Madden K. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NIH 2624 / FGSC A1156.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH476598 Genomic DNA. Translation: EAU35501.1.
RefSeq	XP_001212877.1. XM_001212877.1.
3D structure databases
ProteinModelPortal	Q0CRI5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADATEAT00009639; CADATEAP00009639; CADATEAG00009639.
GeneID	4318193.
Phylogenomic databases
GeneTree	EFGT00050000002229.
OrthoDB	EOG4QG0P2.
Family and domain databases
InterPro	IPR002938. mOase_FAD-bd. IPR003042. Rng_hydrolase-like. [Graphical view]
Pfam	PF01494. FAD_binding_3. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_ASPTN

Accession

Primary (citable) accession number: Q0CRI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	October 17, 2006
Last modified:	June 28, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program