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Q0CR35

- EXGA_ASPTN

UniProt

Q0CR35 - EXGA_ASPTN

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Protein

Probable glucan 1,3-beta-glucosidase A

Gene
exgA, exg1, ATEG_03849
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase By similarity.

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Cofactori

Manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei209 – 2091Proton donor By similarity
Active sitei308 – 3081Nucleophile By similarity

GO - Molecular functioni

  1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase A (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase 1
Exo-1,3-beta-glucanase A
Gene namesi
Name:exgA
Synonyms:exg1
ORF Names:ATEG_03849
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 416395Probable glucan 1,3-beta-glucosidase APRO_0000393531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi290 ↔ 415 By similarity
Disulfide bondi316 ↔ 341 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi33178.CADATEAP00008924.

Structurei

3D structure databases

ProteinModelPortaliQ0CR35.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2730.
HOGENOMiHOG000114462.
OMAiIINEPNT.
OrthoDBiEOG7JT75H.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CR35-1 [UniParc]FASTAAdd to Basket

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MLYNLSKAVL ALSVLAASAD AAGIRLEKRA STFDYETEMV RGVCLGGWLV    50
LEPWLSPGLF DAAPDGAVDE WTYTEILGQD EAKARLIGHW DTFITEQDFF 100
DIAAAGMNHV RIPIGYWAVE ALPGDPYVDG QLEYLDRAIE WAGAAGLKVI 150
VDLHGAPGSQ NGFDNSGRKG AIQWGQGDTL GQTVNAFRKL AERYVPSSDV 200
VTAIEAVNEP FIPGGVNEDQ LKEYYQQAYD IVTQMSPDVD LVFSDGFINP 250
TPWNGFISDS GNIVMDNHHY EVFDINLLRM SVDDHVRSVC DFGRTQLAPA 300
TKPVVVGEWT GAMTDCARYL NGRGVGARYD GAMGGESVGD CGPFIQGSVS 350
DLSPDDQKNM RRFIEAQLDA WEMKSGWLFW NWKTEQGAPG WDMKDLLDNG 400
VFPFPLESRK YPGQCG 416
Length:416
Mass (Da):45,747
Last modified:October 17, 2006 - v1
Checksum:i24F9987F9D3BA259
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476598 Genomic DNA. Translation: EAU35651.1.
RefSeqiXP_001213027.1. XM_001213027.1.

Genome annotation databases

EnsemblFungiiCADATEAT00008924; CADATEAP00008924; CADATEAG00008924.
GeneIDi4318487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476598 Genomic DNA. Translation: EAU35651.1 .
RefSeqi XP_001213027.1. XM_001213027.1.

3D structure databases

ProteinModelPortali Q0CR35.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00008924.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00008924 ; CADATEAP00008924 ; CADATEAG00008924 .
GeneIDi 4318487.

Phylogenomic databases

eggNOGi COG2730.
HOGENOMi HOG000114462.
OMAi IINEPNT.
OrthoDBi EOG7JT75H.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiEXGA_ASPTN
AccessioniPrimary (citable) accession number: Q0CR35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi