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Q0CNC7

- NTE1_ASPTN

UniProt

Q0CNC7 - NTE1_ASPTN

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Protein
Lysophospholipase nte1
Gene
nte1, ATEG_04807
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1257 – 12571 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi685 – 804120cNMP 1
Add
BLAST
Nucleotide bindingi846 – 966121cNMP 2
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:ATEG_04807
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6969Cytoplasmic By similarity
Add
BLAST
Transmembranei70 – 9021Helical; Reviewed prediction
Add
BLAST
Topological domaini91 – 11222Lumenal By similarity
Add
BLAST
Transmembranei113 – 13321Helical; Reviewed prediction
Add
BLAST
Topological domaini134 – 15271394Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15271527Lysophospholipase nte1
PRO_0000295313Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00008780.

Structurei

3D structure databases

ProteinModelPortaliQ0CNC7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1224 – 1388165Patatin
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BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1255 – 12595GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 5242Ser-rich
Add
BLAST
Compositional biasi55 – 6410Poly-Pro

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0CNC7-1 [UniParc]FASTAAdd to Basket

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MADDGGPFPL SSSLLHASSS TTILESSSSS LLATSSPAIA ATFSSFSGRP     50
SSYLPPPPLP PPAPSTMVGW IGWVFSFVFQ VIPSILYWAI TFCTITLPTW 100
LFTLFSMSLT FTMNFTTLLL IALAIVSTVS WFIRYRFLNM YSRLPPEPQR 150
KEPQLDLFPD VQEGDSKPGL ANYLDEFLSA IKVFGYLERP VFHELTRTMQ 200
TRKLIAGETL LLEEEKGFCL VVDGLVQIFV KSIRDGKSPA DHELNLAGDD 250
STDEEGQNVD GRQGYQLLTE VKNGASMSSL FSILSLFTED IQLRTSESLS 300
SSVSSVGPNL ARVPDSSPSS PRGLVHSPVP VREPSESGHN LPTNGEFLPT 350
VPPLHLEESR GTPDHDHQPE SRTRPGKKRR KSVHPDIVAR AMVDTTIAII 400
PASAFRRLTR VYPRATAHIV QVILTRLQRV TFATAHSYLG LTNEVLGIEK 450
QMTKFTTYDL PNDMRGAALD RLKDKFIKER DRLGHEEVTK GIALHNPSAG 500
RRRRSSSFLR KEAALQARMA TTPRRPTATG SQENMSFHDR DAAGVSPGDL 550
LSTIQLSRFG PRYEHLAPKI YSPLAEKEQS PFRPPTMRGP ASPFHRKESL 600
DEDALFRESI LDCIMKALGL TSSTRDILRK SSHNSGDASP KLLSYDSRRQ 650
KAVFSNNAFG FIDPYEGSVD GETESMMSMS VTSAGGTSPI VNLREELRND 700
IEIVYFPQGS VLVEQGERHP GLYYVIDGFL DVGMPACDKG DDLVGATRPA 750
HGEEAFPTLK RTTTASSRTS SVAPGGSDSK RRRQSRKSLY LIKPGGIQGY 800
VGSVASYRSY TDVLAKTDVY VGFLPRASLE RIAERYPIAL LTLAKRLTSL 850
LPRLLLHIDF ALEWVQVNAG QVIYHQGDES DAIYLVLNGR LRSVLEGTDG 900
KMNVVGEYGQ GESVGELEVM TESTRPATLH AIRDTELAKF PRSLFNSLAQ 950
EHPGITIQVS KLIAQRMRDL VERPMTEKGA EHGAGSIKTA TSTVNLRTVS 1000
ILPVTAGVPV VEFGHRLLNA LHQIGVTNGV TSLNQAAILN HLGRHAFTKM 1050
GKLKLSQYLA DLEEKYGMVL YIADTNVNSP WTQTCITQAD CILLVGLAES 1100
TPSIGEYERF LLGMKTTSRK ELVLLHADRY CPPGLTRRWL KNRVWINGGH 1150
HHIQMGFRLT AEPSHPQTKR FGTVLKERVQ VIQAEIQKYT SRRIHQTALY 1200
SAQTPFKGDF HRLARRLCGR SVGLVLGGGG ARGIAQVGVI KALEEAGIPI 1250
DIIGGTSIGA FNGALYARDA DVVPMYGRAK KFAGRMGSMW RFALDLTYPT 1300
VSYTTGHEFN RGIFKTFGDS QIEDFWLEFY CNTTNISKSR PEYHSSGYVW 1350
RYVRASMTLA GLIPPICDEG SMLLDGGYID NLTVPHMKGL GADVIFAVDV 1400
GSIDDNTPQG YGDSLSGFWA TINRWNPFSS VPNPPTLSEI QARLAYVSSF 1450
ENLEQAKTTP GCLYMRPPID PYGTLDFGKF DEIYQVGYKY GKEYLEKLKN 1500
EGTLPLREET EEKKKLQRTL APRRASI 1527
Length:1,527
Mass (Da):168,858
Last modified:October 17, 2006 - v1
Checksum:iBD39EDE81FBB46C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476599 Genomic DNA. Translation: EAU35254.1.
RefSeqiXP_001213985.1. XM_001213985.1.

Genome annotation databases

EnsemblFungiiCADATEAT00008780; CADATEAP00008780; CADATEAG00008780.
GeneIDi4320057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476599 Genomic DNA. Translation: EAU35254.1 .
RefSeqi XP_001213985.1. XM_001213985.1.

3D structure databases

ProteinModelPortali Q0CNC7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00008780.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00008780 ; CADATEAP00008780 ; CADATEAG00008780 .
GeneIDi 4320057.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
OMAi SPWTQTC.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiNTE1_ASPTN
AccessioniPrimary (citable) accession number: Q0CNC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 17, 2006
Last modified: February 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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