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Q0CMM0

- NCPR_ASPTN

UniProt

Q0CMM0 - NCPR_ASPTN

Protein

NADPH--cytochrome P450 reductase

Gene

cprA

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis By similarity.By similarity

    Catalytic activityi

    NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.By similarity

    Cofactori

    FAD.By similarity
    FMN.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi72 – 765FMNBy similarityPROSITE-ProRule annotation
    Nucleotide bindingi166 – 19732FMNBy similarityPROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi317 – 32812FADBy similarityAdd
    BLAST
    Nucleotide bindingi447 – 45812FADBy similarityAdd
    BLAST
    Nucleotide bindingi547 – 56519NADPBy similarityAdd
    BLAST
    Nucleotide bindingi642 – 65817NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. FMN binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. NADPH-hemoprotein reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. sterol biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    FAD, Flavoprotein, FMN, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADPH--cytochrome P450 reductaseImported (EC:1.6.2.4)
    Short name:
    CPRBy similarity
    Short name:
    P450RBy similarity
    Gene namesi
    Name:cprABy similarity
    ORF Names:ATEG_05064
    OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
    Taxonomic identifieri341663 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000007963: Unassembled WGS sequence

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass membrane protein By similarity. Cell membrane By similarity; Single-pass membrane protein By similarity. Microsome By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 695695NADPH--cytochrome P450 reductasePRO_0000404331Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi33178.CADATEAP00003797.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 3123HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini66 – 221156Flavodoxin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini277 – 538262FAD-binding FR-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.Sequence Analysis
    Contains 1 FAD-binding FR-type domain.PROSITE-ProRule annotation
    Contains 1 flavodoxin-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0369.
    HOGENOMiHOG000282027.
    OMAiFLYREEW.
    OrthoDBiEOG744TKC.

    Family and domain databases

    Gene3Di1.20.990.10. 1 hit.
    3.40.50.360. 1 hit.
    InterProiIPR003097. FAD-binding_1.
    IPR017927. Fd_Rdtase_FAD-bd.
    IPR001094. Flavdoxin.
    IPR008254. Flavodoxin/NO_synth.
    IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
    IPR029039. Flavoprotein-like.
    IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
    IPR001433. OxRdtase_FAD/NAD-bd.
    IPR023208. P450R.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view]
    PfamiPF00667. FAD_binding_1. 1 hit.
    PF00258. Flavodoxin_1. 1 hit.
    PF00175. NAD_binding_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000208. P450R. 1 hit.
    PRINTSiPR00369. FLAVODOXIN.
    PR00371. FPNCR.
    SUPFAMiSSF52218. SSF52218. 1 hit.
    SSF63380. SSF63380. 1 hit.
    PROSITEiPS51384. FAD_FR. 1 hit.
    PS50902. FLAVODOXIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0CMM0-1 [UniParc]FASTAAdd to Basket

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    MAQLDTLDLV VLVVLLVGSA AYFTKGTYWA VPKDPYAASG PAMNGGAKAG    50
    KSRDIIEKME ETGKNCVIFY GSQTGTAEDY ASRLAKEGSQ RFGLKTMVAD 100
    LEDYDYENLD KFPEDKVAFF VMATYGEGEP TDNAVEFYQF ISGEDVAFES 150
    GASADDKPLS SLKYVTFGLG NNTYEHYQAM VRNLDAALTK LGAQRIGDAG 200
    EGDDGAGTME EDFLAWKEPM WTALSEAMNL QEREAVYEPV FSVTEDESLS 250
    PEDEAVYLGE PTKGHRDGTP SGPYSAHNPF IAPIVESREL FNVKDRNCLH 300
    MEISIAGSNL SYQTGDHIAI WPTNAGAEVD RFLQVFGLEN KRHSVINIKG 350
    IDVTAKVPIP TPTTYDAAVR YYMEIAAPVS RQFVATLAAF APDEETKAEI 400
    VRLGSDKDYF HEKISNQCFT IAQALQSVTS KPFSAVPFSL LIEGLNKLQP 450
    RYYSISSSSM VQKDKISITA VVESTRLPGA AHLVKGVTTN YLLALKQKQN 500
    GDPSPDPHGL TYTITGPRNK YDGIHVPVHV RHSNFKLPSD PSRPIIMVGP 550
    GTGVAPFRGF IQERAALAAK GENVGPTVLF FGCRRRDEDF MYADEFKTYQ 600
    EQLGDKLQII TAFSRETSQK VYVQHRLREH SDLVSSLLKQ KANFYVCGDA 650
    ANMAREVNLV LGQIIAQQRG LPAERAEEMV KHMRSSGSYQ EDVWS 695
    Length:695
    Mass (Da):76,664
    Last modified:October 17, 2006 - v1
    Checksum:i7E536AF152337CCE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476600 Genomic DNA. Translation: EAU34133.1.
    RefSeqiXP_001214242.1. XM_001214242.1.

    Genome annotation databases

    EnsemblFungiiCADATEAT00003797; CADATEAP00003797; CADATEAG00003797.
    GeneIDi4321140.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476600 Genomic DNA. Translation: EAU34133.1 .
    RefSeqi XP_001214242.1. XM_001214242.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33178.CADATEAP00003797.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADATEAT00003797 ; CADATEAP00003797 ; CADATEAG00003797 .
    GeneIDi 4321140.

    Phylogenomic databases

    eggNOGi COG0369.
    HOGENOMi HOG000282027.
    OMAi FLYREEW.
    OrthoDBi EOG744TKC.

    Family and domain databases

    Gene3Di 1.20.990.10. 1 hit.
    3.40.50.360. 1 hit.
    InterProi IPR003097. FAD-binding_1.
    IPR017927. Fd_Rdtase_FAD-bd.
    IPR001094. Flavdoxin.
    IPR008254. Flavodoxin/NO_synth.
    IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
    IPR029039. Flavoprotein-like.
    IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
    IPR001433. OxRdtase_FAD/NAD-bd.
    IPR023208. P450R.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view ]
    Pfami PF00667. FAD_binding_1. 1 hit.
    PF00258. Flavodoxin_1. 1 hit.
    PF00175. NAD_binding_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000208. P450R. 1 hit.
    PRINTSi PR00369. FLAVODOXIN.
    PR00371. FPNCR.
    SUPFAMi SSF52218. SSF52218. 1 hit.
    SSF63380. SSF63380. 1 hit.
    PROSITEi PS51384. FAD_FR. 1 hit.
    PS50902. FLAVODOXIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NIH 2624 / FGSC A1156.

    Entry informationi

    Entry nameiNCPR_ASPTN
    AccessioniPrimary (citable) accession number: Q0CMM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 8, 2011
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3