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Q0CMM0

- NCPR_ASPTN

UniProt

Q0CMM0 - NCPR_ASPTN

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Protein

NADPH--cytochrome P450 reductase

Gene

cprA

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis (By similarity).By similarity

Catalytic activityi

NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.By similarity

Cofactori

Protein has several cofactor binding sites:
  • FADBy similarity
  • FMNBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 765FMNBy similarityPROSITE-ProRule annotation
Nucleotide bindingi166 – 19732FMNBy similarityPROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi317 – 32812FADBy similarityAdd
BLAST
Nucleotide bindingi447 – 45812FADBy similarityAdd
BLAST
Nucleotide bindingi547 – 56519NADPBy similarityAdd
BLAST
Nucleotide bindingi642 – 65817NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. NADPH-hemoprotein reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. sterol biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

FAD, Flavoprotein, FMN, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH--cytochrome P450 reductaseImported (EC:1.6.2.4)
Short name:
CPRBy similarity
Short name:
P450RBy similarity
Gene namesi
Name:cprABy similarity
ORF Names:ATEG_05064
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Single-pass membrane protein By similarity. Cell membrane By similarity; Single-pass membrane protein By similarity. Microsome By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 3123HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695NADPH--cytochrome P450 reductasePRO_0000404331Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00003797.

Structurei

3D structure databases

ProteinModelPortaliQ0CMM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 221156Flavodoxin-likePROSITE-ProRule annotationAdd
BLAST
Domaini277 – 538262FAD-binding FR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.Sequence Analysis
Contains 1 FAD-binding FR-type domain.PROSITE-ProRule annotation
Contains 1 flavodoxin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0369.
HOGENOMiHOG000282027.
OMAiFLYREEW.
OrthoDBiEOG744TKC.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000208. P450R. 1 hit.
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0CMM0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLDTLDLV VLVVLLVGSA AYFTKGTYWA VPKDPYAASG PAMNGGAKAG
60 70 80 90 100
KSRDIIEKME ETGKNCVIFY GSQTGTAEDY ASRLAKEGSQ RFGLKTMVAD
110 120 130 140 150
LEDYDYENLD KFPEDKVAFF VMATYGEGEP TDNAVEFYQF ISGEDVAFES
160 170 180 190 200
GASADDKPLS SLKYVTFGLG NNTYEHYQAM VRNLDAALTK LGAQRIGDAG
210 220 230 240 250
EGDDGAGTME EDFLAWKEPM WTALSEAMNL QEREAVYEPV FSVTEDESLS
260 270 280 290 300
PEDEAVYLGE PTKGHRDGTP SGPYSAHNPF IAPIVESREL FNVKDRNCLH
310 320 330 340 350
MEISIAGSNL SYQTGDHIAI WPTNAGAEVD RFLQVFGLEN KRHSVINIKG
360 370 380 390 400
IDVTAKVPIP TPTTYDAAVR YYMEIAAPVS RQFVATLAAF APDEETKAEI
410 420 430 440 450
VRLGSDKDYF HEKISNQCFT IAQALQSVTS KPFSAVPFSL LIEGLNKLQP
460 470 480 490 500
RYYSISSSSM VQKDKISITA VVESTRLPGA AHLVKGVTTN YLLALKQKQN
510 520 530 540 550
GDPSPDPHGL TYTITGPRNK YDGIHVPVHV RHSNFKLPSD PSRPIIMVGP
560 570 580 590 600
GTGVAPFRGF IQERAALAAK GENVGPTVLF FGCRRRDEDF MYADEFKTYQ
610 620 630 640 650
EQLGDKLQII TAFSRETSQK VYVQHRLREH SDLVSSLLKQ KANFYVCGDA
660 670 680 690
ANMAREVNLV LGQIIAQQRG LPAERAEEMV KHMRSSGSYQ EDVWS
Length:695
Mass (Da):76,664
Last modified:October 17, 2006 - v1
Checksum:i7E536AF152337CCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476600 Genomic DNA. Translation: EAU34133.1.
RefSeqiXP_001214242.1. XM_001214242.1.

Genome annotation databases

EnsemblFungiiCADATEAT00003797; CADATEAP00003797; CADATEAG00003797.
GeneIDi4321140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476600 Genomic DNA. Translation: EAU34133.1 .
RefSeqi XP_001214242.1. XM_001214242.1.

3D structure databases

ProteinModelPortali Q0CMM0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00003797.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00003797 ; CADATEAP00003797 ; CADATEAG00003797 .
GeneIDi 4321140.

Phylogenomic databases

eggNOGi COG0369.
HOGENOMi HOG000282027.
OMAi FLYREEW.
OrthoDBi EOG744TKC.

Family and domain databases

Gene3Di 1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
InterProi IPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view ]
Pfami PF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF000208. P450R. 1 hit.
PRINTSi PR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMi SSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEi PS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiNCPR_ASPTN
AccessioniPrimary (citable) accession number: Q0CMM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: October 17, 2006
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3