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Q0CMM0

- NCPR_ASPTN

UniProt

Q0CMM0 - NCPR_ASPTN

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Protein
NADPH--cytochrome P450 reductase
Gene
cprA, ATEG_05064
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis By similarity.

Catalytic activityi

NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.

Cofactori

FAD By similarity.
FMN By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 765FMN By similarity
Nucleotide bindingi166 – 19732FMN By similarity
Add
BLAST
Nucleotide bindingi317 – 32812FAD By similarity
Add
BLAST
Nucleotide bindingi447 – 45812FAD By similarity
Add
BLAST
Nucleotide bindingi547 – 56519NADP By similarity
Add
BLAST
Nucleotide bindingi642 – 65817NADP By similarity
Add
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. NADPH-hemoprotein reductase activity Source: UniProtKB-EC
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. sterol biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

FAD, Flavoprotein, FMN, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH--cytochrome P450 reductase (EC:1.6.2.4)
Short name:
CPR
Short name:
P450R
Gene namesi
Name:cprA
ORF Names:ATEG_05064
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 3123Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695NADPH--cytochrome P450 reductase
PRO_0000404331Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00003797.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 221156Flavodoxin-like
Add
BLAST
Domaini277 – 538262FAD-binding FR-type
Add
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0369.
HOGENOMiHOG000282027.
OMAiFLYREEW.
OrthoDBiEOG744TKC.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000208. P450R. 1 hit.
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0CMM0-1 [UniParc]FASTAAdd to Basket

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MAQLDTLDLV VLVVLLVGSA AYFTKGTYWA VPKDPYAASG PAMNGGAKAG    50
KSRDIIEKME ETGKNCVIFY GSQTGTAEDY ASRLAKEGSQ RFGLKTMVAD 100
LEDYDYENLD KFPEDKVAFF VMATYGEGEP TDNAVEFYQF ISGEDVAFES 150
GASADDKPLS SLKYVTFGLG NNTYEHYQAM VRNLDAALTK LGAQRIGDAG 200
EGDDGAGTME EDFLAWKEPM WTALSEAMNL QEREAVYEPV FSVTEDESLS 250
PEDEAVYLGE PTKGHRDGTP SGPYSAHNPF IAPIVESREL FNVKDRNCLH 300
MEISIAGSNL SYQTGDHIAI WPTNAGAEVD RFLQVFGLEN KRHSVINIKG 350
IDVTAKVPIP TPTTYDAAVR YYMEIAAPVS RQFVATLAAF APDEETKAEI 400
VRLGSDKDYF HEKISNQCFT IAQALQSVTS KPFSAVPFSL LIEGLNKLQP 450
RYYSISSSSM VQKDKISITA VVESTRLPGA AHLVKGVTTN YLLALKQKQN 500
GDPSPDPHGL TYTITGPRNK YDGIHVPVHV RHSNFKLPSD PSRPIIMVGP 550
GTGVAPFRGF IQERAALAAK GENVGPTVLF FGCRRRDEDF MYADEFKTYQ 600
EQLGDKLQII TAFSRETSQK VYVQHRLREH SDLVSSLLKQ KANFYVCGDA 650
ANMAREVNLV LGQIIAQQRG LPAERAEEMV KHMRSSGSYQ EDVWS 695
Length:695
Mass (Da):76,664
Last modified:October 17, 2006 - v1
Checksum:i7E536AF152337CCE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476600 Genomic DNA. Translation: EAU34133.1.
RefSeqiXP_001214242.1. XM_001214242.1.

Genome annotation databases

EnsemblFungiiCADATEAT00003797; CADATEAP00003797; CADATEAG00003797.
GeneIDi4321140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476600 Genomic DNA. Translation: EAU34133.1 .
RefSeqi XP_001214242.1. XM_001214242.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00003797.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00003797 ; CADATEAP00003797 ; CADATEAG00003797 .
GeneIDi 4321140.

Phylogenomic databases

eggNOGi COG0369.
HOGENOMi HOG000282027.
OMAi FLYREEW.
OrthoDBi EOG744TKC.

Family and domain databases

Gene3Di 1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
InterProi IPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view ]
Pfami PF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF000208. P450R. 1 hit.
PRINTSi PR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMi SSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEi PS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiNCPR_ASPTN
AccessioniPrimary (citable) accession number: Q0CMM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi