Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q0CNC7

- NTE1_ASPTN

UniProt

Q0CNC7 - NTE1_ASPTN

Protein

Lysophospholipase nte1

Gene

nte1

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1257 – 12571By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi685 – 804120cNMP 1Add
    BLAST
    Nucleotide bindingi846 – 966121cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase nte1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:nte1
    ORF Names:ATEG_04807
    OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
    Taxonomic identifieri341663 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000007963: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15271527Lysophospholipase nte1PRO_0000295313Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi33178.CADATEAP00008780.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0CNC7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6969CytoplasmicBy similarityAdd
    BLAST
    Topological domaini91 – 11222LumenalBy similarityAdd
    BLAST
    Topological domaini134 – 15271394CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1224 – 1388165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1255 – 12595GXSXG

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi11 – 5242Ser-richAdd
    BLAST
    Compositional biasi55 – 6410Poly-Pro

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000048680.
    OMAiSPWTQTC.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0CNC7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADDGGPFPL SSSLLHASSS TTILESSSSS LLATSSPAIA ATFSSFSGRP     50
    SSYLPPPPLP PPAPSTMVGW IGWVFSFVFQ VIPSILYWAI TFCTITLPTW 100
    LFTLFSMSLT FTMNFTTLLL IALAIVSTVS WFIRYRFLNM YSRLPPEPQR 150
    KEPQLDLFPD VQEGDSKPGL ANYLDEFLSA IKVFGYLERP VFHELTRTMQ 200
    TRKLIAGETL LLEEEKGFCL VVDGLVQIFV KSIRDGKSPA DHELNLAGDD 250
    STDEEGQNVD GRQGYQLLTE VKNGASMSSL FSILSLFTED IQLRTSESLS 300
    SSVSSVGPNL ARVPDSSPSS PRGLVHSPVP VREPSESGHN LPTNGEFLPT 350
    VPPLHLEESR GTPDHDHQPE SRTRPGKKRR KSVHPDIVAR AMVDTTIAII 400
    PASAFRRLTR VYPRATAHIV QVILTRLQRV TFATAHSYLG LTNEVLGIEK 450
    QMTKFTTYDL PNDMRGAALD RLKDKFIKER DRLGHEEVTK GIALHNPSAG 500
    RRRRSSSFLR KEAALQARMA TTPRRPTATG SQENMSFHDR DAAGVSPGDL 550
    LSTIQLSRFG PRYEHLAPKI YSPLAEKEQS PFRPPTMRGP ASPFHRKESL 600
    DEDALFRESI LDCIMKALGL TSSTRDILRK SSHNSGDASP KLLSYDSRRQ 650
    KAVFSNNAFG FIDPYEGSVD GETESMMSMS VTSAGGTSPI VNLREELRND 700
    IEIVYFPQGS VLVEQGERHP GLYYVIDGFL DVGMPACDKG DDLVGATRPA 750
    HGEEAFPTLK RTTTASSRTS SVAPGGSDSK RRRQSRKSLY LIKPGGIQGY 800
    VGSVASYRSY TDVLAKTDVY VGFLPRASLE RIAERYPIAL LTLAKRLTSL 850
    LPRLLLHIDF ALEWVQVNAG QVIYHQGDES DAIYLVLNGR LRSVLEGTDG 900
    KMNVVGEYGQ GESVGELEVM TESTRPATLH AIRDTELAKF PRSLFNSLAQ 950
    EHPGITIQVS KLIAQRMRDL VERPMTEKGA EHGAGSIKTA TSTVNLRTVS 1000
    ILPVTAGVPV VEFGHRLLNA LHQIGVTNGV TSLNQAAILN HLGRHAFTKM 1050
    GKLKLSQYLA DLEEKYGMVL YIADTNVNSP WTQTCITQAD CILLVGLAES 1100
    TPSIGEYERF LLGMKTTSRK ELVLLHADRY CPPGLTRRWL KNRVWINGGH 1150
    HHIQMGFRLT AEPSHPQTKR FGTVLKERVQ VIQAEIQKYT SRRIHQTALY 1200
    SAQTPFKGDF HRLARRLCGR SVGLVLGGGG ARGIAQVGVI KALEEAGIPI 1250
    DIIGGTSIGA FNGALYARDA DVVPMYGRAK KFAGRMGSMW RFALDLTYPT 1300
    VSYTTGHEFN RGIFKTFGDS QIEDFWLEFY CNTTNISKSR PEYHSSGYVW 1350
    RYVRASMTLA GLIPPICDEG SMLLDGGYID NLTVPHMKGL GADVIFAVDV 1400
    GSIDDNTPQG YGDSLSGFWA TINRWNPFSS VPNPPTLSEI QARLAYVSSF 1450
    ENLEQAKTTP GCLYMRPPID PYGTLDFGKF DEIYQVGYKY GKEYLEKLKN 1500
    EGTLPLREET EEKKKLQRTL APRRASI 1527
    Length:1,527
    Mass (Da):168,858
    Last modified:October 17, 2006 - v1
    Checksum:iBD39EDE81FBB46C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476599 Genomic DNA. Translation: EAU35254.1.
    RefSeqiXP_001213985.1. XM_001213985.1.

    Genome annotation databases

    EnsemblFungiiCADATEAT00008780; CADATEAP00008780; CADATEAG00008780.
    GeneIDi4320057.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476599 Genomic DNA. Translation: EAU35254.1 .
    RefSeqi XP_001213985.1. XM_001213985.1.

    3D structure databases

    ProteinModelPortali Q0CNC7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33178.CADATEAP00008780.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADATEAT00008780 ; CADATEAP00008780 ; CADATEAG00008780 .
    GeneIDi 4320057.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000048680.
    OMAi SPWTQTC.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NIH 2624 / FGSC A1156.

    Entry informationi

    Entry nameiNTE1_ASPTN
    AccessioniPrimary (citable) accession number: Q0CNC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3