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Q0CMM0 (NCPR_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADPH--cytochrome P450 reductase

Short name=CPR
Short name=P450R
EC=1.6.2.4
Gene names
Name:cprA
ORF Names:ATEG_05064
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length695 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis By similarity.

Catalytic activity

NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.

Cofactor

FAD By similarity.

FMN By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Cell membrane; Single-pass membrane protein By similarity. Microsome By similarity.

Sequence similarities

In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

Contains 1 FAD-binding FR-type domain.

Contains 1 flavodoxin-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 695695NADPH--cytochrome P450 reductase
PRO_0000404331

Regions

Transmembrane9 – 3123Helical; Potential
Domain66 – 221156Flavodoxin-like
Domain277 – 538262FAD-binding FR-type
Nucleotide binding72 – 765FMN By similarity
Nucleotide binding166 – 19732FMN By similarity
Nucleotide binding317 – 32812FAD By similarity
Nucleotide binding447 – 45812FAD By similarity
Nucleotide binding547 – 56519NADP By similarity
Nucleotide binding642 – 65817NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0CMM0 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 7E536AF152337CCE

FASTA69576,664
        10         20         30         40         50         60 
MAQLDTLDLV VLVVLLVGSA AYFTKGTYWA VPKDPYAASG PAMNGGAKAG KSRDIIEKME 

        70         80         90        100        110        120 
ETGKNCVIFY GSQTGTAEDY ASRLAKEGSQ RFGLKTMVAD LEDYDYENLD KFPEDKVAFF 

       130        140        150        160        170        180 
VMATYGEGEP TDNAVEFYQF ISGEDVAFES GASADDKPLS SLKYVTFGLG NNTYEHYQAM 

       190        200        210        220        230        240 
VRNLDAALTK LGAQRIGDAG EGDDGAGTME EDFLAWKEPM WTALSEAMNL QEREAVYEPV 

       250        260        270        280        290        300 
FSVTEDESLS PEDEAVYLGE PTKGHRDGTP SGPYSAHNPF IAPIVESREL FNVKDRNCLH 

       310        320        330        340        350        360 
MEISIAGSNL SYQTGDHIAI WPTNAGAEVD RFLQVFGLEN KRHSVINIKG IDVTAKVPIP 

       370        380        390        400        410        420 
TPTTYDAAVR YYMEIAAPVS RQFVATLAAF APDEETKAEI VRLGSDKDYF HEKISNQCFT 

       430        440        450        460        470        480 
IAQALQSVTS KPFSAVPFSL LIEGLNKLQP RYYSISSSSM VQKDKISITA VVESTRLPGA 

       490        500        510        520        530        540 
AHLVKGVTTN YLLALKQKQN GDPSPDPHGL TYTITGPRNK YDGIHVPVHV RHSNFKLPSD 

       550        560        570        580        590        600 
PSRPIIMVGP GTGVAPFRGF IQERAALAAK GENVGPTVLF FGCRRRDEDF MYADEFKTYQ 

       610        620        630        640        650        660 
EQLGDKLQII TAFSRETSQK VYVQHRLREH SDLVSSLLKQ KANFYVCGDA ANMAREVNLV 

       670        680        690 
LGQIIAQQRG LPAERAEEMV KHMRSSGSYQ EDVWS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476600 Genomic DNA. Translation: EAU34133.1.
RefSeqXP_001214242.1. XM_001214242.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33178.CADATEAP00003797.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADATEAT00003797; CADATEAP00003797; CADATEAG00003797.
GeneID4321140.

Phylogenomic databases

eggNOGCOG0369.
HOGENOMHOG000282027.
OMAKITGRHS.
OrthoDBEOG744TKC.

Family and domain databases

Gene3D1.20.990.10. 1 hit.
InterProIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PIRSFPIRSF000208. P450R. 1 hit.
PRINTSPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMSSF63380. SSF63380. 1 hit.
PROSITEPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNCPR_ASPTN
AccessionPrimary (citable) accession number: Q0CMM0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: October 17, 2006
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families