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Protein

Probable glucan 1,3-beta-glucosidase A

Gene

exgA

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase (By similarity).By similarity

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei209Proton donorBy similarity1
Active sitei308NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase A (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase 1
Exo-1,3-beta-glucanase A
Gene namesi
Name:exgA
Synonyms:exg1
ORF Names:ATEG_03849
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_03849

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000039353122 – 416Probable glucan 1,3-beta-glucosidase AAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi290 ↔ 415By similarity
Disulfide bondi316 ↔ 341By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi33178.CADATEAP00008924

Structurei

3D structure databases

ProteinModelPortaliQ0CR35
SMRiQ0CR35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000114462
OMAiEGAPGWD
OrthoDBiEOG092C22A6

Family and domain databases

InterProiView protein in InterPro
IPR001547 Glyco_hydro_5
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00150 Cellulase, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CR35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYNLSKAVL ALSVLAASAD AAGIRLEKRA STFDYETEMV RGVCLGGWLV
60 70 80 90 100
LEPWLSPGLF DAAPDGAVDE WTYTEILGQD EAKARLIGHW DTFITEQDFF
110 120 130 140 150
DIAAAGMNHV RIPIGYWAVE ALPGDPYVDG QLEYLDRAIE WAGAAGLKVI
160 170 180 190 200
VDLHGAPGSQ NGFDNSGRKG AIQWGQGDTL GQTVNAFRKL AERYVPSSDV
210 220 230 240 250
VTAIEAVNEP FIPGGVNEDQ LKEYYQQAYD IVTQMSPDVD LVFSDGFINP
260 270 280 290 300
TPWNGFISDS GNIVMDNHHY EVFDINLLRM SVDDHVRSVC DFGRTQLAPA
310 320 330 340 350
TKPVVVGEWT GAMTDCARYL NGRGVGARYD GAMGGESVGD CGPFIQGSVS
360 370 380 390 400
DLSPDDQKNM RRFIEAQLDA WEMKSGWLFW NWKTEQGAPG WDMKDLLDNG
410
VFPFPLESRK YPGQCG
Length:416
Mass (Da):45,747
Last modified:October 17, 2006 - v1
Checksum:i24F9987F9D3BA259
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476598 Genomic DNA Translation: EAU35651.1
RefSeqiXP_001213027.1, XM_001213027.1

Genome annotation databases

EnsemblFungiiCADATEAT00008924; CADATEAP00008924; CADATEAG00008924
GeneIDi4318487

Similar proteinsi

Entry informationi

Entry nameiEXGA_ASPTN
AccessioniPrimary (citable) accession number: Q0CR35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: October 17, 2006
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health