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Q0CQK1 (SSN3_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase ssn3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:ssn3
Synonyms:cdk8
ORF Names:ATEG_04033
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the srb8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Serine/threonine-protein kinase ssn3
PRO_0000312937

Regions

Domain49 – 377329Protein kinase
Nucleotide binding55 – 639ATP By similarity

Sites

Active site1811Proton acceptor By similarity
Binding site791ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0CQK1 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 802A04756FBAE615

FASTA43549,087
        10         20         30         40         50         60 
MYGRNFPFFN SLGGFYPRGN GFPLDAPSLD PRKPSGTGYT SKVRVRDKYR IVGFISSGTY 

        70         80         90        100        110        120 
GRVYKAIGKN GEKREFAIKK FKPDKEGEII QYTGLSQSAI REMSLCSELD HPNVVQLEEI 

       130        140        150        160        170        180 
ILEDKCIFMV FEYTEHDLLQ IIHHHTQPQR HAIPAPMVRS ILFQLLNGLL YLHTNWVLHR 

       190        200        210        220        230        240 
DLKPANILVT SSGAIRVGDL GLARLFYKPL NSLFSGDKVV VTIWYRAPEL LMGSRHYTPA 

       250        260        270        280        290        300 
VDLWAVGCIF AELLSLRPIF KGEEAKMDSK KTVPFQRNQM MKIIEIMGLP TKEIWPGITS 

       310        320        330        340        350        360 
MPEFSQLQSL AMSRAPHFNR SSNLENWYQS CLKNGGYSAN SSAGTPGADG FDLLSRLLEY 

       370        380        390        400        410        420 
DPTKRITARE ALEHPYFKNG GPISANCFEG FEGKYPHRRV TQDDNDIRSG SLPGTKRSGL 

       430 
PDDSLMGRAS KRIKE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476598 Genomic DNA. Translation: EAU35835.1.
RefSeqXP_001213211.1. XM_001213211.1.

3D structure databases

ProteinModelPortalQ0CQK1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33178.CADATEAP00009663.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADATEAT00009663; CADATEAP00009663; CADATEAG00009663.
GeneID4318303.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
OMAVSQDDND.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_ASPTN
AccessionPrimary (citable) accession number: Q0CQK1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families