SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0CPB0

- KYNU1_ASPTN

UniProt

Q0CPB0 - KYNU1_ASPTN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Kynureninase 1
Gene
bna5-1, ATEG_04474
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471Pyridoxal phosphate; via amide nitrogen By similarity
Binding sitei148 – 1481Pyridoxal phosphate By similarity
Binding sitei232 – 2321Pyridoxal phosphate By similarity
Binding sitei261 – 2611Pyridoxal phosphate By similarity
Binding sitei264 – 2641Pyridoxal phosphate By similarity
Binding sitei286 – 2861Pyridoxal phosphate By similarity
Binding sitei326 – 3261Pyridoxal phosphate By similarity
Binding sitei354 – 3541Pyridoxal phosphate By similarity

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynureninase 1 (EC:3.7.1.3)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5-1
L-kynurenine hydrolase 1
Gene namesi
Name:bna5-1
ORF Names:ATEG_04474
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Kynureninase 1UniRule annotation
PRO_0000356971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei287 – 2871N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi33178.CADATEAP00009046.

Structurei

3D structure databases

ProteinModelPortaliQ0CPB0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni175 – 1784Pyridoxal phosphate binding By similarity

Sequence similaritiesi

Belongs to the kynureninase family.

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242438.
OMAiGLMNDIV.
OrthoDBiEOG7V1G0J.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0CPB0-1 [UniParc]FASTAAdd to Basket

« Hide

MGSRLHLRDI KHGPPLPYHD DIRAFTKEYA ESLDAQDPLR KFRDEFIIPS    50
KKDLKRTVLA ADENTDDSTD PRCIYLCGNS LGLQPRSTRK YIDRYLRTWA 100
IKGVTGHFTP HDDQLLPPFV DVDVAGAKLM APVVGALESE VAVMDTLTTN 150
LHLLMASFYR PTQERYKIII EGKAFPSDHY AVESQIRHHN REPSEAMVLI 200
EPEDPKHPIL TTDQILRVID ENASSAALIL LSAIQFYTGQ YFDIKTITAH 250
AQSKGIIVGW DCAHAAGNVD LQLHDWNVDF AAWCNYKYLN SGPGGMAGLF 300
VHERHGHVES KNGAQNEGFR PRLSGWWGGD KETRFLMDNN FRPQVGAAGF 350
QLSNPSVLDM NAVVASLEIF SRASMEKIRQ KSLHLTGYLE HLLVTYPLDA 400
PPEEKPFTII TPSNPAERGA QLSLRLGPGL LEKVLEVLEE QGVIIDERKP 450
DVIRVAPAPL YNTYAELSSS GIHIAYSSYN QYS 483
Length:483
Mass (Da):54,112
Last modified:October 17, 2006 - v1
Checksum:i6BCC62116EAB97BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476599 Genomic DNA. Translation: EAU34921.1.
RefSeqiXP_001213652.1. XM_001213652.1.

Genome annotation databases

EnsemblFungiiCADATEAT00009046; CADATEAP00009046; CADATEAG00009046.
GeneIDi4320432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476599 Genomic DNA. Translation: EAU34921.1 .
RefSeqi XP_001213652.1. XM_001213652.1.

3D structure databases

ProteinModelPortali Q0CPB0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00009046.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00009046 ; CADATEAP00009046 ; CADATEAG00009046 .
GeneIDi 4320432.

Phylogenomic databases

eggNOGi COG3844.
HOGENOMi HOG000242438.
OMAi GLMNDIV.
OrthoDBi EOG7V1G0J.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiKYNU1_ASPTN
AccessioniPrimary (citable) accession number: Q0CPB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi