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Q0CNC7

- NTE1_ASPTN

UniProt

Q0CNC7 - NTE1_ASPTN

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Protein

Lysophospholipase nte1

Gene

nte1

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1257 – 12571By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi685 – 804120cNMP 1Add
BLAST
Nucleotide bindingi846 – 966121cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:ATEG_04807
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15271527Lysophospholipase nte1PRO_0000295313Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00008780.

Structurei

3D structure databases

ProteinModelPortaliQ0CNC7.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6969CytoplasmicBy similarityAdd
BLAST
Topological domaini91 – 11222LumenalBy similarityAdd
BLAST
Topological domaini134 – 15271394CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei70 – 9021HelicalSequence AnalysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1224 – 1388165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1255 – 12595GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 5242Ser-richAdd
BLAST
Compositional biasi55 – 6410Poly-Pro

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0CNC7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADDGGPFPL SSSLLHASSS TTILESSSSS LLATSSPAIA ATFSSFSGRP
60 70 80 90 100
SSYLPPPPLP PPAPSTMVGW IGWVFSFVFQ VIPSILYWAI TFCTITLPTW
110 120 130 140 150
LFTLFSMSLT FTMNFTTLLL IALAIVSTVS WFIRYRFLNM YSRLPPEPQR
160 170 180 190 200
KEPQLDLFPD VQEGDSKPGL ANYLDEFLSA IKVFGYLERP VFHELTRTMQ
210 220 230 240 250
TRKLIAGETL LLEEEKGFCL VVDGLVQIFV KSIRDGKSPA DHELNLAGDD
260 270 280 290 300
STDEEGQNVD GRQGYQLLTE VKNGASMSSL FSILSLFTED IQLRTSESLS
310 320 330 340 350
SSVSSVGPNL ARVPDSSPSS PRGLVHSPVP VREPSESGHN LPTNGEFLPT
360 370 380 390 400
VPPLHLEESR GTPDHDHQPE SRTRPGKKRR KSVHPDIVAR AMVDTTIAII
410 420 430 440 450
PASAFRRLTR VYPRATAHIV QVILTRLQRV TFATAHSYLG LTNEVLGIEK
460 470 480 490 500
QMTKFTTYDL PNDMRGAALD RLKDKFIKER DRLGHEEVTK GIALHNPSAG
510 520 530 540 550
RRRRSSSFLR KEAALQARMA TTPRRPTATG SQENMSFHDR DAAGVSPGDL
560 570 580 590 600
LSTIQLSRFG PRYEHLAPKI YSPLAEKEQS PFRPPTMRGP ASPFHRKESL
610 620 630 640 650
DEDALFRESI LDCIMKALGL TSSTRDILRK SSHNSGDASP KLLSYDSRRQ
660 670 680 690 700
KAVFSNNAFG FIDPYEGSVD GETESMMSMS VTSAGGTSPI VNLREELRND
710 720 730 740 750
IEIVYFPQGS VLVEQGERHP GLYYVIDGFL DVGMPACDKG DDLVGATRPA
760 770 780 790 800
HGEEAFPTLK RTTTASSRTS SVAPGGSDSK RRRQSRKSLY LIKPGGIQGY
810 820 830 840 850
VGSVASYRSY TDVLAKTDVY VGFLPRASLE RIAERYPIAL LTLAKRLTSL
860 870 880 890 900
LPRLLLHIDF ALEWVQVNAG QVIYHQGDES DAIYLVLNGR LRSVLEGTDG
910 920 930 940 950
KMNVVGEYGQ GESVGELEVM TESTRPATLH AIRDTELAKF PRSLFNSLAQ
960 970 980 990 1000
EHPGITIQVS KLIAQRMRDL VERPMTEKGA EHGAGSIKTA TSTVNLRTVS
1010 1020 1030 1040 1050
ILPVTAGVPV VEFGHRLLNA LHQIGVTNGV TSLNQAAILN HLGRHAFTKM
1060 1070 1080 1090 1100
GKLKLSQYLA DLEEKYGMVL YIADTNVNSP WTQTCITQAD CILLVGLAES
1110 1120 1130 1140 1150
TPSIGEYERF LLGMKTTSRK ELVLLHADRY CPPGLTRRWL KNRVWINGGH
1160 1170 1180 1190 1200
HHIQMGFRLT AEPSHPQTKR FGTVLKERVQ VIQAEIQKYT SRRIHQTALY
1210 1220 1230 1240 1250
SAQTPFKGDF HRLARRLCGR SVGLVLGGGG ARGIAQVGVI KALEEAGIPI
1260 1270 1280 1290 1300
DIIGGTSIGA FNGALYARDA DVVPMYGRAK KFAGRMGSMW RFALDLTYPT
1310 1320 1330 1340 1350
VSYTTGHEFN RGIFKTFGDS QIEDFWLEFY CNTTNISKSR PEYHSSGYVW
1360 1370 1380 1390 1400
RYVRASMTLA GLIPPICDEG SMLLDGGYID NLTVPHMKGL GADVIFAVDV
1410 1420 1430 1440 1450
GSIDDNTPQG YGDSLSGFWA TINRWNPFSS VPNPPTLSEI QARLAYVSSF
1460 1470 1480 1490 1500
ENLEQAKTTP GCLYMRPPID PYGTLDFGKF DEIYQVGYKY GKEYLEKLKN
1510 1520
EGTLPLREET EEKKKLQRTL APRRASI
Length:1,527
Mass (Da):168,858
Last modified:October 17, 2006 - v1
Checksum:iBD39EDE81FBB46C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476599 Genomic DNA. Translation: EAU35254.1.
RefSeqiXP_001213985.1. XM_001213985.1.

Genome annotation databases

EnsemblFungiiCADATEAT00008780; CADATEAP00008780; CADATEAG00008780.
GeneIDi4320057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476599 Genomic DNA. Translation: EAU35254.1 .
RefSeqi XP_001213985.1. XM_001213985.1.

3D structure databases

ProteinModelPortali Q0CNC7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00008780.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00008780 ; CADATEAP00008780 ; CADATEAG00008780 .
GeneIDi 4320057.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
OMAi SPWTQTC.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiNTE1_ASPTN
AccessioniPrimary (citable) accession number: Q0CNC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3