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Protein

Serine/threonine-protein kinase ssn3

Gene

ssn3

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791ATPPROSITE-ProRule annotation
Active sitei181 – 1811Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi55 – 639ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ssn3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:ssn3
Synonyms:cdk8
ORF Names:ATEG_04033
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_04033.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Serine/threonine-protein kinase ssn3PRO_0000312937Add
BLAST

Interactioni

Subunit structurei

Component of the srb8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi33178.CADATEAP00009663.

Structurei

3D structure databases

ProteinModelPortaliQ0CQK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 377329Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
OMAiVSQDDND.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0CQK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGRNFPFFN SLGGFYPRGN GFPLDAPSLD PRKPSGTGYT SKVRVRDKYR
60 70 80 90 100
IVGFISSGTY GRVYKAIGKN GEKREFAIKK FKPDKEGEII QYTGLSQSAI
110 120 130 140 150
REMSLCSELD HPNVVQLEEI ILEDKCIFMV FEYTEHDLLQ IIHHHTQPQR
160 170 180 190 200
HAIPAPMVRS ILFQLLNGLL YLHTNWVLHR DLKPANILVT SSGAIRVGDL
210 220 230 240 250
GLARLFYKPL NSLFSGDKVV VTIWYRAPEL LMGSRHYTPA VDLWAVGCIF
260 270 280 290 300
AELLSLRPIF KGEEAKMDSK KTVPFQRNQM MKIIEIMGLP TKEIWPGITS
310 320 330 340 350
MPEFSQLQSL AMSRAPHFNR SSNLENWYQS CLKNGGYSAN SSAGTPGADG
360 370 380 390 400
FDLLSRLLEY DPTKRITARE ALEHPYFKNG GPISANCFEG FEGKYPHRRV
410 420 430
TQDDNDIRSG SLPGTKRSGL PDDSLMGRAS KRIKE
Length:435
Mass (Da):49,087
Last modified:October 17, 2006 - v1
Checksum:i802A04756FBAE615
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476598 Genomic DNA. Translation: EAU35835.1.
RefSeqiXP_001213211.1. XM_001213211.1.

Genome annotation databases

EnsemblFungiiCADATEAT00009663; CADATEAP00009663; CADATEAG00009663.
GeneIDi4318303.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476598 Genomic DNA. Translation: EAU35835.1.
RefSeqiXP_001213211.1. XM_001213211.1.

3D structure databases

ProteinModelPortaliQ0CQK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi33178.CADATEAP00009663.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADATEAT00009663; CADATEAP00009663; CADATEAG00009663.
GeneIDi4318303.

Organism-specific databases

EuPathDBiFungiDB:ATEG_04033.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
OMAiVSQDDND.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiSSN3_ASPTN
AccessioniPrimary (citable) accession number: Q0CQK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: April 29, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.