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Protein

Protein hir1

Gene

hir1

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.By similarity

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein hir1
Gene namesi
Name:hir1
ORF Names:ATEG_04180
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_04180

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002864041 – 999Protein hir1Add BLAST999

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00009500

Structurei

3D structure databases

ProteinModelPortaliQ0CQ54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 54WD 1Add BLAST40
Repeati69 – 108WD 2Add BLAST40
Repeati130 – 169WD 3Add BLAST40
Repeati172 – 211WD 4Add BLAST40
Repeati233 – 276WD 5Add BLAST44
Repeati279 – 339WD 6Add BLAST61
Repeati343 – 384WD 7Add BLAST42

Sequence similaritiesi

Belongs to the WD repeat HIR1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000208205
OMAiLLGPVHY
OrthoDBiEOG092C0UNU

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR031120 HIR1
IPR011494 Hira
IPR019015 HIRA_B_motif
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13831 PTHR13831, 1 hit
PfamiView protein in Pfam
PF07569 Hira, 1 hit
PF09453 HIRA_B, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q0CQ54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHIIKPVWLT HGGKLVVHDS SSSWHGPLTP TLLSTGERKD FEVYSCDVSP
60 70 80 90 100
DGSRLVTAAG DGYVRIWSTE AIRNTDDSSQ KPKQLASMSN HSGTIHTVRF
110 120 130 140 150
SPNGKYLASG ADDKIVCIYT LDANPPSHST FGWSYDSSIL VSVGLDSKVV
160 170 180 190 200
VWSGHTFEKL KTLSVHQSHV KGITFDPANK YFATASDDRT VKIFRFTSPA
210 220 230 240 250
PNSTAHDQMN NFVLETTISA PFQNSPLTAY FRRCSWSPDG MHIAAANAVN
260 270 280 290 300
GPVSSVAIIN RGSWDGDINL IGHEAPVEVC AFSPRLYSTQ PPNKQTPDNQ
310 320 330 340 350
GQAVTVIACA GGDKSLSIWI TTNPRPIVVA QELAAKSISD LAWSPDGTCL
360 370 380 390 400
YATALDGTIL AVRFEDGDLG YPMAMEENEK SLTKFGTNRR GAGITETTDG
410 420 430 440 450
LLLEEKSKAG ELKGVEGRMG ALMGDGHASA EATVNGKALS SNGAAPAQGT
460 470 480 490 500
SPTADAQKTQ TNGTTTPAAQ EADKPDPYQA KLERLKQRPT YTKDGKKRIA
510 520 530 540 550
PLLVSGAGAA ESSLPQARLM ASVSSQVKAD TPQSIVDLSK PFDGLPKGGL
560 570 580 590 600
AALLFGNKRK LAQLEGDEDG HVEKRVALAS QNGATPIMAN TPDGLLPAQP
610 620 630 640 650
QPPATGQQQT PEYIRPAVTN PCMAISQLRL AVPKVRSQIV RAIDSTGKPT
660 670 680 690 700
EPPGASSEAN KSRVDLVFEA RNPSPASLTG RAVDREPVRL TLFRGEQPLW
710 720 730 740 750
QDFLPRTVLL VTGNQSMWAA ACEDGSVYIW TPAGRRLVSA LVLEAQPVIL
760 770 780 790 800
ECNGPWILCI SAVGMCYVWN VKHLSSPHPP ISLQPVLDAA VHTLGAHPSS
810 820 830 840 850
APAITNARIN SEGRVIVALS NGEGYAYSPS MYTWQRMSEA WWAVGSQYWN
860 870 880 890 900
TTEAPVGNLQ STDSQDKDAK AAVSAGIIPF LERNTTNETL LRGRAYFLQR
910 920 930 940 950
LIKVLLSREG YESFESSVSI AHLENRLAAA LSLGAKEEFR LYLSMYAKRI
960 970 980 990
GAEGLKNKVE ELLKGLIGGK HRDLQRVTVP YAKLLGVVDE SEAGDAMET
Length:999
Mass (Da):107,339
Last modified:October 17, 2006 - v1
Checksum:iAA6AC51A5225F32F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476598 Genomic DNA Translation: EAU35982.1
RefSeqiXP_001213358.1, XM_001213358.1

Genome annotation databases

EnsemblFungiiCADATEAT00009500; CADATEAP00009500; CADATEAG00009500
GeneIDi4318578

Similar proteinsi

Entry informationi

Entry nameiHIR1_ASPTN
AccessioniPrimary (citable) accession number: Q0CQ54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 17, 2006
Last modified: April 25, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health